Find Aminocaproic Acid manufacturers, exporters & distributors on PharmaCompass

DRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.

Virtual Booth

ACCESS ALL DATA
Browse all information
CHEMISTRY
Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

22 API Suppliers, 10 USDMF, 5 EU WC, 8 NDC API, 17 Listed Suppliers, $ API Reference Price

22 API Suppliers
10 USDMF
5 EU WC
8 NDC API
17 Listed Suppliers
$ API Reference Price

FINISHED DOSAGE FORMULATIONS

42 FDF Dossiers, 34 FDA Orange Book, 2 Europe, 6 Listed Dossiers

42 FDF Dossiers
34 FDA Orange Book
2 Europe
6 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

TABLET;ORAL - 1GM, TABLET;ORAL - 500MG

drugProductComposition
TABLET;ORAL - 1GM
TABLET;ORAL - 500MG

RELATED EXCIPIENT COMPANIES

6 Rochem International Inc, 2 SPI Pharma, 6 DKSH, 1 Pharm-RX Chemical, 3 Faran Shimi Pharmaceutical, 5 Boai NKY Pharmaceuticals Ltd, 3 Gangwal Healthcare, 6 Nanjing Well Pharmaceutical, 8 Actylis, 1 Alcedo Pharmachem, 2 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 24 BASF, 2 Clariant, 2 Finar, 7 Gangwal Chemicals, 1 Ideal Cures Pvt Ltd, 2 Kerry, 1 Kima Chemical, 12 Microlex e.U, 1 Nanjing Bold Chemical, 2 Novo Excipients, 2 Pharmatrans-Sanaq, 4 Pluviaendo, 1 Prachin Chemical, 11 Roquette, 1 Seppic, 1 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 1 Shijiazhuang Huaxu Pharmaceutical, 1 Sigachi Industries, 1 The Dow Chemical Company, 1 Ulanqab Kema New Material, 1 Valens Pharmachem, 1 Vasa Pharmachem, 2 Zhejiang Huakang Pharmaceutical

EXCIPIENTS BY APPLICATIONS

25 Fillers, Diluents & Binders, 18 Thickeners and Stabilizers, 17 Solubilizers, 17 Topical, 17 Coating Systems & Additives, 16 Film Formers & Plasticizers, 15 Direct Compression, 15 Lubricants & Glidants, 15 Disintegrants & Superdisintegrants, 14 Granulation, 14 Parenteral, 13 Taste Masking, 9 Chewable & Orodispersible Aids, 7 Rheology Modifiers, 7 Controlled & Modified Release, 4 Co-Processed Excipients, 3 Surfactant & Foaming Agents, 2 Coloring Agents, 2 Emulsifying Agents, 1 Soft Gelatin, 1 API Stability Enhancers

DIGITAL CONTENT

1 DATA COMPILATION #PharmaFlow, 12 NEWS #PharmaBuzz

media
1 DATA COMPILATION #PharmaFlow
12 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions, 3 Finished Drug Prices

globalSalesInformation
1 US Medicaid Prescriptions
3 Finished Drug Prices

MARKET PLACE

16 APIs, 1 EXCIPIENTS

marketPlace
16 APIs
1 EXCIPIENTS

REF. STANDARDS & IMPURITIES

1 EDQM , 1 USP , 1 Others

otherSolutions
1 EDQM
1 USP
1 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 305

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

370,242

Annual Reports (USD Million)

Finished Drug Prices

125 RELATED EXCIPIENT COMPANIES

232EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown

Click the button for full data set

Also known as: 6-aminohexanoic acid, 6-aminocaproic acid, 60-32-2, Amicar, Eaca, Hexanoic acid, 6-amino-

Molecular Formula

C₆H₁₃NO₂

Molecular Weight

131.17 g/mol

InChI Key

SLXKOJJOQWFEFD-UHFFFAOYSA-N

FDA UNII

U6F3787206

An antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties.

Aminocaproic acid is an Antifibrinolytic Agent. The physiologic effect of aminocaproic acid is by means of Decreased Fibrinolysis.

1 2D Structure

Aminocaproic Acid

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

6-aminohexanoic acid

2.1.2 InChI

InChI=1S/C6H13NO2/c7-5-3-1-2-4-6(8)9/h1-5,7H2,(H,8,9)

2.1.3 InChI Key

SLXKOJJOQWFEFD-UHFFFAOYSA-N

2.1.4 Canonical SMILES

C(CCC(=O)O)CCN

2.2 Other Identifiers

2.2.1 UNII

U6F3787206

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 6 Aminocaproic Acid

2. 6 Aminohexanoic Acid

3. 6-aminocaproic Acid

4. 6-aminohexanoic Acid

5. Amicar

6. Capralense

7. Capramol

8. Caproamin

9. Caprocid

10. Caprolest

11. Cy 116

12. Cy-116

13. Cy116

14. Epsamon

15. Epsikapron

16. Epsilon Aminocaproic Acid

17. Epsilon-aminocaproic Acid

18. Hemocaprol

19. Hexalense

2.3.2 Depositor-Supplied Synonyms

1. 6-aminohexanoic Acid

2. 6-aminocaproic Acid

3. 60-32-2

4. Amicar

5. Eaca

6. Hexanoic Acid, 6-amino-

7. Epsikapron

8. Epsilcapramin

9. Capramol

10. Caprocid

11. Epsamon

12. Acepramin

13. Acepramine

14. Caprolisin

15. Epsicapron

16. Hemocaprol

17. Respramin

18. Amikar

19. Hepin

20. Epsilon-aminocaproic Acid

21. Aminokapron

22. Caplamin

23. Capracid

24. Afibrin

25. Atsemin

26. Hemopar

27. Ipsilon

28. Epsilon S

29. Aminocaproic

30. Capralense

31. Eacs

32. Epsilon-leucine

33. Omega-aminocaproic Acid

34. Epsilcapramine

35. Epsilon-norleucine

36. 6-amino-n-hexanoic Acid

37. Epsilon-aminohexanoic Acid

38. Omega-aminohexanoic Acid

39. 6-amino-hexanoic Acid

40. Capranol

41. Eaca Kabi

42. Aminohexanoic Acid

43. Epsilon Aminocaproic Acid

44. Epsilon-amino-n-hexanoic Acid

45. Epsilon-aminocapronzuur

46. Acido Aminocaproico

47. Epsilon-aminocapronsaeure

48. Cl 10304

49. Acidum Aminocaproicum

50. Cy 116

51. Cy-116

52. Nsc-26154

53. 6-aminohexanoate

54. Epsilon-amino-n-caproic Acid

55. 177 J.d.

