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ACTIVE PHARMA INGREDIENTS

55 API Suppliers, 11 CEP/COS, 14 JDMF, 7 EU WC, 13 KDMF, 2 NDC API, 43 Listed Suppliers, $ API Reference Price

55 API Suppliers
11 CEP/COS
14 JDMF
7 EU WC
13 KDMF
2 NDC API
43 Listed Suppliers
$ API Reference Price

INTERMEDIATES

8 Intermediates Suppliers

8 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

93 FDF Dossiers, 34 Europe, 59 Listed Dossiers

93 FDF Dossiers
34 Europe
59 Listed Dossiers

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1 DATA COMPILATION #PharmaFlow, 8 NEWS #PharmaBuzz

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18 Finished Drug Prices, 3 Annual Reports

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18 Finished Drug Prices
3 Annual Reports

MARKET PLACE

19 APIs, 10 FDF Dossiers

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19 APIs
10 FDF Dossiers

REF. STANDARDS & IMPURITIES

1 EDQM

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1 EDQM

Atman Ambroxol Hydrochloride

Synopsis

ACTIVE PHARMA INGREDIENTS

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US Patents

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Health Canada Patents

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Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

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336

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Chemistry

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Also known as: 23828-92-4, Ambroxol hcl, Mucoangin, Mucosolvan, Ambroxolhydrochloride, 1384955-66-1

Molecular Formula

C₁₃H₁₉Br₂ClN₂O

Molecular Weight

414.56 g/mol

InChI Key

QNVKOSLOVOTXKF-UHFFFAOYSA-N

FDA UNII

R3593UZ7HS

A metabolite of BROMHEXINE that stimulates mucociliary action and clears the air passages in the respiratory tract. It is usually administered as the hydrochloride.

1 2D Structure

Ambroxol Hydrochloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

4-[(2-amino-3,5-dibromophenyl)methylamino]cyclohexan-1-ol;hydrochloride

2.1.2 InChI

InChI=1S/C13H18Br2N2O.ClH/c14-9-5-8(13(16)12(15)6-9)7-17-10-1-3-11(18)4-2-10;/h5-6,10-11,17-18H,1-4,7,16H2;1H

2.1.3 InChI Key

QNVKOSLOVOTXKF-UHFFFAOYSA-N

2.1.4 Canonical SMILES

C1CC(CCC1NCC2=C(C(=CC(=C2)Br)Br)N)O.Cl

2.2 Other Identifiers

2.2.1 UNII

R3593UZ7HS

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 4-(((2-amino-3,5-dibromophenyl)methyl)amino)cyclohexanol

