Find Aluminum Chloride manufacturers, exporters & distributors on PharmaCompass

Granules India Limited has high volume world-class facilities for APIs, PFIs, & FDFs, serving customers in over 80 countries.

Virtual Booth

ACCESS ALL DATA
Browse all information
CHEMISTRY
Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

$ API Reference Price

$ API Reference Price

FINISHED DOSAGE FORMULATIONS

8 FDF Dossiers, 7 Europe, 1 Listed Dossiers

8 FDF Dossiers
7 Europe
1 Listed Dossiers

RELATED EXCIPIENT COMPANIES

1 Evonik, 1 Rochem International Inc, 1 SPI Pharma, 2 DKSH, 1 Jai Radhe Sales, 1 Pharm-RX Chemical, 1 Faran Shimi Pharmaceutical, 6 Nanjing Well Pharmaceutical, 1 Pfanstiehl, 8 Actylis, 17 BASF, 3 Finar, 4 Gangwal Chemicals, 9 Kerry, 1 Microlex e.U, 1 Nanjing Bold Chemical, 2 Pluviaendo, 1 Roquette, 11 Seppic, 1 Valens Pharmachem

EXCIPIENTS BY APPLICATIONS

30 Topical, 22 Solubilizers, 15 Parenteral, 11 Thickeners and Stabilizers, 9 Co-Processed Excipients, 7 Emulsifying Agents, 6 Coating Systems & Additives, 5 Surfactant & Foaming Agents, 5 Film Formers & Plasticizers, 3 Direct Compression, 3 Controlled & Modified Release, 3 Rheology Modifiers, 3 Taste Masking, 3 API Stability Enhancers, 2 Granulation, 1 Fillers, Diluents & Binders, 1 Disintegrants & Superdisintegrants

excipientsByApplications
30 Topical
22 Solubilizers
15 Parenteral
11 Thickeners and Stabilizers
9 Co-Processed Excipients
7 Emulsifying Agents
6 Coating Systems & Additives
5 Surfactant & Foaming Agents
5 Film Formers & Plasticizers
3 Direct Compression
3 Controlled & Modified Release
3 Rheology Modifiers
3 Taste Masking
3 API Stability Enhancers
2 Granulation
1 Fillers, Diluents & Binders
1 Disintegrants & Superdisintegrants

GLOBAL SALES INFORMATION

7 Finished Drug Prices

globalSalesInformation
7 Finished Drug Prices

MARKET PLACE

2 APIs, 1 Intermediates

marketPlace
2 APIs
1 Intermediates

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 6

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

73 RELATED EXCIPIENT COMPANIES

129EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown

Click the button for full data set

Also known as: Aluminum trichloride, Aluminium chloride, 7446-70-0, Aluminium trichloride, Trichloroalumane, Trichloroaluminum

Molecular Formula

AlCl₃

Molecular Weight

133.34 g/mol

InChI Key

VSCWAEJMTAWNJL-UHFFFAOYSA-K

A compound with the chemical formula AlCl3; the anhydrous salt is used as a catalyst in organic chemical synthesis, and hydrated salts are used topically as antiperspirants, and for the management of HYPERHYDROSIS.