56. Acide Aminocaproique [french]

57. Acidum Aminocaproicum [latin]

58. Epsilon-aminocaproate

59. .epsilon.-aminocaproic Acid

60. Amicar (tn)

61. Acido Aminocaproico [dcit,spanish]

62. Mfcd00008238

63. Kyselina Omega-aminokapronova [czech]

64. 1319-82-0

65. Acs

66. Nsc 26154

67. Hexanoic Acid,6-amino

68. 6-amino-n-caproic Acid

69. .epsilon.-norleucine

70. 6-amino Caproic Acid

71. Epsilon-aminocaproic Acid (jan)

72. H-acp-oh

73. E-amino-n-caproic Acid

74. Cy116

75. .omega.-aminocaproic Acid

76. .omega.-aminohexanoic Acid

77. Nsc-400230

78. 177 J.d

79. .epsilon.-aminohexanoic Acid

80. Cl-10304

81. Chebi:16586

82. .epsilon. S

83. .epsilon.-leucine

84. Nsc26154

85. 177 Jd

86. 177-jd

87. Nsc400230

88. Cas-60-32-2

89. Ncgc00015092-02

90. Caproamin

91. Dsstox_cid_70

92. U6f3787206

93. Wln: Z5vq

94. Dsstox_rid_75347

95. Dsstox_gsid_20070

96. Acide Aminocaproique

97. E-aminocaproic Acid

98. Epsicaprom

99. Epsilon-ahx

100. Epsilon-aminocaproic Acid [jan]

101. Acide Aminocaproque

102. Kyselina Omega-aminokapronova

103. Jd 177

104. Smr000059162

105. Aminocaproic Acid In Plastic Container

106. Ccris 7706

107. Hsdb 3005

108. Acide Aminocaproique [inn-french]

109. Acido Aminocaproico [inn-spanish]

110. Acidum Aminocaproicum [inn-latin]

111. Sr-01000075688

112. Aminocaproic Acid (usp)

113. Aminocaproic Acid [usan:ban:inn]

114. Einecs 200-469-3

115. Nsc 400230

116. Brn 0906872

117. Acikaprin

118. Epsilon

119. Amino Caproic

120. E-aminocaproate

121. W-aminocaproate

122. Aminocaproic Acid (usp/inn)

123. E-norleucine

124. Ai3-14512

125. E-aminohexanoate

126. W-aminohexanoate

127. 6-aminocaproate

128. E-leucine

129. Epsilon-s

130. Aminocaproic-acid

131. 1cea

132. 3kiv

133. 6-amino-hexanoate

134. 6aminocaproic Acid

135. Omega-aminocaproate

136. Unii-u6f3787206

137. Amino Caproic Acid

138. Trifluoroacctic Acid

139. H-epsilon-acp-oh

140. Omega-aminohexanoate

141. W-aminocaproic Acid

142. E-amino-n-hexanoate

143. E-aminohexanoic Acid

144. W-aminohexanoic Acid

145. 6-amino-n-hexanoate

146. Epsilon-aminohexanoate

147. Epsillon-aminocaproate

148. H-eahx-oh

149. Aminocaproic Acid [usan:usp:inn:ban]

150. Spectrum_000038

151. E-amino-n-hexanoic Acid

152. E-aminocaproic Acid Usp

153. Epsilon-amino-n-hexanoate

154. H-6-ahx-oh

155. Prestwick0_000960

156. Prestwick1_000960

157. Prestwick2_000960

158. Prestwick3_000960

159. Spectrum2_000131

160. Spectrum4_000143

161. Spectrum5_000780

162. Lopac-a-7824

163. Epsillon-aminocaproic Acid

164. Epsilon-amino Caproic Acid

165. Bmse000394

166. H-acp(6)-oh

167. A 7824

168. Aminocaproic Acid (amicar)

169. 6-aminocaproic Acid; Eaca

170. _6-__-_aminocaproic Acid

171. 6-aca

172. Chembl1046

173. Lopac0_000082

174. Schembl15293

175. Bspbio_000960

176. Cbdive_004370

177. Kbiogr_000586

178. Kbioss_000398

179. (6-)

180. A-?aminocaproic Acid

181. Epsilon-aminocaproic Acid Usp

182. Mls001335991

183. Mls002695931

184. Bidd:gt0162

185. Divk1c_000551

186. Nh2-(ch2)5-cooh

187. Spectrum1500114

188. Spbio_000202

189. Spbio_003109

190. (6-)epsilon-aminocaproic Acid

191. Bpbio1_001056

192. Gtpl6574

193. .epsilon.-amino-n-caproic Acid

194. Aminocaproic Acid [inn]

195. Aminocaproic Acid [hsdb]

196. Aminocaproic Acid [usan]

197. Dtxsid0020070

198. .epsilon.-amino-n-hexanoic Acid

199. Chebi:79212

200. Hms501l13

201. Kbio1_000551

202. Kbio2_000398

203. Kbio2_002966

204. Kbio2_005534

205. Aminocaproic Acid [vandf]

206. Aminocaproic Acid [mart.]

207. Ninds_000551

208. Hms1570p22

209. Hms1920c07

210. Hms2091i07

211. Hms2097p22

212. Hms2231f21

213. Hms3260a06

214. Hms3373f09

215. Hms3655m17

216. Hms3714p22

217. Pharmakon1600-01500114

218. Aminocaproic Acid [usp-rs]

219. Aminocaproic Acid [who-dd]

220. 6-aminocaproic Acid [inci]

221. Albb-022460

222. Bcp24729

223. Bcp27495

224. Hy-b0236

225. Zinc1529425

226. Tox21_110081

227. Tox21_500082

228. Ac-035

229. Bdbm50357211

230. Ccg-38935

231. Lmfa01100035

232. Nsc212532

233. Nsc755867

234. S1671

235. Stk246894

236. Akos000118734

237. Tox21_110081_1

238. Am82438

239. Aminocaproic Acid [ep Impurity]

240. Aminocaproic Acid [orange Book]

241. Db00513

242. Ks-5276

243. Lp00082

244. Nsc-212532

245. Nsc-755867

246. Pb43139

247. Sdccgsbi-0050070.p005

248. Aminocaproic Acid [ep Monograph]

249. Idi1_000551

250. Pound 6- Pound(c)

251. A-aminocaproic Acid

252. 6-aminocaproic Acid, Bioultra, >=99%

253. Aminocaproic Acid [usp Monograph]

254. Epsillon-aminocaproic Acid' Epsilcapramin

255. Ncgc00015092-01

256. Ncgc00015092-03

257. Ncgc00015092-04

258. Ncgc00015092-05

259. Ncgc00015092-06

260. Ncgc00015092-07

261. Ncgc00015092-09

262. Ncgc00015092-10

263. Ncgc00015092-17

264. Ncgc00093587-01

265. Ncgc00093587-02

266. Ncgc00093587-03

267. Ncgc00093587-04

268. Ncgc00260767-01

269. Pound 6- Pound(c)

270. A-?aminocaproic Acid

271. .epsilon.-aminocaproic Acid [mi]

272. 6-aminohexanoic Acid, >=98.5% (nt)

273. Aminocaproic Acid (aminocaproic Acid).

274. Bp-20395

275. Sy003109

276. .epsilon.-aminocaproic Acid [jan]

277. 008e238

278. Sbi-0050070.p004

279. A0312

280. Ab00051911

281. Eu-0100082

282. Ft-0620933

283. Sw197248-3

284. Aminocaproic Acid 1000 Microg/ml In Methanol

285. 3-propyl-2'-(n-methyl-n-ethynylamino)pyridine

286. A-5295

287. A15677

288. C02378

289. D00160

290. P19609

291. Zinc Acexamate Impurity B [ep Impurity]

292. Ab00051911-08

293. Ab00051911_09

294. Ab00051911_10

295. 319a820

296. 6-aminocaproic Acid, >=99% (titration), Powder

297. A929179

298. Q255968

299. 6-aminocaproic Acid, Saj Special Grade, >=99.0%

300. Sr-01000075688-1

301. Sr-01000075688-3

302. Sr-01000075688-6

303. Eaca;epsilon-amino-n-caproic Acid;6-aminohexanoic Acid

304. F2191-0201

305. C3bdd377-8f43-4bec-900a-d5850050ba82

306. Aminocaproic Acid, European Pharmacopoeia (ep) Reference Standard

307. Aminocaproic Acid, United States Pharmacopeia (usp) Reference Standard

308. Acepramine; 6-amino-n-hexanoic Acid; 6-aminocaproic Acid; 6-aminohexanoic Acid

309. Aminocaproic Acid, Pharmaceutical Secondary Standard; Certified Reference Material

2.4 Create Date

2004-09-16

3 Chemical and Physical Properties

Molecular Formula	C₆H₁₃NO₂
Molecular Weight	131.17 g/mol
XLogP3	-3
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	5
Exact Mass	131.094628657 g/mol
Monoisotopic Mass	131.094628657 g/mol
Topological Polar Surface Area	63.3 Å²
Heavy Atom Count	9
Formal Charge	0
Complexity	83.1
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Information

1 of 8
Drug Name	Amicar
PubMed Health	Aminocaproic Acid (Injection)
Drug Classes	Hemostatic
Drug Label	AMICAR (aminocaproic acid) is 6-aminohexanoic acid, which acts as an inhibitor of fibrinolysis.Its chemical structure is:AMICAR is soluble in water, acid, and alkaline solutions; it is sparingly soluble in methanol and practically insoluble in chloro...
Active Ingredient	Aminocaproic acid
Dosage Form	Tablet; Syrup
Route	Oral
Strength	1.25gm/5ml; 1gm; 500mg
Market Status	Prescription
Company	Clover Pharms

