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Also known as: 2609-46-3, Amipramidin, Midamor, Guanamprazine, Amipramizid, Amipramizide
Molecular Formula
C6H8ClN7O
Molecular Weight
229.63  g/mol
InChI Key
XSDQTOBWRPYKKA-UHFFFAOYSA-N
FDA UNII
7DZO8EB0Z3

Amiloride Hydrochloride
A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)
Amiloride is a Potassium-sparing Diuretic. The physiologic effect of amiloride is by means of Decreased Renal K+ Excretion, and Increased Diuresis.
1 2D Structure

Amiloride Hydrochloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide
2.1.2 InChI
InChI=1S/C6H8ClN7O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11/h(H4,8,9,13)(H4,10,11,14,15)
2.1.3 InChI Key
XSDQTOBWRPYKKA-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N
2.2 Other Identifiers
2.2.1 UNII
7DZO8EB0Z3
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Amidal

2. Amiduret Trom

3. Amiloberag

4. Amiloride Hydrochloride

5. Amiloride Hydrochloride, Anhydrous

6. Anhydrous Amiloride Hydrochloride

7. Hydrochloride, Amiloride

8. Hydrochloride, Anhydrous Amiloride

9. Kaluril

10. Midamor

11. Midoride

12. Modamide

13. Trom, Amiduret

2.3.2 Depositor-Supplied Synonyms

1. 2609-46-3

2. Amipramidin

3. Midamor

4. Guanamprazine

5. Amipramizid

6. Amipramizide

7. Guanamprazin

8. Amilorida

9. 3,5-diamino-n-carbamimidoyl-6-chloropyrazine-2-carboxamide

10. Amiloridum

11. Amyloride

12. Amiloridum [inn-latin]

13. Amilorida [inn-spanish]

14. Amiclaran

15. N-amidino-3,5-diamino-6-chloropyrazinecarboxamide

16. N-amidino-3,5-diamino-6-chlorpyrazincarboxamid

17. 3,5-diamino-6-chloro-n-(diaminomethylidene)pyrazine-2-carboxamide

18. Amiloride (inn)

19. Pyrazinecarboxamide, 3,5-diamino-n-(aminoiminomethyl)-6-chloro-

20. 3,5-diamino-n-(aminoiminomethyl)-6-chloropyrazinecarboxamide

21. Mk-870

22. Chembl945

23. 7dzo8eb0z3

24. Chebi:2639

25. 137053-86-2

26. Ncgc00015089-08

27. Amiloride [inn]

28. Amiloride [inn:ban]

29. Amipramidine

30. Dsstox_cid_23853

31. Dsstox_rid_80077

32. Dsstox_gsid_43853

33. Amiclaran (tn)

34. Cas-2609-46-3

35. Ccris 6545

36. Einecs 220-024-7

37. Unii-7dzo8eb0z3

38. Amiloridehcl

39. Amikal (hydrochloride Dihydrate)

40. Midamor (hydrochloride Dihydrate)

41. Mk-870 (hydrochloride Dihydrate)

42. Amipramidin, Midamor

43. N-amidino-3,5-diamino-6-chloro-2-pyrazinecarboxamide

44. Spectrum_000034

45. Tocris-0890

46. 1f5l

47. Amiloride [mi]

48. Prestwick0_000007

49. Prestwick1_000007

50. Prestwick2_000007

51. Prestwick3_000007

52. Spectrum2_000118

53. Spectrum3_000293

54. Spectrum4_000132

55. Spectrum5_000776

56. Amiloride [vandf]

57. Lopac-a-7410

58. Amiloride [who-dd]

59. Lopac0_000111

60. Schembl27562

61. Bspbio_000013

62. Bspbio_001572

63. Bspbio_001826

64. Kbiogr_000292

65. Kbiogr_000544

66. Kbioss_000292

67. Kbioss_000394

68. Mls001060798

69. Bidd:gt0466

70. Divk1c_000182

71. Spbio_000136

72. Spbio_001934

73. Bpbio1_000015

74. Gtpl2421

75. Dtxsid9043853

76. Bcbcmap01_000101

77. Bdbm16173

78. Kbio1_000182

79. Kbio2_000292

80. Kbio2_000394

81. Kbio2_002860

82. Kbio2_002962

83. Kbio2_005428

84. Kbio2_005530

85. Kbio3_000583

86. Kbio3_000584

87. Kbio3_001326

88. Ninds_000182

89. Bio1_000359

90. Bio1_000848

