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Chemistry

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Also known as: 2091134-68-6, Azd-4205, Azd4205, Unii-3by9z3m34g, Jak1-in-3, 3by9z3m34g
Molecular Formula
C25H31N9O2
Molecular Weight
489.6  g/mol
InChI Key
CVCVOSPZEVINRM-MRXNPFEDSA-N
FDA UNII
3BY9Z3M34G

Golidocitinib
Golidocitinib is an orally available inhibitor of Janus-associated kinase 1 (JAK1), with potential antineoplastic activity. Upon oral administration, golidocitinib inhibits JAK-dependent signaling and may lead to an inhibition of cellular proliferation in JAK1-overexpressing tumor cells. The JAK-STAT (signal transducer and activator of transcription) signaling pathway is a major mediator of cytokine activity and is often dysregulated in a variety of tumor cell types. Additionally, JAK1 may be a primary driver of STAT3 phosphorylation and signaling, which plays a role in neoplastic transformation, resistance to apoptosis, tumor angiogenesis, metastasis, immune evasion, and treatment resistance.
1 2D Structure

Golidocitinib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2R)-N-[3-[2-[(3-methoxy-1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]-1H-indol-7-yl]-2-(4-methylpiperazin-1-yl)propanamide
2.1.2 InChI
InChI=1S/C25H31N9O2/c1-16(34-12-10-32(2)11-13-34)23(35)28-20-7-5-6-17-18(14-27-22(17)20)19-8-9-26-25(29-19)30-21-15-33(3)31-24(21)36-4/h5-9,14-16,27H,10-13H2,1-4H3,(H,28,35)(H,26,29,30)/t16-/m1/s1
2.1.3 InChI Key
CVCVOSPZEVINRM-MRXNPFEDSA-N
2.1.4 Canonical SMILES
CC(C(=O)NC1=CC=CC2=C1NC=C2C3=NC(=NC=C3)NC4=CN(N=C4OC)C)N5CCN(CC5)C
2.1.5 Isomeric SMILES
C[C@H](C(=O)NC1=CC=CC2=C1NC=C2C3=NC(=NC=C3)NC4=CN(N=C4OC)C)N5CCN(CC5)C
2.2 Other Identifiers
2.2.1 UNII
3BY9Z3M34G
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. 2091134-68-6

2. Azd-4205

3. Azd4205

4. Unii-3by9z3m34g

5. Jak1-in-3

6. 3by9z3m34g

7. (2r)-n-[3-[2-[(3-methoxy-1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]-1h-indol-7-yl]-2-(4-methylpiperazin-1-yl)propanamide

8. Golidocitinib [inn]

9. Chembl4577523

10. Schembl18662606

11. Gtpl10744

12. Bdbm264212

13. Ex-a2671

14. Example 32 [us9714236b2]

15. Nsc801813

16. Nsc-801813

17. Compound 21 [pmid: 32297743]

18. Ac-36748

19. Ba177711

20. Hy-107361

21. Cs-0028212

22. Us9714236, 32

23. (.alpha.r)-n-(3-(2-((3-methoxy-1-methyl-1h-pyrazol-4-yl)amino)-4-pyrimidinyl)-1h-indol-7-yl)-.alpha.,4-dimethyl-1-piperazineacetamide

24. (2r)-n-(3-{2-[(3- Methoxy-1-methyl- 1h-pyrazol-4-yl)amino] Pyrimidin-4- Yl}-1h-indol-7-yl)-2-(4- Methylpiperazin-1- Yl)propanamide

25. 1-piperazineacetamide, N-(3-(2-((3-methoxy-1-methyl-1h-pyrazol-4-yl)amino)-4-pyrimidinyl)-1h-indol-7-yl)-.alpha.,4-dimethyl-, (.alpha.r)-

26. 1-piperazineacetamide, N-(3-(2-((3-methoxy-1-methyl-1h-pyrazol-4-yl)amino)-4-pyrimidinyl)-1h-indol-7-yl)-alpha,4-dimethyl-, (alphar)-

2.4 Create Date
2017-04-22
3 Chemical and Physical Properties
Molecular Weight 489.6 g/mol
Molecular Formula C25H31N9O2
XLogP31.9
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count7
Exact Mass489.26007127 g/mol
Monoisotopic Mass489.26007127 g/mol
Topological Polar Surface Area116 Ų
Heavy Atom Count36
Formal Charge0
Complexity736
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Looking for 2091134-68-6 / Golidocitinib API manufacturers, exporters & distributors?

Golidocitinib manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Golidocitinib API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Golidocitinib manufacturer or Golidocitinib supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Golidocitinib manufacturer or Golidocitinib supplier.