2 of 8
Drug Name	Aminocaproic
PubMed Health	Aminocaproic Acid (Injection)
Drug Classes	Hemostatic
Drug Label	Aminocaproic Acid Injection, USP is a 6-aminohexanoic acid, which acts as an inhibitor of fibrinolysis.Aminocaproic Acid is soluble in water, acid and alkaline solutions; it is sparingly soluble in methanol and practically insoluble in chloroform.Ami...
Active Ingredient	Aminocaproic acid
Dosage Form	Tablet
Route	Oral
Strength	500mg
Market Status	Prescription
Company	Mikart

3 of 8
Drug Name	Aminocaproic acid
PubMed Health	Aminocaproic Acid
Drug Classes	Hemostatic
Drug Label	Aminocaproic Acid Injection, USP is a 6-aminohexanoic acid, which acts as an inhibitor of fibrinolysis.Aminocaproic Acid is soluble in water, acid and alkaline solutions; it is sparingly soluble in methanol and practically insoluble in chloroform.Ami...
Active Ingredient	Aminocaproic acid
Dosage Form	Injectable; Syrup
Route	Injection; Oral
Strength	1.25gm/5ml; 250mg/ml
Market Status	Prescription
Company	Luitpold; Mikart

4 of 8
Drug Name	Aminocaproic acid in plastic container
Active Ingredient	Aminocaproic acid
Dosage Form	Injectable
Route	Injection
Strength	250mg/ml
Market Status	Prescription
Company	Hospira

5 of 8
Drug Name	Amicar
PubMed Health	Aminocaproic Acid (Injection)
Drug Classes	Hemostatic
Drug Label	AMICAR (aminocaproic acid) is 6-aminohexanoic acid, which acts as an inhibitor of fibrinolysis.Its chemical structure is:AMICAR is soluble in water, acid, and alkaline solutions; it is sparingly soluble in methanol and practically insoluble in chloro...
Active Ingredient	Aminocaproic acid
Dosage Form	Tablet; Syrup
Route	Oral
Strength	1.25gm/5ml; 1gm; 500mg
Market Status	Prescription
Company	Clover Pharms

6 of 8
Drug Name	Aminocaproic
PubMed Health	Aminocaproic Acid (Injection)
Drug Classes	Hemostatic
Drug Label	Aminocaproic Acid Injection, USP is a 6-aminohexanoic acid, which acts as an inhibitor of fibrinolysis.Aminocaproic Acid is soluble in water, acid and alkaline solutions; it is sparingly soluble in methanol and practically insoluble in chloroform.Ami...
Active Ingredient	Aminocaproic acid
Dosage Form	Tablet
Route	Oral
Strength	500mg
Market Status	Prescription
Company	Mikart

7 of 8
Drug Name	Aminocaproic acid
PubMed Health	Aminocaproic Acid
Drug Classes	Hemostatic
Drug Label	Aminocaproic Acid Injection, USP is a 6-aminohexanoic acid, which acts as an inhibitor of fibrinolysis.Aminocaproic Acid is soluble in water, acid and alkaline solutions; it is sparingly soluble in methanol and practically insoluble in chloroform.Ami...
Active Ingredient	Aminocaproic acid
Dosage Form	Injectable; Syrup
Route	Injection; Oral
Strength	1.25gm/5ml; 250mg/ml
Market Status	Prescription
Company	Luitpold; Mikart

8 of 8
Drug Name	Aminocaproic acid in plastic container
Active Ingredient	Aminocaproic acid
Dosage Form	Injectable
Route	Injection
Strength	250mg/ml
Market Status	Prescription
Company	Hospira

4.2 Therapeutic Uses

Antifibrinolytic Agents

National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)

...USED IN TREATMENT OF PROCEDURES OR DISORDERS IN WHICH FIBRINOLYSIS IS ENHANCED...CARDIAC BYPASS, POSTCAVAL SHUNT, MAJOR THORACIC SURGERY, PROSTATIC POSTOPERATIVE HEMATURIA...NONSURGICAL HEMATURIA, LEUKEMIA, METASTATIC PROSTATIC CARCINOMA, CIRRHOSIS & OTHER HEPATIC DISEASES, ECLAMPSIA, INTRAUTERINE FETAL DEATH, AMNIOTIC FLUID EMBOLISM & ABRUPTIO PLACENTAE. THE DRUG IS OF NO VALUE IN HEMORRHAGE DUE TO THROMBOCYTOPENIA, HYPERHEPARINEMIA, OR OTHER COAGULATION DEFECTS, OR TO VASCULAR DISRUPTION.

Osol, A. (ed.). Remington's Pharmaceutical Sciences. 16th ed. Easton, Pennsylvania: Mack Publishing Co., 1980., p. 771

FOR IV ADMIN...SHOULD BE DILUTED IN ISOTONIC OR DEXTROSE SOLN & INJECTED SLOWLY. AFTER 8 HR TREATMENT, PATIENT'S CONDITION SHOULD BE REEVALUATED.

Osol, A. (ed.). Remington's Pharmaceutical Sciences. 16th ed. Easton, Pennsylvania: Mack Publishing Co., 1980., p. 771

...SPECIFIC ANTIDOTE FOR AN OVERDOSE OF A FIBRINOLYTIC AGENT. ...

Gilman, A. G., L. S. Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 6th ed. New York: Macmillan Publishing Co., Inc. 1980., p. 1362

For more Therapeutic Uses (Complete) data for 6-AMINOCAPROIC ACID (9 total), please visit the HSDB record page.

4.3 Drug Warning

RAPID IV ADMIN SHOULD BE AVOIDED TO PREVENT HYPOTENSION, BRADYCARDIA, & OTHER ARRHYTHMIAS.

Gilman, A. G., L. S. Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 6th ed. New York: Macmillan Publishing Co., Inc. 1980., p. 1362

...TERATOGENIC IN ANIMALS & HENCE SHOULD NOT BE USED IN HUMANS IN FIRST 2 TRIMESTERS OF PREGNANCY & IN THIRD TRIMESTER ONLY IF ITS USE IS IMPERATIVE.

Osol, A. (ed.). Remington's Pharmaceutical Sciences. 16th ed. Easton, Pennsylvania: Mack Publishing Co., 1980., p. 771

IF AMINOCAPROIC ACID IS GIVEN TO PT WITH DIC /DIFFUSE INTRAVASCULAR COAGULATION/ IT MAY CAUSE SERIOUS OR EVEN FATAL THROMBUS FORMATION. ...MOST EXPERTS DO NOT USE AMINOCAPROIC ACID TO TREAT "FIBRINOLYTIC" HEMORRHAGE UNLESS THERE IS DEFINITIVE PROOF THAT DIC IS NOT THE UNDERLYING CAUSE.

American Medical Association, AMA Department of Drugs. AMA Drug Evaluations. 4th ed. Chicago: American Medical Association, 1980., p. 1109

WHEN AMINOCAPROIC ACID IS GIVEN DURING SURGERY, CARE MUST BE TAKEN TO FREE THE BODY CAVITIES OF BLOOD CLOTS SINCE THE DRUG REMAINS IN HIGH CONCN IN THE CLOTS, THEREBY INHIBITING THEIR PHYSIOLOGIC DISSOLUTION.

American Medical Association, AMA Department of Drugs. AMA Drug Evaluations. 4th ed. Chicago: American Medical Association, 1980., p. 1110

INCIDENCE OF THROMBOTIC EVENTS SECONDARY TO INHIBITION OF FIBRINOLYTIC SYSTEM BY DRUG IS UNKNOWN, BUT MAY BE PARTICULARLY INCR IN PT WITH UNDERLYING PREDISPOSITION TO DEVELOP THROMBOSIS.

GRIFFIN JD, ELLMAN L; EPSILON-AMINOCAPROIC ACID (EACA); SEMIN THROMB HEMOSTAS 5(1) 27 (1978)

4.4 Drug Indication

For use in the treatment of excessive postoperative bleeding.

