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Also known as: Salbutamol sulfate, 51022-70-9, Salbutamol hemisulfate, Proventil, Venetlin, Loftan
Molecular Formula
C26H44N2O10S
Molecular Weight
576.7  g/mol
InChI Key
BNPSSFBOAGDEEL-UHFFFAOYSA-N
FDA UNII
021SEF3731

Salbutamol Sulphate
A short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat ASTHMA. Albuterol is prepared as a racemic mixture of R(-) and S(+) stereoisomers. The stereospecific preparation of R(-) isomer of albuterol is referred to as levalbuterol.
1 2D Structure

Salbutamol Sulphate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-[2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol;sulfuric acid
2.1.2 InChI
InChI=1S/2C13H21NO3.H2O4S/c2*1-13(2,3)14-7-12(17)9-4-5-11(16)10(6-9)8-15;1-5(2,3)4/h2*4-6,12,14-17H,7-8H2,1-3H3;(H2,1,2,3,4)
2.1.3 InChI Key
BNPSSFBOAGDEEL-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC(C)(C)NCC(C1=CC(=C(C=C1)O)CO)O.CC(C)(C)NCC(C1=CC(=C(C=C1)O)CO)O.OS(=O)(=O)O
2.2 Other Identifiers
2.2.1 UNII
021SEF3731
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 2-t-butylamino-1-(4-hydroxy-3-hydroxy-3-hydroxymethyl)phenylethanol

2. Albuterol

3. Proventil

4. Salbutamol

5. Sultanol

6. Ventolin

2.3.2 Depositor-Supplied Synonyms

1. Salbutamol Sulfate

2. 51022-70-9

3. Salbutamol Hemisulfate

4. Proventil

5. Venetlin

6. Loftan

7. Albuterol Hemisulfate

8. Bronchospray

9. Ventolin

10. Accuneb

11. Proventil-hfa

12. Salbutamol Sulphate

13. Sch 13949w Sulfate

14. Proair

15. Ventolin Rotacaps

16. Proair Respiclick

17. Vospire Er

18. Sultanol

19. Ventilastin

20. Ecovent

21. Salbumol

22. Vospire

23. Albuterol Sulfate(2:1)

24. Albuterol Sulphate

25. 36519-31-0

26. Buventol

27. Salamol

28. Salbutamol (as Sulfate)

29. Sch 13949w Sulphate

30. Sch-13949w Sulphate

31. Sulbutamol (as Sulphate)

32. Sch-13949w Sulfate

33. 4-[2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol;sulfuric Acid

34. R03ac02

35. R03cc02

36. Aerolin

37. Airomir

38. 021sef3731

39. Nsc-289928

40. Aerotec

41. Aloprol

42. Amocasin

43. Broncodil

44. Dipulmin

45. Fartolin

46. Inspiryl

47. Emican

48. Proventil (tn)

49. Epaq

50. Broncho Inhalat

51. Huma-salmol

52. Ventolin Hfa

53. Dl-salbutamol Sulfate

54. (+-)-salbutamol Sulfate

55. 2-(tert-butylamino)-1-(4-hydroxy-3-hydroxymethylphenyl)ethanol Hemisulfate

56. 5-[2-(tert-butylamino)-1-hydroxyethyl]-2-hydroxybenzyl Alcohol Hemisulfate

57. Albuterol Sulfate [usan]

58. Proair Hfa

59. Ah-3365

60. Einecs 256-916-8

61. Salbutamol Hemisulfate Salt

62. Nsc 289928

63. Accuvent

64. Pediavent

65. Torpex

66. Volare

67. Albuterol Sulfate [usan:usp]

68. Ventolin Nebules

69. Ventolin Sulfate

70. Unii-021sef3731

71. Salbutamol Diskus

72. Salbutamoli Sulfas

73. Buventol Easyhaler

74. Proventil Repetabs

75. Pulvinal Salbutamol

76. Sulbutamol Sulphate

77. Proventil Repetabs, Solution, Syrup, And Tablets

78. Ventolin (tn)

79. Accuneb (tn)

80. Salbutamol Easyhaler

81. Ventolin Easy-breathe

82. Albuterol Sulfate,(s)

83. Albuterol Sulfate (usp)

84. Albuterol Sulfate- Bio-x

85. 1-(4-hydroxy-3-hydroxymethylphenyl)-2-(tert-butylamino)ethanol Sulfate

86. Salbutamol Sulfate (jp17)

87. Tbs-7

88. Schembl33279

89. Alpha(sup 1)-((tert-butylamino)methyl)-4-hydroxy-m-xylene-alpha,alpha'-diol Sulfate (2:1) (salt)

90. Albuterol Sulfate [mi]

91. Chebi:2550

92. (+-)-ysulfate(2:1)(salt)

