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ACTIVE PHARMA INGREDIENTS

55 API Suppliers, 11 CEP/COS, 14 JDMF, 7 EU WC, 13 KDMF, 2 NDC API, 43 Listed Suppliers, $ API Reference Price

55 API Suppliers
11 CEP/COS
14 JDMF
7 EU WC
13 KDMF
2 NDC API
43 Listed Suppliers
$ API Reference Price

INTERMEDIATES

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8 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

92 FDF Dossiers, 34 Europe, 58 Listed Dossiers

92 FDF Dossiers
34 Europe
58 Listed Dossiers

DIGITAL CONTENT

1 DATA COMPILATION #PharmaFlow, 8 NEWS #PharmaBuzz

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1 DATA COMPILATION #PharmaFlow
8 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

18 Finished Drug Prices, 3 Annual Reports

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18 Finished Drug Prices
3 Annual Reports

MARKET PLACE

18 APIs, 10 FDF Dossiers

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18 APIs
10 FDF Dossiers

REF. STANDARDS & IMPURITIES

1 EDQM

otherSolutions
1 EDQM

Atman Ambroxol Hydrochloride

Synopsis

Chemistry

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Also known as: 23828-92-4, Ambroxol hcl, Mucoangin, Mucosolvan, Ambroxolhydrochloride, 1384955-66-1

Molecular Formula

C₁₃H₁₉Br₂ClN₂O

Molecular Weight

414.56 g/mol

InChI Key

QNVKOSLOVOTXKF-UHFFFAOYSA-N

FDA UNII

R3593UZ7HS

A metabolite of BROMHEXINE that stimulates mucociliary action and clears the air passages in the respiratory tract. It is usually administered as the hydrochloride.

1 2D Structure

Ambroxol Hydrochloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

4-[(2-amino-3,5-dibromophenyl)methylamino]cyclohexan-1-ol;hydrochloride

2.1.2 InChI

InChI=1S/C13H18Br2N2O.ClH/c14-9-5-8(13(16)12(15)6-9)7-17-10-1-3-11(18)4-2-10;/h5-6,10-11,17-18H,1-4,7,16H2;1H

2.1.3 InChI Key

QNVKOSLOVOTXKF-UHFFFAOYSA-N

2.1.4 Canonical SMILES

C1CC(CCC1NCC2=C(C(=CC(=C2)Br)Br)N)O.Cl

2.2 Other Identifiers

2.2.1 UNII

R3593UZ7HS

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 4-(((2-amino-3,5-dibromophenyl)methyl)amino)cyclohexanol

