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Chemistry

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Also known as: 2508-72-7, Antazoline hcl, Phenazoline hydrochloride, Antazoline (hydrochloride), 2-(n-benzylanilinomethyl)-2-imidazoline hydrochloride, N-benzyl-n-(4,5-dihydro-1h-imidazol-2-ylmethyl)aniline hydrochloride
Molecular Formula
C17H20ClN3
Molecular Weight
301.8  g/mol
InChI Key
SWKDMSRRIBZZAY-UHFFFAOYSA-N
FDA UNII
FP8Q8F72JH

Antazoline HCl
An antagonist of histamine H1 receptors.
1 2D Structure

Antazoline HCl

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline;hydrochloride
2.1.2 InChI
InChI=1S/C17H19N3.ClH/c1-3-7-15(8-4-1)13-20(14-17-18-11-12-19-17)16-9-5-2-6-10-16;/h1-10H,11-14H2,(H,18,19);1H
2.1.3 InChI Key
SWKDMSRRIBZZAY-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1CN=C(N1)CN(CC2=CC=CC=C2)C3=CC=CC=C3.Cl
2.2 Other Identifiers
2.2.1 UNII
FP8Q8F72JH
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Analergine

2. Antasten

3. Antazoline

4. Antazoline Phosphate

5. Antazoline Phosphate (1:1)

6. Antistine

7. Arithmin

8. Hydrochloride, Antazoline

9. Imidamine

10. Phenazoline

11. Phosphate, Antazoline

2.3.2 Depositor-Supplied Synonyms

1. 2508-72-7

2. Antazoline Hcl

3. Phenazoline Hydrochloride

4. Antazoline (hydrochloride)

5. 2-(n-benzylanilinomethyl)-2-imidazoline Hydrochloride

6. N-benzyl-n-(4,5-dihydro-1h-imidazol-2-ylmethyl)aniline Hydrochloride

7. Fp8q8f72jh

8. Mls000028599

9. Fenazolina

10. N-benzyl-n-(4,5-dihydro-1h-imidazol-2-ylmethyl)aniline,hydrochloride

11. N-benzyl-n-((4,5-dihydro-1h-imidazol-2-yl)methyl)aniline Hydrochloride

12. 2-(n-benzylanilino)methyl-2-imidazoline, Hydrochloride

13. Histazine

14. Smr000058731

15. 2508-72-7 (hcl)

16. N-benzyl-n-(4,5-dihydro-1h-imidazol-2-ylmethyl)aniline;hydrochloride

17. Dsstox_cid_27762

18. Dsstox_rid_82539

19. Dsstox_gsid_47782

20. Antazolinium Chloratum

21. Antistine Hydrochloride

22. N-benzyl-n-[(4,5-dihydro-1h-imidazol-2-yl)methyl]aniline Hydrochloride

23. Sr-01000000255

24. Ncgc00016613-01

25. Einecs 219-719-8

26. Cas-2508-72-7

27. Unii-fp8q8f72jh

28. Antazoline Hydrochloride [usp]

29. Phenazocine Hcl

30. Prestwick_82

31. 2-phenylbenzylaminomethylimidazoline Hydrochloride

32. Phenazolinum (tn)

33. Mfcd00058145

34. 2-(n-phenyl-n-benzylaminomethyl)imidazoline Hydrochloride

35. 2-imidazoline, 2-((n-benzylanilino)methyl)-, Monohydrochloride

36. Opera_id_1387

37. Antazoline Hydrochloride,(s)

38. Mls001148371

39. Mls002153486

40. Mls002222161

41. Regid_for_cid_17275

42. Chembl1256819

43. Dtxsid1047782

44. Hms1568d18

45. Bcp32138

46. Hy-b1067

47. Tox21_110524

48. 2-imidazoline, 2-((n-benzylanilino)methyl)-, Hydrochloride

49. Antazoline Hydrochloride [mi]

50. S4199

51. Akos015916586

52. Tox21_110524_1

53. Ac-8174

54. Ccg-220258

55. Cs-4623

56. 4,5-dihydro-n-phenyl-n-(phenylmethyl)-1h-imidazole-2-methanamine Hydrochloride

57. Antazoline Hcl;phenazoline Hydrochloride

58. Antazoline Hydrochloride [mart.]

59. Antazoline Hydrochloride [vandf]

60. Antazoline Hydrochloride [who-dd]

61. Ncgc00016613-10

62. Ncgc00180986-01

63. 6-(boc-amino)-3-pyridazinecarboxylicacid

64. As-74198

65. Sw196394-3

66. A16411

67. Antazoline Hydrochloride [ep Monograph]

68. D07459

69. H11312

70. Sr-01000000255-3

71. Sr-01000000255-6

72. Q27278115

73. Antazoline Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)

74. Antazoline Hydrochloride, European Pharmacopoeia (ep) Reference Standard

75. N-benzyl-n-((4,5-dihydro-1h-imidazol-2-yl)methyl)anilinehydrochloride

76. 1h-imidazole-2-methanamine, 4,5-dihydro-n-phenyl-n-(phenylmethyl)-, Hydrochloride (1:1)

2.4 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 301.8 g/mol
Molecular Formula C17H20ClN3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count5
Exact Mass301.1345753 g/mol
Monoisotopic Mass301.1345753 g/mol
Topological Polar Surface Area27.6 Ų
Heavy Atom Count21
Formal Charge0
Complexity314
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Histamine H1 Antagonists

Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)


Anti-Allergic Agents

Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475) (See all compounds classified as Anti-Allergic Agents.)


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ABOUT THIS PAGE

Antazoline HCl Manufacturers

A Antazoline HCl manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Antazoline HCl, including repackagers and relabelers. The FDA regulates Antazoline HCl manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Antazoline HCl API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Antazoline HCl manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Antazoline HCl Suppliers

A Antazoline HCl supplier is an individual or a company that provides Antazoline HCl active pharmaceutical ingredient (API) or Antazoline HCl finished formulations upon request. The Antazoline HCl suppliers may include Antazoline HCl API manufacturers, exporters, distributors and traders.

click here to find a list of Antazoline HCl suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Antazoline HCl CEP

A Antazoline HCl CEP of the European Pharmacopoeia monograph is often referred to as a Antazoline HCl Certificate of Suitability (COS). The purpose of a Antazoline HCl CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Antazoline HCl EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Antazoline HCl to their clients by showing that a Antazoline HCl CEP has been issued for it. The manufacturer submits a Antazoline HCl CEP (COS) as part of the market authorization procedure, and it takes on the role of a Antazoline HCl CEP holder for the record. Additionally, the data presented in the Antazoline HCl CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Antazoline HCl DMF.

A Antazoline HCl CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Antazoline HCl CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Antazoline HCl suppliers with CEP (COS) on PharmaCompass.

Antazoline HCl GMP

Antazoline HCl Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Antazoline HCl GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Antazoline HCl GMP manufacturer or Antazoline HCl GMP API supplier for your needs.

Antazoline HCl CoA

A Antazoline HCl CoA (Certificate of Analysis) is a formal document that attests to Antazoline HCl's compliance with Antazoline HCl specifications and serves as a tool for batch-level quality control.

Antazoline HCl CoA mostly includes findings from lab analyses of a specific batch. For each Antazoline HCl CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Antazoline HCl may be tested according to a variety of international standards, such as European Pharmacopoeia (Antazoline HCl EP), Antazoline HCl JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Antazoline HCl USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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