93. Chembl1441059

94. Salbutamol Sulfate [jan]

95. Albuterol Sulfate [vandf]

96. Dtxsid10881180

97. Hms3263k18

98. Hms3266d17

99. Torpex (albuterol Sulfate)

100. Albuterol Sulfate [usp-rs]

101. Salbutamol Sulfate [mart.]

102. Bis((tert-butyl)(beta,3,4-trihydroxyphenethyl)ammonium) Sulphate

103. Salbutamol Sulfate [who-dd]

104. Salbutamol Sulfate [who-ip]

105. Tox21_501098

106. Mfcd00055200

107. Salbutamol Hemisulfate Salt, >=98%

108. Akos015994719

109. Albuterol Sulfate [green Book]

110. Albuterol Sulfate [orange Book]

111. Ccg-222402

112. Ks-5056

113. Lp01098

114. Tq-1016

115. Albuterol Sulfate [usp Impurity]

116. Salbutamol Sulfate [ep Impurity]

117. Salbutamol Sulphate (albuterol Sulphate)

118. Albuterol Sulfate [usp Monograph]

119. Duoneb Component Albuterol Sulfate

120. Ncgc00094370-01

121. Ncgc00261783-01

122. Salbutamol Sulfate [ep Monograph]

123. 1,3-benzenedimethanol, Alpha(sup 1)-(((1,1-dimethylethyl)amino)methyl)-4-hydroxy-, Sulfate (2:1) (salt)

124. 1,3-benzenedimethanol, Alpha1-(((1,1-dimethylethyl)amino)methyl)-4-hydroxy-, Sulfate (2:1) (salt)

125. Ba164388

126. Salbutamoli Sulfas [who-ip Latin]

127. Combivent Component Albuterol Sulfate

128. Albuterol Sulfate Component Of Duoneb

129. Eu-0101098

130. Ft-0650809

131. S0531

132. Salbutamol Sulfate 100 Microg/ml In Methanol

133. A51088

134. Albuterol Sulfate Component Of Combivent

135. D00683

136. S 5013

137. 022s709

138. A828402

139. Q27231480

140. Salbutamol Hemisulfate Salt, Vetranal(tm), Analytical Standard

141. Salbutamol Sulfate, British Pharmacopoeia (bp) Reference Standard

142. Salbutamol Sulfate, European Pharmacopoeia (ep) Reference Standard

143. Albuterol Sulfate, United States Pharmacopeia (usp) Reference Standard

144. Albuterol Sulfate, Pharmaceutical Secondary Standard; Certified Reference Material

145. Salbutamol Sulfate For System Suitability, European Pharmacopoeia (ep) Reference Standard

146. Salbutamol Sulphate (albuterol Sulphate) 1.0 Mg/ml In Methanol (as Free Base)

147. (+/-)-2-tert-butylamino-1-(4-hydroxy-3-hydroxymethylphenyl)ethanol Sulfate Salt (2:1)

148. .alpha.(sup 1)-((tert-butylamino)methyl)-4-hydroxy-m-xylene-.alpha.,.alpha.'-diol Sulfate (2:1) (salt)

149. .alpha.(sup 1)-((tert-butylamino)methyl)-4-hydroxy-m-xylene-.alpha.,.alpha.'-diol Sulphate (2:1) (salt)

150. 1,3-benzenedimethanol,.alpha.(sup 1)-(((1,1 Dimethylethyl)amino)methyl)-4-hydroxy-, Sulfate (2:1) (salt)

151. 1,3-benzenedimethanol,.alpha.(sup 1)-(((1,1 Dimethylethyl)amino)methyl)-4-hydroxy-, Sulphate (2:1) (salt)

152. 1,3-benzenedimethanol,.alpha.1-(((1,1-dimethylethyl)amino)methyl)-4-hydroxy-, Sulfate (2:1) (salt)

