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Chemistry

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Also known as: 848141-11-7, Alvelestat (azd9668), Alvelestat [inn], Alvelestat; azd 9668, Avelestat-azd9668, Azd 9668
Molecular Formula
C25H22F3N5O4S
Molecular Weight
545.5  g/mol
InChI Key
QNQZWEGMKJBHEM-UHFFFAOYSA-N
FDA UNII
6Y5629322X

Alvelestat
Alvelestat is an orally bioavailable, selective and reversible inhibitor of human neutrophil elastase (NE), with potential anti-inflammatory activity. Upon administration, alvelestat binds to and inhibits the activity of human NE. This inhibits NE-mediated inflammatory responses, which may prevent lung inflammation and injury, and may improve lung function associated with NE-induced respiratory diseases. NE, a serine protease released by neutrophils during inflammation, is upregulated in a number of respiratory diseases.
1 2D Structure

Alvelestat

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
6-methyl-5-(2-methylpyrazol-3-yl)-N-[(5-methylsulfonylpyridin-2-yl)methyl]-2-oxo-1-[3-(trifluoromethyl)phenyl]pyridine-3-carboxamide
2.1.2 InChI
InChI=1S/C25H22F3N5O4S/c1-15-20(22-9-10-31-32(22)2)12-21(23(34)30-13-17-7-8-19(14-29-17)38(3,36)37)24(35)33(15)18-6-4-5-16(11-18)25(26,27)28/h4-12,14H,13H2,1-3H3,(H,30,34)
2.1.3 InChI Key
QNQZWEGMKJBHEM-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1=C(C=C(C(=O)N1C2=CC=CC(=C2)C(F)(F)F)C(=O)NCC3=NC=C(C=C3)S(=O)(=O)C)C4=CC=NN4C
2.2 Other Identifiers
2.2.1 UNII
6Y5629322X
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Azd9668

2. N-((5-(methanesulfonyl)pyridin-2-yl)methyl)-6-methyl-5-(1-methyl-1h-pyrazol-5-yl)-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamide

2.3.2 Depositor-Supplied Synonyms

1. 848141-11-7

2. Alvelestat (azd9668)

3. Alvelestat [inn]

4. Alvelestat; Azd 9668

5. Avelestat-azd9668

6. Azd 9668

7. Azd-9668

8. Azd9668

9. Azd9668;azd-9668;azd 9668

10. Alvelestat (azd9688)

11. Mph966

12. Chembl3617964

13. Mph-966

14. 6-methyl-5-(1-methyl-1h-pyrazol-5-yl)-n-((5-(methylsulfonyl)pyridin-2-yl)methyl)-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamide

15. N-((5-(methanesulfonyl)pyridin-2-yl)methyl)-6-methyl-5-(1-methyl-1h-pyrazol-5-yl)-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamide

16. 6y5629322x

17. 6-methyl-5-(2-methylpyrazol-3-yl)-n-[(5-methylsulfonylpyridin-2-yl)methyl]-2-oxo-1-[3-(trifluoromethyl)phenyl]pyridine-3-carboxamide

18. Avelestat

19. 3-pyridinecarboxamide, 1,2-dihydro-6-methyl-5-(1-methyl-1h-pyrazol-5-yl)-n-[[5-(methylsulfonyl)-2-pyridinyl]methyl]-2-oxo-1-[3-(trifluoromethyl)phenyl]-

20. Unii-6y5629322x

21. 3-pyridinecarboxamide, 1,2-dihydro-6-methyl-5-(1-methyl-1h-pyrazol-5-yl)-n-((5-(methylsulfonyl)-2-pyridinyl)methyl)-2-oxo-1-(3-(trifluoromethyl)phenyl)-

22. 6-methyl-5-(1-methyl-1h-pyrazol-5-yl)-n-((5-(methylsulfonyl)pyridin-2-yl)methyl)-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide

23. 6-methyl-5-(1-methyl-1h-pyrazol-5-yl)-n-{[5-(methylsulfonyl)pyridin-2-yl]methyl}-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide

24. N-{[5-(methanesulfonyl)pyridin-2-yl]methyl}-6-methyl-5-(1-methyl-1h-pyrazol-5-yl)-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide

25. Alvelestat [who-dd]

26. Schembl560757

27. Gtpl6476

28. Dtxsid40233875

29. Bcp07945

30. Ex-a2004

31. Alvelestat (azd848141-11-7

32. Bdbm50120430

33. Zinc72316197

34. Cs-1684

35. Db11863

36. Sb19590

37. Ncgc00378593-01

38. Ncgc00378593-04

39. Ncgc00378593-05

40. Ncgc00378593-07

41. Ncgc00378593-08

42. Ac-32671

43. As-56012

44. Da-35310

45. Hy-15651

46. Kb-105160

47. Ft-0722953

48. C76706

49. Q27074417

50. N-[(5-methanesulfonylpyridin-2-yl)methyl]-6-methyl-5-(1-methyl-1h-pyrazol-5-yl)-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide

2.4 Create Date
2010-09-07
3 Chemical and Physical Properties
Molecular Weight 545.5 g/mol
Molecular Formula C25H22F3N5O4S
XLogP32.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count9
Rotatable Bond Count6
Exact Mass545.13445986 g/mol
Monoisotopic Mass545.13445986 g/mol
Topological Polar Surface Area123 Ų
Heavy Atom Count38
Formal Charge0
Complexity1100
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Alvelestat Manufacturers

A Alvelestat manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Alvelestat, including repackagers and relabelers. The FDA regulates Alvelestat manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Alvelestat API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Alvelestat Suppliers

A Alvelestat supplier is an individual or a company that provides Alvelestat active pharmaceutical ingredient (API) or Alvelestat finished formulations upon request. The Alvelestat suppliers may include Alvelestat API manufacturers, exporters, distributors and traders.

Alvelestat GMP

Alvelestat Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Alvelestat GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Alvelestat GMP manufacturer or Alvelestat GMP API supplier for your needs.

Alvelestat CoA

A Alvelestat CoA (Certificate of Analysis) is a formal document that attests to Alvelestat's compliance with Alvelestat specifications and serves as a tool for batch-level quality control.

Alvelestat CoA mostly includes findings from lab analyses of a specific batch. For each Alvelestat CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Alvelestat may be tested according to a variety of international standards, such as European Pharmacopoeia (Alvelestat EP), Alvelestat JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Alvelestat USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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