1 2D Structure

Aluminum Chloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

trichloroalumane

2.1.2 InChI

InChI=1S/Al.3ClH/h;3*1H/q+3;;;/p-3

2.1.3 InChI Key

VSCWAEJMTAWNJL-UHFFFAOYSA-K

2.1.4 Canonical SMILES

[Al](Cl)(Cl)Cl

2.2 Synonyms

2.2.1 MeSH Synonyms

1. Alcl3

2. Aluminum Chloride Hexahydrate

3. Aluminum Chloride, Anhydrous

4. Aluminum Trichloride

5. Anhydrous Aluminum Chloride

6. Drysol

2.2.2 Depositor-Supplied Synonyms

1. Aluminum Trichloride

2. Aluminium Chloride

3. 7446-70-0

4. Aluminium Trichloride

5. Trichloroalumane

6. Trichloroaluminum

7. Alcl3

8. Aluminum Chloride (alcl3)

9. Aluminum Chloride Anhydrous

10. Aluminiumchlorid

11. Aluminum Chloride (1:3)

12. Aluminum Chloride, Anhydrous

13. Chlorure D'aluminium

14. Alluminio(cloruro Di)

15. Aluminium, (chlorure D')

16. Aluminium(ii)chloride

17. Aluminum Chloride, Anhydrous, Powder

18. Mfcd00003422

19. Nsc-143015

20. Nsc-143016

21. Wln: Al G3

22. Pearsall

23. Tk Flock

24. Caswell No. 029

25. Aluminiumchlorid [german]

26. Aluminum Chloride - Ethanol Solution

27. Hemoban

28. Aluminum Chloride (anhydrous)

29. Chlorure D'aluminium [french]

30. Ccris 6871

31. Hsdb 607

32. Alluminio(cloruro Di) [italian]

33. Trichloridoaluminium

34. Aluminum, (chlorure D') [french]

35. Aluminium, (chlorure D') [french]

36. Einecs 231-208-1

37. Un1726

38. Un2581

39. Epa Pesticide Chemical Code 013901

40. Nsc 143015

41. Nsc 143016

42. Aluminium(3+) Chloride

43. Ai3-01917

44. [alcl3]

45. Aluminum, (chlorure D')

46. Aluminum Chloride, Solution

47. Unii-lif1n9568y

48. Aluminum Chloride, Ultra Dry

49. Aluminium Chloride, Anhydrous

50. Chembl3833401

51. Dtxsid6029674

52. Chebi:30114

53. Bcp21020

54. Nsc143015

55. Nsc143016

56. Aluminum Chloride, Puriss., 98.0%

57. Akos015902776

58. Aluminium Chloride, Anhydrous, Reagent

59. Aluminum Chloride, Anhydrous, Granular

60. Aluminum Chloride, Reagent Grade, 98%

61. Db11081

62. Ncgc00180999-01

63. Aluminum Chloride, Reagentplus(r), 99%

64. Bp-10698

65. Aluminum Chloride, 6.0n Standardized Solution

66. Aluminum Chloride, 99.99% Trace Metals Basis

67. Aluminum Chloride, Anhydrous, Sublimed, >=98%

68. Aluminum Chloride, Saj First Grade, >=98.0%

69. Ec 231-208-1

70. Aluminum Chloride Solution, 1.0 M In Nitrobenzene

71. Q314036

72. Aluminum Chloride, Solution [un2581] [corrosive]

73. Aluminum Chloride, Anhydrous [un1726] [corrosive]

74. Aluminum Chloride, Purum, Anhydrous, >=98.0% (at)

75. Aluminum Chloride, 99.98% Trace Metals Grade Anhydrous, Powder

76. Aluminum Chloride, Anhydrous, Powder, 99.99% Trace Metals Basis

77. Aluminum Chloride, Anhydrous, Powder, 99.999% Trace Metals Basis

78. Aluminum Standard For Aas, Analytical Standard, Traceable To Bam

79. Aluminum Chloride, Reagentplus(r), Anhydrous, >=99.9% Trace Metals Basis

80. Aluminum Chloride - Ethanol Solution, ~11% In Ethanol/water, For Tlc Derivatization

81. Aluminum Chloride, Anhydrous, Crystallized 4-6 Mesh Size (crystalline Chunks)

82. Aluminum Atomic Spectroscopy Standard Concentrate 1.00 G Al, 1.00 G/l, For 1 L Standard Solution, Analytical Standard

83. Aluminum Atomic Spectroscopy Standard Concentrate 10.00 G Al, 10.00 G/l, For 1 L Standard Solution, Analytical Standard

2.3 Create Date

2004-09-16

3 Chemical and Physical Properties

Molecular Formula	AlCl₃
Molecular Weight	133.34 g/mol
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	0
Rotatable Bond Count	0
Exact Mass	131.888096 g/mol
Monoisotopic Mass	131.888096 g/mol
Topological Polar Surface Area	0 Å²
Heavy Atom Count	4
Formal Charge	0
Complexity	8
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Therapeutic Uses