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 576.7 g/mol
Molecular Formula C26H44N2O10S
Hydrogen Bond Donor Count10
Hydrogen Bond Acceptor Count12
Rotatable Bond Count10
Exact Mass576.27166678 g/mol
Monoisotopic Mass576.27166678 g/mol
Topological Polar Surface Area228 Ų
Heavy Atom Count39
Formal Charge0
Complexity309
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count2
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3
4 Drug and Medication Information
4.1 Drug Information
1 of 12  
Drug NameAccuneb
PubMed HealthAlbuterol (By breathing)
Drug ClassesBronchodilator
Drug LabelAlbuterol Sulfate Inhalation Solution is a relatively selective beta2-adrenergic bronchodilator (see CLINICAL PHARMACOLOGY section below). Albuterol sulfate, the racemic form of albuterol, has the chemical name 1-[(tert-Butylamino)methyl]-4-hydroxy...
Active IngredientAlbuterol sulfate
Dosage FormSolution
RouteInhalation
Strengtheq 0.021% base; eq 0.042% base
Market StatusPrescription
CompanyMylan Speclt

2 of 12  
Drug NameAlbuterol sulfate
PubMed HealthAlbuterol
Drug ClassesBronchodilator, Cardiovascular Agent
Drug LabelThe active component of VENTOLIN HFA is albuterol sulfate, USP, the racemic form of albuterol and a relatively selective beta2-adrenergic bronchodilator. Albuterol sulfate has the chemical name 1-[(tert-butylamino)methyl]-4-hydroxy-m-xylene-,...
Active IngredientAlbuterol sulfate
Dosage FormTablet, extended release; Tablet; Syrup; Solution
RouteInhalation; Oral
Strengtheq 4mg base; eq 0.083% base; eq 2mg base; eq 0.021% base; eq 0.5% base; eq 2mg base/5ml; eq 0.042% base; eq 8mg base
Market StatusPrescription
CompanyWatson Labs; Amneal Pharms; Vistapharm; Teva Pharms; Hi Tech Pharma; Ritedose; Actavis Mid Atlantic; Mutual Pharm; Teva; Vintage; Bausch And Lomb; Landela Pharm; Nephron; Mylan Speclt; Mylan

3 of 12  
Drug NameProair hfa
Active IngredientAlbuterol sulfate
Dosage FormAerosol, metered
RouteInhalation
Strengtheq 0.09mg base/inh
Market StatusPrescription
CompanyTeva Branded Pharm

4 of 12  
Drug NameProventil-hfa
Active IngredientAlbuterol sulfate
Dosage FormAerosol, metered
RouteInhalation
Strengtheq 0.09mg base/inh
Market StatusPrescription
Company3m

5 of 12  
Drug NameVentolin hfa
Drug LabelAlbuterol extended-release tablets contain albuterol sulfate, the racemic form of albuterol and a relatively selective beta2-adrenergic bronchodilator, in an extended-release formulation. Albuterol sulfate has the chemical name () 1-[(tert-butyla...
Active IngredientAlbuterol sulfate
Dosage FormAerosol, metered
RouteInhalation
Strengtheq 0.09mg base/inh
Market StatusPrescription
CompanyGlaxo Grp

6 of 12  
Drug NameVospire er
Drug LabelThe active ingredient of PROAIR HFA (albuterol sulfate) Inhalation Aerosol is albuterol sulfate, a racemic salt, of albuterol. Albuterol sulfate has the chemical name 1-[(tert-butylamino) methyl]-4-hydroxy-m-xylene-,'-diol sulfate (2:1) (salt),...
Active IngredientAlbuterol sulfate
Dosage FormTablet, extended release
RouteOral
Strengtheq 4mg base; eq 8mg base
Market StatusPrescription
CompanyDava Pharms

7 of 12  
Drug NameAccuneb
PubMed HealthAlbuterol (By breathing)
Drug ClassesBronchodilator
Drug LabelAlbuterol Sulfate Inhalation Solution is a relatively selective beta2-adrenergic bronchodilator (see CLINICAL PHARMACOLOGY section below). Albuterol sulfate, the racemic form of albuterol, has the chemical name 1-[(tert-Butylamino)methyl]-4-hydroxy...
Active IngredientAlbuterol sulfate
Dosage FormSolution
RouteInhalation
Strengtheq 0.021% base; eq 0.042% base
Market StatusPrescription
CompanyMylan Speclt

