Find Angiotensin (1-7) manufacturers, exporters & distributors on PharmaCompass

Angiotensin (1-7)

Polfa Tarchomin is a leading Polish pharmaceutical company with 200 year tradition in manufacture and sale of pharmaceutical products.

ACCESS ALL DATA
Browse all information
CHEMISTRY
Discover Molecule Insights

DEVELOPMENTS

4 Drugs in Development

4 Drugs in Development

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

4DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown

Click the button for full data set

Also known as: 51833-78-4, Angiotensin 1-7, Asp-arg-val-tyr-ile-his-pro, Txa127, Angiotensin i (1-7), Angiotensin-(1-7)

Molecular Formula

C₄₁H₆₂N₁₂O₁₁

Molecular Weight

899.0 g/mol

InChI Key

PVHLMTREZMEJCG-GDTLVBQBSA-N

Therapeutic Angiotensin-(1-7) is a synthetic heptapeptide identical to endogenous angiotensin-(1-7) with vasodilator and antiproliferative activities. Therapeutic angiotensin 1-7 may inhibit cyclooxygenase 2 (COX-2) and the production of proinflammatory prostaglandins and may activate the angiotensin-(1-7) receptor Mas, resulting in diminished tumor cell proliferation. Activation of the angiotensin-(1-7) receptor Mas, a G-protein coupled, seven transmembrane protein, may down-regulate the phosphorylation and activation of Erk1 and Erk2 in the Erk1/Erk2 MAPK signaling pathway. In the renin-angiotensin system, the vasodilating activity of angiotensin- (1-7), hydrolysed from angiotensin II by the type I transmembrane metallopeptidase and carboxypeptidase angiotensin converting enzyme 2 (ACE2) in vivo, counteracts the vasoconstricting activity of angiotensin II.

1 2D Structure

Angiotensin (1-7)

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-carboxypropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carboxylic acid

2.1.2 InChI

InChI=1S/C41H62N12O11/c1-5-22(4)33(38(61)50-29(17-24-19-45-20-47-24)39(62)53-15-7-9-30(53)40(63)64)52-36(59)28(16-23-10-12-25(54)13-11-23)49-37(60)32(21(2)3)51-35(58)27(8-6-14-46-41(43)44)48-34(57)26(42)18-31(55)56/h10-13,19-22,26-30,32-33,54H,5-9,14-18,42H2,1-4H3,(H,45,47)(H,48,57)(H,49,60)(H,50,61)(H,51,58)(H,52,59)(H,55,56)(H,63,64)(H4,43,44,46)/t22-,26-,27-,28-,29-,30-,32-,33-/m0/s1

2.1.3 InChI Key

PVHLMTREZMEJCG-GDTLVBQBSA-N

2.1.4 Canonical SMILES

CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)O)NC(=O)C(CC3=CC=C(C=C3)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(=O)O)N

2.1.5 Isomeric SMILES

CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)N2CCC[C@H]2C(=O)O)NC(=O)[C@H](CC3=CC=C(C=C3)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(=O)O)N

2.2 Synonyms

2.2.1 MeSH Synonyms

1. Ang I (1-7)

2. Angiotensin 1-7

3. Angiotensin I (1-7)

4. Angiotensin Ii (1-7)

5. Angiotensin Ii (1-7) Heptapeptide

6. Angiotensin Ii-(1-7)

7. Angiotensin-(1-7)

8. Angiotensin-i (1-7)

9. Txa-127

10. Txa127

2.2.2 Depositor-Supplied Synonyms

1. 51833-78-4

2. Angiotensin 1-7

3. Asp-arg-val-tyr-ile-his-pro

4. Txa127

5. Angiotensin I (1-7)

6. Angiotensin-(1-7)

7. Angiotensin Ii (1-7) Heptapeptide

8. Angiotensin Ii (1-7)

9. 8-des-phe-angiotensin Ii

10. Ang-(1-7)

11. Txa-127

12. 39386-80-6

13. Angiotensin I/ii (1-7)

14. Chebi:55438

15. Ile(5)-angiotensin Ii (1-7)

16. L-alpha-aspartyl-l-arginyl-l-valyl-l-tyrosyl-l-isoleucyl-l-histidyl-l-proline

17. L-aspartyl-l-arginyl-l-valyl-l-tyrosyl-l-isoleucyl-l-histidyl-l-proline

18. (2s)-1-[(2s)-2-[[(2s,3s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-amino-3-carboxypropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(1h-imidazol-5-yl)propanoyl]pyrrolidine-2-carboxylic Acid