91. Bio1_001337

92. Bio2_000292

93. Bio2_000772

94. Hms1791o14

95. Hms1989o14

96. Hms2089h05

97. Hms2213e05

98. Hms3355k04

99. Act05635

100. Act05652

101. Bcp16815

102. Hy-b0285

103. Zinc4340269

104. Tox21_110080

105. 3,5-diamino-n-[amino(imino)methyl]-6-chloropyrazine-2-carboxamide

106. Bbl028157

107. Stl373007

108. Akos015961348

109. Tox21_110080_1

110. Ccg-204206

111. Db00594

112. Sb74937

113. Sdccgsbi-0050099.p005

114. Idi1_000182

115. Idi1_034042

116. Ncgc00015089-01

117. Ncgc00015089-02

118. Ncgc00015089-03

119. Ncgc00015089-04

120. Ncgc00015089-05

121. Ncgc00015089-06

122. Ncgc00015089-07

123. Ncgc00015089-09

124. Ncgc00015089-11

125. Ncgc00015089-12

126. Ncgc00015089-13

127. Ncgc00015089-14

128. Ncgc00015089-15

129. Ncgc00015089-16

130. Ncgc00015089-17

131. Ncgc00015089-24

132. Ncgc00024443-02

133. Ncgc00024443-05

134. Ncgc00024443-06

135. Ncgc00024443-07

136. Ncgc00024443-09

137. Ac-13631

138. Ls-13128

139. Smr000486264

140. (3,5-diamino-6-chloropyrazinoyl)guanidine

141. Sbi-0050099.p004

142. N-amidino-3,5-diamino-6-chloropyrazinamide

143. Ab00053415

144. Ft-0703177

145. C06821

146. D07447

147. Ab00053415-24

148. Ab00053415-25

149. Ab00053415_26

150. Ab00053415_27

151. Ab00053415_28

152. 609a463

153. Q419995

154. J-016249

155. Brd-k97181089-003-02-3

156. Brd-k97181089-310-03-0

157. N-amidino 3,5-diamino-6-chloro-2-pyrazinecarboxamide

158. F2173-0531

159. N-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidine

160. 3,5-diamino-n-carbamimidoyl-6-chloro-pyrazine-2-carboxamide

161. 3,5-diamino-6-chloro-n-(diaminomethylene)pyrazinamide;hydrochloride

2.3.3 Other Synonyms

1. Amilorid Hydrochlorid-2-wasser

2. Amiloride Hydrochloride Dihydrate

2.4 Create Date
2005-03-27
3 Chemical and Physical Properties
Molecular Weight 229.63 g/mol
Molecular Formula C6H8ClN7O
XLogP3-0.7
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count5
Rotatable Bond Count1
Exact Mass229.0478856 g/mol
Monoisotopic Mass229.0478856 g/mol
Topological Polar Surface Area159 Ų
Heavy Atom Count15
Formal Charge0
Complexity279
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameMidamor
PubMed HealthAmiloride (By mouth)
Drug ClassesCardiovascular Agent
Drug LabelAmiloride HCl, an antikaliuretic-diuretic agent, is a pyrazine-carbonyl-guanidine that is unrelated chemically to other known antikaliuretic or diuretic agents. It is the salt of a moderately strong base (pKa 8.7). It is designated chemically as 3,5-...
Active IngredientAmiloride hydrochloride
Dosage FormTablet
RouteOral
Strength5mg
Market StatusPrescription
CompanyPaddock

2 of 2  
Drug NameMidamor
PubMed HealthAmiloride (By mouth)
Drug ClassesCardiovascular Agent
Drug LabelAmiloride HCl, an antikaliuretic-diuretic agent, is a pyrazine-carbonyl-guanidine that is unrelated chemically to other known antikaliuretic or diuretic agents. It is the salt of a moderately strong base (pKa 8.7). It is designated chemically as 3,5-...
Active IngredientAmiloride hydrochloride
Dosage FormTablet
RouteOral
Strength5mg
Market StatusPrescription
CompanyPaddock

4.2 Drug Indication

For use as adjunctive treatment with thiazide diuretics or other kaliuretic-diuretic agents in congestive heart failure or hypertension.


