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Aluminium Chlorohydrate

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ACTIVE PHARMA INGREDIENTS

4 API Suppliers, 2 USDMF, 1 JDMF, 1 EU WC, $ API Reference Price

4 API Suppliers
2 USDMF
1 JDMF
1 EU WC
$ API Reference Price

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1 FDF Dossiers, 1 Listed Dossiers

1 FDF Dossiers
1 Listed Dossiers

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3 APIs, 1 FDF Dossiers, 1 EXCIPIENTS

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3 APIs
1 FDF Dossiers
1 EXCIPIENTS

Synopsis

ACTIVE PHARMA INGREDIENTS

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Chemistry

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Also known as: Db11573, Q27280046

Molecular Formula

Al₂ClH₇O₆

Molecular Weight

192.47 g/mol

InChI Key

ZLVPDILYQLCEJO-UHFFFAOYSA-H

Aluminum chlorohydrate is a group of water-soluble aluminum complexes with the general formula AlnCl(3n-m)(OH)m. It is included up to 25% in over-the-counter hygiene products as an active antiperspirant agent. The primary site of action of aluminum chlorohydrate is at the level of the stratum corneum layer, which is relatively near the skin surface. It is also used as a coagulant in the water purification process.

1 2D Structure

Aluminium Chlorohydrate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

dialuminum;chloride;pentahydroxide;hydrate

2.1.2 InChI

InChI=1S/2Al.ClH.6H2O/h;;1H;6*1H2/q2*+3;;;;;;;/p-6

2.1.3 InChI Key

ZLVPDILYQLCEJO-UHFFFAOYSA-H

2.1.4 Canonical SMILES

O.[OH-].[OH-].[OH-].[OH-].[OH-].[Al+3].[Al+3].[Cl-]

2.2 Synonyms

2.2.1 Depositor-Supplied Synonyms

1. Db11573

2. Q27280046

2.3 Create Date

2013-07-08

3 Chemical and Physical Properties

Molecular Formula	Al₂ClH₇O₆
Molecular Weight	192.47 g/mol
Hydrogen Bond Donor Count	6
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	0
Exact Mass	191.956192 g/mol
Monoisotopic Mass	191.956192 g/mol
Topological Polar Surface Area	6 Å²
Heavy Atom Count	9
Formal Charge	0
Complexity	0
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	9

4 Drug and Medication Information

4.1 Drug Indication

Indicated for use as an antiperspirant.

5 Pharmacology and Biochemistry

5.1 Pharmacology

Aluminum chlorohydrate serves to reduce excessive sweating by directly blocking the sweat ducts.

5.2 Absorption, Distribution and Excretion

Absorption

Penetration of aluminum chlorohydrate following dermal application is minimal, with the rate being around 0.01% and up to 0.06% in pre-damaged skin. In a preliminary study, dermally applied aluminium chlorohydrate displayed 0.012% of the applied aluminium being absorbed through the skin, which accounts for 4 mcg of aluminum following a single dermal application. This is about 2.5% of the aluminium typically absorbed by the gut from food over the same time period.

Route of Elimination