FDA Label

5 Pharmacology and Biochemistry

5.1 Pharmacology

Aminocaproic acid works as an antifibrinolytic. It is a derivative of the amino acid lysine. The fibrinolysis-inhibitory effects of aminocaproic acid appear to be exerted principally via inhibition of plasminogen activators and to a lesser degree through antiplasmin activity. Aminocaproic acid may be a possible prophylactic for vascular disease, as it may prevent formation of lipoprotein (a), a risk factor for vascular disease.

5.2 MeSH Pharmacological Classification

Antifibrinolytic Agents

Agents that prevent fibrinolysis or lysis of a blood clot or thrombus. Several endogenous antiplasmins are known. The drugs are used to control massive hemorrhage and in other coagulation disorders. (See all compounds classified as Antifibrinolytic Agents.)

5.3 FDA Pharmacological Classification

5.3.1 Active Moiety

AMINOCAPROIC ACID

5.3.2 FDA UNII

U6F3787206

5.3.3 Pharmacological Classes

Decreased Fibrinolysis [PE]; Antifibrinolytic Agent [EPC]

5.4 ATC Code

B - Blood and blood forming organs

B02 - Antihemorrhagics

B02A - Antifibrinolytics

B02AA - Amino acids

B02AA01 - Aminocaproic acid

5.5 Absorption, Distribution and Excretion

Absorption

Absorbed rapidly following oral administration. In adults, oral absorption appears to be a zero-order process with an absorption rate of 5.2 g/hr. The mean lag time in absorption is 10 minutes. After a single oral dose of 5 g, absorption was complete (F=1).

Route of Elimination

Renal excretion is the primary route of elimination, whether aminocaproic acid is administered orally or intravenously.

Volume of Distribution

23.1 6.6 L

Clearance

169 mL/min

AMINOCAPROIC ACID IS WELL ABSORBED ORALLY... THIS DRUG IS EXCRETED RAPIDLY IN URINE, LARGELY UNCHANGED, & PEAK PLASMA LEVELS ARE OBTAINED ABOUT 2 HR AFTER A SINGLE ORAL DOSE.

American Medical Association, AMA Department of Drugs. AMA Drug Evaluations. 4th ed. Chicago: American Medical Association, 1980., p. 1109

5.6 Metabolism/Metabolites

Sixty-five percent of the dose is recovered in the urine as unchanged drug and 11% of the dose appears as the metabolite adipic acid.

5.7 Biological Half-Life

The terminal elimination half-life is approximately 2 hours.

5.8 Mechanism of Action

Aminocaproic acid binds reversibly to the kringle domain of plasminogen and blocks the binding of plasminogen to fibrin and its activation to plasmin. With NO activation of plasmin, there is a reduction in fibrinolysis. This consequently will reduce the amount of bleeding post surgery. Elevated plasma levels of lipoprotein(a) have been shown to increase the risk of vascular disease. Lipoprotein 9a)a has two components, apolipoprotein B-100, linked to apolipoprotein (a). Aminocaproic acid may change the conformation of apoliprotein (a), changing its binding properties and potentially preventing the formation of lipoprotein (a).

A COMPETITIVE INHIBITOR OF ACTIVATORS OF PROFIBRINOLYSIN &, TO LESSER EXTENT, OF FIBRINOLYSIN. AS A CONSEQUENCE, IT SUPPRESSES FORMATION OF FIBRINOLYSIN, AN ENZYME WHICH DESTROYS FIBRINOGEN, FIBRIN, & OTHER CLOTTING COMPONENTS.

Osol, A. (ed.). Remington's Pharmaceutical Sciences. 16th ed. Easton, Pennsylvania: Mack Publishing Co., 1980., p. 771

MICROCALORIMETRY AND UV AND IR SPECTROSCOPY WERE USED TO STUDY THE INTERMOLECULAR INTERACTIONS OF PLASMINOGEN AND PLASMIN WITH EPSILON-AMINOCAPROIC ACID (I) TO DETERMINE THE MECHANISM OF FIBRINOLYSIS INHIBITION. AT LOW DOSES, THE INHIBITORY EFFECT WAS DUE MAINLY TO BLOCKADE OF THE STAGE OF ACTIVATION OF PLASMINOGEN, WHEREAS THE EFFECTIVENESS OF HIGH CONCENTRATIONS OF I WAS ACHIEVED ALSO BY INACTIVATION OF THE ENZYMIC ACTIVITY OF PLASMIN.

AMIRKHANVYAN VB; STUDY OF THE MOLECULAR MECHANISM OF THE INHIBITION OF FIBRINOLYSIS BY EPSILON-AMINO CAPROIC ACID; KHIM-FARM ZH 14(8) 20 (1980)

API SUPPLIERS

01

Biophore India Pharmaceuticals Pvt...

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Medlab Asia & Asia Health

Not Confirmed

Biophore is a research-driven global pharmaceutical company focused on niche APIs for the generic industry.

Contact Supplier

India

Virtual Booth

Digital Content

USDMF

Click Us!

CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

02

LGM Pharma

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Medlab Asia & Asia Health

Not Confirmed

LGM Pharma accelerates & optimizes the new product pathway from early development through commercialization.

Contact Supplier

U.S.A

Virtual Booth

Digital Content

USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

03

HRV Global Life Sciences

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPHI Middle east

Attending

HRV Global Life Sciences - Market Expansion Leader in Pharmaceuticals.

Contact Supplier

India

Virtual Booth

Digital Content

USDMF CEP/COS JDMF EU-WC NDC KDMF VMF AU

AUDIT

04

MSN Laboratories

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Medlab Asia & Asia Health

Not Confirmed

05

Emcure Pharmaceuticals

India

Taiwan

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Medlab Asia & Asia Health

Not Confirmed

09

Sekisui Medical Co. Ltd

Japan

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Medlab Asia & Asia Health

Not Confirmed

10

Micro Labs Limited

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Medlab Asia & Asia Health

Not Confirmed

Only 10 entries up to this point, click to access all

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

USDMF

01

Biophore India Pharmaceuticals Pvt L...

India

Medlab Asia & Asia Health

Not Confirmed

Biophore is a research-driven global pharmaceutical company focused on niche APIs for the generic industry.

Contact Supplier

India

Virtual Booth

Digital Content

Aminocaproic Acid

GDUFA

DMF Review : Complete

Rev. Date : 2017-05-16

Pay. Date : 2017-04-27

DMF Number : 31478

Submission : 2017-04-26

Status : Active

Type : II

02

Dasami Lab Private Ltd

India

Medlab Asia & Asia Health

Not Confirmed

03

Dipharma Francis Srl

Italy

Medlab Asia & Asia Health

Not Confirmed

04

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

EU WC

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

NDC API

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

Listed Suppliers

01

Biophore India Pharmaceuticals Pvt ...

India

Medlab Asia & Asia Health

Not Confirmed

Biophore is a research-driven global pharmaceutical company focused on niche APIs for the generic industry.

Contact Supplier

India

Virtual Booth

Digital Content

Aminocaproic Acid

About the Company : Biophore, founded in 2007, has established itself as a reliable partner in the development and manufacturing of niche and complex pharmaceutical products. With 4 USFDA and EU-appro...

Biophore, founded in 2007, has established itself as a reliable partner in the development and manufacturing of niche and complex pharmaceutical products. With 4 USFDA and EU-approved API manufacturing facilities, a dedicated intermediate facility, and a R&D laboratory housing 400 scientists, Biophore has positioned itself as a global leader among API companies. It consistently ranks among the top 10 US DMF filers and has obtained over 150 patents worldwide in process and polymorph areas. Biophore's facilities have an impressive track record of successful audits by regulatory bodies such as USFDA, EMEA, ANVISA, COFEPRIS, and WHO GMP.

02

LGM Pharma

U.S.A

Medlab Asia & Asia Health

Not Confirmed

LGM Pharma accelerates & optimizes the new product pathway from early development through commercialization.

Contact Supplier

U.S.A

Virtual Booth

Digital Content

Aminocaproic Acid

About the Company : LGM Pharma is a global leader in sourcing hard-to-find APIs and intermediates for the pharmaceutical and biotech industries. LGM is also a full service CDMO providing formulation, ...

