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1. 2'-iodo-3'-hydroxy-4'-epi-4-demethoxydoxorubicin
1. 92689-49-1
2. 2'-iodo-3'-hydroxy-4'-epi-4-demethoxydoxorubicin
3. Snu299m83q
4. (7s,9s)-7-(((2r,3r,4r,5r,6s)-4,5-dihydroxy-3-iodo-6-methyltetrahydro-2h-pyran-2-yl)oxy)-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-7,8,9,10-tetrahydrotetracene-5,12-dione
5. 5,12-naphthacenedione, 7-((2,6-dideoxy-2-iodo-alpha-l-mannopyranosyl)oxy)-7,8,9,10-tetrahydro-6,9,11-trihydroxy-9-(hydroxyacetyl)-, (7s-cis)-
6. Unii-snu299m83q
7. Ar-522
8. (7s,9s)-7-[(2r,3r,4r,5r,6s)-4,5-dihydroxy-3-iodo-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-8,10-dihydro-7h-tetracene-5,12-dione
9. Schembl19368
10. Dtxsid901027238
11. Zinc3918134
12. Db06420
13. 689a491
14. Q4767903
| Molecular Weight | 640.4 g/mol |
|---|---|
| Molecular Formula | C26H25IO11 |
| XLogP3 | 2.2 |
| Hydrogen Bond Donor Count | 6 |
| Hydrogen Bond Acceptor Count | 11 |
| Rotatable Bond Count | 4 |
| Exact Mass | 640.04416 g/mol |
| Monoisotopic Mass | 640.04416 g/mol |
| Topological Polar Surface Area | 191 Ų |
| Heavy Atom Count | 38 |
| Formal Charge | 0 |
| Complexity | 962 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 7 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Investigated for use/treatment in breast cancer and leukemia (unspecified).
Antibiotics, Antineoplastic
Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms. (See all compounds classified as Antibiotics, Antineoplastic.)
Annamycin belongs to the anthracycline class of drugs, and has a pleiotropic mechanism of action where it targets topoisomerase II, causing strand breaks in DNA. Annamycin forms complexes with DNA by intercalation between base pairs, and it inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the ligation-religation reaction that topoisomerase II catalyzes.
Drugs in Development
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A Annamycin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Annamycin, including repackagers and relabelers. The FDA regulates Annamycin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Annamycin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.
A Annamycin supplier is an individual or a company that provides Annamycin active pharmaceutical ingredient (API) or Annamycin finished formulations upon request. The Annamycin suppliers may include Annamycin API manufacturers, exporters, distributors and traders.
National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Annamycin as an active pharmaceutical ingredient (API).
The FDA updates the NDC directory daily. The NDC numbers for Annamycin API and other APIs are published in this directory by the FDA.
The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.
Pharmaceutical companies that manufacture Annamycin as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.
The NDC directory also contains data on finished compounded human drug products that contain Annamycin and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Annamycin NDC to their finished compounded human drug products, they may choose to do so.
click here to find a list of Annamycin suppliers with NDC on PharmaCompass.
Annamycin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.
GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).
PharmaCompass offers a list of Annamycin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Annamycin GMP manufacturer or Annamycin GMP API supplier for your needs.
A Annamycin CoA (Certificate of Analysis) is a formal document that attests to Annamycin's compliance with Annamycin specifications and serves as a tool for batch-level quality control.
Annamycin CoA mostly includes findings from lab analyses of a specific batch. For each Annamycin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.
Annamycin may be tested according to a variety of international standards, such as European Pharmacopoeia (Annamycin EP), Annamycin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Annamycin USP).
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