Astringents

National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)

Some aluminum compounds are employed therapeutically, eg, aluminum hydroxide is one component of the antacids recommended in the treatment of stomach ulcers and gastritis. Large doses of aluminum hydroxide (in the order of grams) are prescribed for patients who, as a result of renal dysfunction, have high blood phosphate levels. Aluminum acetotartrate in solution is used in the treatment of sores and for other dermatological purposes. The solution inhibits bacteria and has astringent properties. Aluminum chloride hexahydrate is very commonly used in deodorants, and a solution of aluminum sulfate has been tried without significant success against stings of fire ants. /Aluminum chloride hexahydrate/

Friberg, L., Nordberg, G.F., Kessler, E. and Vouk, V.B. (eds). Handbook of the Toxicology of Metals. 2nd ed. Vols I, II.: Amsterdam: Elsevier Science Publishers B.V., 1986., p. 4

Antiperspirant

Gilman, A.G., L.S.Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 7th ed. New York: Macmillan Publishing Co., Inc., 1985., p. 949

Anhydrotic. /Aluminum chloride hexahydrate/

O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. 13th Edition, Whitehouse Station, NJ: Merck and Co., Inc., 2001., p. 61

Aluminum chloride shown to exhibit good antiperspirant action in pilocarpine-induced sweating in rat foot pads and this result is in accordance with observations in human tests.

LANSDOWN ABG; J SOC COSMET CHEM 24 (OCT 14th): 677-684 (1972)

4.2 Drug Indication

- Indicated for the control of minor hemorrhage during dental restorative procedures. - Indicated to reduce underarm perspiration.

5 Pharmacology and Biochemistry

5.1 Pharmacology

Aluminum chloride is a hemostatic and antiperspirant agent.

5.2 MeSH Pharmacological Classification

Antiperspirants

Agents that are put on the SKIN to reduce SWEATING or prevent excess sweating (HYPERHIDROSIS). (See all compounds classified as Antiperspirants.)

5.3 ATC Code

D - Dermatologicals

D10 - Anti-acne preparations

D10A - Anti-acne preparations for topical use

D10AX - Other anti-acne preparations for topical use

D10AX01 - Aluminium chloride

5.4 Absorption, Distribution and Excretion

Absorption

It is reported that about 17-30 % of aluminum chloride formed from the reaction between orally ingested aluminum hydroxide and hydrochloric acid of the stomach is absorbed. In rabbits, administration of a single maximum safe oral dose aluminum chloride (333 mg Al/kg) resulted in aluminum absorption of 0.57 %. Aluminum chloride may be absorbed via dermal route, with the uptake increasing in the microgram range but with an upper limit.

Route of Elimination

Absorbed aluminum chloride is rapidly excreted by the kidneys in individuals with normal renal function. Aluminum chloride may be absorbed dermally.

Volume of Distribution

Following oral administration of 8.1 mg/kg of aluminum chloride, the steadystate volume of distribution of aluminum was 38.4 6.4 mL/kg.

Clearance

Following oral administration of 8.1 mg/kg of aluminum chloride, the clearance of aluminum was 8.87 1.76 mL/(h*kg).

Rainbow trout (9 to 220 g) were individually placed in 1 liter chambers having aerated, fresh flowing water for 1 hr (control conditions, aluminum concentration= 0.033 mg/L, pH 4.61). They were then exposed to an aerated artificial medium (flow rate= 297 + or - 11 mL/min, pH= 5.4) containing 0.954 + or - 0.133 mg/L aluminum (as aluminum chloride) for up to 1 hr. There was no significant difference (p= 0.05) between episodic aluminum levels and episodic blank (no fish) aluminum levels, indicating that the flow rate through the chambers was sufficient to maintain aluminum levels such that absorption of aluminum from the apparatus was negligible. Fish were removed for tissue sampling after 5, 10, 20, 30, and 60 min exposure. Skin and blood showed no significant increase in aluminum content (p=0.05). Gill tissue episodic aluminum values were significantly higher (p=0.05)) than control levels at 30 and 60 min, having increased from 8 ug/g to 50 ug/g wet weight in 1 hr. Mucous aluminum content was significantly higher (p=0.05) than control values after 5 min of exposure increased to 4.5 mg/L from 0.2 mg/L. Mucous cells on the secondary lamellae showed discharged mucous globules on the gill surface after 1 hr of episodic exposure, a feature not shown by unexposed gill lamellae.

