Find Almitrine manufacturers, exporters & distributors on PharmaCompass

PharmaCompass

Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

0

CEP/COS

CEP/COS Certifications

0

JDMF

JDMFs Filed

0

EU WC

EU WC

0

KDMF

KDMF

0

NDC API

NDC API

0

VMF

NDC API

0

Listed Suppliers

Other Suppliers

API REF. PRICE (USD/KG)

$
$ 0

MARKET PLACE

0

API

0

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

0

FDF Dossiers

FDF Dossiers

0

FDA Orange Book

FDA (Orange Book)

0

Europe

Europe

0

Canada

Canada

0

Australia

Australia

0

South Africa

South Africa

0

Listed Dossiers

Listed Dossiers

0 DRUGS IN DEVELOPMENT

FDF Dossiers

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

0

EDQM

0

USP

0

JP

0

Others

PATENTS & EXCLUSIVITIES

0

US Patents

0

US Exclusivities

0

Health Canada Patents

DIGITAL CONTENT

0

Data Compilation #PharmaFlow

0

Stock Recap #PipelineProspector

0

Weekly News Recap #Phispers

0

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid

NA

Annual Reports

NA

Finished Drug Prices

NA

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown
read-moreClick the button for full data set
Also known as: Almitrine dimesylate, 29608-49-9, Almitrine bismesylate, Almitrine dimethanesulfonate, Almitrine dimesilate, Vectarion
Molecular Formula
C28H37F2N7O6S2
Molecular Weight
669.8  g/mol
InChI Key
MRDBGMJEPGXQHJ-UHFFFAOYSA-N
FDA UNII
6RY6V6XM8T

Almitrine
A respiratory stimulant that enhances respiration by acting as an agonist of peripheral chemoreceptors located on the carotid bodies. The drug increases arterial oxygen tension while decreasing arterial carbon dioxide tension in patients with chronic obstructive pulmonary disease. It may also prove useful in the treatment of nocturnal oxygen desaturation without impairing the quality of sleep.
1 2D Structure

Almitrine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
6-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-2-N,4-N-bis(prop-2-enyl)-1,3,5-triazine-2,4-diamine;methanesulfonic acid
2.1.2 InChI
InChI=1S/C26H29F2N7.2CH4O3S/c1-3-13-29-24-31-25(30-14-4-2)33-26(32-24)35-17-15-34(16-18-35)23(19-5-9-21(27)10-6-19)20-7-11-22(28)12-8-20;2*1-5(2,3)4/h3-12,23H,1-2,13-18H2,(H2,29,30,31,32,33);2*1H3,(H,2,3,4)
2.1.3 InChI Key
MRDBGMJEPGXQHJ-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CS(=O)(=O)O.CS(=O)(=O)O.C=CCNC1=NC(=NC(=N1)N2CCN(CC2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F)NCC=C
2.2 Other Identifiers
2.2.1 UNII
6RY6V6XM8T
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Almitrine

2. Almitrine Bis(methanesulfonate)

3. Almitrine Bismesylate

4. Almitrine Dimesylate

5. Almitrine Monomesylate

6. Monomesylate, Almitrine

7. Vectarion

2.3.2 Depositor-Supplied Synonyms

1. Almitrine Dimesylate

2. 29608-49-9

3. Almitrine Bismesylate

4. Almitrine Dimethanesulfonate

5. Almitrine Dimesilate

6. Vectarion

7. Almitrine Mesilate

8. Almitrine Mesylate [usan]

9. Almitrine Bismesilate

10. 6ry6v6xm8t

11. 6-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-2-n,4-n-bis(prop-2-enyl)-1,3,5-triazine-2,4-diamine;methanesulfonic Acid

12. Chebi:53779

13. S-2620

14. N2,n4-diallyl-6-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)-1,3,5-triazine-2,4-diamine Dimethanesulfonate

15. Almitrine Mesylate (usan)

16. (diallylamino-4'-6'-triazinyl-2')-1-(bis P-fluorobenzydryl)-4 Piperazine Bis Methanesulfonate

17. 2,4-bis(allylamino)-6-(4-(bis(p-fluorophenyl)methyl)-1-piperazinyl)-s-triazine Dimethanesulfonate

18. 6-(4-(bis(4-fluorophenyl)methyl)-1-piperazinyl)-n,n'-di-2-propenyl-1,3,5-triazine-2,4-diamine Dimethanesulfonate