FDA Label


5 Pharmacology and Biochemistry
5.1 Pharmacology

Amiloride, an antikaliuretic-diuretic agent, is a pyrazine-carbonyl-guanidine that is unrelated chemically to other known antikaliuretic or diuretic agents. It is an antihypertensive, potassium-sparing diuretic that was first approved for use in 1967 and helps to treat hypertension and congestive heart failure. The drug is often used in conjunction with thiazide or loop diuretics. Due to its potassium-sparing capacities, hyperkalemia (high blood potassium levels) are occasionally observed in patients taking amiloride. The risk is high in concurrent use of ACE inhibitors or spironolactone. Patients are also advised not to use potassium-containing salt replacements.


5.2 MeSH Pharmacological Classification

Acid Sensing Ion Channel Blockers

A subclass of sodium channel blockers that are specific for ACID-SENSING SODIUM CHANNELS. (See all compounds classified as Acid Sensing Ion Channel Blockers.)


Diuretics

Agents that promote the excretion of urine through their effects on kidney function. (See all compounds classified as Diuretics.)


Epithelial Sodium Channel Blockers

A subclass of sodium channel blockers that are specific for EPITHELIAL SODIUM CHANNELS. (See all compounds classified as Epithelial Sodium Channel Blockers.)


5.3 FDA Pharmacological Classification
5.3.1 Active Moiety
AMILORIDE
5.3.2 FDA UNII
7DZO8EB0Z3
5.3.3 Pharmacological Classes
Established Pharmacologic Class [EPC] - Potassium-sparing Diuretic
5.4 ATC Code

C - Cardiovascular system

C03 - Diuretics

C03D - Aldosterone antagonists and other potassium-sparing agents

C03DB - Other potassium-sparing agents

C03DB01 - Amiloride


5.5 Absorption, Distribution and Excretion

Absorption

Readily absorbed following oral administration.


Route of Elimination

Amiloride HCl is not metabolized by the liver but is excreted unchanged by the kidneys. About 50 percent of a 20 mg dose of amiloride HCl is excreted in the urine and 40 percent in the stool within 72 hours.


5.6 Metabolism/Metabolites

Amiloride is not metabolized by the liver but is excreted unchanged by the kidneys.


5.7 Biological Half-Life

Plasma half-life varies from 6 to 9 hours.


5.8 Mechanism of Action

Amiloride works by inhibiting sodium reabsorption in the distal convoluted tubules and collecting ducts in the kidneys by binding to the amiloride-sensitive sodium channels. This promotes the loss of sodium and water from the body, but without depleting potassium. Amiloride exerts its potassium sparing effect through the inhibition of sodium reabsorption at the distal convoluted tubule, cortical collecting tubule and collecting duct; this decreases the net negative potential of the tubular lumen and reduces both potassium and hydrogen secretion and their subsequent excretion. Amiloride is not an aldosterone antagonist and its effects are seen even in the absence of aldosterone.