2. Abrohexal

3. Am, Bisolvon

4. Ambril

5. Ambro Puren

6. Ambro-puren

7. Ambrobeta

8. Ambrofur

9. Ambrohexal

10. Ambrols

11. Ambrolitic

12. Ambropp

13. Ambropuren

14. Ambroten

15. Ambroxin

16. Ambroxocompren

17. Ambroxol

18. Bisolvon Am

19. Bromhexine Metabolite Viii

20. Bronchopront

21. Bronchowern

22. Broxol

23. Contac Husten Trunk

24. Contac Husten-trunk

25. Contac Hustentrunk

26. Dinobroxol

27. Duramucal

28. Ebromin

29. Expeflen

30. Expit

31. Farmabroxol

32. Flavamed

33. Frenopect

34. Gelopol

35. Hustenlser, Pect

36. Hustenlser, Therapin

37. Larylin Husten Lser

38. Larylin Husten-lser

39. Larylin Hustenlser

40. Lasolvan

41. Metabolite Viii, Bromhexine

42. Mibrox

43. Motosol

44. Muco Fips

45. Muco-fips

46. Mucofips

47. Mucosolvan

48. Mucotablin

49. Na 872

50. Na-872

51. Na872

52. Pdiamuc

53. Pect Hustenlser

54. Pulmonal S

55. Pulmonal, Ringelheimer

56. Ringelheimer Pulmonal

57. Sekretovit

58. Stas Hustenlser

59. Stas-hustenlser

60. Stashustenlser

61. Surbronc

62. Therapin Hustenlser

2.3.2 Depositor-Supplied Synonyms

1. 23828-92-4

2. Ambroxol Hcl

3. Mucoangin

4. Mucosolvan

5. Ambroxolhydrochloride

6. 1384955-66-1

7. 1146648-86-3

8. Lasolvan

9. 15942-05-9

10. Trans-4-((2-amino-3,5-dibromobenzyl)amino)cyclohexanol Hydrochloride

11. Ambroxol Impurity D Hcl

12. 4-((2-amino-3,5-dibromobenzyl)amino)cyclohexan-1-ol Hydrochloride

13. Cis-4-((2-amino-3,5-dibromobenzyl)amino)cyclohexanol Hydrochloride

14. Ambroxol Hydrochloride [jan]

15. Ambroxol Hydrochloride

16. Ambroxol (hydrochloride)

17. Ambroxol Hydrochloride, Cis-

18. 4-[(2-amino-3,5-dibromophenyl)methylamino]cyclohexan-1-ol;hydrochloride

19. Cc995zmv90

20. R3593uz7hs

21. Ambroxol Impurity D Hydrochloride

22. Na-872

23. Mfcd00078932

24. Nsc-758224

25. Ambroxol Hydrochloride (jan)

26. Ambroxol Hydrochloride 100 Microg/ml In Acetonitrile

27. Mucolear

28. Ambroxol Lozenge

29. Cis-4-[(2-amino-3,5-dibromobenzyl)amino]cyclohexanol Hydrochloride

30. Cyclohexanol, 4-(((2-amino-3,5-dibromophenyl)methyl)amino)-, Hydrochloride (1:1), Cis-

31. Smr000875269

32. Na 872 Hydrochloride

33. Ncgc00016781-04

34. Cas-23828-92-4

35. Unii-cc995zmv90

36. Lazolvan

37. Ponophen

38. 4-(2-amino-3,5-dibromobenzylamino)cyclohexanol Hydrochloride

39. Ccris 8686

40. Mucosolvan-l

41. Sr-05000001463

42. Mucosal-l

43. Trans-4-[(2-amino-3,5-dibromobenzyl)amino]cyclohexanol Hydrochloride

44. Hustless (tn)

45. Prestwick_717

46. Einecs 245-899-2

47. Dsstox_cid_25442

48. Dsstox_rid_80883

49. Unii-r3593uz7hs

50. Dsstox_gsid_45442

51. Schembl99455

52. Ambroxol Hydrochloride ,(s)

53. Ambroxol Hydrochloride, 98%

54. Mls001333105

55. Mls001333106

56. Mls002153788

57. Spectrum1503080

58. (e)-4-hdmb

59. Na-872et

60. Chembl1514634

61. Dtxsid2045442

62. Chebi:31198

63. Hy-b1039a

64. Dtxsid60936098

65. Exr-202

66. Hms1569i13

67. Hms1922c19

68. Pharmakon1600-01503080

69. Ambroxol Hydrochloride [mi]

70. 4-((2-amino-3,5-dibromobenzyl)amino)cyclohexanol Hydrochloride

71. Bcp04490

72. Tox21_110607

73. Ac-024

74. Ccg-39174

75. Nsc758224

76. S3064

77. (1r,4r)-4-((2-amino-3,5-dibromobenzyl)amino)cyclohexanol Hydrochloride

78. Akos015895175

79. Akos015951294

80. Akos024462505

81. Ambroxol Hydrochloride [mart.]

82. Ambroxol Hydrochloride [who-dd]

83. Bcp9000284

84. Ccg-220366

85. Ks-5248

86. Nsc 758224

87. Ncgc00016781-03