2. Abrohexal

3. Am, Bisolvon

4. Ambril

5. Ambro Puren

6. Ambro-puren

7. Ambrobeta

8. Ambrofur

9. Ambrohexal

10. Ambrols

11. Ambrolitic

12. Ambropp

13. Ambropuren

14. Ambroten

15. Ambroxin

16. Ambroxocompren

17. Ambroxol

18. Bisolvon Am

19. Bromhexine Metabolite Viii

20. Bronchopront

21. Bronchowern

22. Broxol

23. Contac Husten Trunk

24. Contac Husten-trunk

25. Contac Hustentrunk

26. Dinobroxol

27. Duramucal

28. Ebromin

29. Expeflen

30. Expit

31. Farmabroxol

32. Flavamed

33. Frenopect

34. Gelopol

35. Hustenlser, Pect

36. Hustenlser, Therapin

37. Larylin Husten Lser

38. Larylin Husten-lser

39. Larylin Hustenlser

40. Lasolvan

41. Metabolite Viii, Bromhexine

42. Mibrox

43. Motosol

44. Muco Fips

45. Muco-fips

46. Mucofips

47. Mucosolvan

48. Mucotablin

49. Na 872

50. Na-872

51. Na872

52. Pdiamuc

53. Pect Hustenlser

54. Pulmonal S

55. Pulmonal, Ringelheimer

56. Ringelheimer Pulmonal

57. Sekretovit

58. Stas Hustenlser

59. Stas-hustenlser

60. Stashustenlser

61. Surbronc

62. Therapin Hustenlser

2.3.2 Depositor-Supplied Synonyms

1. 23828-92-4

2. Ambroxol Hcl

3. Mucoangin

4. Mucosolvan

5. Ambroxolhydrochloride

6. 1384955-66-1

7. 1146648-86-3

8. Lasolvan

9. 15942-05-9

10. Trans-4-((2-amino-3,5-dibromobenzyl)amino)cyclohexanol Hydrochloride

11. Ambroxol Impurity D Hcl

12. 4-((2-amino-3,5-dibromobenzyl)amino)cyclohexan-1-ol Hydrochloride

13. Cis-4-((2-amino-3,5-dibromobenzyl)amino)cyclohexanol Hydrochloride

14. Ambroxol Hydrochloride [jan]

15. Ambroxol Hydrochloride

16. Ambroxol (hydrochloride)

17. Ambroxol Hydrochloride, Cis-

18. 4-[(2-amino-3,5-dibromophenyl)methylamino]cyclohexan-1-ol;hydrochloride

19. Cc995zmv90

20. R3593uz7hs

21. Ambroxol Impurity D Hydrochloride

22. Na-872

23. Mfcd00078932

24. Nsc-758224

25. Ambroxol Hydrochloride (jan)

26. Ambroxol Hydrochloride 100 Microg/ml In Acetonitrile

27. Mucolear

28. Ambroxol Lozenge

29. Cis-4-[(2-amino-3,5-dibromobenzyl)amino]cyclohexanol Hydrochloride

30. Cyclohexanol, 4-(((2-amino-3,5-dibromophenyl)methyl)amino)-, Hydrochloride (1:1), Cis-

31. Smr000875269

32. Na 872 Hydrochloride

33. Ncgc00016781-04

34. Cas-23828-92-4

35. Unii-cc995zmv90

36. Lazolvan

37. Ponophen

38. 4-(2-amino-3,5-dibromobenzylamino)cyclohexanol Hydrochloride

39. Ccris 8686

40. Mucosolvan-l

41. Sr-05000001463

42. Mucosal-l

43. Trans-4-[(2-amino-3,5-dibromobenzyl)amino]cyclohexanol Hydrochloride

44. Hustless (tn)

45. Prestwick_717

46. Einecs 245-899-2

47. Dsstox_cid_25442

48. Dsstox_rid_80883

49. Unii-r3593uz7hs

50. Dsstox_gsid_45442

51. Schembl99455

52. Ambroxol Hydrochloride ,(s)

53. Ambroxol Hydrochloride, 98%

54. Mls001333105

55. Mls001333106

56. Mls002153788

57. Spectrum1503080

58. (e)-4-hdmb

59. Na-872et

60. Chembl1514634

61. Dtxsid2045442

62. Chebi:31198

63. Hy-b1039a

64. Dtxsid60936098

65. Exr-202

66. Hms1569i13

67. Hms1922c19

68. Pharmakon1600-01503080

69. Ambroxol Hydrochloride [mi]

70. 4-((2-amino-3,5-dibromobenzyl)amino)cyclohexanol Hydrochloride

71. Bcp04490

72. Tox21_110607

73. Ac-024

74. Ccg-39174

75. Nsc758224

76. S3064

77. (1r,4r)-4-((2-amino-3,5-dibromobenzyl)amino)cyclohexanol Hydrochloride

78. Akos015895175

79. Akos015951294

80. Akos024462505

81. Ambroxol Hydrochloride [mart.]

82. Ambroxol Hydrochloride [who-dd]

83. Bcp9000284

84. Ccg-220366

85. Ks-5248

86. Nsc 758224

87. Ncgc00016781-03

88. Ncgc00092387-01

89. Ncgc00094999-01

90. Ncgc00094999-02

91. Ba166015

92. Sy052506

93. Ambroxol Hydrochloride, Analytical Standard

94. Bcp0726000073

95. Ambroxol Hydrochloride [ep Impurity]

96. Ambroxol Hydrochloride [ep Monograph]

97. B2267

98. Cs-0013219

99. Ft-0630506

100. Sw198832-2

101. A16398

102. D01479

103. H11915

104. A816928

105. Sr-01000837516

106. Q-100980

107. Sr-01000837516-3

108. Sr-05000001463-2

109. Q27275396

110. Ambroxol Hydrochloride Pound Ep2001/cp2000 Pound(c)

111. F1131-0002

112. Ambroxol Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)

113. Trans-4-(2-amino-3,5-dibromobenzylamino)cyclohexanol Hydrochloride

114. (1r,4r)-4-((2-amino-3,5-dibromobenzyl)amino)cyclohexan-1-ol Hydrochloride

115. (1r,4r)-4-(2-amino-3,5-dibromobenzylamino)cyclohexanol Hydrochloride

116. 4-[(2-amino-3,5-dibromobenzyl)amino]cyclohexanol Hydrochloride, Aldrichcpr