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MALPENSA","supplierAddress":"","customerAddress":"OLD NO.1\/63, NEW NO.1\/5B PUDUPAKKAMVILLAGE, VIA VANDALLUR"},{"dataSource":"API Import","activeIngredients":"","year":"2021","qtr":"Q3","strtotime":1627669800,"product":"AMILORIDE HYDROCHLORIDE DIHYDRATE PH.EUR","address":"PLOT NO.2, MAITRIVIHAR,BEHIND MAITRIVANAM, AMEERPET,","city":"HYDERABAD\/ANDHRA PRADESH","supplier":"OLON S.P.A","supplierCountry":"ITALY","foreign_port":"","customer":"AUROBINDO PHARMA LIMITED","customerCountry":"INDIA","quantity":"2.20","actualQuantity":"2.2","unit":"KGS","unitRateFc":"600","totalValueFC":"1590.5","currency":"EUR","unitRateINR":"53880","date":"31-Jul-2021","totalValueINR":"118536","totalValueInUsd":"1590.5","indian_port":"HYDERABAD AIR","hs_no":"29339990","bill_no":"4885292","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"","supplierAddress":"","customerAddress":"PLOT NO.2, MAITRIVIHAR,BEHIND MAITRIVANAM, AMEERPET,"},{"dataSource":"API Import","activeIngredients":"","year":"2021","qtr":"Q3","strtotime":1627669800,"product":"AMILORIDE HYDROCHLORIDE DIHYDRATE PH.EUR","address":"PLOT NO.2, MAITRIVIHAR,BEHIND MAITRIVANAM, AMEERPET,","city":"HYDERABAD\/ANDHRA PRADESH","supplier":"OLON S.P.A","supplierCountry":"ITALY","foreign_port":"","customer":"AUROBINDO PHARMA LIMITED","customerCountry":"INDIA","quantity":"6.20","actualQuantity":"6.2","unit":"KGS","unitRateFc":"600","totalValueFC":"4482.4","currency":"EUR","unitRateINR":"53880","date":"31-Jul-2021","totalValueINR":"334056","totalValueInUsd":"4482.4","indian_port":"HYDERABAD AIR","hs_no":"29339990","bill_no":"4885292","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"","supplierAddress":"","customerAddress":"PLOT NO.2, MAITRIVIHAR,BEHIND MAITRIVANAM, AMEERPET,"},{"dataSource":"API Import","activeIngredients":"","year":"2021","qtr":"Q3","strtotime":1627669800,"product":"AMILORIDE HYDROCHLORIDE DIHYDRATE PH.EUR","address":"PLOT NO.2, MAITRIVIHAR,BEHIND MAITRIVANAM, AMEERPET,","city":"HYDERABAD\/ANDHRA PRADESH","supplier":"OLON S.P.A","supplierCountry":"ITALY","foreign_port":"","customer":"AUROBINDO PHARMA LIMITED","customerCountry":"INDIA","quantity":"16.60","actualQuantity":"16.6","unit":"KGS","unitRateFc":"600","totalValueFC":"12001.2","currency":"EUR","unitRateINR":"53880","date":"31-Jul-2021","totalValueINR":"894408","totalValueInUsd":"12001.2","indian_port":"HYDERABAD AIR","hs_no":"29339990","bill_no":"4885292","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"","supplierAddress":"","customerAddress":"PLOT NO.2, MAITRIVIHAR,BEHIND MAITRIVANAM, AMEERPET,"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q2","strtotime":1650652200,"product":"AMILORIDE HYDROCHLORIDE DIHYDRATE C3100 BATCH NO. 2150003059","address":"No. 9\/215, Pudupakkam - Vandalur Main Road Pudupakkam","city":"Kelambakkam","supplier":"OLON S.P.A","supplierCountry":"ITALY","foreign_port":"NA","customer":"PAR PHARMACEUTICAL","customerCountry":"INDIA","quantity":"10.00","actualQuantity":"10","unit":"KGS","unitRateFc":"870","totalValueFC":"8896.2","currency":"USD","unitRateINR":"67120.5","date":"23-Apr-2022","totalValueINR":"671205","totalValueInUsd":"8896.2","indian_port":"MADRAS AIR","hs_no":"29339990","bill_no":"8393814","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"No. 9\/215, Pudupakkam - Vandalur Main Road Pudupakkam"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q1","strtotime":1675708200,"product":"AMILORIDE HYDROCHLORIDE DIHYDRATE C3100 BATCH NO.2250002065","address":"No. 9\/215, Pudupakkam - Vandalur Main Road Pudupakkam","city":"Kelambakkam","supplier":"OLON S.P.A","supplierCountry":"ITALY","foreign_port":"NA","customer":"PAR PHARMACEUTICAL","customerCountry":"INDIA","quantity":"10.00","actualQuantity":"10","unit":"KGS","unitRateFc":"870","totalValueFC":"8716.9","currency":"USD","unitRateINR":"71992.5","date":"07-Feb-2023","totalValueINR":"719925","totalValueInUsd":"8716.9","indian_port":"MADRAS AIR","hs_no":"29339990","bill_no":"4530884","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"No. 9\/215, Pudupakkam - Vandalur Main Road Pudupakkam"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q2","strtotime":1685471400,"product":"AMILORIDE HYDROCHLORIDE DIHYDRATE BP EP","address":"NO.49D, BOMMASANDRA INDUSTRIAL AREA, ANEKAL TQ.","city":"BANGALORE","supplier":"BIO INDUSTRIA L I M","supplierCountry":"ITALY","foreign_port":"MILAN MALPENSA","customer":"ADCOCK INGRAM","customerCountry":"INDIA","quantity":"10.00","actualQuantity":"10","unit":"KGS","unitRateFc":"1200","totalValueFC":"13263.8","currency":"EUR","unitRateINR":"109140","date":"31-May-2023","totalValueINR":"1091400","totalValueInUsd":"13263.8","indian_port":"BANGALORE AIR","hs_no":"29339990","bill_no":"0","productDescription":"API","marketType":"REGULATED MARKET","country":"Italy","selfForZScoreResived":"Pharma Grade","supplierPort":"MILAN MALPENSA","supplierAddress":"","customerAddress":"NO.49D, BOMMASANDRA INDUSTRIAL AREA, ANEKAL TQ."