88. Ncgc00092387-01

89. Ncgc00094999-01

90. Ncgc00094999-02

91. Ba166015

92. Sy052506

93. Ambroxol Hydrochloride, Analytical Standard

94. Bcp0726000073

95. Ambroxol Hydrochloride [ep Impurity]

96. Ambroxol Hydrochloride [ep Monograph]

97. B2267

98. Cs-0013219

99. Ft-0630506

100. Sw198832-2

101. A16398

102. D01479

103. H11915

104. A816928

105. Sr-01000837516

106. Q-100980

107. Sr-01000837516-3

108. Sr-05000001463-2

109. Q27275396

110. Ambroxol Hydrochloride Pound Ep2001/cp2000 Pound(c)

111. F1131-0002

112. Ambroxol Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)

113. Trans-4-(2-amino-3,5-dibromobenzylamino)cyclohexanol Hydrochloride

114. (1r,4r)-4-((2-amino-3,5-dibromobenzyl)amino)cyclohexan-1-ol Hydrochloride

115. (1r,4r)-4-(2-amino-3,5-dibromobenzylamino)cyclohexanol Hydrochloride

116. 4-[(2-amino-3,5-dibromobenzyl)amino]cyclohexanol Hydrochloride, Aldrichcpr

117. Ambroxol Hydrochloride, European Pharmacopoeia (ep) Reference Standard

118. Cyclohexanol, 4-((2-amino-3,5-dibromobenzyl)amino)-, Hydrochloride, Trans-

119. Cyclohexanol, 4-(n-(2-amino-3,5-dibromobenzyl)amino)-, Hydrochloride (e)-

120. Cyclohexanol, 4-[[(2-amino-3,5-dibromophenyl)methyl]amino]-, Hydrochloride

121. Cyclohexanol,4-[[(2-amino-3,5-dibromophenyl)methyl]amino]-,hydrochloride

122. Trans-4-((2-amino-3,5-dibromobenzyl)-amino)cyclohexanol Hydrochloride

123. 4-{[(2-amino-3,5-dibromophenyl)methyl]amino}cyclohexan-1-ol--hydrogen Chloride (1/1)

124. Cyclohexanol, 4-(((2-amino-3,5-dibromophenyl)methyl)amino)-, Monohydrochloride, Trans-

125. Cyclohexanol, 4-[[(2-amino-3,5-dibromophenyl)methyl]amino]-, Hydrochloride (1:1), Trans-

126. Imp. D (ep): Cis-4-[(2-amino-3,5-dibromobenzyl)amino]-cyclohexanol Hcl

127. Trans-4-(((2-amino-3,5-dibromophenyl)methyl)amino)cyclohexan-1-ol Hydrochloride

128. Trans-4-[[(2-amino-3,5-dibromo-phenyl)methyl]amino]-cyclohexanol Hydrochloride

129. Trans-4-[[(2-amino-3,5-dibromophenyl)methyl]amino]cyclohexanol Hydrochloride

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₁₃H₁₉Br₂ClN₂O
Molecular Weight	414.56 g/mol
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Exact Mass	413.95322 g/mol
Monoisotopic Mass	411.95527 g/mol
Topological Polar Surface Area	58.3 Å²
Heavy Atom Count	19
Formal Charge	0
Complexity	259
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Expectorants

Agents that increase mucous excretion. Mucolytic agents, that is drugs that liquefy mucous secretions, are also included here. (See all compounds classified as Expectorants.)

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API Reference Price

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LIMITED","customerCountry":"INDIA","quantity":"550.00","actualQuantity":"550","unit":"KGS","unitRateFc":"59","totalValueFC":"32729.1","currency":"USD","unitRateINR":"4991.4","date":"03-Aug-2024","totalValueINR":"2745270","totalValueInUsd":"32729.1","indian_port":"Madras Sea","hs_no":"29222190","bill_no":"4860252","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"KAOHSIUNG","supplierAddress":"3F., NO.133,YINGMING 1ST RD.CIANJHEN DISTRICT,KAOHSIUNG CITY806,TAIWAN TW","customerAddress":"12 6 214 A1 SHILPA HOUSE HYDERABAD ROAD"}]

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Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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ACTIVE PHARMA INGREDIENTS

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