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Amosulalol Hydrochloride

Amosulalol Hydrochloride

Synopsis, Chemistry

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Also known as: Amosulalol hcl, 93633-92-2, 70958-86-0, Amosulalol monohydrochloride, Ym 09538, Ym-09538

Molecular Formula

C₁₈H₂₅ClN₂O₅S

Molecular Weight

416.9 g/mol

InChI Key

JRVCPDVOFCWKAG-UHFFFAOYSA-N

FDA UNII

4O4S698PEE

1 2D Structure

Amosulalol Hydrochloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

5-[1-hydroxy-2-[2-(2-methoxyphenoxy)ethylamino]ethyl]-2-methylbenzenesulfonamide;hydrochloride

2.1.2 InChI

InChI=1S/C18H24N2O5S.ClH/c1-13-7-8-14(11-18(13)26(19,22)23)15(21)12-20-9-10-25-17-6-4-3-5-16(17)24-2;/h3-8,11,15,20-21H,9-10,12H2,1-2H3,(H2,19,22,23);1H

2.1.3 InChI Key

JRVCPDVOFCWKAG-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC1=C(C=C(C=C1)C(CNCCOC2=CC=CC=C2OC)O)S(=O)(=O)N.Cl

2.2 Other Identifiers

2.2.1 UNII

4O4S698PEE

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 5-(1-hydroxy-2-((2-(2-methoxyphenoxy)ethyl)amino)ethyl)-2-methylbenzenesulfonamide

2. Amosulalol

3. Ym 09538

4. Ym-09538

2.3.2 Depositor-Supplied Synonyms

1. Amosulalol Hcl

2. 93633-92-2

3. 70958-86-0

4. Amosulalol Monohydrochloride

5. Ym 09538

6. Ym-09538

7. 5-(1-hydroxy-2-((2-(2-methoxyphenoxy)ethyl)amino)ethyl)-2-methylbenzenesulfonamide Hydrochloride

8. Lowgan

9. Amosulalol Hydrochloride [jan]

10. Amosulalol (hydrochloride)

11. 4o4s698pee

12. 93633-92-2 ( Hcl)

13. 5-[1-hydroxy-2-[2-(2-methoxyphenoxy)ethylamino]ethyl]-2-methylbenzenesulfonamide;hydrochloride

14. Amosulalolhcl

15. Unii-4o4s698pee

16. Lowgan (tn)

17. Schembl50631

18. Amosulalol Hydrochloride (jp17)

19. Chebi:31208

20. Dtxsid00918277

21. (+-)-5-hydroxy-2-(2-(2-methoxyphenoxy)ethylamino)ethyl)-2-methylbenzolsulfonamid Hydrochlorid

22. Amosulalol Hydrochloride [mart.]

23. Amosulalol Hydrochloride [who-dd]

24. Amosulalol Monohydrochloride [mi]

25. Benzenesulfonamide, 5-(1-hydroxy-2-((2-(2-methoxyphenoxy)ethyl)amino)ethyl)-2-methyl-, Hydrochloride, (+-)-

26. Benzenesulfonamide, 5-(1-hydroxy-2-((2-(2-methoxyphenoxy)ethyl)amino)ethyl)-2-methyl-, Monohydrochloride

27. D01469

28. Q27260271

29. 5-(1-hydroxy-2-{[2-(2-methoxyphenoxy)ethyl]amino}ethyl)-2-methylbenzene-1-sulfonamide--hydrogen Chloride (1/1)

30. Benzenesulfonamide, 5-(1-hydroxy-2-((2-(2-methoxyphenoxy)ethyl)amino)ethyl)-2-methyl-, Hydrochloride (1:1)

31. Benzenesulfonamide, 5-(1-hydroxy-2-((2-(2-methoxyphenoxy)ethyl)amino)ethyl)-2-methyl-, Hydrochloride, (+/-)-

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₁₈H₂₅ClN₂O₅S
Molecular Weight	416.9 g/mol
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	9
Exact Mass	416.1172708 g/mol
Monoisotopic Mass	416.1172708 g/mol
Topological Polar Surface Area	119 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	510
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Adrenergic beta-Antagonists

Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety. (See all compounds classified as Adrenergic beta-Antagonists.)

Antihypertensive Agents

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

Adrenergic alpha-Antagonists

Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma. (See all compounds classified as Adrenergic alpha-Antagonists.)