},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1688495400,"product":"AMILORIDE HYDROCHLORIDE DIHYDRATE PH.EUR","address":"PLOT NO.2, MAITRIVIHAR BEHIND MAITRIVANAM, AMEERPET","city":"HYDERABAD","supplier":"OLON S.P.A","supplierCountry":"ITALY","foreign_port":"NA","customer":"AUROBINDO PHARMA LIMITED","customerCountry":"INDIA","quantity":"23.17","actualQuantity":"23.17","unit":"KGS","unitRateFc":"600","totalValueFC":"15307.7","currency":"EUR","unitRateINR":"54299.9","date":"05-Jul-2023","totalValueINR":"1258130.713","totalValueInUsd":"15307.7","indian_port":"HYDERABAD AIR","hs_no":"29339990","bill_no":"0","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"PLOT NO.2, MAITRIVIHAR BEHIND MAITRIVANAM, AMEERPET"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1690309800,"product":"AMILORIDE HYDROCHLORIDE DIHYDRATE C3100 BATCH NO.2350001172","address":"No. 9\/215, Pudupakkam - Vandalur Main Road Pudupakkam","city":"Kelambakkam","supplier":"OLON S.P.A","supplierCountry":"ITALY","foreign_port":"NA","customer":"PAR PHARMACEUTICAL","customerCountry":"INDIA","quantity":"10.00","actualQuantity":"10","unit":"KGS","unitRateFc":"870","totalValueFC":"8780.5","currency":"USD","unitRateINR":"72166.1","date":"26-Jul-2023","totalValueINR":"721665.385","totalValueInUsd":"8780.5","indian_port":"MADRAS AIR","hs_no":"29339990","bill_no":"0","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"No. 9\/215, Pudupakkam - Vandalur Main Road Pudupakkam"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1695407400,"product":"AMILORIDE HYDROCHLORIDE API BATCH NO.2150001151 \/ 2050002828","address":"OLD NO.1\/63, NEW NO.1\/58 PUDUPAKKAM","city":"","supplier":"ENDO VENTURES LIMITED","supplierCountry":"UNITED STATES","foreign_port":"NEW YORK - JOHN F. K","customer":"PAR PHARMACEUTICAL","customerCountry":"INDIA","quantity":"9.36","actualQuantity":"9.362","unit":"KGS","unitRateFc":"870","totalValueFC":"8788.9","currency":"USD","unitRateINR":"77926.6","date":"23-Sep-2023","totalValueINR":"729548.96","totalValueInUsd":"8788.9","indian_port":"Madras Air","hs_no":"29339990","bill_no":"7978373","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"NEW YORK - JOHN F. K","supplierAddress":"1ST FLOOR MINERVA HOUSESIMMONS COURT ROADBALLSBRIDGE DUBLIN4 IRELAND","customerAddress":"OLD NO.1\/63, NEW NO.1\/58 PUDUPAKKAM"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1696012200,"product":"AMILORIDE HYDROCHLORIDE USP\/BP CAS :17440-83-4 C3100 BATCH N O.2350001174","address":"OLD NO.1\/63, NEW NO.1\/58 PUDUPAKKAM","city":"","supplier":"N\/A","supplierCountry":"ITALY","foreign_port":"N\/A","customer":"PAR PHARMACEUTICAL","customerCountry":"INDIA","quantity":"10.00","actualQuantity":"10","unit":"KGS","unitRateFc":"870","totalValueFC":"8809.2","currency":"USD","unitRateINR":"73123.5","date":"30-Sep-2023","totalValueINR":"731235","totalValueInUsd":"8809.2","indian_port":"Madras Air","hs_no":"29339990","bill_no":"8080606","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"N\/A","customerAddress":"OLD NO.1\/63, NEW NO.1\/58 PUDUPAKKAM"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1714069800,"product":"AMILORIDE HYDROCHLORIDE DIHYDRATE C3100 BATCH NO.2350001156","address":"OLD NO.1\/63, NEW NO.1\/58 PUDUPAKKAM","city":"","supplier":"OLON S.P.A","supplierCountry":"ITALY","foreign_port":"MILAN - MALPENSA","customer":"PAR PHARMACEUTICAL","customerCountry":"INDIA","quantity":"10.00","actualQuantity":"10","unit":"KGS","unitRateFc":"870","totalValueFC":"8793","currency":"USD","unitRateINR":"73428","date":"26-Apr-2024","totalValueINR":"734280","totalValueInUsd":"8793","indian_port":"Madras Air","hs_no":"29339990","bill_no":"3213516","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"MILAN - MALPENSA","supplierAddress":"SEDE LEGALE STRADARIVOLTANA KM 6\/7 RODANO (MI)SDNF ITALY","customerAddress":"OLD NO.1\/63, NEW NO.1\/58 PUDUPAKKAM"}]
07-Jan-2021
13-Nov-2024
KGS
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Average Price (USD/KGS)

