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Also known as: Dried aluminum hydroxide gel, Aluminum;trihydroxide, Aluminium hydroxide gel, dried, Dried aluminium hydroxide, Aluminum hydroxide, dried, Aluminium hydroxide, dried
Molecular Formula
AlH3O3
Molecular Weight
78.004  g/mol
InChI Key
WNROFYMDJYEPJX-UHFFFAOYSA-K
FDA UNII
5QB0T2IUN0

Aluminium Hydroxide
Aluminum hydroxide is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects.
1 2D Structure

Aluminium Hydroxide

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
aluminum;trihydroxide
2.1.2 InChI
InChI=1S/Al.3H2O/h;3*1H2/q+3;;;/p-3
2.1.3 InChI Key
WNROFYMDJYEPJX-UHFFFAOYSA-K
2.1.4 Canonical SMILES
[OH-].[OH-].[OH-].[Al+3]
2.2 Other Identifiers
2.2.1 UNII
5QB0T2IUN0
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. Dried Aluminum Hydroxide Gel

2. Aluminum;trihydroxide

3. Aluminium Hydroxide Gel, Dried

4. Dried Aluminium Hydroxide

5. Aluminum Hydroxide, Dried

6. Aluminium Hydroxide, Dried

7. Aluminum Hydroxide Gel, Dried

8. Nsc-664400

9. Aluminum Hydrate

10. Aluminum Hyroxide

11. Aluminium Trihydroxide

12. Hydroxyde D' Aluminium

13. Algeldrate Anhydrous

14. Aluminum (as Hydroxide)

15. Aluminum Hydroxide [ii]

16. Aluminum Hydroxide [mi]

17. Chembl1200706

18. Dtxsid2036405

19. Niosh/bd0708000

20. Aluminum Hydroxide [inci]

21. Di-mu-hydroxytetrahydroxydialuminum

22. Aluminum Hydroxide [vandf]

23. Aluminium Hydroxide[who-ip]

24. Aluminum Hydroxide [mart.]

25. Aluminum Hydroxide Gel,dried

26. Aluminium Hydroxide Dried Gel

27. Af-260

28. Aluminium Hydroxide [who-dd]

29. Akos015904617

30. Aluminum, Di-mu-hydroxytetrahydroxydi-

31. Db06723

32. Aluminum Hydroxide [orange Book]

33. Aluminii Hydroxidum[who-ip Latin]

34. Aluminum (as Hydroxide) [vandf]

35. Aluminum Hydroxide [usp Impurity]

36. Aluminum Hydroxide, Dried [hsdb]

37. As04 Component Aluminum Hydroxide

38. Aluminum Hydroxide Gel, Dried [ii]

39. Foamcoat Component Aluminum Hydroxide

40. Foamicon Component Aluminum Hydroxide

41. Gaviscon Component Aluminum Hydroxide

42. Aluminum Hydroxide Gel,dried [vandf]

43. Bd07080000

44. Dried Aluminum Hydroxide Gel [usp-rs]

45. Aluminum Hydroxide Component Of Foamcoat

46. Aluminum Hydroxide Component Of Foamicon

47. Aluminum Hydroxide Component Of Gaviscon

48. Aluminium Hydroxide Gel, Dried [who-dd]

49. Aluminum Hydroxide, Dried [usp Impurity]

50. Q407125

51. J-014205

52. 8012-63-3

2.4 Create Date
2006-10-25
3 Chemical and Physical Properties
Molecular Weight 78.004 g/mol
Molecular Formula AlH3O3
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count0
Exact Mass77.9897574 g/mol
Monoisotopic Mass77.9897574 g/mol
Topological Polar Surface Area3 Ų
Heavy Atom Count4
Formal Charge0
Complexity0
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count4
4 Drug and Medication Information
4.1 Drug Indication

For relief of heartburn and acid indigestion.


5 Pharmacology and Biochemistry
5.1 Pharmacology

Gastric-peptic disease occurs as a result of an imbalance between protective factors, such as mucus, bicarbonate, and prostaglandin secretion, and aggressive factors, such as hydrochloric acid, pepsin, and Helicobacter pylori (H. pylori). Antacids work by restoring acid-base balance, attenuating the pepsin activity and increasing bicarbonate and prostaglandin secretion.


5.2 Absorption, Distribution and Excretion

Absorption

Approximately 17-30% of the aluminum chloride formed is absorbed.


Route of Elimination

Absorbed aluminum chloride is rapidly eliminated by the kidneys in patients with normal renal function.


5.3 Metabolism/Metabolites

Not metabolized.


