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Amifampridine Phosphate

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ACTIVE PHARMA INGREDIENTS

2 API Suppliers, 2 USDMF, 3 NDC API, 1 Listed Suppliers, $ API Reference Price

2 API Suppliers
2 USDMF
3 NDC API
1 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

15 Drugs in Development

15 Drugs in Development

FINISHED DOSAGE FORMULATIONS

2 FDF Dossiers, 1 FDA Orange Book, 1 Europe

2 FDF Dossiers
1 FDA Orange Book
1 Europe

DIGITAL CONTENT

1 DATA COMPILATION #PharmaFlow, 8 NEWS #PharmaBuzz

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1 DATA COMPILATION #PharmaFlow
8 NEWS #PharmaBuzz

PATENTS & EXCLUSIVITIES

6 US Patents, 2 US Exclusivities

patents
6 US Patents
2 US Exclusivities

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Zenas, 3,4-diaminopyridine phosphate, 446254-47-3, Firdapse (tn), Amifampridine phosphate [mi], 3,4-pyridinediamine, phosphate (1:1)

Molecular Formula

C₅H₁₀N₃O₄P

Molecular Weight

207.12 g/mol

InChI Key

KAICRBBQCRKMPO-UHFFFAOYSA-N

FDA UNII

8HF8FIN815

4-Aminopyridine derivative that acts as a POTASSIUM CHANNEL blocker to increase release of ACETYLCHOLINE from nerve terminals. It is used in the treatment of CONGENITAL MYASTHENIC SYNDROMES.

1 2D Structure

Amifampridine Phosphate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

phosphoric acid;pyridine-3,4-diamine

2.1.2 InChI

InChI=1S/C5H7N3.H3O4P/c6-4-1-2-8-3-5(4)7;1-5(2,3)4/h1-3H,7H2,(H2,6,8);(H3,1,2,3,4)

2.1.3 InChI Key

KAICRBBQCRKMPO-UHFFFAOYSA-N

2.1.4 Canonical SMILES

C1=CN=CC(=C1N)N.OP(=O)(O)O

2.2 Other Identifiers

2.2.1 UNII

8HF8FIN815

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 3,4 Diaminopyridine

2. 3,4-diaminopyridine

3. Amifampridine

4. Firdapse

5. Ruzurgi

2.3.2 Depositor-Supplied Synonyms

1. Zenas

2. 3,4-diaminopyridine Phosphate

3. 446254-47-3

4. Firdapse (tn)

5. Amifampridine Phosphate [mi]

6. 3,4-pyridinediamine, Phosphate (1:1)

7. Amifampridine Phosphate [usan]

8. Amifampridine Phosphate [mart.]

9. Amifampridine Phosphate [who-dd]

10. 446254-47-3 (phosphate)

11. Amifampridine (phosphate)

12. Amifampridine Phosphate [ema Epar]

13. 3,4-dapp

14. 8hf8fin815

15. Pyridine-3,4-diamine Phosphate

16. Amifampridine Phosphate (usan)

17. Unii-8hf8fin815

18. Phosphoric Acid;pyridine-3,4-diamine

19. Starbld0005260

20. Schembl3958357

21. Chembl3301611

22. Dtxsid40196254

23. Hy-14946a

24. Amifampridine Phosphate [orange Book]

25. Cs-0009524

26. 3,4-diaminopyridin-1-ium Dihydrogen Phosphate

27. D10689

28. Q27270515

2.4 Create Date

2006-10-25

3 Chemical and Physical Properties

Molecular Formula	C₅H₁₀N₃O₄P
Molecular Weight	207.12 g/mol
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	0
Exact Mass	207.04089281 g/mol
Monoisotopic Mass	207.04089281 g/mol
Topological Polar Surface Area	143 Å²
Heavy Atom Count	13
Formal Charge	0
Complexity	124
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Neuromuscular Agents

Drugs used for their actions on skeletal muscle. Included are agents that act directly on skeletal muscle, those that alter neuromuscular transmission (NEUROMUSCULAR BLOCKING AGENTS), and drugs that act centrally as skeletal muscle relaxants (MUSCLE RELAXANTS, CENTRAL). Drugs used in the treatment of movement disorders are ANTI-DYSKINESIA AGENTS. (See all compounds classified as Neuromuscular Agents.)

Potassium Channel Blockers

A class of drugs that act by inhibition of potassium efflux through cell membranes. Blockade of potassium channels prolongs the duration of ACTION POTENTIALS. They are used as ANTI-ARRHYTHMIA AGENTS and VASODILATOR AGENTS. (See all compounds classified as Potassium Channel Blockers.)

4.2 FDA Pharmacological Classification

4.2.1 Pharmacological Classes

Potassium Channel Blocker [EPC]; Potassium Channel Antagonists [MoA]

API SUPPLIERS

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USDMF

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NDC API

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Listed Suppliers

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API Reference Price

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