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Chemistry

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Also known as: Ansamitocin p3, 66584-72-3, Ansamitomicin p-3, Maytansinol isobutyrate, Antibiotic c 15003p3, 2'-de(acetylmethylamino)-2'-methylmaytansine
Molecular Formula
C32H43ClN2O9
Molecular Weight
635.1  g/mol
InChI Key
OPQNCARIZFLNLF-JBHFWYGFSA-N
FDA UNII
7SUK7876BG

Ansamitocin P3
Ansamitomicin P-3 is an ansamacrolide and maytansine analogue originally isolated from the Ethiopian shrub Maytenus serrata with antineoplastic activity. Ansamitomicin P-3 binds to tubulin at the maytansine-binding site, thereby inhibiting microtubule assembly, inducing microtubule disassembly, and disrupting mitosis.
1 2D Structure

Ansamitocin P3

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
[(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl] 2-methylpropanoate
2.1.2 InChI
InChI=1S/C32H43ClN2O9/c1-17(2)29(37)43-25-15-26(36)35(6)21-13-20(14-22(40-7)27(21)33)12-18(3)10-9-11-24(41-8)32(39)16-23(42-30(38)34-32)19(4)28-31(25,5)44-28/h9-11,13-14,17,19,23-25,28,39H,12,15-16H2,1-8H3,(H,34,38)/b11-9+,18-10+/t19-,23+,24-,25+,28+,31+,32+/m1/s1
2.1.3 InChI Key
OPQNCARIZFLNLF-JBHFWYGFSA-N
2.1.4 Canonical SMILES
CC1C2CC(C(C=CC=C(CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)CC(C4(C1O4)C)OC(=O)C(C)C)C)C)OC)(NC(=O)O2)O
2.1.5 Isomeric SMILES
C[C@@H]1[C@@H]2C[C@]([C@@H](/C=C/C=C(/CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)C[C@@H]([C@]4([C@H]1O4)C)OC(=O)C(C)C)C)\C)OC)(NC(=O)O2)O
2.2 Other Identifiers
2.2.1 UNII
7SUK7876BG
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Ansamitocin P 3

2. Ansamitocin P 3'

3. Ansamitocin P 4

4. Ansamitocins

5. Ansamitomicin P-3

2.3.2 Depositor-Supplied Synonyms

1. Ansamitocin P3

2. 66584-72-3

3. Ansamitomicin P-3

4. Maytansinol Isobutyrate

5. Antibiotic C 15003p3

6. 2'-de(acetylmethylamino)-2'-methylmaytansine

7. Antibiotic C15003p3

8. 7suk7876bg

9. Chebi:29515

10. C15003p3

11. [(1s,2r,3s,5s,6s,16e,18e,20r,21s)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl] 2-methylpropanoate

12. Ansamitocin P 3

13. Maytansine, 2'-de(acetylmethylamino)-2'-methyl-

14. Ansamitosin P3

15. Ansamitosin P 3

16. Ansamitocin-p-3

17. Ansamitosin P-3

18. Nsc-292222

19. Maytansinol-isobutyrate

20. Nsc 292222

21. C 15003p3

22. Unii-7suk7876bg

23. Chembl507305

24. Schembl15706083

25. Ex-a492

26. Zinc4102313

27. Lmpk04000039

28. S2447

29. Cs-1568

30. Ac-35339

31. Hy-15739

32. Q27110111

33. (1s,2r,3s,5s,6s,16e,18e,20r,21s)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1(10,14).0(3,5)]hexacosa-10(26),11,13,16,18-pentaen-6-yl 2-methylpropanoate

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 635.1 g/mol
Molecular Formula C32H43ClN2O9
XLogP33.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count5
Exact Mass634.2657086 g/mol
Monoisotopic Mass634.2657086 g/mol
Topological Polar Surface Area136 Ų
Heavy Atom Count44
Formal Charge0
Complexity1150
Isotope Atom Count0
Defined Atom Stereocenter Count7
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count2
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Tubulin Modulators

Agents that interact with TUBULIN to inhibit or promote polymerization of MICROTUBULES. (See all compounds classified as Tubulin Modulators.)


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ABOUT THIS PAGE

Ansamitocin P3 Manufacturers

A Ansamitocin P3 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Ansamitocin P3, including repackagers and relabelers. The FDA regulates Ansamitocin P3 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Ansamitocin P3 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Ansamitocin P3 Suppliers

A Ansamitocin P3 supplier is an individual or a company that provides Ansamitocin P3 active pharmaceutical ingredient (API) or Ansamitocin P3 finished formulations upon request. The Ansamitocin P3 suppliers may include Ansamitocin P3 API manufacturers, exporters, distributors and traders.

click here to find a list of Ansamitocin P3 suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Ansamitocin P3 USDMF

A Ansamitocin P3 DMF (Drug Master File) is a document detailing the whole manufacturing process of Ansamitocin P3 active pharmaceutical ingredient (API) in detail. Different forms of Ansamitocin P3 DMFs exist exist since differing nations have different regulations, such as Ansamitocin P3 USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Ansamitocin P3 DMF submitted to regulatory agencies in the US is known as a USDMF. Ansamitocin P3 USDMF includes data on Ansamitocin P3's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Ansamitocin P3 USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Ansamitocin P3 suppliers with USDMF on PharmaCompass.

Ansamitocin P3 GMP

Ansamitocin P3 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Ansamitocin P3 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Ansamitocin P3 GMP manufacturer or Ansamitocin P3 GMP API supplier for your needs.

Ansamitocin P3 CoA

A Ansamitocin P3 CoA (Certificate of Analysis) is a formal document that attests to Ansamitocin P3's compliance with Ansamitocin P3 specifications and serves as a tool for batch-level quality control.

Ansamitocin P3 CoA mostly includes findings from lab analyses of a specific batch. For each Ansamitocin P3 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Ansamitocin P3 may be tested according to a variety of international standards, such as European Pharmacopoeia (Ansamitocin P3 EP), Ansamitocin P3 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Ansamitocin P3 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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