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Chemistry

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Also known as: 5560-59-8, Alverine (citrate), Antispasmin, Spacolin, Gamatran citrate, Nsc 35459
Molecular Formula
C26H35NO7
Molecular Weight
473.6  g/mol
InChI Key
RYHCACJBKCOBTJ-UHFFFAOYSA-N
FDA UNII
9JFB58YK1E

Alverine
1 2D Structure

Alverine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
N-ethyl-3-phenyl-N-(3-phenylpropyl)propan-1-amine;2-hydroxypropane-1,2,3-tricarboxylic acid
2.1.2 InChI
InChI=1S/C20H27N.C6H8O7/c1-2-21(17-9-15-19-11-5-3-6-12-19)18-10-16-20-13-7-4-8-14-20;7-3(8)1-6(13,5(11)12)2-4(9)10/h3-8,11-14H,2,9-10,15-18H2,1H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
2.1.3 InChI Key
RYHCACJBKCOBTJ-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CCN(CCCC1=CC=CC=C1)CCCC2=CC=CC=C2.C(C(=O)O)C(CC(=O)O)(C(=O)O)O
2.2 Other Identifiers
2.2.1 UNII
9JFB58YK1E
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Alverine

2. Alverine Hydrochloride

3. Spasmaverine

4. Spasmonal

2.3.2 Depositor-Supplied Synonyms

1. 5560-59-8

2. Alverine (citrate)

3. Antispasmin

4. Spacolin

5. Gamatran Citrate

6. Nsc 35459

7. Spasmaverine

8. Alverine Citrate Salt

9. Calmabel

10. Profenine

11. Prophelan

12. Proverine

13. Profenil Citrate

14. Nci 85x

15. Alverine Citrate [usan]

16. Nsc-35459

17. Phenpropamine Citrate

18. N-ethyl-3,3'-diphenyldipropylamine Citrate (1:1)

19. 9jfb58yk1e

20. Mls000069524

21. 5560-59-8 (citrate)

22. Chebi:53785

23. N-ethyl-3-phenyl-n-(3-phenylpropyl)propan-1-amine 2-hydroxypropane-1,2,3-tricarboxylate

24. Dipropylamine, N-ethyl-3,3'-diphenyl-, Citrate (1:1)

25. Ncgc00017047-01

26. Smr000058631

27. Cas-5560-59-8

28. Alverine Citrate (usan)

29. Benzenepropanamine, N-ethyl-n-(3-phenylpropyl)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)

30. Dsstox_cid_25562

31. Dsstox_rid_80959

32. Dsstox_gsid_45562

33. Alverine Dihydrogen Citrate

34. N-ethyl-3-phenyl-n-(3-phenylpropyl)propan-1-amine;2-hydroxypropane-1,2,3-tricarboxylic Acid

35. Sr-01000003029

36. Unii-9jfb58yk1e

37. Alverine Citrate [usan:nf]

38. Prestwick_912

39. Einecs 226-929-3

40. Alverinecitrate

41. Opera_id_1477

42. Dipropylamine, N-ethyl-3,3'-diphenyl-, Citrate

43. N-ethyl-bis(3-phenylpropyl)amin-dihydrogencitrat

44. Mls001148462

45. Mls002207301

46. Mls002222279

47. Mls004712036

48. Alverine Citrate [mi]

49. Schembl352008

50. Spectrum1500109

51. Regid_for_cid_21718

52. Chembl1408594

53. Dtxsid3045562

54. Alverine Citrate [mart.]

55. Alverine Citrate [who-dd]

56. Hms1568d09

57. Hms1920a17

58. Hms2091g17

59. Hms2095d09

60. Hms2232d03

61. Hms3371i14

62. Hms3651f18

63. Hms3712d09

64. Hms3885o05

65. Pharmakon1600-01500109

66. Hy-b0500

67. Tox21_110757

68. Dipropylamine,3'-diphenyl-, Citrate

69. Mfcd00035086

70. Nsc755859

71. S3054

72. Akos015895657

73. Tox21_110757_1

74. Alverine Citrate [ep Monograph]

75. Ccg-212472

76. Nsc-755859

77. Ncgc00017047-02

78. Ncgc00017047-03

79. Ncgc00021122-08

80. Ncgc00094581-01

81. Ncgc00094581-02

82. As-56723

83. Db-052764

84. N-ethyl-3,3'-diphenyldipropylamine Citrate

85. Dipropylamine,3'-diphenyl-, Citrate (1:1)

86. Ft-0622247

87. Sw197030-3

88. A16396

89. D02877

90. D84224

91. A830720

92. Sr-01000003029-2

93. Sr-01000003029-4

94. Q27124210

95. Benzenepropanamine, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)

96. Citric Acid; N-ethyl-3-phenyl-n-(3-phenylpropyl)propan-1-amine

97. 2-hydroxypropane-1,2,3-tricarboxylic Acid; Ethylbis(3-phenylpropyl)amine

98. Alverine Citrate Salt, European Pharmacopoeia (ep) Reference Standard

99. Alverine For Peak Identification, European Pharmacopoeia (ep) Reference Standard

2.4 Create Date
2005-03-26
3 Chemical and Physical Properties
Molecular Weight 473.6 g/mol
Molecular Formula C26H35NO7
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count8
Rotatable Bond Count14
Exact Mass473.24135246 g/mol
Monoisotopic Mass473.24135246 g/mol
Topological Polar Surface Area135 Ų
Heavy Atom Count34
Formal Charge0
Complexity442
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Parasympatholytics

Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS. (See all compounds classified as Parasympatholytics.)


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12-Apr-2022
15-Oct-2024
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ABOUT THIS PAGE

Alverine Manufacturers

A Alverine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Alverine, including repackagers and relabelers. The FDA regulates Alverine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Alverine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Alverine manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Alverine Suppliers

A Alverine supplier is an individual or a company that provides Alverine active pharmaceutical ingredient (API) or Alverine finished formulations upon request. The Alverine suppliers may include Alverine API manufacturers, exporters, distributors and traders.

click here to find a list of Alverine suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Alverine USDMF

A Alverine DMF (Drug Master File) is a document detailing the whole manufacturing process of Alverine active pharmaceutical ingredient (API) in detail. Different forms of Alverine DMFs exist exist since differing nations have different regulations, such as Alverine USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Alverine DMF submitted to regulatory agencies in the US is known as a USDMF. Alverine USDMF includes data on Alverine's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Alverine USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Alverine suppliers with USDMF on PharmaCompass.

Alverine KDMF

In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

Pharmaceutical companies submit a Alverine Drug Master File in Korea (Alverine KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Alverine. The MFDS reviews the Alverine KDMF as part of the drug registration process and uses the information provided in the Alverine KDMF to evaluate the safety and efficacy of the drug.

After submitting a Alverine KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Alverine API can apply through the Korea Drug Master File (KDMF).

click here to find a list of Alverine suppliers with KDMF on PharmaCompass.

Alverine GMP

Alverine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Alverine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Alverine GMP manufacturer or Alverine GMP API supplier for your needs.

Alverine CoA

A Alverine CoA (Certificate of Analysis) is a formal document that attests to Alverine's compliance with Alverine specifications and serves as a tool for batch-level quality control.

Alverine CoA mostly includes findings from lab analyses of a specific batch. For each Alverine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Alverine may be tested according to a variety of international standards, such as European Pharmacopoeia (Alverine EP), Alverine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Alverine USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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