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    Also known as: 5875-06-9, Proparacaine hcl, Proxymetacaine hydrochloride, Alcaine, 2-(diethylamino)ethyl 3-amino-4-propoxybenzoate hydrochloride, Proparacaine, hcl
    Molecular Formula
    C16H27ClN2O3
    Molecular Weight
    330.8  g/mol
    InChI Key
    BFUUJUGQJUTPAF-UHFFFAOYSA-N
    FDA UNII
    U96OL57GOY
    Proparacaine hydrochloride
    Proparacaine Hydrochloride is the hydrochloride salt form of proparacaine, a benzoic acid derivative with local anesthetic property. Proparacaine hydrochloride stabilizes the neuronal membrane by binding to and inhibiting voltage-gated sodium channels, thereby inhibiting sodium ion influx required for the initiation and conduction of impulses within the neuronal cell, and resulting in a loss of sensation.
    1 2D Structure

    Proparacaine hydrochloride

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-(diethylamino)ethyl 3-amino-4-propoxybenzoate;hydrochloride
    2.1.2 InChI
    InChI=1S/C16H26N2O3.ClH/c1-4-10-20-15-8-7-13(12-14(15)17)16(19)21-11-9-18(5-2)6-3;/h7-8,12H,4-6,9-11,17H2,1-3H3;1H
    2.1.3 InChI Key
    BFUUJUGQJUTPAF-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CCCOC1=C(C=C(C=C1)C(=O)OCCN(CC)CC)N.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    U96OL57GOY
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 2-(diethylamino)ethyl 3-amino-4-propoxybenzoate

    2. 2-(diethylamino)ethyl 3-amino-4-propoxybenzoate Monohydrochloride

    3. Ak-taine

    4. Alcaine

    5. Benzoic Acid, 3-amino-4-propoxy-, 2-(diethylamino)ethyl Ester

    6. Benzoic Acid, 3-amino-4-propoxy-, 2-(diethylamino)ethyl Ester, Monohydrochloride*benzoic Acid, 3-amino-4-propoxy-, 2-(diethylamino)ethyl Ester, Monohydrochloride