19. Unii-ij3fuk8mof

20. Angiotensin, Canine, Rat

21. Human Angiotensin-(1-7)

22. 1-7-human Angiotensin Ii

23. Angiotensin Ii, Des-phe(8)-

24. Txa 127

25. Ang-1-7 Acetate

26. Angiotensin(1-7)

27. Mfcd00153513

28. Sh-heptapeptide-13

29. Angiotensini(1-7)

30. Bf-angiotensin 1-7

31. Angiotensin Ii, Des-phenylalanine(8)-

32. Ij3fuk8mof

33. Angiotensin, Canine, Ra

34. Angiotensin I/ii(1-7)

35. Ang 1-7

36. Angiotensin Fragment 1-7

37. 5-ile-angiotensin-(1-7)

38. Angiotensin Peptide (1-7)

39. Gtpl582

40. Ang(1-7)

41. Human Angiotensin Ii (1-7)

42. Angiotensin Ii, 5-l-isoleucine-8-de-l-phenylalanine-

43. Gtpl5578

44. [ile5]angiotensin I (1-7)

45. Angiotensin 1-7 Acetate

46. Chembl3545347

47. Schembl15926158

48. Bdbm85556

49. [125i]ang-(1-7)

50. Txa127; Ang-(1-7)

51. Zinc96077632

52. Akos024456667

53. Cs-3413

54. Db11720

55. Angiotensin Ii, 8-de-l-phenylalanine-

56. Ncgc00167219-01

57. As-76407

58. Hy-12403

59. [125i]angiotensin-(1-7) (human, Mouse, Rat)

60. 833a784

61. A901408

62. Angiotensin I/ii Fragment 1-7 Trifluoroacetate Salt

63. Q27074464

64. Aspartyl-argininyl-valinyl-tyrosinyl-isoleucinyl-histidinyl-proline;angiotensin 1-7

65. (2s)-1-[(2s)-2-[[(2s,3s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-amino-4-hydroxy-4-oxobutanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(3h-imidazol-4-yl)propanoyl]pyrrolidine-2-carboxylic Acid

66. (s)-1-((6s,9s,12s,15s,18s)-18-((1h-imidazol-4-yl)methyl)-1-amino-6-((s)-2-amino-3-carboxypropanamido)-15-sec-butyl-12-(4-hydroxybenzyl)-1-imino-9-isopropyl-7,10,13,16-tetraoxo-2,8,11,14,17-pentaazanonadecane)pyrrolidine-2-carboxylic Acid

2.3 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	C₄₁H₆₂N₁₂O₁₁
Molecular Weight	899.0 g/mol
XLogP3	-3
Hydrogen Bond Donor Count	12
Hydrogen Bond Acceptor Count	14
Rotatable Bond Count	25
Exact Mass	898.46610084 g/mol
Monoisotopic Mass	898.46610084 g/mol
Topological Polar Surface Area	380 Å²
Heavy Atom Count	64
Formal Charge	0
Complexity	1660
Isotope Atom Count	0
Defined Atom Stereocenter Count	8
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Antihypertensive Agents

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

Vasodilator Agents

Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)

Drugs in Development

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

ABOUT THIS PAGE

Angiotensin (1-7) Manufacturers

A Angiotensin (1-7) manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Angiotensin (1-7), including repackagers and relabelers. The FDA regulates Angiotensin (1-7) manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Angiotensin (1-7) API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Angiotensin (1-7) Suppliers

A Angiotensin (1-7) supplier is an individual or a company that provides Angiotensin (1-7) active pharmaceutical ingredient (API) or Angiotensin (1-7) finished formulations upon request. The Angiotensin (1-7) suppliers may include Angiotensin (1-7) API manufacturers, exporters, distributors and traders.

Angiotensin (1-7) GMP

Angiotensin (1-7) Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Angiotensin (1-7) GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Angiotensin (1-7) GMP manufacturer or Angiotensin (1-7) GMP API supplier for your needs.

Angiotensin (1-7) CoA

A Angiotensin (1-7) CoA (Certificate of Analysis) is a formal document that attests to Angiotensin (1-7)'s compliance with Angiotensin (1-7) specifications and serves as a tool for batch-level quality control.

Angiotensin (1-7) CoA mostly includes findings from lab analyses of a specific batch. For each Angiotensin (1-7) CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Angiotensin (1-7) may be tested according to a variety of international standards, such as European Pharmacopoeia (Angiotensin (1-7) EP), Angiotensin (1-7) JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Angiotensin (1-7) USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.