Handy RD, Eddy FB; J Fish Biol 34 (6): 865-74 (1989)

Aluminum hydroxide or oxide is slowly solubilized in the stomach and reacts with hydrochloric acid to form aluminum chloride and water. In addition to forming aluminum chloride, dihydroxyaluminum sodium carbonate and aluminum carbonate form carbon dioxide, and aluminum phosphate forms phosphoric acid. About 17-30% of the aluminum chloride formed is absorbed and is rapidly excreted by the kidneys in patients with normal renal functions. In the small intestine, aluminum chloride is rapidly converted to insoluble poorly absorbed basic aluminum salts which probably /include/ a mixture of hydrated aluminum oxide, oxyaluminum hydroxide, various basic aluminum carbonates, and aluminum soaps. Aluminum-containing antacids (except aluminum phosphate) also combine with dietary phosphate in the intestine forming insoluble, nonabsorbable aluminum phosphate which is excreted in the feces. If phosphate intake is limited in patients with normal renal function, aluminum antacids (except aluminum phosphate) decrease phosphate absorption and hypophosphatemia and hypophosphaturia occur; calcium absorption is increased. In vitro studies indicate that aluminum hydroxide binds bile salts with an affinity & capacity similar to that of cholestyramine; aluminum phosphate binds bile salts, but to a much lesser degree than does aluminum hydroxide. /Aluminum antacids/

McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2004. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2004 (Plus Supplements)., p. 2758

Evidence of transdermal uptake of aluminum was reported... when /aluminum chloride/ was chronically placed on the skin of mice. Uptake increased in the microgram range and appeared to have an upper limit, failing to increase at larger doses. ...A similar finding was reported when /aluminum chloride/ was placed in the nasal passages of experimental animals; apparently aluminum wa translocated to the olfactory region of the brain. However, the chemically irritant nature of this mode of administration and the potential damage to the mucosa so treated was not factored into the evaluation of the integrity of this barrier.

Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1-9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. V2 370

Following a single maximum safe oral dose of the water soluble compounds aluminum chloride (333 mg Al/kg), aluminum nitrate (934 mg Al/kg), aluminum citrate (1,081 mg Al/kg), and aluminum lactate (2,942 mg Al/kg) in rabbits, aluminum absorption was 0.57, 1.16, 2.18, and 0.63%, respectively.

DHHS/ATSDR; Toxicological Profile for Aluminum (July 1999). Available from, as of May 21, 2004: https://www.atsdr.cdc.gov/toxprofiles/index.asp

For more Absorption, Distribution and Excretion (Complete) data for ALUMINUM CHLORIDE (12 total), please visit the HSDB record page.

5.5 Metabolism/Metabolites

In the small intestine, aluminum chloride is rapidly converted to insoluble poorly absorbed basic aluminum salts, consisting of a mixture of hydrated aluminum oxide, oxyaluminum hydroxide, various basic aluminum carbonates, and aluminum soaps.

5.6 Biological Half-Life

Following oral administration of 8.1 mg/kg of aluminum chloride, the half-life of aluminum was 5.29 0.47 h.

5.7 Mechanism of Action

Aluminum chloride is commonly used topical antiperspirant. It is proposed that aluminum chloride works by causing an obstruction of the distal sweat gland ducts, where the metal ions precipitate with mucopolysaccharides, damaging epithelial cells along the lumen of the duct and forming a plug that blocks sweat output. Aluminum chloride is also an astringent that promotes hemostasis; it precipitates proteins on the superficial layer of mucosa and make it mechanically stronger. It creates superficial and local coagulation in minor hemorrhages.

