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Ampalex

Pfanstiehl, a global leader in the manufacture of cGMP high purity, low endotoxin, low metals (HPLE-LM)TM injectable grade excipients.

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Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 154235-83-3, Piperidin-1-yl(quinoxalin-6-yl)methanone, Cx-516, Cx516, Bdp 12, 1-(quinoxalin-6-ylcarbonyl)piperidine

Molecular Formula

C₁₄H₁₅N₃O

Molecular Weight

241.29 g/mol

InChI Key

ANDGGVOPIJEHOF-UHFFFAOYSA-N

FDA UNII

Z5QU38B4V9

1 2D Structure

Ampalex

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

piperidin-1-yl(quinoxalin-6-yl)methanone

2.1.2 InChI

InChI=1S/C14H15N3O/c18-14(17-8-2-1-3-9-17)11-4-5-12-13(10-11)16-7-6-15-12/h4-7,10H,1-3,8-9H2

2.1.3 InChI Key

ANDGGVOPIJEHOF-UHFFFAOYSA-N

2.1.4 Canonical SMILES

C1CCN(CC1)C(=O)C2=CC3=NC=CN=C3C=C2

2.2 Other Identifiers

2.2.1 UNII

Z5QU38B4V9

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 1-(quinoxalin-6-ylcarbonyl)piperidine

2. Bdp 12

3. Bdp-12

4. Cx516

2.3.2 Depositor-Supplied Synonyms

1. 154235-83-3

2. Piperidin-1-yl(quinoxalin-6-yl)methanone

3. Cx-516

4. Cx516

5. Bdp 12

6. 1-(quinoxalin-6-ylcarbonyl)piperidine

7. 1-(6-quinoxalinylcarbonyl)piperidine

8. Bdp-12

9. Cx 516

10. Abt-224

11. Piperidine, 1-(6-quinoxalinylcarbonyl)-

12. 6-(piperidine-1-carbonyl)quinoxaline

13. 1-piperidyl(quinoxalin-6-yl)methanone

14. Chembl136800

15. Z5qu38b4v9

16. 173047-75-1

17. Chebi:34605

18. 287399-47-7

19. 1-(quinoxalin-6-ylcarbonyl)-piperidine

20. Piperidin-1-yl-quinoxalin-6-yl-methanone

21. Unii-z5qu38b4v9

22. Spd-420

23. Ampakine Cx516

24. 1-piperidinyl-6-quinoxalinylmethanone

25. Ampalex-[d10]

26. Bdp-12(ampalex)

27. Ampalex (cx-516)

28. Ampalex, Cx-516

29. Schembl194605

30. Gtpl4165

31. Zinc6489

32. Ampalex I(1/4)oecx-516

33. Dtxsid70165574

34. Ex-a265

35. Amy14816

36. Bcp04606

37. Ac-001

38. Bdbm50094009

39. Mfcd00943201

40. Akos008927689

41. 1-piperidinyl-6-quinoxalinyl-methanone

42. Bcp9000296

43. Cs-1086

44. Db06247

45. Ds-1548

46. Fs-3368

47. 6-[(piperidin-1-yl)carbonyl]quinoxaline

48. Ncgc00371146-01

49. Cx516, >=98% (hplc)

50. Hy-10933

51. Bcp0726000046

52. Ft-0657266

53. Vu0430675-1

54. 235a833

55. J-009084

56. Q5014875

57. Cx5

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₁₄H₁₅N₃O
Molecular Weight	241.29 g/mol
XLogP3	1.8
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	1
Exact Mass	241.121512110 g/mol
Monoisotopic Mass	241.121512110 g/mol
Topological Polar Surface Area	46.1 Å²
Heavy Atom Count	18
Formal Charge	0
Complexity	301
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Indication

Investigated for use/treatment in alzheimer's disease, memory loss, autism, neurologic disorders, dementia, schizophrenia and schizoaffective disorders, attention deficit/hyperactivity disorder (ADHD), and sleep disorders.

5 Pharmacology and Biochemistry

5.1 Mechanism of Action

CX 516 is a benzylpiperidine AMPAkine, an AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) modulator, that enhances the function of glutamate when it binds allosterically to the AMPA receptor channel complex. CX 516 slows receptor deactivation with a longer open time, slower excitatory postsynaptic potential (EPSP) decay and improvement of hippocampal long term potentiation (LTP).

ABOUT THIS PAGE

Ampalex Manufacturers

A Ampalex manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Ampalex, including repackagers and relabelers. The FDA regulates Ampalex manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Ampalex API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Ampalex Suppliers

A Ampalex supplier is an individual or a company that provides Ampalex active pharmaceutical ingredient (API) or Ampalex finished formulations upon request. The Ampalex suppliers may include Ampalex API manufacturers, exporters, distributors and traders.

Ampalex GMP

Ampalex Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Ampalex GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Ampalex GMP manufacturer or Ampalex GMP API supplier for your needs.

Ampalex CoA

A Ampalex CoA (Certificate of Analysis) is a formal document that attests to Ampalex's compliance with Ampalex specifications and serves as a tool for batch-level quality control.

Ampalex CoA mostly includes findings from lab analyses of a specific batch. For each Ampalex CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Ampalex may be tested according to a variety of international standards, such as European Pharmacopoeia (Ampalex EP), Ampalex JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Ampalex USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.