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ACTIVE PHARMA INGREDIENTS

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Chemistry

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Also known as: Aminaftone, Aminaphthone, 14748-94-8, Aminaphtone, (1,4-dihydroxy-3-methylnaphthalen-2-yl) 4-aminobenzoate, 03jlx11pe9
Molecular Formula
C18H15NO4
Molecular Weight
309.3  g/mol
InChI Key
YLMPBJUYFTWHKJ-UHFFFAOYSA-N
FDA UNII
03JLX11PE9

Aminaftone
Aminaftone has been investigated for the treatment of Cockett Syndrome, May-Thurner Syndrome, and Iliac Vein Obstruction.
1 2D Structure

Aminaftone

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(1,4-dihydroxy-3-methylnaphthalen-2-yl) 4-aminobenzoate
2.1.2 InChI
InChI=1S/C18H15NO4/c1-10-15(20)13-4-2-3-5-14(13)16(21)17(10)23-18(22)11-6-8-12(19)9-7-11/h2-9,20-21H,19H2,1H3
2.1.3 InChI Key
YLMPBJUYFTWHKJ-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1=C(C2=CC=CC=C2C(=C1OC(=O)C3=CC=C(C=C3)N)O)O
2.2 Other Identifiers
2.2.1 UNII
03JLX11PE9
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Aminaftone

2. Aminaphthone

3. Capilarema

4. Capillarema

2.3.2 Depositor-Supplied Synonyms

1. Aminaftone

2. Aminaphthone

3. 14748-94-8

4. Aminaphtone

5. (1,4-dihydroxy-3-methylnaphthalen-2-yl) 4-aminobenzoate

6. 03jlx11pe9

7. Capilarema

8. Unii-03jlx11pe9

9. Capillarema

10. Menatriol

11. Capillarema (tn)

12. Einecs 238-809-8

13. Aminonaphthone

14. Aminaphthone [mart.]

15. Aminaphtone [who-dd]

16. Schembl12157532

17. Dtxsid00163725

18. Chebi:135317

19. Zinc5419379

20. Cs-6667

21. Db13039

22. Hy-19890

23. D07566

24. 3-methyl-1,2,4-naphthalenetriol-2-(4-aminobenzoate)

25. Q17620495

26. 1,2,4-naphthalenetriol, 3-methyl-, 2-(4-aminobenzoate)

27. 1,2,4-naphthalenetriol, 3-methyl-, 2-(p-aminobenzoate)

2.4 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 309.3 g/mol
Molecular Formula C18H15NO4
XLogP33.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Exact Mass309.10010796 g/mol
Monoisotopic Mass309.10010796 g/mol
Topological Polar Surface Area92.8 Ų
Heavy Atom Count23
Formal Charge0
Complexity421
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Hemostatics

Agents acting to arrest the flow of blood. Absorbable hemostatics arrest bleeding either by the formation of an artificial clot or by providing a mechanical matrix that facilitates clotting when applied directly to the bleeding surface. These agents function more at the capillary level and are not effective at stemming arterial or venous bleeding under any significant intravascular pressure. (See all compounds classified as Hemostatics.)


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Aminaftone

About the Company : Globe Quimica S.A. is a major Brazilian API producer, GMP certificated by ANVISA, manufactures more than 20 different API's such as Antiretrovirals, Anxiolytic, Antidepressant, Ant...

Globe Quimica S.A. is a major Brazilian API producer, GMP certificated by ANVISA, manufactures more than 20 different API's such as Antiretrovirals, Anxiolytic, Antidepressant, Antithrombotic, Analgesic. In 2012 Globe Quimica has started-up its new API plant for Active Ingredients for Oncologic Drugs.
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Aminaftone Manufacturers

A Aminaftone manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Aminaftone, including repackagers and relabelers. The FDA regulates Aminaftone manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Aminaftone API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Aminaftone manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Aminaftone Suppliers

A Aminaftone supplier is an individual or a company that provides Aminaftone active pharmaceutical ingredient (API) or Aminaftone finished formulations upon request. The Aminaftone suppliers may include Aminaftone API manufacturers, exporters, distributors and traders.

click here to find a list of Aminaftone suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Aminaftone GMP

Aminaftone Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Aminaftone GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Aminaftone GMP manufacturer or Aminaftone GMP API supplier for your needs.

Aminaftone CoA

A Aminaftone CoA (Certificate of Analysis) is a formal document that attests to Aminaftone's compliance with Aminaftone specifications and serves as a tool for batch-level quality control.

Aminaftone CoA mostly includes findings from lab analyses of a specific batch. For each Aminaftone CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Aminaftone may be tested according to a variety of international standards, such as European Pharmacopoeia (Aminaftone EP), Aminaftone JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Aminaftone USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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