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Chemistry

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Also known as: 18683-91-5, 107814-37-9, Rac-cis-ambroxol, 36557-04-7, Ambroxol base, 4-((2-amino-3,5-dibromobenzyl)amino)cyclohexan-1-ol
Molecular Formula
C13H18Br2N2O
Molecular Weight
378.10  g/mol
InChI Key
JBDGDEWWOUBZPM-UHFFFAOYSA-N
FDA UNII
QH6ZT6J071

Ambroxol
A metabolite of BROMHEXINE that stimulates mucociliary action and clears the air passages in the respiratory tract. It is usually administered as the hydrochloride.
1 2D Structure

Ambroxol

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-[(2-amino-3,5-dibromophenyl)methylamino]cyclohexan-1-ol
2.1.2 InChI
InChI=1S/C13H18Br2N2O/c14-9-5-8(13(16)12(15)6-9)7-17-10-1-3-11(18)4-2-10/h5-6,10-11,17-18H,1-4,7,16H2
2.1.3 InChI Key
JBDGDEWWOUBZPM-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1CC(CCC1NCC2=C(C(=CC(=C2)Br)Br)N)O
2.2 Other Identifiers
2.2.1 UNII
QH6ZT6J071
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 4-(((2-amino-3,5-dibromophenyl)methyl)amino)cyclohexanol

