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ACTIVE PHARMA INGREDIENTS

8 API Suppliers, 3 USDMF, 2 CEP/COS, 1 JDMF, 8 NDC API, 2 VMF, 6 Listed Suppliers, $ API Reference Price

8 API Suppliers
3 USDMF
2 CEP/COS
1 JDMF
8 NDC API
2 VMF
6 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

1 Drugs in Development

1 Drugs in Development

FINISHED DOSAGE FORMULATIONS

14 FDF Dossiers, 5 FDA Orange Book, 5 Europe, 3 Canada, 1 South Africa

14 FDF Dossiers
5 FDA Orange Book
5 Europe
3 Canada
1 South Africa

GLOBAL SALES INFORMATION

3 Finished Drug Prices

globalSalesInformation
3 Finished Drug Prices

MARKET PLACE

3 APIs

marketPlace
3 APIs

REF. STANDARDS & IMPURITIES

1 USP , 3 Others

otherSolutions
1 USP
3 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

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Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

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News #PharmaBuzz

GLOBAL SALES INFORMATION

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Chemistry

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Also known as: Trimeprazine tartrate, 4330-99-8, Trimeprazine hemitartrate salt, Nsc-17475, Nsc-757358, Prestwick_144

Molecular Formula

C₄₀H₅₀N₄O₆S₂

Molecular Weight

747.0 g/mol

InChI Key

AJZJIYUOOJLBAU-UHFFFAOYSA-N

1 2D Structure

Alimemazine

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2,3-dihydroxybutanedioic acid;N,N,2-trimethyl-3-phenothiazin-10-ylpropan-1-amine

2.1.2 InChI

InChI=1S/2C18H22N2S.C4H6O6/c2*1-14(12-19(2)3)13-20-15-8-4-6-10-17(15)21-18-11-7-5-9-16(18)20;5-1(3(7)8)2(6)4(9)10/h2*4-11,14H,12-13H2,1-3H3;1-2,5-6H,(H,7,8)(H,9,10)

2.1.3 InChI Key

AJZJIYUOOJLBAU-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC(CN1C2=CC=CC=C2SC3=CC=CC=C31)CN(C)C.CC(CN1C2=CC=CC=C2SC3=CC=CC=C31)CN(C)C.C(C(C(=O)O)O)(C(=O)O)O

2.2 Synonyms

2.2.1 MeSH Synonyms

1. Temaril

2. Theralen

3. Theraline

4. Trimeprazine Tartrate

2.2.2 Depositor-Supplied Synonyms

1. Trimeprazine Tartrate

2. 4330-99-8

3. Trimeprazine Hemitartrate Salt

4. Nsc-17475

5. Nsc-757358

6. Prestwick_144

7. Chembl3989885

8. Hms1570j05

9. Hms3714j05

10. Trimeprazine Hemi-(+)-tartrate Salt

11. Ccg-220842

2.3 Create Date

2006-04-14

3 Chemical and Physical Properties

Molecular Formula	C₄₀H₅₀N₄O₆S₂
Molecular Weight	747.0 g/mol
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	12
Rotatable Bond Count	11
Exact Mass	746.31717767 g/mol
Monoisotopic Mass	746.31717767 g/mol
Topological Polar Surface Area	179 Å²
Heavy Atom Count	52
Formal Charge	0
Complexity	445
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	4
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	3

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Histamine H1 Antagonists

Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)

API SUPPLIERS

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USDMF

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CEP/COS

01

PCAS Ecully FR

France

American Pharma Summit

Not Confirmed

Seqens is an integrated global leader in pharmaceutical solutions & specialty ingredients & provides custom-made solutions.

Contact Supplier

France

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Digital Content

Alimemazine hemitartrate

Certificate Number : R1-CEP 2015-165 - Rev 00

Status : Valid

Issue Date : 2021-06-08

Type : Chemical

Substance Number : 2650

02

R L FINE CHEM PVT. LTD. Bengaluru I...

India

American Pharma Summit

Not Confirmed

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JDMF

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NDC API

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VMF

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Listed Suppliers

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API Reference Price

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AIRPORT","customer":"DARMERICA","customerCountry":"UNITED STATES","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"4859.1","totalValueFC":"4808.9","currency":"USD","unitRateINR":350097.5,"date":"15-Mar-2021","totalValueINR":"350097.5","totalValueInUsd":"4808.9","indian_port":"BANGALORE AIR","hs_no":"29420090","bill_no":"9367391","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"BANGALORE AIR","supplierAddress":"RAY HOUSE, HIG NO. 2000, YELAHANKA NEW TOWN, YELAHANKA, MOTHER DIARY, ROAD, YELAHANKA NEW TOWN, BANGALORE","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2021","qtr":"Q3","strtotime":1628706600,"product":"TRIMEPRAZINE TARTARATE (ALIMEMAZINE TART ARATE)(PHARMACEUTICAL BULK DRUG)BATCH NO :ALMT\/002","address":"RAY HOUSE, HIG NO. 2000, YELAHANKA NEW TOWN, YELAHANKA, MOTHER DIARY","city":"ROAD, YELAHANKA NEW TOWN, BANGALORE","supplier":"R L FINE CHEM","supplierCountry":"INDIA","foreign_port":"ORLANDO INT. 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