5.4 Mechanism of Action

Aluminum hydroxide is a basic inorganic salt that acts by neutralizing hydrochloric acid in gastric secretions. Aluminum hydroxide is slowly solubilized in the stomach and reacts with hydrochloric acid to form aluminum chloride and water. It also inhibits the action of pepsin by increasing the pH and via adsorption. Cytoprotective effects may occur through increases in bicarbonate ion (HCO3-) and prostaglandins.


Listed Suppliers

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01

  • fda
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Virtual BoothRochem, your partner in developing, sourcing, and supplying pharmaceutical & animal health ingredients of Chinese origin.

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Aluminium Hydroxide

About the Company : Established in 1994, Rochem is a distributor of pharmaceutical, food, nutritional and animal health ingredients to some of the largest companies in the world. It sources high-quali...

Established in 1994, Rochem is a distributor of pharmaceutical, food, nutritional and animal health ingredients to some of the largest companies in the world. It sources high-quality ingredients manufactured in China. Headquartered in the Hauppauge, New York, Rochem has 16 offices spread across the globe to cater to the needs of its customers. Rochem’s operations are fully cGMP compliant and has been audited by the USFDA as well as several multinational organizations. It also trains and audits its partners to ensure all of their technologies and systems are FDA-compliant.
Rochem

02

DKSH

Switzerland
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Antibody Engineering
Not Confirmed
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothDKSH is your trusted partner for companies looking to grow their business in Asia & beyond.

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Aluminium Hydroxide

About the Company : DKSH, founded with the goal of improving people's lives, assists businesses with market expansion and business growth in both existing and emerging markets. It has been fostering g...

DKSH, founded with the goal of improving people's lives, assists businesses with market expansion and business growth in both existing and emerging markets. It has been fostering growth for businesses in Asia and beyond for over 155 years. DKSH operates in 36 markets, is listed on the SIX Swiss Exchange, employs 33,100 specialists, and generated net sales of CHF 11.1 billion in 2021. It is the leading global distributor of innovative pharma ingredients for pharmaceutical synthesis and formulation. It offers a range of products, ranging from animal care products to packaging materials, intermediates to nutraceuticals, and APIs to excipients.
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03

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  • fda
  • EDQM
  • WHO-GMP

Virtual BoothPharm-Rx is a reputed global importer and distributor of pharmaceutical active ingredients.

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Digital Content Digital Content

Aluminium Hydroxide

About the Company : Pharm-Rx has earned an outstanding reputation since its establishment in 1991, serving as a reputable importer and distributor of active ingredients to the pharmaceutical, nutritio...

Pharm-Rx has earned an outstanding reputation since its establishment in 1991, serving as a reputable importer and distributor of active ingredients to the pharmaceutical, nutritional supplement, and food industries. The company maintains an exceptionally selective approach to its suppliers, personally visiting manufacturers overseas to ensure the highest standards. The sustained growth of Pharm-Rx can be attributed to its steadfast commitment to three core values: quality ingredients, competitive pricing, and unparalleled customer service.
Pharm RX

04

  • fda
  • EDQM
  • WHO-GMP

Virtual BoothOctavius has been empowering lives since 1980 by providing quality products like DC granules, APIs and FDFs.

Flag India
Digital Content Digital Content

Aluminium Hydroxide

About the Company : Octavius Pharma is a global leader in Directly Compressible Granules with over 40 years of experience in Formulation development, manufacturing and commercialization. It offers a w...

Octavius Pharma is a global leader in Directly Compressible Granules with over 40 years of experience in Formulation development, manufacturing and commercialization. It offers a wide range of products such as tablets, capsules, syrups and ointments. Its portfolio includes finished dosage formulations, herbal/food supplements and APIs. It exports bulk drugs, finished formulations and APIs, while maintaining quality in compliance with WHO GMP norms. With an experienced team, Octavius Pharma provides consulting services for formulation development and marketing. Octavius exports to LATAM, Middle East, African, Asian and CIS countries.
Octavius Pharma

05

Antibody Engineering
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Aluminum Hydroxide

About the Company : ChemiGnition is a specialty pharmaceutical company engaged in development, manufacture and marketing of high-quality, industry-leading Intermediates and Active Pharmaceutical Ingre...

ChemiGnition is a specialty pharmaceutical company engaged in development, manufacture and marketing of high-quality, industry-leading Intermediates and Active Pharmaceutical Ingredients (APIs), Speciality Chemical in domestic and international markets. We have steadily built scale in our product offerings and reach. We supply various molecules domestic and international markets. From product selection & development to commercialization, we wisely blend science, technology and economics to stay ahead of the curve.
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06

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Aluminum Hydroxide

About the Company : Guangzhou Tosun Pharmaceutical was founded in 1999, which mainly focuses on importation & exportation of Active Pharmaceutical Ingrediants, Chemical Raw Materials, Intermediate, Ex...