2. Abrohexal

3. Am, Bisolvon

4. Ambril

5. Ambro Puren

6. Ambro-puren

7. Ambrobeta

8. Ambrofur

9. Ambrohexal

10. Ambrols

11. Ambrolitic

12. Ambropp

13. Ambropuren

14. Ambroten

15. Ambroxin

16. Ambroxocompren

17. Bisolvon Am

18. Bromhexine Metabolite Viii

19. Bronchopront

20. Bronchowern

21. Broxol

22. Contac Husten Trunk

23. Contac Husten-trunk

24. Contac Hustentrunk

25. Dinobroxol

26. Duramucal

27. Ebromin

28. Expeflen

29. Expit

30. Farmabroxol

31. Flavamed

32. Frenopect

33. Gelopol

34. Hustenlser, Pect

35. Hustenlser, Therapin

36. Larylin Husten Lser

37. Larylin Husten-lser

38. Larylin Hustenlser

39. Lasolvan

40. Metabolite Viii, Bromhexine

41. Mibrox

42. Motosol

43. Muco Fips

44. Muco-fips

45. Mucofips

46. Mucosolvan

47. Mucotablin

48. Na 872

49. Na-872

50. Na872

51. Pdiamuc

52. Pect Hustenlser

53. Pulmonal S

54. Pulmonal, Ringelheimer

55. Ringelheimer Pulmonal

56. Sekretovit

57. Stas Hustenlser

58. Stas-hustenlser

59. Stashustenlser

60. Surbronc

61. Therapin Hustenlser

2.3.2 Depositor-Supplied Synonyms

1. 18683-91-5

2. 107814-37-9

3. Rac-cis-ambroxol

4. 36557-04-7

5. Ambroxol Base

6. 4-((2-amino-3,5-dibromobenzyl)amino)cyclohexan-1-ol

7. Ambroxolum

8. Bisolvon Metabolite Viii

9. 4-[(2-amino-3,5-dibromobenzyl)amino]cyclohexanol

10. Bromhexine-metabolite Viii

11. Na-872

12. Tabcin

13. Trans-4-((2-amino-3,5-dibromobenzyl)amino)cyclohexanol

14. Ambroxol, Cis-

15. Cis-4-((2-amino-3,5-dibromobenzyl)amino)cyclohexanol

16. Ambroxol [inn]

17. Cyclohexanol, 4-[[(2-amino-3,5-dibromophenyl)methyl]amino]-, Trans-

18. 4-[(2-amino-3,5-dibromophenyl)methylamino]cyclohexan-1-ol

19. Trans-4-((2-amino-3,5-dibromobencil)amino)ciclohexanol

20. Trans-4-((2-amino-3,5-dibromobenzyl)amine)cyclohexanol

21. Trans-4-[(2-amino-3,5-dibromobenzyl)amino]cyclohexanol

22. Qh6zt6j071

23. Cyclohexanol, 4-((2-amino-3,5-dibromobenzyl)amino)- (e)-

24. N-(2-amino-3,4-dibromocyclohexyl)-trans-4-aminocyclohexanol

25. 4-hydroxydemethylbromhexine, Cis-

26. N-(trans-4-hydroxycyclohexyl)-(2-amino-3,5-dibromobenzyl)-amine

27. N-(trans-p-hydroxycyclohexyl)-(2-amino-3,5-dibromobenzyl)amine

28. Ambroxol (inn)

29. Cyclohexanol, 4-(((2-amino-3,5-dibromophenyl)methyl)amino)-, Trans-

30. 200168s0cl

31. N-(2-amino-3,4-dibromociclohexil)-trans-4-aminociclohexanol

32. N-(trans-4-hidroxiciclohexil)-(2-amino-3,5-dibromobencil)amina

33. Ambroxol [inn:ban]

34. Cis-4-(((2-amino-3,5-dibromophenyl)methyl)amino)cyclohexanol

35. Ambroxolum [inn-latin]

36. Cyclohexanol, 4-(((2-amino-3,5-dibromophenyl)methyl)amino)-, Cis-

37. Cyclohexanol, 4-(((2-amino-3,5-dibromophenyl)methyl)amino)-, Trans- (9ci)

38. Bromhexine Metabolite Viii

39. Ncgc00016781-04

40. Einecs 242-500-3

41. Cas-23828-92-4

42. Amboxol

43. Cis-ambroxol

44. Sr-05000001463

45. Unii-200168s0cl

46. Tabcin (tn)

47. Spectrum_001346

48. 4-{[(2-amino-3,5-dibromophenyl)methyl]amino}cyclohexan-1-ol

49. Ambroxol [mi]

50. Rac-cis-ambroxol-[d5]

51. Prestwick0_000366

52. Prestwick1_000366

53. Prestwick2_000366

54. Prestwick3_000366

55. Spectrum2_001518

56. Spectrum3_000955

57. Spectrum4_001068

58. Spectrum5_001021

59. Trans-4-((2-amino-3,5-dibromobencil)amino)ciclohexanol [spanish]

60. N-(2-amino-3,4-dibromociclohexil)-trans-4-aminociclohexanol [spanish]

61. Ambroxol [who-dd]

62. Ec 242-500-3

63. N-(trans-4-hidroxiciclohexil)-(2-amino-3,5-dibromobencil)amina [spanish]

64. Unii-qh6zt6j071

65. Oprea1_766685

66. Schembl18702

67. Bspbio_000491

68. Kbiogr_001396

69. Kbioss_001826

70. Mls001306470

71. Divk1c_000027

72. Schembl423712

73. Spbio_001595

74. Spbio_002412

75. Bpbio1_000541

76. Chembl153479

77. Schembl7855003

78. 4-[(2-amino-3,5-dibromo-phenyl)methylamino]cyclohexanol

79. Chembl1477775

80. Dtxsid8022583

81. Schembl21765132

82. Bcbcmap01_000092

83. Chebi:92994

84. Gtpl10692

85. Kbio1_000027

86. Kbio2_001826

87. Kbio2_004394

88. Kbio2_006962

89. Kbio3_002050

90. Dtxsid60860228

91. Chebi:135590

92. Ninds_000027

93. Cyclohexanol, 4-[[(2-amino-3,5-dibromophenyl)methyl]amino]-

94. Hms2089d06

95. Hms2231b19

96. Hms3373j22

97. Hms3886m18

98. Zinc587613

99. Albb-022461

100. Bcp04489

101. Hy-b1039

102. Bbl009896

103. Bdbm50395322

104. Mfcd00242702

105. Mfcd28143339

106. S5710

107. Stk711075

108. Akos005530704

109. Akos015889660

110. Akos027338704

111. Zinc100001905

112. Zinc100070274

113. Ac-8362

114. Ambroxol Hydrochloride Impurity D [ep]

115. Bcp9000283

116. Ccg-207907

117. Cs-4558

118. Db06742

119. Sb17463

120. Sb82866

121. Idi1_000027

122. Smp1_000014

123. Ncgc00016781-01

124. Ncgc00016781-02

125. Ncgc00016781-08

126. Ncgc00159399-02

127. Ncgc00371077-02

128. As-56023

129. Smr000718792

130. Vs-02240

131. 4-hydroxydemethylbromhexine, Trans-

132. Bcp0726000066

133. Sbi-0051766.p002

134. Ab00514663

135. Cs-0323348

136. Ft-0622261

137. Ft-0630430

138. Ft-0661549

139. D07442

140. 4-(2-amino-3,5-dibromobenzylamino)cyclohexanol

141. Ab00053639_13

142. Ab01275465-01

143. 683a915

144. A813089

145. Q221637

146. Sr-05000001463-1

147. Ambroxol Hydrochloride Impurity D [ep Impurity]

148. Brd-k11223672-003-03-7

149. Brd-k11223672-003-04-5

