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Chemistry

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Also known as: 64315-16-8, Angiotensinogen (1-14), porcine, Renin substrate tetradecapeptide porcine, >=97% (hplc), Angiotensinogen from porcine plasma, lyophilized powder, 1,500-3,000 units/g protein
Molecular Formula
C85H123N21O20
Molecular Weight
1759.0  g/mol
InChI Key
XJFQCYIFOWHHFN-UHFFFAOYSA-N

Angiotensinogen
An alpha-globulin of about 453 amino acids, depending on the species. It is produced by the liver in response to lowered blood pressure and secreted into blood circulation. Angiotensinogen is the inactive precursor of the ANGIOTENSINS produced in the body by successive enzyme cleavages. Cleavage of angiotensinogen by RENIN yields the decapeptide ANGIOTENSIN I. Further cleavage of angiotensin I (by ANGIOTENSIN CONVERTING ENZYME) yields the potent vasoconstrictor octapeptide ANGIOTENSIN II; and then, via other enzymes, other angiotensins also involved in the hemodynamic-regulating RENIN-ANGIOTENSIN SYSTEM.
1 2D Structure

Angiotensinogen

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
3-amino-4-[[5-carbamimidamido-1-[[1-[[1-[[1-[[1-[2-[[1-[[1-[[1-[[1-[[1-[[1-[(1-carboxy-2-hydroxyethyl)amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxopentan-2-yl]amino]-4-oxobutanoic acid
2.1.2 InChI
InChI=1S/C85H123N21O20/c1-11-48(10)70(105-78(119)62(35-51-23-27-55(109)28-24-51)100-80(121)68(46(6)7)103-72(113)57(19-15-29-91-85(87)88)94-71(112)56(86)38-67(110)111)82(123)101-64(37-53-40-90-43-93-53)83(124)106-30-16-20-66(106)79(120)98-60(33-49-17-13-12-14-18-49)74(115)97-63(36-52-39-89-42-92-52)76(117)95-58(31-44(2)3)73(114)96-59(32-45(4)5)77(118)104-69(47(8)9)81(122)99-61(34-50-21-25-54(108)26-22-50)75(116)102-65(41-107)84(125)126/h12-14,17-18,21-28,39-40,42-48,56-66,68-70,107-109H,11,15-16,19-20,29-38,41,86H2,1-10H3,(H,89,92)(H,90,93)(H,94,112)(H,95,117)(H,96,114)(H,97,115)(H,98,120)(H,99,122)(H,100,121)(H,101,123)(H,102,116)(H,103,113)(H,104,118)(H,105,119)(H,110,111)(H,125,126)(H4,87,88,91)
2.1.3 InChI Key
XJFQCYIFOWHHFN-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CC4=CN=CN4)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(CC5=CC=C(C=C5)O)C(=O)NC(CO)C(=O)O)NC(=O)C(CC6=CC=C(C=C6)O)NC(=O)C(C(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(=O)O)N
2.2 Synonyms
2.2.1 MeSH Synonyms

1. Hypertensinogen

2. Proangiotensin

3. Renin Substrate

4. Renin Substrate Tetradecapeptide

5. Renin-substrate

6. Serpin A8

7. Serpina8

8. Tetradecapeptide, Renin Substrate

2.2.2 Depositor-Supplied Synonyms

1. 64315-16-8

2. Angiotensinogen (1-14), Porcine

3. Renin Substrate Tetradecapeptide Porcine, >=97% (hplc)

4. Angiotensinogen From Porcine Plasma, Lyophilized Powder, 1,500-3,000 Units/g Protein

2.3 Create Date
2007-07-04
3 Chemical and Physical Properties
Molecular Weight 1759.0 g/mol
Molecular Formula C85H123N21O20
XLogP30.8
Hydrogen Bond Donor Count23
Hydrogen Bond Acceptor Count24
Rotatable Bond Count52
Exact Mass1757.92532540 g/mol
Monoisotopic Mass1757.92532540 g/mol
Topological Polar Surface Area650 Ų
Heavy Atom Count126
Formal Charge0
Complexity3610
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count15
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Serine Proteinase Inhibitors

Exogenous or endogenous compounds which inhibit SERINE ENDOPEPTIDASES. (See all compounds classified as Serine Proteinase Inhibitors.)


ABOUT THIS PAGE

Angiotensinogen Manufacturers

A Angiotensinogen manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Angiotensinogen, including repackagers and relabelers. The FDA regulates Angiotensinogen manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Angiotensinogen API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Angiotensinogen Suppliers

A Angiotensinogen supplier is an individual or a company that provides Angiotensinogen active pharmaceutical ingredient (API) or Angiotensinogen finished formulations upon request. The Angiotensinogen suppliers may include Angiotensinogen API manufacturers, exporters, distributors and traders.

click here to find a list of Angiotensinogen suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Angiotensinogen USDMF

A Angiotensinogen DMF (Drug Master File) is a document detailing the whole manufacturing process of Angiotensinogen active pharmaceutical ingredient (API) in detail. Different forms of Angiotensinogen DMFs exist exist since differing nations have different regulations, such as Angiotensinogen USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Angiotensinogen DMF submitted to regulatory agencies in the US is known as a USDMF. Angiotensinogen USDMF includes data on Angiotensinogen's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Angiotensinogen USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Angiotensinogen suppliers with USDMF on PharmaCompass.

Angiotensinogen GMP

Angiotensinogen Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Angiotensinogen GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Angiotensinogen GMP manufacturer or Angiotensinogen GMP API supplier for your needs.

Angiotensinogen CoA

A Angiotensinogen CoA (Certificate of Analysis) is a formal document that attests to Angiotensinogen's compliance with Angiotensinogen specifications and serves as a tool for batch-level quality control.

Angiotensinogen CoA mostly includes findings from lab analyses of a specific batch. For each Angiotensinogen CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Angiotensinogen may be tested according to a variety of international standards, such as European Pharmacopoeia (Angiotensinogen EP), Angiotensinogen JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Angiotensinogen USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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