117. Ambroxol Hydrochloride, European Pharmacopoeia (ep) Reference Standard

118. Cyclohexanol, 4-((2-amino-3,5-dibromobenzyl)amino)-, Hydrochloride, Trans-

119. Cyclohexanol, 4-(n-(2-amino-3,5-dibromobenzyl)amino)-, Hydrochloride (e)-

120. Cyclohexanol, 4-[[(2-amino-3,5-dibromophenyl)methyl]amino]-, Hydrochloride

121. Cyclohexanol,4-[[(2-amino-3,5-dibromophenyl)methyl]amino]-,hydrochloride

122. Trans-4-((2-amino-3,5-dibromobenzyl)-amino)cyclohexanol Hydrochloride

123. 4-{[(2-amino-3,5-dibromophenyl)methyl]amino}cyclohexan-1-ol--hydrogen Chloride (1/1)

124. Cyclohexanol, 4-(((2-amino-3,5-dibromophenyl)methyl)amino)-, Monohydrochloride, Trans-

125. Cyclohexanol, 4-[[(2-amino-3,5-dibromophenyl)methyl]amino]-, Hydrochloride (1:1), Trans-

126. Imp. D (ep): Cis-4-[(2-amino-3,5-dibromobenzyl)amino]-cyclohexanol Hcl

127. Trans-4-(((2-amino-3,5-dibromophenyl)methyl)amino)cyclohexan-1-ol Hydrochloride

128. Trans-4-[[(2-amino-3,5-dibromo-phenyl)methyl]amino]-cyclohexanol Hydrochloride

129. Trans-4-[[(2-amino-3,5-dibromophenyl)methyl]amino]cyclohexanol Hydrochloride

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₁₃H₁₉Br₂ClN₂O
Molecular Weight	414.56 g/mol
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Exact Mass	413.95322 g/mol
Monoisotopic Mass	411.95527 g/mol
Topological Polar Surface Area	58.3 Å²
Heavy Atom Count	19
Formal Charge	0
Complexity	259
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Expectorants

Agents that increase mucous excretion. Mucolytic agents, that is drugs that liquefy mucous secretions, are also included here. (See all compounds classified as Expectorants.)

API SUPPLIERS

01

Atman Pharmaceuticals

India

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Jai Radhe Sales

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Ami Lifesciences Private Limited

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Ambroxol hydrochloride

Certificate Number : CEP 2014-135 - Rev 03

Status : Valid

Issue Date : 2024-03-25

Type : Chemical

Substance Number : 1489

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Ambroxol hydrochloride, Process II

Certificate Number : R0-CEP 2023-168 - Rev 00

Status : Valid

Issue Date : 2023-08-23

Type : Chemical

Substance Number : 1489

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Atman Pharmaceuticals

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About the Company : Atman Pharmaceuticals is a fully integrated pharmaceutical company that has distinguished itself as a leader in Bulk Drugs (API) marketing both domestically in India and overseas. ...

Atman Pharmaceuticals is a fully integrated pharmaceutical company that has distinguished itself as a leader in Bulk Drugs (API) marketing both domestically in India and overseas. With a heritage spanning over 33 years and vast experience, we have earned a reputation for delivering high-quality and abundant services within the industry. Our emergence as prominent solution providers in the pharmaceutical business underscores our commitment to excellence.

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LGM Pharma

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About the Company : LGM Pharma is a global leader in sourcing hard-to-find APIs and intermediates for the pharmaceutical and biotech industries. LGM is also a full service CDMO providing formulation, ...

LGM Pharma is a global leader in sourcing hard-to-find APIs and intermediates for the pharmaceutical and biotech industries. LGM is also a full service CDMO providing formulation, analytical method development and testing, and commercial manufacturing. LGM Pharma offers custom API synthesis, analytical development, and regulatory services. With a network of over 300 accredited CGMP manufacturing partners, LGM provides unparalleled supply chain security. And, with over 100,000 square feet of FDA-inspected cGMP manufacturing and warehouse capacity, LGM Pharma provides a one-stop solution for solid dose, powder, semi-solid and liquid drugs.

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Emay Pharmaceuticals

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About the Company : Emay Pharmaceuticals Pvt Ltd functions as the merchant export division of M/s. Bhavna Laboratories Pvt Ltd. As a GMP-approved API manufacturing company, we boast over three decades...