8 of 12  
Drug NameAlbuterol sulfate
PubMed HealthAlbuterol
Drug ClassesBronchodilator, Cardiovascular Agent
Drug LabelThe active component of VENTOLIN HFA is albuterol sulfate, USP, the racemic form of albuterol and a relatively selective beta2-adrenergic bronchodilator. Albuterol sulfate has the chemical name 1-[(tert-butylamino)methyl]-4-hydroxy-m-xylene-,...
Active IngredientAlbuterol sulfate
Dosage FormTablet, extended release; Tablet; Syrup; Solution
RouteInhalation; Oral
Strengtheq 4mg base; eq 0.083% base; eq 2mg base; eq 0.021% base; eq 0.5% base; eq 2mg base/5ml; eq 0.042% base; eq 8mg base
Market StatusPrescription
CompanyWatson Labs; Amneal Pharms; Vistapharm; Teva Pharms; Hi Tech Pharma; Ritedose; Actavis Mid Atlantic; Mutual Pharm; Teva; Vintage; Bausch And Lomb; Landela Pharm; Nephron; Mylan Speclt; Mylan

9 of 12  
Drug NameProair hfa
Active IngredientAlbuterol sulfate
Dosage FormAerosol, metered
RouteInhalation
Strengtheq 0.09mg base/inh
Market StatusPrescription
CompanyTeva Branded Pharm

10 of 12  
Drug NameProventil-hfa
Active IngredientAlbuterol sulfate
Dosage FormAerosol, metered
RouteInhalation
Strengtheq 0.09mg base/inh
Market StatusPrescription
Company3m

11 of 12  
Drug NameVentolin hfa
Drug LabelAlbuterol extended-release tablets contain albuterol sulfate, the racemic form of albuterol and a relatively selective beta2-adrenergic bronchodilator, in an extended-release formulation. Albuterol sulfate has the chemical name () 1-[(tert-butyla...
Active IngredientAlbuterol sulfate
Dosage FormAerosol, metered
RouteInhalation
Strengtheq 0.09mg base/inh
Market StatusPrescription
CompanyGlaxo Grp

12 of 12  
Drug NameVospire er
Drug LabelThe active ingredient of PROAIR HFA (albuterol sulfate) Inhalation Aerosol is albuterol sulfate, a racemic salt, of albuterol. Albuterol sulfate has the chemical name 1-[(tert-butylamino) methyl]-4-hydroxy-m-xylene-,'-diol sulfate (2:1) (salt),...
Active IngredientAlbuterol sulfate
Dosage FormTablet, extended release
RouteOral
Strengtheq 4mg base; eq 8mg base
Market StatusPrescription
CompanyDava Pharms

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Adrenergic beta-2 Receptor Agonists

Compounds bind to and activate ADRENERGIC BETA-2 RECEPTORS. (See all compounds classified as Adrenergic beta-2 Receptor Agonists.)


Tocolytic Agents

Drugs that prevent preterm labor and immature birth by suppressing uterine contractions (TOCOLYSIS). Agents used to delay premature uterine activity include magnesium sulfate, beta-mimetics, oxytocin antagonists, calcium channel inhibitors, and adrenergic beta-receptor agonists. The use of intravenous alcohol as a tocolytic is now obsolete. (See all compounds classified as Tocolytic Agents.)


Bronchodilator Agents

Agents that cause an increase in the expansion of a bronchus or bronchial tubes. (See all compounds classified as Bronchodilator Agents.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
beta2-Adrenergic Agonist [EPC]; Adrenergic beta2-Agonists [MoA]

API Reference Price

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02-Jan-2021
30-Sep-2024
KGS
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DOSAGE - AEROSOL, METERED;INHALATION - EQ 0.0...DOSAGE - AEROSOL, METERED;INHALATION - EQ 0.09MG BASE/INH

USFDA APPLICATION NUMBER - 20503

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DOSAGE - SOLUTION;INHALATION - EQ 0.083% BASE...DOSAGE - SOLUTION;INHALATION - EQ 0.083% BASE;0.017% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 20950

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DOSAGE - AEROSOL, METERED;INHALATION - EQ 0.0...DOSAGE - AEROSOL, METERED;INHALATION - EQ 0.09MG BASE/INH

USFDA APPLICATION NUMBER - 20983

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DOSAGE - AEROSOL, METERED;INHALATION - EQ 0.0...DOSAGE - AEROSOL, METERED;INHALATION - EQ 0.09MG BASE/INH

USFDA APPLICATION NUMBER - 21457

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SPI Pharma

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Virtual BoothSPI Pharma has been solving formulation challenges using superior functional materials.

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DKSH

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