    7. Chibro-kerakain

    8. Kracaine

    9. Kainair

    10. Minims Proxymetacaine Hydrochloride

    11. Ocu-caine

    12. Ophthaine

    13. Ophthetic

    14. Parcaine

    15. Proparacaine

    16. Proparacaine Hcl

    17. Proparakain-pos

    18. Proxymetacaine

    19. Proxymetacaine Hydrochloride

    20. Proxymetacaine Monohydrochloride

    21. Proxymethacaine

    2.3.2 Depositor-Supplied Synonyms

    1. 5875-06-9

    2. Proparacaine Hcl

    3. Proxymetacaine Hydrochloride

    4. Alcaine

    5. 2-(diethylamino)ethyl 3-amino-4-propoxybenzoate Hydrochloride

    6. Proparacaine, Hcl

    7. Ophthaine

    8. Ak-taine

    9. Proparacaine (hydrochloride)

    10. Kainair

    11. Ophthetic

    12. 2-(diethylamino)ethyl 3-amino-4-propoxybenzoate;hydrochloride

    13. Nsc-759896

    14. U96ol57goy

    15. Dsstox_cid_28948

    16. Dsstox_rid_83213

    17. Dsstox_gsid_49022

    18. Proparacaine Hydrochloride (usp)

    19. Proparacaine Hydrochloride [usp]

    20. Ophthain

    21. 2-(diethylamino)ethyl 3-amino-4-propoxybenzoate Monohydrochloride

    22. Benzoic Acid, 3-amino-4-propoxy-, 2-(diethylamino)ethyl Ester, Monohydrochloride

    23. Smr000875264

    24. Cas-5875-06-9

    25. Ncgc00016991-03

    26. Mfcd00083467

    27. Keracaine

    28. Chibro-heracaine

    29. Ophthetic (tn)

    30. Alcaine (tn)

    31. Proparacainehydrochloride

    32. Benzoic Acid, 3-amino-4-propoxy-, 2-(diethylamino)ethyl Ester, Hydrochloride

    33. Unii-u96ol57goy

    34. Schembl93880

    35. Mls001333067

    36. Mls001333068

    37. Mls002154072

    38. Chembl1200464

    39. Dtxsid0049022

    40. 2-diethylaminoethyl 3-amino-4-propoxybenzoate Hydrochloride

    41. Hms1570p20

    42. Pharmakon1600-01505688

    43. Einecs 227-541-7

    44. Tox21_113547

    45. Nsc759896

    46. S1828

    47. Akos015844989

    48. Tox21_113547_1

    49. Ac-3399

    50. Ccg-213513

    51. Ks-5058

    52. Nc00586

    53. Nsc 759896

    54. Proparacaine Hydrochloride [mi]

    55. Benzoic Acid, 3-amino-4-propoxy-, 2-(diethylamino)ethyl Ester,monohydrochloride

    56. Ncgc00016991-05

    57. Hy-66012

    58. Proparacaine Hydrochloride [vandf]

    59. Proxymetacaine Hydrochloride, Proparacaine

    60. Proparacaine Hydrochloride [usp-rs]

    61. Proxymetacaine Hydrochloride [mart.]

    62. P2156

    63. Proxymetacaine Hydrochloride [who-dd]

    64. Sw197338-3

    65. Proparacaine Hydrochloride, Analytical Standard

    66. C75748

    67. D02098

    68. Proparacaine Hydrochloride [green Book]

    69. Proparacaine Hydrochloride [orange Book]

    70. 875p069

    71. A832009

    72. Proparacaine Hydrochloride [usp Monograph]

    73. 2-(diethylamino)ethyl 3-amino-4-propoxybenzoate Hcl

    74. Sr-05000001759-3

    75. Q27290947

    76. 2-diethylaminoethyl3-amino-4-propoxy-benzoatehydrochloride

    77. Benzoic Acid,3-amino-4-propoxy-,2-(diethylamino)ethyl Ester

    78. Beta-(diethylamino)ethyl 3-amino-4-n-propoxybenzoate Hydrochloride

    79. 3-amino-4-propoxybenzoic Acid 2-(diethylamino)ethyl Ester Hydrochloride

    80. 2-(diethylamino)ethyl 3-amino-4-propoxy-benzoate Hydrochloride;proparacaine Hcl

    81. Proparacaine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

    2.4 Create Date
    2005-03-27
    3 Chemical and Physical Properties
    Molecular Weight 330.8 g/mol
    Molecular Formula C16H27ClN2O3
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count5
    Rotatable Bond Count10
    Exact Mass330.1710204 g/mol
    Monoisotopic Mass330.1710204 g/mol
    Topological Polar Surface Area64.8 Ų
    Heavy Atom Count22
    Formal Charge0
    Complexity295
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameProparacaine hydrochloride
    Drug LabelALCAINE (proparacaine hydrochloride ophthalmic solution, USP) 0.5% is a topical local anesthetic for ophthalmic use. The active ingredient is represented by the structural formula:Established name:Proparacaine Hydrochloride Chemical name:Benzoic ac...
    Active IngredientProparacaine hydrochloride
    Dosage FormSolution/drops
    RouteOphthalmic
    Strength0.5%
    Market StatusPrescription
    CompanyBausch And Lomb; Akorn

    2 of 2  
    Drug NameProparacaine hydrochloride
    Drug LabelALCAINE (proparacaine hydrochloride ophthalmic solution, USP) 0.5% is a topical local anesthetic for ophthalmic use. The active ingredient is represented by the structural formula:Established name:Proparacaine Hydrochloride Chemical name:Benzoic ac...
    Active IngredientProparacaine hydrochloride
    Dosage FormSolution/drops
    RouteOphthalmic
    Strength0.5%
    Market StatusPrescription
    CompanyBausch And Lomb; Akorn

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Anesthetics, Local

    Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate. (See all compounds classified as Anesthetics, Local.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Local Anesthetic [EPC]; Local Anesthesia [PE]

    API Reference Price

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PLC","customerCountry":"BANGLADESH","quantity":"0.50","actualQuantity":"500","unit":"GMS","unitRateFc":"5","totalValueFC":"2410.4","currency":"N\/A","unitRateINR":419.23559999999998,"date":"26-Feb-2025","totalValueINR":"209617.8","totalValueInUsd":"2410.4","indian_port":"Bombay Air","hs_no":"29225013","bill_no":"8510245","productDescription":"API","marketType":"","country":"BANGLADESH","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"206, ERIC HOUSE, 16TH ROAD,, MUMBAI, MAHARASHTRA.","customerAddress":""},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1716748200,"product":"200872 PROPARACAINE HYDROCHLORIDE HCI USP\/BP","address":"208, OKHLA INDUSTRIAL ESTATE,,PHAS","city":"NEW DELHI,DELHI","supplier":"SIEGFRIED AG","supplierCountry":"SWITZERLAND","foreign_port":"ZURICH","customer":"MANKIND PHARMA","customerCountry":"INDIA","quantity":"25.00","actualQuantity":"25","unit":"KGS","unitRateFc":"6240","totalValueFC":"176953.4","currency":"CHF","unitRateINR":"589992","date":"27-May-2024","totalValueINR":"14749800","totalValueInUsd":"176953.4","indian_port":"Delhi Air","hs_no":"29225090","bill_no":"3688552","productDescription":"API","marketType":"REGULATED MARKET","country":"SWITZERLAND","selfForZScoreResived":"Pharma Grade","supplierPort":"ZURICH","supplierAddress":"UNTERE BRUHLSTRASSE44800 ZOFINGENSDNF SWITZERLAND","customerAddress":"208, OKHLA INDUSTRIAL ESTATE,,PHAS"}]
    03-Aug-2021
    26-Feb-2025
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    ABOUT THIS PAGE

    Looking for 5875-06-9 / Proparacaine hydrochloride API manufacturers, exporters & distributors?