PharmaCompass also assists you with knowing the Golidocitinib API Price utilized in the formulation of products. Golidocitinib API Price is not always fixed or binding as the Golidocitinib Price is obtained through a variety of data sources. The Golidocitinib Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Golidocitinib

Synonyms

2091134-68-6, Azd-4205, Azd4205, Unii-3by9z3m34g, Jak1-in-3, 3by9z3m34g

Cas Number

2091134-68-6

Unique Ingredient Identifier (UNII)

3BY9Z3M34G

About Golidocitinib

Golidocitinib is an orally available inhibitor of Janus-associated kinase 1 (JAK1), with potential antineoplastic activity. Upon oral administration, golidocitinib inhibits JAK-dependent signaling and may lead to an inhibition of cellular proliferation in JAK1-overexpressing tumor cells. The JAK-STAT (signal transducer and activator of transcription) signaling pathway is a major mediator of cytokine activity and is often dysregulated in a variety of tumor cell types. Additionally, JAK1 may be a primary driver of STAT3 phosphorylation and signaling, which plays a role in neoplastic transformation, resistance to apoptosis, tumor angiogenesis, metastasis, immune evasion, and treatment resistance.

(.ALPHA.R)-N-(3-(2-((3-METHOXY-1-METHYL-1H-PYRAZOL-4-YL)AMINO)-4-PYRIMIDINYL)-1H-INDOL-7-YL)-.ALPHA.,4-DIMETHYL-1-PIPERAZINEACETAMIDE Manufacturers

A (.ALPHA.R)-N-(3-(2-((3-METHOXY-1-METHYL-1H-PYRAZOL-4-YL)AMINO)-4-PYRIMIDINYL)-1H-INDOL-7-YL)-.ALPHA.,4-DIMETHYL-1-PIPERAZINEACETAMIDE manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of (.ALPHA.R)-N-(3-(2-((3-METHOXY-1-METHYL-1H-PYRAZOL-4-YL)AMINO)-4-PYRIMIDINYL)-1H-INDOL-7-YL)-.ALPHA.,4-DIMETHYL-1-PIPERAZINEACETAMIDE, including repackagers and relabelers. The FDA regulates (.ALPHA.R)-N-(3-(2-((3-METHOXY-1-METHYL-1H-PYRAZOL-4-YL)AMINO)-4-PYRIMIDINYL)-1H-INDOL-7-YL)-.ALPHA.,4-DIMETHYL-1-PIPERAZINEACETAMIDE manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. (.ALPHA.R)-N-(3-(2-((3-METHOXY-1-METHYL-1H-PYRAZOL-4-YL)AMINO)-4-PYRIMIDINYL)-1H-INDOL-7-YL)-.ALPHA.,4-DIMETHYL-1-PIPERAZINEACETAMIDE API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

(.ALPHA.R)-N-(3-(2-((3-METHOXY-1-METHYL-1H-PYRAZOL-4-YL)AMINO)-4-PYRIMIDINYL)-1H-INDOL-7-YL)-.ALPHA.,4-DIMETHYL-1-PIPERAZINEACETAMIDE Suppliers

A (.ALPHA.R)-N-(3-(2-((3-METHOXY-1-METHYL-1H-PYRAZOL-4-YL)AMINO)-4-PYRIMIDINYL)-1H-INDOL-7-YL)-.ALPHA.,4-DIMETHYL-1-PIPERAZINEACETAMIDE supplier is an individual or a company that provides (.ALPHA.R)-N-(3-(2-((3-METHOXY-1-METHYL-1H-PYRAZOL-4-YL)AMINO)-4-PYRIMIDINYL)-1H-INDOL-7-YL)-.ALPHA.,4-DIMETHYL-1-PIPERAZINEACETAMIDE active pharmaceutical ingredient (API) or (.ALPHA.R)-N-(3-(2-((3-METHOXY-1-METHYL-1H-PYRAZOL-4-YL)AMINO)-4-PYRIMIDINYL)-1H-INDOL-7-YL)-.ALPHA.,4-DIMETHYL-1-PIPERAZINEACETAMIDE finished formulations upon request. The (.ALPHA.R)-N-(3-(2-((3-METHOXY-1-METHYL-1H-PYRAZOL-4-YL)AMINO)-4-PYRIMIDINYL)-1H-INDOL-7-YL)-.ALPHA.,4-DIMETHYL-1-PIPERAZINEACETAMIDE suppliers may include (.ALPHA.R)-N-(3-(2-((3-METHOXY-1-METHYL-1H-PYRAZOL-4-YL)AMINO)-4-PYRIMIDINYL)-1H-INDOL-7-YL)-.ALPHA.,4-DIMETHYL-1-PIPERAZINEACETAMIDE API manufacturers, exporters, distributors and traders.