Aluminum (10, 12.5, 17.5, 25 and 50 uM, as aluminum trichloride) inhibited yeast glucose-6-phosphate dehydrogenase (EC 1.1.1.49) by a pseudo-first-order reaction. The inhibition was proportional to the incubation time (10 to 60 sec) and the concn of aluminum. Aluminum was a better inhibitor when added to the buffered enzyme prior to the addition of glucose-6-phosphate or NADP+. When aluminum trichloride was added to the buffered mixture of enzyme and glucose-6-phosphate , more than 10 times aluminum trichloride was needed to observe a comparable inhibition. The inhibitory effect of aluminum chloride on glucose-6-phosphate dehydrogenase was negligible when aluminum chloride was premixed with NADP+. Double reciprocal plots gave a straight line with a k(inact) of 8.3/min and indicated the presence of a binding step prior to inhibition. The kinetic study showed that 1 mol of aluminum was bound per mol of enzyme subunit. A marked incr in sensitivity to aluminum was observed as the pH decr. An inhibitory effect of aluminum was predominant below pH 7.0, but above pH 8.0, aluminum did not significantly affect the reaction rate of glucose-6-phosphate dehydrogenase.

PMID:2665187 Cho SW, Joshi JG; Toxicol Lett 47 (3): 215-9 (1989)

The effect of aluminum on intestinal calcium absorption was determined in male Sprague-Dawley rats using an everted intestinal sac technique. Bidirectional calcium flux in the duodena and ilea of normal rats was assessed by means of dual calcium isotopes. Addition of 2 uM aluminum (as aluminum chloride) to the buffer solution significantly inhibited net calcium absorption in the duodenum through suppression of mucosa-to-serosa flux. Serosa-to-mucosa calcium flux was not similarly influenced by aluminum. In the ileum, aluminum had no effect on any component of calcium flux. Aluminum did not induce any suppression of glucose transport in either the duodenum or ileum, suggesting that the effect on calcium transport is relatively specific.

Adler AJ et al; Am J Physiol 257 (3,1): G433-7 (1989)

ATP pools extracted from the cyanobacterium Anabaena cylindrica, grown in the absence or presence of aluminum chloride were measured using the luciferin-luciferase assay. Addition of low concn of aluminum chloride (3.6-36 uM) incr the ATP pool 20-40% within 24 hr, the effect being more marked with time. When using the Tris-EDTA boiling technique for extraction of cellular ATP, the ATP from aluminum-exposed cells appeared more stable during the extraction than the ATP from untreated cells. The higher ATP pools in aluminum-exposed cells were also evident after dark treatment and addition of the phosphorylating inhibitors carbonylcyanide m-chlorophenylhydrazone and N,N'-dicyclohexylcarbodiimide. The formation of elevated ATP pools in cells exposed to aluminum was curtailed by high concn of cellular phosphate and postincubation at high pH (> 8).

Pettersson A, Bergman B; Physiol Plant 76 (4): 527-34 (1989)

Very few investigations have been made on the metabolism and mode of action of aluminum compounds for the reason that it is very poorly absorbed and of low toxicity. The existing evidence indicates that the small portion of aluminum ion that hydrolyzes combines with available phosphate, becomes insoluble and unabsorbed, and so is excreted along with the un-ionized portion. In high doses aluminum compounds have been shown to affect phosphorus metabolism of rats and mice. At lower levels (170 and 355 ppm aluminum as aluminum chloride) aluminum balance studies showed intake and fecal excretion of aluminum were higher at the higher dose, but urinary excretion and retention were not. In phosphorus balance studies made at 160 to 180 and 355 ppm in the diet, the higher dose lowered phosphorus retention, although phosphorus content of the liver and femur were not affected. Chronic and acute poisoning by aluminum chloride caused, on intraperitoneal administration of (32)H-labelled disodium hydrogen phosphate, decreased incorporation of (32)phosphorus in the phospholipids and nucleic acids of various rat tissues. Decreased adenosine triphosphate levels and a rise in the adenosine diphosphate level in plasma also occurred, indicating interference with tissue phosphorylation process.

Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982., p. 1500

For more Mechanism of Action (Complete) data for ALUMINUM CHLORIDE (10 total), please visit the HSDB record page.

FDF Dossiers