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country Total Quantity
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Europe

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01

Pharma, Lab & Chemical Expo
Not Confirmed
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Amiloride; Hydrochlorothiazide

Brand Name : Moduretic

Dosage Form : Amiloride+Hydrochlorothiazide 5+50Mg 20 Joined' Oral Use

Dosage Strength : 20 CPR 5 mg + 50 mg

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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02

Pharma, Lab & Chemical Expo
Not Confirmed
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Hydrochlorothiazide, Amiloride hydrochloride

Brand Name : Normorix Mite

Dosage Form : Tablet

Dosage Strength : 25 mg/2.5 mg

Packaging : Boks 100item

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Norway

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03

Mylan AB

U.S.A
Pharma, Lab & Chemical Expo
Not Confirmed
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Mylan AB

U.S.A
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Pharma, Lab & Chemical Expo
Not Confirmed

amiloride hydrochloride (dihydrate)

Brand Name : amiloride Mylan

Dosage Form : TABLET

Dosage Strength : 5 MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Sweden

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04

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Pharma, Lab & Chemical Expo
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Country
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Pharma, Lab & Chemical Expo
Not Confirmed

Amiloride; Hydrochlorothiazide

Brand Name : Ameride 5/50Mg 60 Tablets

Dosage Form : Tablet

Dosage Strength :

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Spain

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05

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Pharma, Lab & Chemical Expo
Not Confirmed
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Pharma, Lab & Chemical Expo
Not Confirmed

Amiloride; Hydrochlorothiazide

Brand Name : Diuzine 5/50Mg 60 Tablets

Dosage Form : Tablet

Dosage Strength :

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Spain

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USP

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USP

U.S.A
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USP

U.S.A
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Amiloride Related Compound A (30 mg) (Methyl ...