LGM Pharma is a global leader in sourcing hard-to-find APIs and intermediates for the pharmaceutical and biotech industries. LGM is also a full service CDMO providing formulation, analytical method development and testing, and commercial manufacturing. LGM Pharma offers custom API synthesis, analytical development, and regulatory services. With a network of over 300 accredited CGMP manufacturing partners, LGM provides unparalleled supply chain security. And, with over 100,000 square feet of FDA-inspected cGMP manufacturing and warehouse capacity, LGM Pharma provides a one-stop solution for solid dose, powder, semi-solid and liquid drugs.

03

HRV Global Life Sciences

India

CPHI Middle east

Attending

HRV Global Life Sciences - Market Expansion Leader in Pharmaceuticals.

Contact Supplier

India

Virtual Booth

Digital Content

Aminocaproic Acid

About the Company : HRV Global is a leading global manufacturer, seller & exporter of a wide range of APIs, advanced intermediates, pellets, food grade chemicals, food additives & food ingredients. It...

HRV Global is a leading global manufacturer, seller & exporter of a wide range of APIs, advanced intermediates, pellets, food grade chemicals, food additives & food ingredients. It offers services such as sourcing, manufacturing & supply, helping partners enter new markets worldwide. Its strong partnerships with major players in the pharma and food additive industries help HRV Global effectively promote projects and products. HRV Global represents over 30 large Indian drugmakers, primarily targeting Europe, the US & the Middle East markets. Headquartered in India, HRV Global has offices in the US, Switzerland, Dubai, Lithuania & Turkey.