19. Unii-6ry6v6xm8t

20. S 2620 Bismethanesulfonate

21. Almitrine Bismethane Sulfonate

22. Almitrinemesylate

23. Vectarion (tn)

24. Einecs 249-726-1

25. Almitrine Bismethanesulfonate

26. Dsstox_cid_31492

27. Dsstox_rid_97377

28. Dsstox_gsid_57703

29. Schembl2228917

30. Chembl3181957

31. Dtxsid5057703

32. Tox21_113959

33. Almitrine Dimesilate [mart.]

34. Mfcd01679060

35. S4439

36. Almitrine Dimesilate [who-dd]

37. Akos027327548

38. Almitrine Dimethanesulfonate [mi]

39. Ncgc00262968-01

40. Ds-11817

41. Cas-29608-49-9

42. Hy-107319

43. Cs-0028130

44. D02822

45. 608a499

46. Q27104813

47. 1,3,5-triazine-2,4-diamine, 6-(4-(bis(4-fluorophenyl)methyl)-1-piperazinyl)-n,n'-di-2-propenyl-, Dimethanesulfonate

48. 2,4-bis(allylamino)-6-(4-(bis(p-fluorophenyl)methyl)-1-piperazinyl)-s-triazine Dimethanesulphonate

49. 6-4-(bis(4-fluorophenyl)methyl)-1-piperazinyl)-n,n'-di-2-propenyl-1,3,5-triazine-2,4-diamine Dimethanesulfonate

50. 6-4-(bis(4-fluorophenyl)methyl)-1-piperazinyl)-n,n'-di-2-propenyl-1,3,5-triazine-2,4-diamine Dimethanesulphonate

51. N,n'-diallyl-6-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)-1,3,5-triazine-2,4-diamine Dimethanesulphonate

52. N,n'-diallyl-6-{4-[bis(4-fluorophenyl)methyl]piperazin-1-yl}-1,3,5-triazine-2,4-diamine Dimethanesulfonate

53. N2,n4-diallyl-6-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)-1,3,5-triazine-2,4-diaminedimethanesulfonate

2.4 Create Date
2006-07-28
3 Chemical and Physical Properties
Molecular Weight 669.8 g/mol
Molecular Formula C28H37F2N7O6S2
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count15
Rotatable Bond Count10
Exact Mass669.22148060 g/mol
Monoisotopic Mass669.22148060 g/mol
Topological Polar Surface Area195 Ų
Heavy Atom Count45
Formal Charge0
Complexity694
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Respiratory System Agents

Drugs used for their effects on the respiratory system. (See all compounds classified as Respiratory System Agents.)


ABOUT THIS PAGE

Almitrine Manufacturers

A Almitrine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Almitrine, including repackagers and relabelers. The FDA regulates Almitrine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Almitrine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Almitrine Suppliers

A Almitrine supplier is an individual or a company that provides Almitrine active pharmaceutical ingredient (API) or Almitrine finished formulations upon request. The Almitrine suppliers may include Almitrine API manufacturers, exporters, distributors and traders.

click here to find a list of Almitrine suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Almitrine USDMF

A Almitrine DMF (Drug Master File) is a document detailing the whole manufacturing process of Almitrine active pharmaceutical ingredient (API) in detail. Different forms of Almitrine DMFs exist exist since differing nations have different regulations, such as Almitrine USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Almitrine DMF submitted to regulatory agencies in the US is known as a USDMF. Almitrine USDMF includes data on Almitrine's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Almitrine USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Almitrine suppliers with USDMF on PharmaCompass.

Almitrine GMP

Almitrine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Almitrine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Almitrine GMP manufacturer or Almitrine GMP API supplier for your needs.

Almitrine CoA

A Almitrine CoA (Certificate of Analysis) is a formal document that attests to Almitrine's compliance with Almitrine specifications and serves as a tool for batch-level quality control.

Almitrine CoA mostly includes findings from lab analyses of a specific batch. For each Almitrine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Almitrine may be tested according to a variety of international standards, such as European Pharmacopoeia (Almitrine EP), Almitrine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Almitrine USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
Ask Us for Pharmaceutical Supplier and Partner
Ask Us, Find A Supplier / Partner
No Commissions, No Strings Attached, Get Connected for FREE

What are you looking for?

How can we help you?

The request can't be empty

Please read our Privacy Policy carefully

You must agree to the privacy policy

The name can't be empty
The company can't be empty.
The email can't be empty Please enter a valid email.
The mobile can't be empty