Guangzhou Tosun Pharmaceutical was founded in 1999, which mainly focuses on importation & exportation of Active Pharmaceutical Ingrediants, Chemical Raw Materials, Intermediate, Excipients, Herbal extracts, Formulation of Chinese & Western Medicine. With abundant economic strength, the group has successfully developed to a pharmaceutical group enterprise wich intergrets operation of medicine & related products, processing & manufacturing, and importation & exportation together.
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07

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Aluminum Hydroxide

About the Company : Nitika Pharmaceutical Specialities was found in 1991 as a small manufacturing unit has grown today into a dynamic production center for a range of products finding applications in ...

Nitika Pharmaceutical Specialities was found in 1991 as a small manufacturing unit has grown today into a dynamic production center for a range of products finding applications in various Industry Verticals. 15 years after its foundation the company has been able to adapt to the fast growing technological changes to have an edge in the global market place. Our focus is on the customer and achieving a high degree of customer satisfaction by providing quality prod
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08

Antibody Engineering
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Aluminium Hydroxide

About the Company : Rumit group of companies is a young, dynamic & Robustly growing company established in 1993. We specialise in pharmaceutical raw material, Bulk API, dye stuff, dyes intermediates &...

Rumit group of companies is a young, dynamic & Robustly growing company established in 1993. We specialise in pharmaceutical raw material, Bulk API, dye stuff, dyes intermediates & chemicals. The promoters of the company are Mr. Asit Dhruva and Mr. Nikhil Desai – experienced in this industry for the past 30 years. The company consists of a strong administrative and marketing team, ready at your service. Our mission is to create reliable & convenient supply chain solution which is fast, dependable & cost effective. We envisage ourselves as the undisputed market leaders that shape each market, we choose to step in.
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09

Sino-Aluminas

United Kingdom
Antibody Engineering
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Sino-Aluminas

United Kingdom
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Aluminium Hydroxide

About the Company : Sino-Aluminas Ltd, registered in the UK, is the designated sales representative of CHALCO in Europe. The services provided by Sino-Aluminas are to promote alumina chemicals manufac...

Sino-Aluminas Ltd, registered in the UK, is the designated sales representative of CHALCO in Europe. The services provided by Sino-Aluminas are to promote alumina chemicals manufactured by CHALCO Shangdong and to develop, manage and coordinate its business with European clients.Sino-Aluminas Ltd is a UK company, specialising in wholesale of the following categories of chemicals, covering more than 100 varieties of different products with a wide range of applications
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API Reference Price