04

Dipharma

Italy

Medlab Asia & Asia Health

Not Confirmed

05

Emcure Pharmaceuticals

India

Medlab Asia & Asia Health

Not Confirmed

06

Medilux Laboratories

India

Medlab Asia & Asia Health

Not Confirmed

07

10

Raks Pharma

India

Medlab Asia & Asia Health

Not Confirmed

Only 10 entries up to this point, click to access all

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

API Reference Price

[{"dataSource":"API Export","activeIngredients":"AMINOCAPROIC ACID","year":"2021","qtr":"Q1","strtotime":1614105000,"product":"AMINOCAPROIC ACID (TAX INVOICE NO:EXPORT 110\/2020-21 DT:22\/02\/2021) (GROUP:A SRL NO:1575","address":"43-11-56, SUBBALAKSHMI NAGARRAILWAY NEW COLONY","city":"VISAKHAPATNAM, A.P.","supplier":"SIONC PHARMACEUTICALS","supplierCountry":"INDIA","foreign_port":"NEW YORK","customer":"BIOPHORE INDIA PHARMACEUTICALS PVT LTD","customerCountry":"UNITED STATES","quantity":"250.00","actualQuantity":"250","unit":"KGS","unitRateFc":"316","totalValueFC":"78167.1","currency":"USD","unitRateINR":22764.356,"date":"24-Feb-2021","totalValueINR":"5691089","totalValueInUsd":"78167.1","indian_port":"HYDERABAD AIR","hs_no":"29379090","bill_no":"8892557","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"HYDERABAD AIR","supplierAddress":"43-11-56, SUBBALAKSHMI NAGARRAILWAY NEW COLONY, VISAKHAPATNAM, A.P.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"AMINOCAPROIC ACID","year":"2021","qtr":"Q2","strtotime":1618857000,"product":"AMINOCAPROIC ACID","address":"PLOT NO.131,3RD FLOOR,NARMADAARCADE,SNEHAPURI COLONY,NACHARAM,","city":"HYDERABAD. AP","supplier":"OPTIMUS DRUGS PRIVATE ","supplierCountry":"INDIA","foreign_port":"TIANJIN","customer":"GREENPINE PHARMA GROUP ","customerCountry":"CHINA","quantity":"84.00","actualQuantity":"84","unit":"KGS","unitRateFc":"412.1","totalValueFC":"33503","currency":"USD","unitRateINR":29693.647738095238,"date":"20-Apr-2021","totalValueINR":"2494266.41","totalValueInUsd":"33503","indian_port":"HYDERABAD AIR","hs_no":"29212990","bill_no":"1228158","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"HYDERABAD AIR","supplierAddress":"PLOT NO.131,3RD FLOOR,NARMADAARCADE,SNEHAPURI COLONY,NACHARAM,, HYDERABAD. AP","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2021","qtr":"Q2","strtotime":1622745000,"product":"AMINOCAPROIC ACID (GROUP:A)(TAX INV NO:5 910215029 DT:27.05.2021","address":"1ST FLOOR,PLOT NO.497,VIVEKANANDANAGAR COLONY, KUKATPALLY","city":"HYDERABAD","supplier":"MSN LABORATORIES","supplierCountry":"INDIA","foreign_port":"NEWARK NJ","customer":"MSN PHARMACEUTICALS INC","customerCountry":"UNITED STATES","quantity":"93.00","actualQuantity":"93","unit":"KGS","unitRateFc":"265.3","totalValueFC":"24169.8","currency":"USD","unitRateINR":19113.814516129034,"date":"04-Jun-2021","totalValueINR":"1777584.75","totalValueInUsd":"24169.8","indian_port":"HYDERABAD AIR","hs_no":"29223900","bill_no":"2220791","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"HYDERABAD AIR","supplierAddress":"1ST FLOOR,PLOT NO.497,VIVEKANANDANAGAR COLONY, KUKATPALLY, HYDERABAD","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2021","qtr":"Q2","strtotime":1623004200,"product":"AMINOCAPROIC ACID (GROUP:A)(TAX INV NO:5 910215030 DT:27.05.2021","address":"1ST FLOOR,PLOT NO.497,VIVEKANANDANAGAR COLONY, KUKATPALLY","city":"HYDERABAD","supplier":"MSN LABORATORIES","supplierCountry":"INDIA","foreign_port":"NEWARK NJ","customer":"MSN PHARMACEUTICALS INC","customerCountry":"UNITED STATES","quantity":"62.00","actualQuantity":"62","unit":"KGS","unitRateFc":"265.1","totalValueFC":"16102.2","currency":"USD","unitRateINR":19100.701612903227,"date":"07-Jun-2021","totalValueINR":"1184243.5","totalValueInUsd":"16102.2","indian_port":"HYDERABAD AIR","hs_no":"29223900","bill_no":"2260572","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"HYDERABAD AIR","supplierAddress":"1ST FLOOR,PLOT NO.497,VIVEKANANDANAGAR COLONY, KUKATPALLY, HYDERABAD","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2021","qtr":"Q3","strtotime":1626892200,"product":"AMINOCAPROIC ACID (TAX INVOICE NO:SPP21 22-U1ES-026 DT:15\/07\/2021","address":"43-11-56, SUBBALAKSHMI NAGARRAILWAY NEW COLONY","city":"VISAKHAPATNAM, A.P.","supplier":"SIONC PHARMACEUTICALS","supplierCountry":"INDIA","foreign_port":"PHILADELPHIA METROP","customer":"BIOPHORE INDIA PHARMACEUTICALS PVT LTD","customerCountry":"UNITED STATES","quantity":"250.00","actualQuantity":"250","unit":"KGS","unitRateFc":"322.1","totalValueFC":"77847.2","currency":"USD","unitRateINR":23206.804,"date":"22-Jul-2021","totalValueINR":"5801701","totalValueInUsd":"77847.2","indian_port":"HYDERABAD AIR","hs_no":"29379090","bill_no":"3315632","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"HYDERABAD AIR","supplierAddress":"43-11-56, SUBBALAKSHMI NAGARRAILWAY NEW COLONY, VISAKHAPATNAM, A.P.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2022","qtr":"Q2","strtotime":1649010600,"product":"AMINOCAPROIC ACID (TAX INVOICE NO:SPP212","address":"43-11-56, SUBBALAKSHMI NAGAR,RAILW AY NEW COLONY","city":"VISAKHAPATNAM,ANDHRA PRADESH","supplier":"SIONC PHARMACEUTICALS","supplierCountry":"INDIA","foreign_port":"NEW YORK","customer":"BIOPHORE INDIA PHARMACEUTICALS PVT LTD","customerCountry":"UNITED STATES","quantity":"150.00","actualQuantity":"150","unit":"KGS","unitRateFc":"325","totalValueFC":"47078.2","currency":"USD","unitRateINR":23680,"date":"04-Apr-2022","totalValueINR":"3552000","totalValueInUsd":"47078.2","indian_port":"HYDERABAD AIR","hs_no":"29379090","bill_no":"9468821","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"HYDERABAD AIR","supplierAddress":"43-11-56, SUBBALAKSHMI NAGAR,RAILW AY NEW COLONY, VISAKHAPATNAM,ANDHRA PRADESH","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2022","qtr":"Q2","strtotime":1649788200,"product":"AMINOCAPROIC ACID (TAX INVOICE NO:SPP222","address":"43-11-56, SUBBALAKSHMI NAGAR,RAILW AY NEW COLONY","city":"VISAKHAPATNAM,ANDHRA PRADESH","supplier":"SIONC PHARMACEUTICALS","supplierCountry":"INDIA","foreign_port":"NEW YORK","customer":"BIOPHORE INDIA PHARMACEUTICALS PVT LTD","customerCountry":"UNITED STATES","quantity":"199.49","actualQuantity":"199.49","unit":"KGS","unitRateFc":"325","totalValueFC":"62519.1","currency":"USD","unitRateINR":23645.295503534009,"date":"13-Apr-2022","totalValueINR":"4717000","totalValueInUsd":"62519.1","indian_port":"HYDERABAD AIR","hs_no":"29379090","bill_no":"9686977","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"HYDERABAD AIR","supplierAddress":"43-11-56, SUBBALAKSHMI NAGAR,RAILW AY NEW COLONY, VISAKHAPATNAM,ANDHRA PRADESH","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2022","qtr":"Q3","strtotime":1663525800,"product":"AMINOCAPROIC ACID (TAX INVOICE NO:SPP222","address":"43-11-56, SUBBALAKSHMI NAGAR,RAILW AY NEW COLONY","city":"VISAKHAPATNAM,ANDHRA PRADESH","supplier":"SIONC PHARMACEUTICALS","supplierCountry":"INDIA","foreign_port":"SINGAPORE","customer":"M\/S.GUTEN EXPORTRADE PTE LTD","customerCountry":"SINGAPORE","quantity":"5.00","actualQuantity":"5","unit":"KGS","unitRateFc":"325","totalValueFC":"1534.8","currency":"USD","unitRateINR":24600,"date":"19-Sep-2022","totalValueINR":"123000","totalValueInUsd":"1534.8","indian_port":"HYDERABAD AIR","hs_no":"29379090","bill_no":"4279883","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"SINGAPORE","selfForZScoreResived":"Pharma Grade","supplierPort":"HYDERABAD AIR","supplierAddress":"43-11-56, SUBBALAKSHMI NAGAR,RAILW AY NEW COLONY, VISAKHAPATNAM,ANDHRA PRADESH","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2022","qtr":"Q4","strtotime":1672252200,"product":"AMINOCAPROIC ACID","address":"RAKSHIT HOUSE 425\/3RT,DNO.7-1-621\/","city":"HYDERABAD. AP.","supplier":"RAKS PHARMA","supplierCountry":"INDIA","foreign_port":"JOHN F. KENNEDY APT\/","customer":"AMNEAL PHARMACEUTICALS","customerCountry":"UNITED STATES","quantity":"300.00","actualQuantity":"300","unit":"KGS","unitRateFc":"425","totalValueFC":"126562","currency":"USD","unitRateINR":34765,"date":"29-Dec-2022","totalValueINR":"10429500","totalValueInUsd":"126562","indian_port":"Dahez-SEZ","hs_no":"29222990","bill_no":"4014773","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"Dahez-SEZ","supplierAddress":"RAKSHIT HOUSE 425\/3RT,DNO.7-1-621\/, HYDERABAD. AP.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1692642600,"product":"AMINOCAPROIC ACID (TAX INVOICE NO:SPP2324-U1ES-043 DT:11.08.2023)","address":"43-11-56 SUBBALAKSHMI NAGARRAILW AY NEW COLONY","city":"VISAKHAPATNAM","supplier":"SIONC PHARMACEUTICALS","supplierCountry":"INDIA","foreign_port":"NA","customer":"TO THE ORDER OF","customerCountry":"GERMANY","quantity":"25.00","actualQuantity":"25","unit":"KGS","unitRateFc":"294.4","totalValueFC":"7303.6","currency":"USD","unitRateINR":24199.998936,"date":"22-Aug-2023","totalValueINR":"604999.9734","totalValueInUsd":"7303.6","indian_port":"HYDERABAD ICD","hs_no":"29379090","bill_no":"0","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"HYDERABAD ICD","supplierAddress":"43-11-56 SUBBALAKSHMI NAGARRAILW AY NEW COLONY, VISAKHAPATNAM","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1707762600,"product":"AMINOCAPROIC ACID (TAX INVOICE NO:SPP2324-U1ES-105, DT:06.02.2024)","address":"43-11-56, SUBBALAKSHMI NAGAR","city":"VISAKHAPATNAM, A.P.","supplier":"SIONC PHARMACEUTICALS","supplierCountry":"INDIA","foreign_port":"NEW YORK","customer":"BIOPHORE INDIA PHARMACEUTICALS PVT LTD","customerCountry":"UNITED STATES","quantity":"201.82","actualQuantity":"201.82","unit":"KGS","unitRateFc":"300","totalValueFC":"58807","currency":"USD","unitRateINR":24177.178674066003,"date":"13-Feb-2024","totalValueINR":"4879438.2","totalValueInUsd":"58807","indian_port":"Hyderabad Air","hs_no":"29379090","bill_no":"7505218","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"43-11-56, SUBBALAKSHMI NAGAR, VISAKHAPATNAM, A.P.