(.ALPHA.R)-N-(3-(2-((3-METHOXY-1-METHYL-1H-PYRAZOL-4-YL)AMINO)-4-PYRIMIDINYL)-1H-INDOL-7-YL)-.ALPHA.,4-DIMETHYL-1-PIPERAZINEACETAMIDE GMP

(.ALPHA.R)-N-(3-(2-((3-METHOXY-1-METHYL-1H-PYRAZOL-4-YL)AMINO)-4-PYRIMIDINYL)-1H-INDOL-7-YL)-.ALPHA.,4-DIMETHYL-1-PIPERAZINEACETAMIDE Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of (.ALPHA.R)-N-(3-(2-((3-METHOXY-1-METHYL-1H-PYRAZOL-4-YL)AMINO)-4-PYRIMIDINYL)-1H-INDOL-7-YL)-.ALPHA.,4-DIMETHYL-1-PIPERAZINEACETAMIDE GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right (.ALPHA.R)-N-(3-(2-((3-METHOXY-1-METHYL-1H-PYRAZOL-4-YL)AMINO)-4-PYRIMIDINYL)-1H-INDOL-7-YL)-.ALPHA.,4-DIMETHYL-1-PIPERAZINEACETAMIDE GMP manufacturer or (.ALPHA.R)-N-(3-(2-((3-METHOXY-1-METHYL-1H-PYRAZOL-4-YL)AMINO)-4-PYRIMIDINYL)-1H-INDOL-7-YL)-.ALPHA.,4-DIMETHYL-1-PIPERAZINEACETAMIDE GMP API supplier for your needs.

(.ALPHA.R)-N-(3-(2-((3-METHOXY-1-METHYL-1H-PYRAZOL-4-YL)AMINO)-4-PYRIMIDINYL)-1H-INDOL-7-YL)-.ALPHA.,4-DIMETHYL-1-PIPERAZINEACETAMIDE CoA

A (.ALPHA.R)-N-(3-(2-((3-METHOXY-1-METHYL-1H-PYRAZOL-4-YL)AMINO)-4-PYRIMIDINYL)-1H-INDOL-7-YL)-.ALPHA.,4-DIMETHYL-1-PIPERAZINEACETAMIDE CoA (Certificate of Analysis) is a formal document that attests to (.ALPHA.R)-N-(3-(2-((3-METHOXY-1-METHYL-1H-PYRAZOL-4-YL)AMINO)-4-PYRIMIDINYL)-1H-INDOL-7-YL)-.ALPHA.,4-DIMETHYL-1-PIPERAZINEACETAMIDE's compliance with (.ALPHA.R)-N-(3-(2-((3-METHOXY-1-METHYL-1H-PYRAZOL-4-YL)AMINO)-4-PYRIMIDINYL)-1H-INDOL-7-YL)-.ALPHA.,4-DIMETHYL-1-PIPERAZINEACETAMIDE specifications and serves as a tool for batch-level quality control.

(.ALPHA.R)-N-(3-(2-((3-METHOXY-1-METHYL-1H-PYRAZOL-4-YL)AMINO)-4-PYRIMIDINYL)-1H-INDOL-7-YL)-.ALPHA.,4-DIMETHYL-1-PIPERAZINEACETAMIDE CoA mostly includes findings from lab analyses of a specific batch. For each (.ALPHA.R)-N-(3-(2-((3-METHOXY-1-METHYL-1H-PYRAZOL-4-YL)AMINO)-4-PYRIMIDINYL)-1H-INDOL-7-YL)-.ALPHA.,4-DIMETHYL-1-PIPERAZINEACETAMIDE CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

(.ALPHA.R)-N-(3-(2-((3-METHOXY-1-METHYL-1H-PYRAZOL-4-YL)AMINO)-4-PYRIMIDINYL)-1H-INDOL-7-YL)-.ALPHA.,4-DIMETHYL-1-PIPERAZINEACETAMIDE may be tested according to a variety of international standards, such as European Pharmacopoeia ((.ALPHA.R)-N-(3-(2-((3-METHOXY-1-METHYL-1H-PYRAZOL-4-YL)AMINO)-4-PYRIMIDINYL)-1H-INDOL-7-YL)-.ALPHA.,4-DIMETHYL-1-PIPERAZINEACETAMIDE EP), (.ALPHA.R)-N-(3-(2-((3-METHOXY-1-METHYL-1H-PYRAZOL-4-YL)AMINO)-4-PYRIMIDINYL)-1H-INDOL-7-YL)-.ALPHA.,4-DIMETHYL-1-PIPERAZINEACETAMIDE JP (Japanese Pharmacopeia) and the US Pharmacopoeia ((.ALPHA.R)-N-(3-(2-((3-METHOXY-1-METHYL-1H-PYRAZOL-4-YL)AMINO)-4-PYRIMIDINYL)-1H-INDOL-7-YL)-.ALPHA.,4-DIMETHYL-1-PIPERAZINEACETAMIDE USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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