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Chemistry

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Also known as: 882697-00-9, Anle-138b, Emrusolmin, Emrusolmin [inn], 3-(1,3-benzodioxol-5-yl)-5-(3-bromophenyl)-1h-pyrazole, E7wra77jet
Molecular Formula
C16H11BrN2O2
Molecular Weight
343.17  g/mol
InChI Key
RCQIIBJSUWYYFU-UHFFFAOYSA-N
FDA UNII
E7WRA77JET

Anle138b
anle138b restores hippocampal synaptic and transcriptional plasticity as well as spatial memory in a mouse model for Alzheimer's disease, when given orally before or after the onset of pathology.
1 2D Structure

Anle138b

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
5-(1,3-benzodioxol-5-yl)-3-(3-bromophenyl)-1H-pyrazole
2.1.2 InChI
InChI=1S/C16H11BrN2O2/c17-12-3-1-2-10(6-12)13-8-14(19-18-13)11-4-5-15-16(7-11)21-9-20-15/h1-8H,9H2,(H,18,19)
2.1.3 InChI Key
RCQIIBJSUWYYFU-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1OC2=C(O1)C=C(C=C2)C3=CC(=NN3)C4=CC(=CC=C4)Br
2.2 Other Identifiers
2.2.1 UNII
E7WRA77JET
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 3-(1,3-benzodioxol-5-yl)-5-(3-bromophenyl)-1h-pyrazole

2.3.2 Depositor-Supplied Synonyms

1. 882697-00-9

2. Anle-138b

3. Emrusolmin

4. Emrusolmin [inn]

5. 3-(1,3-benzodioxol-5-yl)-5-(3-bromophenyl)-1h-pyrazole

6. E7wra77jet

7. 5-(1,3-benzodioxol-5-yl)-3-(3-bromophenyl)-1h-pyrazole

8. Chembl4748063

9. 1h-pyrazole, 3-(1,3-benzodioxol-5-yl)-5-(3-bromophenyl)-

10. 3-(benzo[d][1,3]dioxol-5-yl)-5-(3-bromophenyl)-1h-pyrazole

11. Unii-e7wra77jet

12. Anle 138b; Anle-138b

13. Schembl1660250

14. Schembl21440048

15. Bcp32558

16. Anle138b, >=98% (hplc)

17. Bdbm50553260

18. Nsc805132

19. S6782

20. Zinc68200503

21. Akos037649277

22. Cs-6522

23. Db13927

24. Nsc-805132

25. Bs-17773

26. Hy-101855

27. D80685

28. A858288

29. 3-(1,3-benzodioxole-5-yl)-5-(3-bromophenyl)-1h-pyrazole

2.4 Create Date
2010-02-15
3 Chemical and Physical Properties
Molecular Weight 343.17 g/mol
Molecular Formula C16H11BrN2O2
XLogP34
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Exact Mass342.00039 g/mol
Monoisotopic Mass342.00039 g/mol
Topological Polar Surface Area47.1 Ų
Heavy Atom Count21
Formal Charge0
Complexity370
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 Mechanism of Action

There is evidence that anle138b blocks the activity of conducting A pores without changing the membrane embedded A-oligomer structure.


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Looking for 882697-00-9 / Anle138b API manufacturers, exporters & distributors?

Anle138b manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Anle138b API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Anle138b manufacturer or Anle138b supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Anle138b manufacturer or Anle138b supplier.

PharmaCompass also assists you with knowing the Anle138b API Price utilized in the formulation of products. Anle138b API Price is not always fixed or binding as the Anle138b Price is obtained through a variety of data sources. The Anle138b Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Anle138b

Synonyms

882697-00-9, Anle-138b, Emrusolmin, Emrusolmin [inn], 3-(1,3-benzodioxol-5-yl)-5-(3-bromophenyl)-1h-pyrazole, E7wra77jet

Cas Number

882697-00-9

Unique Ingredient Identifier (UNII)

E7WRA77JET

About Anle138b

anle138b restores hippocampal synaptic and transcriptional plasticity as well as spatial memory in a mouse model for Alzheimer's disease, when given orally before or after the onset of pathology.

Anle138b Manufacturers

A Anle138b manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Anle138b, including repackagers and relabelers. The FDA regulates Anle138b manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Anle138b API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Anle138b Suppliers

A Anle138b supplier is an individual or a company that provides Anle138b active pharmaceutical ingredient (API) or Anle138b finished formulations upon request. The Anle138b suppliers may include Anle138b API manufacturers, exporters, distributors and traders.

Anle138b GMP

Anle138b Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Anle138b GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Anle138b GMP manufacturer or Anle138b GMP API supplier for your needs.

Anle138b CoA

A Anle138b CoA (Certificate of Analysis) is a formal document that attests to Anle138b's compliance with Anle138b specifications and serves as a tool for batch-level quality control.

Anle138b CoA mostly includes findings from lab analyses of a specific batch. For each Anle138b CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Anle138b may be tested according to a variety of international standards, such as European Pharmacopoeia (Anle138b EP), Anle138b JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Anle138b USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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