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1717439400,"product":"AMINOCAPROIC ACID USP","address":"4A, AMAN ADHAR SOCIETY","city":"VADODARA","supplier":"GLOBAUX IMPEX PRIVATE LIMITED","supplierCountry":"INDIA","foreign_port":"TORONTO","customer":"TO THE ORDER OF","customerCountry":"CANADA","quantity":"100.00","actualQuantity":"100","unit":"KGS","unitRateFc":"260","totalValueFC":"24835.8","currency":"USD","unitRateINR":20732.752499999999,"date":"04-Jun-2024","totalValueINR":"2073275.25","totalValueInUsd":"24835.8","indian_port":"Hyderabad Air","hs_no":"29221990","bill_no":"1420026","productDescription":"API","marketType":"REGULATED MARKET","country":"CANADA","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"4A, AMAN ADHAR SOCIETY, VADODARA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1717525800,"product":"AMINOCAPROIC ACID","address":"43-11-56, SUBBALAKSHMI NAGAR","city":"VISAKHAPATNAM, A.P.","supplier":"SIONC PHARMACEUTICALS","supplierCountry":"INDIA","foreign_port":"NEW YORK - JOHN F. K","customer":"BIOPHORE INDIA PHARMACEUTICALS PVT LTD","customerCountry":"UNITED STATES","quantity":"181.45","actualQuantity":"181.45","unit":"KGS","unitRateFc":"300","totalValueFC":"52760","currency":"USD","unitRateINR":24273.20887296776,"date":"05-Jun-2024","totalValueINR":"4404373.75","totalValueInUsd":"52760","indian_port":"Hyderabad Air","hs_no":"29224990","bill_no":"1448597","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"43-11-56, SUBBALAKSHMI NAGAR, VISAKHAPATNAM, A.P.","customerAddress":""},{"dataSource":"API Import","activeIngredients":"AMINOCAPROIC ACID","year":"2021","qtr":"Q1","strtotime":1616005800,"product":"FMOC-6-AMINOCAPROIC ACID (LAB CHEMICALS","address":"FLAT NO.204,IIND FLOOR,MERIDIANPLAZA,6-3-853\/1,AMEERPET,","city":"HYDERABAD-ANDHRA PRADESH.","supplier":"CHEMTOUR BIOTECH SUZHOU ","supplierCountry":"CHINA","foreign_port":"BEIJING","customer":"NEULAND LABORATORIES","customerCountry":"INDIA","quantity":"0.75","actualQuantity":"0.75","unit":"KGS","unitRateFc":"650.7","totalValueFC":"495.4","currency":"USD","unitRateINR":"48084.3","date":"18-Mar-2021","totalValueINR":"36063.2","totalValueInUsd":"495.4","indian_port":"HYDERABAD AIR","hs_no":"29339990","bill_no":"3190486","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BEIJING","supplierAddress":"","customerAddress":"FLAT NO.204,IIND FLOOR,MERIDIANPLAZA,6-3-853\/1,AMEERPET,"},{"dataSource":"API Import","activeIngredients":"","year":"2021","qtr":"Q3","strtotime":1627842600,"product":"AMINOCAPROIC ACID","address":"TUNG BALAMAJITHA ROAD","city":"AMRITSAR,PUNJAB","supplier":"QUANZHOU FORTUNE TRADE ","supplierCountry":"CHINA","foreign_port":"BEIJING","customer":"KWALITY PHARMACEUTICALS","customerCountry":"INDIA","quantity":"30.00","actualQuantity":"30","unit":"KGS","unitRateFc":"100","totalValueFC":"3049.9","currency":"USD","unitRateINR":"7540","date":"02-Aug-2021","totalValueINR":"226200","totalValueInUsd":"3049.9","indian_port":"DELHI AIR","hs_no":"29339990","bill_no":"4903887","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BEIJING","supplierAddress":"","customerAddress":"TUNG BALAMAJITHA ROAD"},{"dataSource":"API Import","activeIngredients":"","year":"2021","qtr":"Q3","strtotime":1631298600,"product":"6-AMINOCAPROIC ACID (FOR LAB USE)","address":"2\/F,SATAM INDL.EST.,C WING,2ND FLR.DR.CARDINAL GRACIOUS RD.,CHAKALA,","city":"ANDHERI-E,MUMBAI,MAH.","supplier":"BIOPHARM","supplierCountry":"CHINA","foreign_port":"#N\/A","customer":"SISCO RESEARCH LABORATORIES ","customerCountry":"INDIA","quantity":"50.00","actualQuantity":"50","unit":"KGS","unitRateFc":"124","totalValueFC":"6233.2","currency":"USD","unitRateINR":"9169.8","date":"11-Sep-2021","totalValueINR":"458490","totalValueInUsd":"6233.2","indian_port":"BOMBAY AIR","hs_no":"29159099","bill_no":"5398414","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"#N\/A","supplierAddress":"","customerAddress":"2\/F,SATAM INDL.EST.,C WING,2ND FLR.DR.CARDINAL GRACIOUS RD.,CHAKALA,"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q2","strtotime":1656009000,"product":"AMINOCAPROIC ACID","address":"VILLAGE NAG KALAN,MAJITHA ROAD,MAJ ITHA","city":"AMRITSAR,PUNJAB","supplier":"QUANZHOU FORTUNE TRADE ","supplierCountry":"CHINA","foreign_port":"NA","customer":"KWALITY PHARMACEUTICALS","customerCountry":"INDIA","quantity":"25.00","actualQuantity":"25","unit":"KGS","unitRateFc":"100","totalValueFC":"2530","currency":"USD","unitRateINR":"7895","date":"24-Jun-2022","totalValueINR":"197375","totalValueInUsd":"2530","indian_port":"DELHI AIR","hs_no":"29339990","bill_no":"9257665","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"VILLAGE NAG KALAN,MAJITHA ROAD,MAJ ITHA"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q3","strtotime":1664217000,"product":"AMINOCAPROIC ACID","address":"VILLAGE NAG KALAN,MAJITHA ROAD,MAJ ITHA","city":"AMRITSAR,PUNJAB","supplier":"QUANZHOU FORTUNE TRADE ","supplierCountry":"CHINA","foreign_port":"NA","customer":"KWALITY PHARMACEUTICALS","customerCountry":"INDIA","quantity":"50.00","actualQuantity":"50","unit":"KGS","unitRateFc":"100","totalValueFC":"5016.2","currency":"USD","unitRateINR":"8040","date":"27-Sep-2022","totalValueINR":"402000","totalValueInUsd":"5016.2","indian_port":"DELHI AIR","hs_no":"29339990","bill_no":"2628580","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"VILLAGE NAG KALAN,MAJITHA ROAD,MAJ ITHA"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q1","strtotime":1675103400,"product":"AMINOCAPROIC ACID ( RE-IMPORT FOR REPROCESS & RE-EXPORT VIDESB NO.6219403 DT:30.10.2020)","address":"43-11-56, SUBBALAKSHMI NAGAR,RAILW AY NEW COLONY","city":"VISAKHAPATNAM,ANDHRA PRADESH","supplier":"BIOPHORE INDIA PHARMACEUTICALS PVT LTD","supplierCountry":"INDIA","foreign_port":"NA","customer":"SIONC PHARMACEUTICALS","customerCountry":"INDIA","quantity":"148.05","actualQuantity":"148.05","unit":"KGS","unitRateFc":"400","totalValueFC":"59611.5","currency":"USD","unitRateINR":"32920","date":"31-Jan-2023","totalValueINR":"4873806","totalValueInUsd":"59611.5","indian_port":"HYDERABAD AIR","hs_no":"29379090","bill_no":"4423446","productDescription":"Re-export","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"43-11-56, SUBBALAKSHMI NAGAR,RAILW AY NEW COLONY"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1697049000,"product":"6-AMINOCAPROIC ACID METHYL ESTER HYDROCHLORIDE- 101277 CAS NO.1926-80-3","address":"PLOT.NO.49,CANARA BANK ROAD,","city":"PHASE-I,BANGALORE","supplier":"ARBOR CHEMICAL CO. LTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"ANTHEM BIOSCIENCES","customerCountry":"INDIA","quantity":"1.00","actualQuantity":"1000","unit":"GMS","unitRateFc":"0.5","totalValueFC":"505.5","currency":"USD","unitRateINR":"42.1","date":"12-Oct-2023","totalValueINR":"42075","totalValueInUsd":"505.5","indian_port":"Bangalore Air","hs_no":"29224990","bill_no":"8268938","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"ROOM 401, UNIT 3, BUILDING 10, NO.166, MINDONG ROAD, CAOLU TOWN, PUDONG, SHANGHAI 201209, CHINA China","customerAddress":"PLOT.NO.49,CANARA BANK ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1705257000,"product":"6-AMINOCAPROIC ACID BP\/USP CAS:60-32-2 (FOR PHARMA USE)","address":"PLOT NO 4 GUT NO 66 KHUPRI VILLAGE","city":"MUMBAI,MAHARASHTRA","supplier":"SHINNING PHARMACEUTICAL AND CHEMICAL CO.,LIMITED","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"U S PHARMA (INDIA) PRIVATE LIMITED","customerCountry":"INDIA","quantity":"50.00","actualQuantity":"50","unit":"KGS","unitRateFc":"98","totalValueFC":"4967.1","currency":"USD","unitRateINR":"8256.5","date":"15-Jan-2024","totalValueINR":"412825","totalValueInUsd":"4967.1","indian_port":"Bombay Air","hs_no":"29224990","bill_no":"9666667","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"NO.80-2-1-401 HUANCHENG WEST ROAD,XIANJU, ZHEJIANG, CHINASDNF CHINA","customerAddress":"PLOT NO 4 GUT NO 66 KHUPRI VILLAGE"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1707676200,"product":"[FOC] AMINOCAPROIC ACID USP BATCH NO. AMN008I19 (RE-IMPORT OF INDIAN ORIGIN GOODS, EXPORT VIDE SB NO. 7121517 DT. 30.12.","address":"T-184, MIDC, BHOSARI,","city":"PUNE-MAHARASHTRA","supplier":"QUAGEN PHARMACEUTICALS LLC","supplierCountry":"INDIA","foreign_port":"NEW YORK","customer":"EMCURE PHARMACEUTICALS","customerCountry":"INDIA","quantity":"50.00","actualQuantity":"50","unit":"KGS","unitRateFc":"400","totalValueFC":"20640.9","currency":"USD","unitRateINR":"34253.1","date":"12-Feb-2024","totalValueINR":"1712655.55","totalValueInUsd":"20640.9","indian_port":"JNPT","hs_no":"29224290","bill_no":"2110066","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"NEW YORK","supplierAddress":"23 FAIRFILES PLACE, WEST CALDWELL,NJ 07006SDNF United States","customerAddress":"T-184, MIDC, BHOSARI,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1707676200,"product":"[FOC] AMINOCAPROIC ACID USP BATCH NO. AMN008I19 [RE-IMPORT OF INDIAN ORIGIN GOODS, EXPORT VIDE SB NO. 7121517 DT. 30.12.","address":"T-184, MIDC, BHOSARI,","city":"PUNE-MAHARASHTRA","supplier":"QUAGEN PHARMACEUTICALS LLC","supplierCountry":"INDIA","foreign_port":"NEW YORK","customer":"EMCURE PHARMACEUTICALS","customerCountry":"INDIA","quantity":"46.00","actualQuantity":"46","unit":"KGS","unitRateFc":"400","totalValueFC":"18989.7","currency":"USD","unitRateINR":"34253.1","date":"12-Feb-2024","totalValueINR":"1575643.1","totalValueInUsd":"18989.7","indian_port":"JNPT","hs_no":"29224290","bill_no":"2110066","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"NEW YORK","supplierAddress":"23 FAIRFILES PLACE, WEST CALDWELL,NJ 07006SDNF United States","customerAddress":"T-184, MIDC, BHOSARI,"}]

