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Antazoline HCl

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Chemistry

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Also known as: 2508-72-7, Antazoline hcl, Phenazoline hydrochloride, Antazoline (hydrochloride), 2-(n-benzylanilinomethyl)-2-imidazoline hydrochloride, N-benzyl-n-(4,5-dihydro-1h-imidazol-2-ylmethyl)aniline hydrochloride

Molecular Formula

C₁₇H₂₀ClN₃

Molecular Weight

301.8 g/mol

InChI Key

SWKDMSRRIBZZAY-UHFFFAOYSA-N

FDA UNII

FP8Q8F72JH

An antagonist of histamine H1 receptors.

1 2D Structure

Antazoline HCl

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline;hydrochloride

2.1.2 InChI

InChI=1S/C17H19N3.ClH/c1-3-7-15(8-4-1)13-20(14-17-18-11-12-19-17)16-9-5-2-6-10-16;/h1-10H,11-14H2,(H,18,19);1H

2.1.3 InChI Key

SWKDMSRRIBZZAY-UHFFFAOYSA-N

2.1.4 Canonical SMILES

C1CN=C(N1)CN(CC2=CC=CC=C2)C3=CC=CC=C3.Cl

2.2 Other Identifiers

2.2.1 UNII

FP8Q8F72JH

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Analergine

2. Antasten

3. Antazoline

4. Antazoline Phosphate

5. Antazoline Phosphate (1:1)

6. Antistine

7. Arithmin

8. Hydrochloride, Antazoline

9. Imidamine

10. Phenazoline

11. Phosphate, Antazoline

2.3.2 Depositor-Supplied Synonyms

1. 2508-72-7

2. Antazoline Hcl

3. Phenazoline Hydrochloride

4. Antazoline (hydrochloride)

5. 2-(n-benzylanilinomethyl)-2-imidazoline Hydrochloride

6. N-benzyl-n-(4,5-dihydro-1h-imidazol-2-ylmethyl)aniline Hydrochloride

7. Fp8q8f72jh

8. Mls000028599

9. Fenazolina

10. N-benzyl-n-(4,5-dihydro-1h-imidazol-2-ylmethyl)aniline,hydrochloride

11. N-benzyl-n-((4,5-dihydro-1h-imidazol-2-yl)methyl)aniline Hydrochloride

12. 2-(n-benzylanilino)methyl-2-imidazoline, Hydrochloride

13. Histazine

14. Smr000058731

15. 2508-72-7 (hcl)

16. N-benzyl-n-(4,5-dihydro-1h-imidazol-2-ylmethyl)aniline;hydrochloride

17. Dsstox_cid_27762

18. Dsstox_rid_82539

19. Dsstox_gsid_47782

20. Antazolinium Chloratum

21. Antistine Hydrochloride

22. N-benzyl-n-[(4,5-dihydro-1h-imidazol-2-yl)methyl]aniline Hydrochloride

23. Sr-01000000255

24. Ncgc00016613-01

25. Einecs 219-719-8

26. Cas-2508-72-7

27. Unii-fp8q8f72jh

28. Antazoline Hydrochloride [usp]

29. Phenazocine Hcl

30. Prestwick_82

31. 2-phenylbenzylaminomethylimidazoline Hydrochloride

32. Phenazolinum (tn)

33. Mfcd00058145

34. 2-(n-phenyl-n-benzylaminomethyl)imidazoline Hydrochloride

35. 2-imidazoline, 2-((n-benzylanilino)methyl)-, Monohydrochloride

36. Opera_id_1387

37. Antazoline Hydrochloride,(s)

38. Mls001148371

39. Mls002153486

40. Mls002222161

41. Regid_for_cid_17275

42. Chembl1256819

43. Dtxsid1047782

44. Hms1568d18

45. Bcp32138

46. Hy-b1067

47. Tox21_110524

48. 2-imidazoline, 2-((n-benzylanilino)methyl)-, Hydrochloride

49. Antazoline Hydrochloride [mi]

50. S4199

51. Akos015916586

52. Tox21_110524_1

53. Ac-8174

54. Ccg-220258

55. Cs-4623

56. 4,5-dihydro-n-phenyl-n-(phenylmethyl)-1h-imidazole-2-methanamine Hydrochloride

57. Antazoline Hcl;phenazoline Hydrochloride

58. Antazoline Hydrochloride [mart.]

59. Antazoline Hydrochloride [vandf]

60. Antazoline Hydrochloride [who-dd]

61. Ncgc00016613-10

62. Ncgc00180986-01

63. 6-(boc-amino)-3-pyridazinecarboxylicacid

64. As-74198

65. Sw196394-3

66. A16411

67. Antazoline Hydrochloride [ep Monograph]

68. D07459

69. H11312

70. Sr-01000000255-3

71. Sr-01000000255-6

72. Q27278115

73. Antazoline Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)

74. Antazoline Hydrochloride, European Pharmacopoeia (ep) Reference Standard

75. N-benzyl-n-((4,5-dihydro-1h-imidazol-2-yl)methyl)anilinehydrochloride

76. 1h-imidazole-2-methanamine, 4,5-dihydro-n-phenyl-n-(phenylmethyl)-, Hydrochloride (1:1)

2.4 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	C₁₇H₂₀ClN₃
Molecular Weight	301.8 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	5
Exact Mass	301.1345753 g/mol
Monoisotopic Mass	301.1345753 g/mol
Topological Polar Surface Area	27.6 Å²
Heavy Atom Count	21
Formal Charge	0
Complexity	314
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Histamine H1 Antagonists

Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)

Anti-Allergic Agents

Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475) (See all compounds classified as Anti-Allergic Agents.)

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