    Proparacaine hydrochloride manufacturers, exporters & distributors 1

    25

    PharmaCompass offers a list of Proparacaine hydrochloride API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Proparacaine hydrochloride manufacturer or Proparacaine hydrochloride supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Proparacaine hydrochloride manufacturer or Proparacaine hydrochloride supplier.

    PharmaCompass also assists you with knowing the Proparacaine hydrochloride API Price utilized in the formulation of products. Proparacaine hydrochloride API Price is not always fixed or binding as the Proparacaine hydrochloride Price is obtained through a variety of data sources. The Proparacaine hydrochloride Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Proparacaine hydrochloride

    Synonyms

    5875-06-9, Proparacaine hcl, Proxymetacaine hydrochloride, Alcaine, 2-(diethylamino)ethyl 3-amino-4-propoxybenzoate hydrochloride, Proparacaine, hcl

    Cas Number

    5875-06-9

    Unique Ingredient Identifier (UNII)

    U96OL57GOY

    About Proparacaine hydrochloride

    Proparacaine Hydrochloride is the hydrochloride salt form of proparacaine, a benzoic acid derivative with local anesthetic property. Proparacaine hydrochloride stabilizes the neuronal membrane by binding to and inhibiting voltage-gated sodium channels, thereby inhibiting sodium ion influx required for the initiation and conduction of impulses within the neuronal cell, and resulting in a loss of sensation.

    Alcaine (TN) Manufacturers

    A Alcaine (TN) manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Alcaine (TN), including repackagers and relabelers. The FDA regulates Alcaine (TN) manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Alcaine (TN) API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Alcaine (TN) manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Alcaine (TN) Suppliers

    A Alcaine (TN) supplier is an individual or a company that provides Alcaine (TN) active pharmaceutical ingredient (API) or Alcaine (TN) finished formulations upon request. The Alcaine (TN) suppliers may include Alcaine (TN) API manufacturers, exporters, distributors and traders.

    click here to find a list of Alcaine (TN) suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Alcaine (TN) USDMF

    A Alcaine (TN) DMF (Drug Master File) is a document detailing the whole manufacturing process of Alcaine (TN) active pharmaceutical ingredient (API) in detail. Different forms of Alcaine (TN) DMFs exist exist since differing nations have different regulations, such as Alcaine (TN) USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Alcaine (TN) DMF submitted to regulatory agencies in the US is known as a USDMF. Alcaine (TN) USDMF includes data on Alcaine (TN)'s chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Alcaine (TN) USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Alcaine (TN) suppliers with USDMF on PharmaCompass.

    Alcaine (TN) WC

    A Alcaine (TN) written confirmation (Alcaine (TN) WC) is an official document issued by a regulatory agency to a Alcaine (TN) manufacturer, verifying that the manufacturing facility of a Alcaine (TN) active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Alcaine (TN) APIs or Alcaine (TN) finished pharmaceutical products to another nation, regulatory agencies frequently require a Alcaine (TN) WC (written confirmation) as part of the regulatory process.

    click here to find a list of Alcaine (TN) suppliers with Written Confirmation (WC) on PharmaCompass.

    Alcaine (TN) NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Alcaine (TN) as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Alcaine (TN) API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Alcaine (TN) as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Alcaine (TN) and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Alcaine (TN) NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Alcaine (TN) suppliers with NDC on PharmaCompass.

    Alcaine (TN) GMP

    Alcaine (TN) Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Alcaine (TN) GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Alcaine (TN) GMP manufacturer or Alcaine (TN) GMP API supplier for your needs.

    Alcaine (TN) CoA

    A Alcaine (TN) CoA (Certificate of Analysis) is a formal document that attests to Alcaine (TN)'s compliance with Alcaine (TN) specifications and serves as a tool for batch-level quality control.

    Alcaine (TN) CoA mostly includes findings from lab analyses of a specific batch. For each Alcaine (TN) CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Alcaine (TN) may be tested according to a variety of international standards, such as European Pharmacopoeia (Alcaine (TN) EP), Alcaine (TN) JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Alcaine (TN) USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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