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ACTIVE PHARMA INGREDIENTS

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3 NDC API

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3 Canada
1 South Africa

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3 FDF Dossiers

Synopsis

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NDC API

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FDA Orange Book

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South Africa

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DRUG PRODUCT COMPOSITIONS

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US Patents

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Health Canada Patents

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Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

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Chemistry

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Also known as: 177799-16-5, Ttpa, 9,10-bis[n,n-di(p-tolyl)amino]anthracene, 9-n,9-n,10-n,10-n-tetrakis(4-methylphenyl)anthracene-9,10-diamine, N9,n9,n10,n10-tetra-p-tolylanthracene-9,10-diamine, Schembl1261345

Molecular Formula

C₄₂H₃₆N₂

Molecular Weight

568.7 g/mol

InChI Key

FWXNJWAXBVMBGL-UHFFFAOYSA-N

A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases.

1 2D Structure

Alteplase

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

9-N,9-N,10-N,10-N-tetrakis(4-methylphenyl)anthracene-9,10-diamine

2.1.2 InChI

InChI=1S/C42H36N2/c1-29-13-21-33(22-14-29)43(34-23-15-30(2)16-24-34)41-37-9-5-7-11-39(37)42(40-12-8-6-10-38(40)41)44(35-25-17-31(3)18-26-35)36-27-19-32(4)20-28-36/h5-28H,1-4H3

2.1.3 InChI Key

FWXNJWAXBVMBGL-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC1=CC=C(C=C1)N(C2=CC=C(C=C2)C)C3=C4C=CC=CC4=C(C5=CC=CC=C53)N(C6=CC=C(C=C6)C)C7=CC=C(C=C7)C

2.2 Synonyms

2.2.1 MeSH Synonyms

1. Actilyse

2. Activase

3. Alteplase

4. Lysatec Rt Pa

5. Lysatec Rt-pa

6. Lysatec Rtpa

7. Plasminogen Activator, Tissue

8. Plasminogen Activator, Tissue Type

9. Plasminogen Activator, Tissue-type

10. T Plasminogen Activator

11. T-plasminogen Activator

12. Tisokinase

13. Tissue Activator D 44

14. Tissue Activator D-44

15. Tissue Plasminogen Activator

16. Tissue Type Plasminogen Activator

17. Tissue-type Plasminogen Activator

18. Ttpa

2.2.2 Depositor-Supplied Synonyms

1. 177799-16-5

2. Ttpa

3. 9,10-bis[n,n-di(p-tolyl)amino]anthracene

4. 9-n,9-n,10-n,10-n-tetrakis(4-methylphenyl)anthracene-9,10-diamine

5. N9,n9,n10,n10-tetra-p-tolylanthracene-9,10-diamine

6. Schembl1261345

7. Dtxsid30629288

8. Cha79916

9. 9,10-anthracenediamine, N9,n9,n10,n10-tetrakis(4-methylphenyl)-

10. Mfcd12022465

11. Akos027252460

12. As-71559

13. 9,10-bis[n,n-di(p-tolyl)amino]anthracene, 98%

14. N,n,n',n'-tetrakis(p-tolyl)anthracene-9,10-diamine

15. N,n,n',n'-tetrakis(4-methylphenyl)-9,10-anthracenediamine

16. N~9~,n~9~,n~10~,n~10~-tetrakis(4-methylphenyl)anthracene-9,10-diamine

17. N9,n9,n10,n10-tetrakis(4-methylphenyl)anthracene-9,10-diamine

2.3 Create Date

2007-12-05

3 Chemical and Physical Properties

Molecular Formula	C₄₂H₃₆N₂
Molecular Weight	568.7 g/mol
XLogP3	12.4
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	6
Exact Mass	568.287849157 g/mol
Monoisotopic Mass	568.287849157 g/mol
Topological Polar Surface Area	6.5 Å²
Heavy Atom Count	44
Formal Charge	0
Complexity	728
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1