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Amtolmetin Guacil

Amtolmetin Guacil

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Also known as: 87344-06-7, 2-methoxyphenyl 2-(2-(1-methyl-5-(4-methylbenzoyl)-1h-pyrrol-2-yl)acetamido)acetate, Artromed, Amtolmetin guacyl, St 679, St-679

Molecular Formula

C₂₄H₂₄N₂O₅

Molecular Weight

420.5 g/mol

InChI Key

CWJNMKKMGIAGDK-UHFFFAOYSA-N

FDA UNII

323A00CRO9

1 2D Structure

Amtolmetin Guacil

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(2-methoxyphenyl) 2-[[2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetyl]amino]acetate

2.1.2 InChI

InChI=1S/C24H24N2O5/c1-16-8-10-17(11-9-16)24(29)19-13-12-18(26(19)2)14-22(27)25-15-23(28)31-21-7-5-4-6-20(21)30-3/h4-13H,14-15H2,1-3H3,(H,25,27)

2.1.3 InChI Key

CWJNMKKMGIAGDK-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC1=CC=C(C=C1)C(=O)C2=CC=C(N2C)CC(=O)NCC(=O)OC3=CC=CC=C3OC

2.2 Other Identifiers

2.2.1 UNII

323A00CRO9

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 2-methoxyphenyl 1-methyl-5-(4-methylbenzoylpyrrol)-2-acetamidoacetate

2. Amtolmetin Guacyl

3. Amtolmetineguacil

4. Artromed

5. Med 15

6. Med-15

7. Med15

8. St 679

9. St-679

2.3.2 Depositor-Supplied Synonyms

1. 87344-06-7

2. 2-methoxyphenyl 2-(2-(1-methyl-5-(4-methylbenzoyl)-1h-pyrrol-2-yl)acetamido)acetate

3. Artromed

4. Amtolmetin Guacyl

5. St 679

6. St-679

7. Med 15

8. Amtolmetin Guacil [inn]

9. Med-15

10. Finrid

11. Med15

12. 104076-16-6

13. 2-methoxyphenyl 1-methyl-5-p-methylbenzoylpyrrole-2-acetoamidoacetate

14. 323a00cro9

15. (2-methoxyphenyl) 2-[[2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetyl]amino]acetate

16. Amtolmetin Guacil (inn)

17. N-((1-methyl-5-p-toluoylpyrrol-2-yl)acetyl)glycine O-methoxyphenyl Ester

18. 2-methoxyphenyl (2-(1-methyl-5-(4-methylbenzoyl)-1h-pyrrol-2-yl)acetyl)glycinate

19. Eufans

20. Amtolmetine Guacil

21. Amtolmetina Guacilo

22. Amtolmetinum Guacilum

23. Amtolmetine Guacil [inn-french]

24. Amtolmetina Guacilo [inn-spanish]

25. Amtolmetinum Guacilum [inn-latin]

26. Unii-323a00cro9

27. Amtolmetin-guacil

28. Artromed (tn)

29. N-((1-methyl-5-(4-methylbenzoyl)-1h-pyrrol-2-yl)acetyl)glycine 2-methoxyphenyl Ester

30. Schembl24555

31. Mls006010220

32. Amtolmetin Guacil [mi]

33. Chembl1766570

34. Dtxsid50236291

35. Amtolmetin Guacil [mart.]

36. Chebi:135678

37. St679

38. Zinc596929

39. Amtolmetin Guacil [who-dd]

40. Bcp28767

41. Mfcd00866153

42. Stl451031

43. Akos015895070

44. Glycine, N-((1-methyl-5-(4-methylbenzoyl)-1h-pyrrol-2-yl)acetyl)-, 2-methoxyphenyl Ester

45. Glycine, N-((5-benzoyl-1-methyl-1h-pyrrol-2-yl)acetyl)-, 2-methoxyphenyl Ester

46. N-[2-[1-methyl-5-(4-methylbenzoyl)-1h-pyrrol-2-yl]acetyl]glycine 2-methoxyphenyl Ester

47. As-30751

48. Smr004701308

49. Hy-107320

50. Cs-0028135

51. Ft-0659812

52. D07453

53. 344a067

54. A842102

55. Sr-01000945065

56. Q4748890

57. Sr-01000945065-1

58. (2-methoxyphenyl)2-[[2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetyl]amino] Acetate

59. 2-methoxyphenyl 2-(1-methyl-5-(4-methylbenzoyl)-1h-pyrrole-2-acetylamino)acetate

60. 2-methoxyphenyl 2-{2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetamido}acetate

61. 2-methoxyphenyl N-({1-methyl-5-[(4-methylphenyl)carbonyl]-1h-pyrrol-2-yl}acetyl)glycinate

62. 2-methoxyphenyl2-(1-methyl-5-(4-methylbenzoyl)-1h-pyrrole-2-acetylamino)acetate

63. (2-methoxyphenyl) 2-[2-[1-methyl-5-(4-methylphenyl)carbonyl-pyrrol-2-yl]ethanoylamino]ethanoate

64. 2-[[2-[1-methyl-5-[(4-methylphenyl)-oxomethyl]-2-pyrrolyl]-1-oxoethyl]amino]acetic Acid (2-methoxyphenyl) Ester

65. Amtolmetin Guacil; 2-methoxyphenyl 2-(1-methyl-5-(4-methylbenzoyl)-1h-pyrrole-2-acetylamino)acetate

2.4 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	C₂₄H₂₄N₂O₅
Molecular Weight	420.5 g/mol
XLogP3	4
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	9
Exact Mass	420.16852187 g/mol
Monoisotopic Mass	420.16852187 g/mol
Topological Polar Surface Area	86.6 Å²
Heavy Atom Count	31
Formal Charge	0
Complexity	632
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Anti-Inflammatory Agents, Non-Steroidal

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)