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Chemistry

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Also known as: 112901-68-5, Anifostine trihydrate, 2-(3-aminopropylamino)ethylsulfanylphosphonic acid trihydrate, 112901-68-5 (trihydrate), M487qf2f4v, Nsc 296961
Molecular Formula
C5H21N2O6PS
Molecular Weight
268.27  g/mol
InChI Key
TXQPXJKRNHJWAX-UHFFFAOYSA-N
FDA UNII
M487QF2F4V

Amifostine Trihydrate
A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.
1 2D Structure

Amifostine Trihydrate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-(3-aminopropylamino)ethylsulfanylphosphonic acid;trihydrate
2.1.2 InChI
InChI=1S/C5H15N2O3PS.3H2O/c6-2-1-3-7-4-5-12-11(8,9)10;;;/h7H,1-6H2,(H2,8,9,10);3*1H2
2.1.3 InChI Key
TXQPXJKRNHJWAX-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C(CN)CNCCSP(=O)(O)O.O.O.O
2.2 Other Identifiers
2.2.1 UNII
M487QF2F4V
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Amifostine

2. Amifostine Anhydrous

3. Amifostine Disodium Salt

4. Amifostine Monohydrate

5. Amifostine Monohydrochloride

6. Aminopropyl Aminoethylthiophosphate

7. Aminopropylaminoethylthiophosphate

8. Aminopropylaminoethylthiophosphoric Acid

9. Apaetp

10. Ethanethiol, 2-((3-aminopropyl)amino)-, Dihydrogen Phosphate (ester), Trihydrate

11. Ethiofos

12. Ethiofos Anhydrous

13. Ethyol

14. Gammaphos

15. Nsc 296961

16. Nsc-296961

17. Nsc296961

18. S-(n-(3-aminopropyl)-2-aminoethyl)thiophosphoric Acid

19. Wr 2721

20. Wr-2721

21. Wr2721

22. Ym 08310

23. Ym-08310

24. Ym08310

2.3.2 Depositor-Supplied Synonyms

1. 112901-68-5

2. Anifostine Trihydrate

3. 2-(3-aminopropylamino)ethylsulfanylphosphonic Acid Trihydrate

4. 112901-68-5 (trihydrate)

5. M487qf2f4v

6. Nsc 296961

7. S-(2-((3-aminopropyl)amino)ethyl) O,o-dihydrogen Phosphorothioate Trihydrate

8. S-(2-((3-aminopropyl)amino)ethyl) Dihydrogen Phosphorothioate, Trihydrate

9. Ethanethiol, 2-((3-aminopropyl)amino)-, Dihydrogen Phosphate (ester), Trihydrate

10. 2-(3-aminopropylamino)ethylsulfanylphosphonic Acid;trihydrate

11. Wr-2721 Trihydrate

12. Unii-m487qf2f4v

13. Amifostine (usp)

14. Wr-2721

15. Ethyol Trihydrate

16. Amifostine [usan:usp:inn:ban]

17. Amifostinetrihydrate

18. Amifostine [usan]

19. Ethyol (tn)

20. Amifostine [vandf]

21. Amifostine [mart.]

22. Amifostine [usp-rs]

23. Amifostinetrihydrateormonohydrate

24. Amifostine [orange Book]

25. Dtxsid40150210

26. Amifostine [usp Monograph]

27. Amifostine Trihydrate [mi]

28. Hms3866g03

29. S4298

30. Akos015901630

31. Amifostine Trihydrate [who-dd]

32. Ac-6800

33. Ccg-267130

34. Ft-0622271

35. Amifostine Trihydrate, >=97% (tlc), Powder

36. A14238

37. D00226

38. F21492

39. 901a685

40. J-002869

41. Q47495771

42. Amifostine, United States Pharmacopeia (usp) Reference Standard

43. Aminopropylamino)ethylsulfanylphosphonic Acid Trihydrate

44. Ethanethiol, 2-[(3-aminopropyl)amino]-, Dihydrogen Phosphate (ester),trihydrate

2.4 Create Date
2005-07-19
3 Chemical and Physical Properties
Molecular Weight 268.27 g/mol
Molecular Formula C5H21N2O6PS
Hydrogen Bond Donor Count7
Hydrogen Bond Acceptor Count9
Rotatable Bond Count7
Exact Mass268.08579457 g/mol
Monoisotopic Mass268.08579457 g/mol
Topological Polar Surface Area124 Ų
Heavy Atom Count15
Formal Charge0
Complexity152
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count4
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Radiation-Protective Agents

Drugs used to protect against ionizing radiation. They are usually of interest for use in radiation therapy but have been considered for other purposes, e.g. military. (See all compounds classified as Radiation-Protective Agents.)


API Reference Price

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06-May-2022
07-Dec-2023
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ABOUT THIS PAGE

Amifostine Trihydrate Manufacturers

A Amifostine Trihydrate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Amifostine Trihydrate, including repackagers and relabelers. The FDA regulates Amifostine Trihydrate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Amifostine Trihydrate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Amifostine Trihydrate manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Amifostine Trihydrate Suppliers

A Amifostine Trihydrate supplier is an individual or a company that provides Amifostine Trihydrate active pharmaceutical ingredient (API) or Amifostine Trihydrate finished formulations upon request. The Amifostine Trihydrate suppliers may include Amifostine Trihydrate API manufacturers, exporters, distributors and traders.

click here to find a list of Amifostine Trihydrate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Amifostine Trihydrate USDMF

A Amifostine Trihydrate DMF (Drug Master File) is a document detailing the whole manufacturing process of Amifostine Trihydrate active pharmaceutical ingredient (API) in detail. Different forms of Amifostine Trihydrate DMFs exist exist since differing nations have different regulations, such as Amifostine Trihydrate USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Amifostine Trihydrate DMF submitted to regulatory agencies in the US is known as a USDMF. Amifostine Trihydrate USDMF includes data on Amifostine Trihydrate's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Amifostine Trihydrate USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Amifostine Trihydrate suppliers with USDMF on PharmaCompass.

Amifostine Trihydrate GMP

Amifostine Trihydrate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Amifostine Trihydrate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Amifostine Trihydrate GMP manufacturer or Amifostine Trihydrate GMP API supplier for your needs.

Amifostine Trihydrate CoA

A Amifostine Trihydrate CoA (Certificate of Analysis) is a formal document that attests to Amifostine Trihydrate's compliance with Amifostine Trihydrate specifications and serves as a tool for batch-level quality control.

Amifostine Trihydrate CoA mostly includes findings from lab analyses of a specific batch. For each Amifostine Trihydrate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Amifostine Trihydrate may be tested according to a variety of international standards, such as European Pharmacopoeia (Amifostine Trihydrate EP), Amifostine Trihydrate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Amifostine Trihydrate USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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