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[{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q2","strtotime":1686594600,"product":"ALUMINIUM HYDROXIDE GEL USP BATCH # DAHG","address":"MANGAL AARAMBH, A-507, KORA KENDRA, S.V. ROAD, BORIVALI-W,","city":"MUMBAI","supplier":"RIA INTERNATIONAL INDIA ","supplierCountry":"INDIA","foreign_port":"NEWARK, NJ","customer":"TO THE ORDER","customerCountry":"UNITED STATES","quantity":"160.00","actualQuantity":"160","unit":"KGS","unitRateFc":"9.5","totalValueFC":"1508.6","currency":"USD","unitRateINR":774.99922500000002,"date":"13-Jun-2023","totalValueINR":"123999.876","totalValueInUsd":"1508.6","indian_port":"BOMBAY AIR","hs_no":"29157090","bill_no":"0","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"BOMBAY AIR","supplierAddress":"MANGAL AARAMBH, A-507, KORA KENDRA, S.V. ROAD, BORIVALI-W,, MUMBAI","customerAddress":""},{"dataSource":"API Import","activeIngredients":"ALUMINIUM HYDROXIDE","year":"2021","qtr":"Q2","strtotime":1622053800,"product":"12618 IN60S4 (CI 77891,ISONONYL ISONONANOATE,STEARIC ACID,ALUMINIUM HYDROXIDE) (RAW MATERIAL FOR COSMETICS USE)","address":"PICCADILY HOUSE,F.F. ,CAPT,275 GAURMARG,SRINIWASPAURI","city":"NEW DELHI","supplier":"CETES COSMETICS AG","supplierCountry":"POLAND","foreign_port":"","customer":"ORIFLAME INDIA PRIVATE ","customerCountry":"INDIA","quantity":"125.00","actualQuantity":"125","unit":"KGS","unitRateFc":"3780.1","totalValueFC":"7025.5","currency":"INR","unitRateINR":"4116.9","date":"27-May-2021","totalValueINR":"514609.75","totalValueInUsd":"7025.5","indian_port":"DELHI TKD ICD","hs_no":"29051690","bill_no":"4106022","productDescription":"API","marketType":"REGULATED MARKET","country":"POLAND","selfForZScoreResived":"Pharma Grade","supplierPort":"","supplierAddress":"","customerAddress":"PICCADILY HOUSE,F.F. ,CAPT,275 GAURMARG,SRINIWASPAURI"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1692297000,"product":"12618 IN60S4 CI 77891,ISONONYL ISONONANOATE,STEARIC ACID,ALUMINIUM HYDROXIDE RAW MATERIAL FOR COSMETICS USE","address":"M-10, SOUTH EXTENSION, PART-II,","city":"DELHI","supplier":"CETES COSMETICS AG","supplierCountry":"POLAND","foreign_port":"NA","customer":"ORIFLAME INDIA PRIVATE ","customerCountry":"INDIA","quantity":"100.00","actualQuantity":"100","unit":"KGS","unitRateFc":"3727.7","totalValueFC":"4625.8","currency":"INR","unitRateINR":"3793.5","date":"18-Aug-2023","totalValueINR":"383183.046","totalValueInUsd":"4625.8","indian_port":"TUGLAKABAD ICD","hs_no":"29051690","bill_no":"0","productDescription":"API","marketType":"REGULATED MARKET","country":"POLAND","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"M-10, SOUTH EXTENSION, PART-II,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1718389800,"product":"12618 IN60S4 (CI 77891,ISONONYL ISONONANOATE,STEARIC ACID,ALUMINIUM HYDROXIDE) (RAW MATERIAL FOR COSMETICS USE)","address":"GROUND FLOOR, CORPORATE ONE","city":"DELHI","supplier":"CETES COSMETICS AG","supplierCountry":"POLAND","foreign_port":"WARSAW","customer":"ORIFLAME INDIA PRIVATE ","customerCountry":"INDIA","quantity":"50.00","actualQuantity":"50","unit":"KGS","unitRateFc":"4460.6","totalValueFC":"3049.7","currency":"INR","unitRateINR":"5091.7","date":"15-Jun-2024","totalValueINR":"254587.31","totalValueInUsd":"3049.7","indian_port":"Delhi Air","hs_no":"29051690","bill_no":"4027544","productDescription":"API","marketType":"REGULATED MARKET","country":"POLAND","selfForZScoreResived":"Pharma Grade","supplierPort":"WARSAW","supplierAddress":"BLEICHEPLATZ 3 CH-8200-SCHAFFHAUSEN., , SWITZERLANDSDNF SWITZERLAND","customerAddress":"GROUND FLOOR, CORPORATE ONE"}]
27-May-2021
15-Jun-2024
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Europe

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01

Melisana AG

Switzerland
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Melisana AG

Switzerland
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Aluminium oxide hydrochloride (Algeldratum); Magnesium hydroxide

Brand Name : Alucol Gel

Dosage Form : Susp Fruit

Dosage Strength :

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Switzerland

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02

Melisana AG

Switzerland
Antibody Engineering
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Melisana AG

Switzerland
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Not Confirmed

Aluminium oxide hydrochloride (Algeldratum); Magnesium hydroxide

Brand Name : Alucol Gel

Dosage Form : Susp Fruit

Dosage Strength :

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Switzerland

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03

Melisana AG

Switzerland
Antibody Engineering
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Melisana AG

Switzerland
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Aluminium oxide hydrochloride (Algeldratum); Magnesium hydroxide

Brand Name : Alucol Gel

Dosage Form : Susp Peppermint

Dosage Strength :

Packaging :

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Application Number :

Regulatory Info :

Registration Country : Switzerland

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04

Melisana AG

Switzerland
Antibody Engineering
Not Confirmed
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Melisana AG

Switzerland
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Antibody Engineering
Not Confirmed

Aluminium oxide hydrochloride (Algeldratum); Magnesium hydroxide

Brand Name : Alucol Gel

Dosage Form : Susp Peppermint

Dosage Strength :

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Switzerland

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05

Nordic Drugs AB

Country
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Nordic Drugs AB

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Several substances refer to content

Brand Name : Gaviscon

Dosage Form : ORAL SUSPENSION

Dosage Strength : -

Packaging :

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Application Number :

Regulatory Info :

Registration Country : Sweden

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Nordic Drugs AB

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Nordic Drugs AB

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Several substances refer to content

Brand Name : Gaviscon

Dosage Form : CHEWABLE TABLET

Dosage Strength : -

Packaging :

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Registration Country : Sweden

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