Emay Pharmaceuticals Pvt Ltd functions as the merchant export division of M/s. Bhavna Laboratories Pvt Ltd. As a GMP-approved API manufacturing company, we boast over three decades of experience in exporting a wide array of Pharmaceutical and allied products, engaging in both manufacturing and export operations. Emay Pharmaceuticals Pvt Ltd comprises a team of seasoned professionals with extensive expertise in Human Health APIs and Veterinary Health APIs. Specializing in the trade of various raw materials for both Human and Veterinary medicine, Emay Pharmaceuticals Pvt Ltd is dedicated to providing quality products.

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Jai Radhe Sales

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About the Company : Jai Radhe Sales was founded in 1999 as an out-of-the-box distribution firm specializing in the global supply of high-quality pharmaceutical ingredients. The firm provides complete ...

Jai Radhe Sales was founded in 1999 as an out-of-the-box distribution firm specializing in the global supply of high-quality pharmaceutical ingredients. The firm provides complete sourcing solutions for pharmaceutical products from India, including technical and regulatory assistance. It believes in providing its customers with high-quality products at reasonable prices. It has always endeavored to achieve global standards in the field of pharmaceuticals and has carved out a niche for itself through new methods based on current market needs. Today, it has established itself as a truly global company, with exports to almost every continent.

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Ami Lifesciences Private Limited

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About the Company : Ami Lifesciences, established in 2006, is one of the fastest growing API manufacturing companies in India. Specializing in cardiovascular, anti-diabetic, CNS, and respiratory thera...

Ami Lifesciences, established in 2006, is one of the fastest growing API manufacturing companies in India. Specializing in cardiovascular, anti-diabetic, CNS, and respiratory therapeutic areas, Ami offers a wide range of APIs, intermediates, key starting materials, as well as contract bulk manufacturing services. Ami's manufacturing units in Gujarat and Karnataka feature dedicated clean rooms for APIs and adhere to international standards like EU-GMP, WHO-GMP, PMDA, and COFEPRIS. Ami serves as a reliable partner for contract development and manufacturing, offering generic APIs to global pharma companies across more than 60 countries.

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Chynops Pharma

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About the Company : Chynops Pharma, a company certified with ISO 9001:2015, is situated in Ahmedabad, India. We specialize in exporting, supplying, and trading a wide range of products, including APIs...

Chynops Pharma, a company certified with ISO 9001:2015, is situated in Ahmedabad, India. We specialize in exporting, supplying, and trading a wide range of products, including APIs, Advanced Drug Intermediates, Impurity Standards, Working Standards, KSMs, Industrial Chemicals, Specialty Chemicals, Excipients, Amino Acids, Vitamins, Minerals, Herbal Extracts, Essential Oils, Prebiotics & Probiotics, Veterinary APIs, Solvents, and more from India. Our commitment extends to providing these products to valued customers in both the domestic and global markets.

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HRV Global Life Sciences

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About the Company : HRV Global is a leading global manufacturer, seller & exporter of a wide range of APIs, advanced intermediates, pellets, food grade chemicals, food additives & food ingredients. It...

HRV Global is a leading global manufacturer, seller & exporter of a wide range of APIs, advanced intermediates, pellets, food grade chemicals, food additives & food ingredients. It offers services such as sourcing, manufacturing & supply, helping partners enter new markets worldwide. Its strong partnerships with major players in the pharma and food additive industries help HRV Global effectively promote projects and products. HRV Global represents over 30 large Indian drugmakers, primarily targeting Europe, the US & the Middle East markets. Headquartered in India, HRV Global has offices in the US, Switzerland, Dubai, Lithuania & Turkey.

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Tenatra Chemie

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About the Company : Tenatra International was established as a proprietorship firm in 1999. It got off to a very good start, supporting clients in the United States, Mexico and Europe. As business opp...

Tenatra International was established as a proprietorship firm in 1999. It got off to a very good start, supporting clients in the United States, Mexico and Europe. As business opportunities grew, it was felt that the proprietorship firm had outlived its usefulness and that it needed a corporate structure. So, Tenatra Chemie Private Limited (TCPL) was incorporated in 2002. Since then, the company has come a long way, gaining valuable experience and knowledge in the fields of chemicals and pharmaceuticals in India.

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Alchymars ICM SM

India

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Atomgrid

India

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API Reference Price

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