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

Upgrade, download data, analyse, strategize, subscribe with us contact

FDF Dossiers

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

FDA Orange Book

India

Medlab Asia & Asia Health

Not Confirmed

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

DRUG PRODUCT COMPOSITIONS

Do you need Business Intel? Ask us

DOSAGE - TABLET;ORAL - 1GM

USFDA APPLICATION NUMBER - 15197

DOSAGE - TABLET;ORAL - 500MG

USFDA APPLICATION NUMBER - 15197

Related Excipient Companies

Upload your portfolio for free, ask us

Excipients by Applications

Click here to find the perfect excipient manufacturers by their capabilities

Fillers, Diluents & Binders

Thickeners and Stabilizers

Solubilizers

Topical

Coating Systems & Additives

Film Formers & Plasticizers

Direct Compression

Lubricants & Glidants

Disintegrants & Superdisintegrants

Granulation

Parenteral

Taste Masking

Chewable & Orodispersible Aids

Rheology Modifiers

Controlled & Modified Release

Co-Processed Excipients

Surfactant & Foaming Agents

Coloring Agents

Emulsifying Agents

Soft Gelatin

API Stability Enhancers

Digital Content

Create Content with PharmaCompass, ask us

DATA COMPILATION #PharmaFlow

FDA approved first 3D printed drug is no fad but a technology you can easily develop

Recently the USFDA approved Aprecia Pharma’s SPRITAM® levetiracetam – a drug for epilepsy treatment manufactured by 3D printing. This approval should encourage other players to pursue drug development with renewed vigor. Last week saw a revolutionary approval from the US Food and Drug Administration (USFDA). For the first time, the USFDA approved a drug manufactured by three dimensional printing (3DP) – Aprecia Pharmaceuticals received the USFDA approval of epilepsy treatment SPRITAM® levetiracetam. Leveitracetam was first approved in 1999. Revolutionary formulation & rapid delivery system Aprecia gained the exclusive licence to 3DP technology from MIT in the late 1980s, and by 2007 it began developing its proprietary ZipDose technology. But SPRITAM is revolutionary, not just because it is 3D printed, but for other reasons as well. SPRITAM® is a porous formulation that rapidly disintegrates with a sip of liquid. The dispersion is significantly superior to a conventional over the counter fast-melt tablet (watch the video: https://www.aprecia.com/zipdose-platform/zipdose-technology.php). In fact, the drug is designed to dissolve in the tongue (rather than swallowed as a whole). The patient experience is enhanced since SPRITAM delivers an extremely high drug load, up to 1,000 mg in a single dose. No measuring is needed as each dose is individually packaged, making it easy to carry this treatment on the go. 3D printers are not even expensive For those not familiar with 3DP (or additive manufacturing), it is a process used to make a three-dimensional object without the use of dies, molds or machining. Instead, additive processes are used, in which successive layers of material are laid down under computer control (watch the video: https://www.youtube.com/watch?v=G0EJmBoLq-g). These objects can often be of virtually any shape or geometry, and are produced from a 3D model or another electronic data source. A 3D printer is a type of industrial robot, and can range from small scale consumer models to large factory units. Now for the moot question – why are pharmaceutical companies not developing drugs with 3D printing? In fact, 3D printers are inexpensive, and the ingredients used to produce the drugs are the same that are currently being used and there are multiple candidates, other than those Aprecia is working on which would benefit from this technological revolution. Making 3D printed drugs is really not that complicated or expensive. A recently published paper by researchers at the University College of London (UCL), “Effect of geometry on drug release from 3D printed tablets” produced different shaped tablets using 3D printing which would be otherwise difficult to produce using traditional methods. Simple guide to make 3D printed drugs The researchers simply purchased water-soluble PVA filament from MakerBot (not currently available but other PVA filaments are available on Amazon for under US $ 50), along with widely used pain reducer and fever reliever, Paracetamol (also known as Acetaminophen) and salts. They cut the filament into small pieces (approximately 2mm in length), basically turning the spool of filament into pellets. This was followed by mixing in the Paracetamol, and extruding the mixture from a Filabot filament extruder (it costs US $ 949) at 180 degrees C. What came out of the printer was a 3D printed drug. PharmaCompass’ potential candidates for 3DP Staying focused on opportunities where an extremely high drug load – up to 1,000 mg – has to be delivered in a single dose we ran a search on the PharmaCompass database to find a few potential candidates for 3D printing. Drug Name Therapeutic Indication Aminocaproic Acid Bleeding disorder treatment Sucralfate Ulcer medication Cefadroxil Antibiotic Colestipol Hydrochloride Lipid lowering Metformin Hydrochloride Diabetes Methenamine Hippurate Urinary Tract Antiseptic Ranolazine Chronic Angina Valacyclovir Hydrochloride Viral Diseases Icosapent Cholesterol reduction In addition to these products, there are multiple other possibilities which can get created by producing combination drugs using 3D printing. Overcoming the challenges of slow 3D printing With nearly three million people in the United States diagnosed with active epilepsy, Aprecia Pharmaceuticals’ revolutionary form of Levetiracetam clearly has a very large market need to address. However, the problem with 3D printing is that it is exceptionally slow when compared with conventional production methods for tablets. Anticipating the problems, Aprecia Pharmaceuticals announced on Feb. 23, 2015, that the company will open a new manufacturing facility in Ohio that will use its powder–liquid three-dimensional printing (3DP) technology. With plans to invest $25 million in a 190,000-ft2 facility, the new facility will be in addition to the company's existing manufacturing and R&D facility in New Jersey. Disrupting healthcare in 3D In the healthcare industry, 3D printers are used by dentists to create replicas of jaws and teeth as well as some finished dental implants and orthopedic surgeons have tested them to make customized hip replacements. In 2012, a two-year-old girl in Illinois, born without a trachea, received a windpipe built with her own stem cells. British scientists have also used 3D printing to create personalized replica models of cancerous parts of the body to allow doctors to target tumors more precisely. Our View The current way of consuming tablets can definitely undergo a serious overhaul. With 3D printing technology rapidly evolving and already inexpensive, there is little reason for the industry not to pursue this area of drug development with greater vigor. In addition, if we can measure our blood sugar levels using diagnostic kits at home, is it unrealistic to imagine a day when we’ll start printing our own medicines in 3D?