150. Brd-k56558538-003-02-8

151. 4-[(2-amino-3,5-dibromophenyl)methylamino-]cyclohexanol

152. 4-[(2-amino-3,5-dibromophenyl)methylamino]cyclohexanol

153. (1s,4s)-4-((2-amino-3,5-dibromobenzyl)amino)cyclohexanol

154. 4-[(2-amino-3,5-dibromobenzyl)amino]cyclohexanol, Trans-

155. (1r,4r)-4-((2-amino-3,5-dibromobenzyl)amino)cyclohexan-1-ol

156. Trans-4-{[(2-amino-3,5-dibromophenyl)methyl]amino}cyclohexanol

157. Cyclohexanol, 4-[[(2-amino-3,5-dibromo-phenyl)methyl]amino]-, Trans

2.4 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 378.10 g/mol
Molecular Formula C13H18Br2N2O
XLogP32.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Exact Mass377.97654 g/mol
Monoisotopic Mass375.97859 g/mol
Topological Polar Surface Area58.3 Ų
Heavy Atom Count18
Formal Charge0
Complexity259
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Ambroxol is indicated for secretolytic therapy in bronchoplmonary disease with abnormal mucus secretion and transport. It allows the mucus to be more easily cleared and ease a patient's breathing.


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Expectorants

Agents that increase mucous excretion. Mucolytic agents, that is drugs that liquefy mucous secretions, are also included here. (See all compounds classified as Expectorants.)


5.2 ATC Code

R05CB06

S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355


R - Respiratory system

R05 - Cough and cold preparations

R05C - Expectorants, excl. combinations with cough suppressants

R05CB - Mucolytics

R05CB06 - Ambroxol


5.3 Absorption, Distribution and Excretion

Absorption

Rapid and almost complete.


5.4 Metabolism/Metabolites

Ambroxol has known human metabolites that include 2-Amino-3,5-dibromobenzaldehyde and 4-Aminocyclohexanol, cis-.

S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560


5.5 Biological Half-Life

7-12 hours


5.6 Mechanism of Action

Ambroxol is a mucolytic agent. Excessive Nitric oxide (NO) is associated with inflammatory and some other disturbances of airways function. NO enhances the activation of soluble guanylate cyclase and cGMP accumulation. Ambroxol has been shown to inhibit the NO-dependent activation of soluble guanylate cyclase. It is also possible that the inhibition of NO-dependent activation of soluble guanylate cyclase can suppress the excessive mucus secretion, therefore it lowers the phlegm viscosity and improves the mucociliary transport of bronchial secretions.


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01-Jan-2021
28-Feb-2025
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ABOUT THIS PAGE

Looking for 107814-37-9 / Ambroxol API manufacturers, exporters & distributors?

Ambroxol manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Ambroxol API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Ambroxol manufacturer or Ambroxol supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Ambroxol manufacturer or Ambroxol supplier.

PharmaCompass also assists you with knowing the Ambroxol API Price utilized in the formulation of products. Ambroxol API Price is not always fixed or binding as the Ambroxol Price is obtained through a variety of data sources. The Ambroxol Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Ambroxol

Synonyms

18683-91-5, 107814-37-9, Rac-cis-ambroxol, 36557-04-7, Ambroxol base, 4-((2-amino-3,5-dibromobenzyl)amino)cyclohexan-1-ol

Cas Number

107814-37-9

Unique Ingredient Identifier (UNII)

QH6ZT6J071

About Ambroxol

A metabolite of BROMHEXINE that stimulates mucociliary action and clears the air passages in the respiratory tract. It is usually administered as the hydrochloride.

Ambroxol Manufacturers

A Ambroxol manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Ambroxol, including repackagers and relabelers. The FDA regulates Ambroxol manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Ambroxol API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Ambroxol manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Ambroxol Suppliers

A Ambroxol supplier is an individual or a company that provides Ambroxol active pharmaceutical ingredient (API) or Ambroxol finished formulations upon request. The Ambroxol suppliers may include Ambroxol API manufacturers, exporters, distributors and traders.

click here to find a list of Ambroxol suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Ambroxol GMP

Ambroxol Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Ambroxol GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Ambroxol GMP manufacturer or Ambroxol GMP API supplier for your needs.

Ambroxol CoA

A Ambroxol CoA (Certificate of Analysis) is a formal document that attests to Ambroxol's compliance with Ambroxol specifications and serves as a tool for batch-level quality control.

Ambroxol CoA mostly includes findings from lab analyses of a specific batch. For each Ambroxol CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Ambroxol may be tested according to a variety of international standards, such as European Pharmacopoeia (Ambroxol EP), Ambroxol JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Ambroxol USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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