CAS Number : 1458-01-1

Quantity Per Vial :

Price ($) : 730

Catalog Number : 1019712

Current Lot : F1E287

Previous Lot : F0E287 (30-JUN-2016)

NDC Code :

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02

USP

U.S.A
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Amiloride Hydrochloride (500 mg)

CAS Number : 17440-83-4

Quantity Per Vial :

Price ($) : 230

Catalog Number : 1019701

Current Lot : R052W0

Previous Lot : H1G197 (31-AUG-2018)

NDC Code :

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ANALYTICAL

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ABOUT THIS PAGE

Amiloride Hydrochloride Manufacturers

A Amiloride Hydrochloride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Amiloride Hydrochloride, including repackagers and relabelers. The FDA regulates Amiloride Hydrochloride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Amiloride Hydrochloride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Amiloride Hydrochloride manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Amiloride Hydrochloride Suppliers

A Amiloride Hydrochloride supplier is an individual or a company that provides Amiloride Hydrochloride active pharmaceutical ingredient (API) or Amiloride Hydrochloride finished formulations upon request. The Amiloride Hydrochloride suppliers may include Amiloride Hydrochloride API manufacturers, exporters, distributors and traders.

click here to find a list of Amiloride Hydrochloride suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Amiloride Hydrochloride USDMF

A Amiloride Hydrochloride DMF (Drug Master File) is a document detailing the whole manufacturing process of Amiloride Hydrochloride active pharmaceutical ingredient (API) in detail. Different forms of Amiloride Hydrochloride DMFs exist exist since differing nations have different regulations, such as Amiloride Hydrochloride USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Amiloride Hydrochloride DMF submitted to regulatory agencies in the US is known as a USDMF. Amiloride Hydrochloride USDMF includes data on Amiloride Hydrochloride's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Amiloride Hydrochloride USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Amiloride Hydrochloride suppliers with USDMF on PharmaCompass.

Amiloride Hydrochloride CEP

A Amiloride Hydrochloride CEP of the European Pharmacopoeia monograph is often referred to as a Amiloride Hydrochloride Certificate of Suitability (COS). The purpose of a Amiloride Hydrochloride CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Amiloride Hydrochloride EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Amiloride Hydrochloride to their clients by showing that a Amiloride Hydrochloride CEP has been issued for it. The manufacturer submits a Amiloride Hydrochloride CEP (COS) as part of the market authorization procedure, and it takes on the role of a Amiloride Hydrochloride CEP holder for the record. Additionally, the data presented in the Amiloride Hydrochloride CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Amiloride Hydrochloride DMF.

A Amiloride Hydrochloride CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Amiloride Hydrochloride CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Amiloride Hydrochloride suppliers with CEP (COS) on PharmaCompass.

Amiloride Hydrochloride WC

A Amiloride Hydrochloride written confirmation (Amiloride Hydrochloride WC) is an official document issued by a regulatory agency to a Amiloride Hydrochloride manufacturer, verifying that the manufacturing facility of a Amiloride Hydrochloride active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Amiloride Hydrochloride APIs or Amiloride Hydrochloride finished pharmaceutical products to another nation, regulatory agencies frequently require a Amiloride Hydrochloride WC (written confirmation) as part of the regulatory process.

click here to find a list of Amiloride Hydrochloride suppliers with Written Confirmation (WC) on PharmaCompass.

Amiloride Hydrochloride NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Amiloride Hydrochloride as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Amiloride Hydrochloride API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Amiloride Hydrochloride as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Amiloride Hydrochloride and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Amiloride Hydrochloride NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Amiloride Hydrochloride suppliers with NDC on PharmaCompass.

Amiloride Hydrochloride GMP

Amiloride Hydrochloride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Amiloride Hydrochloride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Amiloride Hydrochloride GMP manufacturer or Amiloride Hydrochloride GMP API supplier for your needs.

Amiloride Hydrochloride CoA

A Amiloride Hydrochloride CoA (Certificate of Analysis) is a formal document that attests to Amiloride Hydrochloride's compliance with Amiloride Hydrochloride specifications and serves as a tool for batch-level quality control.

Amiloride Hydrochloride CoA mostly includes findings from lab analyses of a specific batch. For each Amiloride Hydrochloride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Amiloride Hydrochloride may be tested according to a variety of international standards, such as European Pharmacopoeia (Amiloride Hydrochloride EP), Amiloride Hydrochloride JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Amiloride Hydrochloride USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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