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Chemistry

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Also known as: Dolasetron mesylate, 878143-33-0, Dalasetron mesylate hydrate, Dalasetron (mesylate hydrate), 115956-13-3, Dolasetron mesilate
Molecular Formula
C20H26N2O7S
Molecular Weight
438.5  g/mol
InChI Key
QTFFGPOXNNGTGZ-RCSCTSIBSA-N

Anzemet Hydrate
Dolasetron Mesylate is an indole derivative with antiemetic activity. As a selective serotonin receptor antagonist, dolasetron mesylate competitively blocks the action of serotonin at 5HT3 receptors, resulting in suppression of chemotherapy- and radiotherapy-induced nausea and vomiting. (NCI04)
1 2D Structure

Anzemet Hydrate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
methanesulfonic acid;[(3S,7R)-10-oxo-8-azatricyclo[5.3.1.03,8]undecan-5-yl] 1H-indole-3-carboxylate;hydrate
2.1.2 InChI
InChI=1S/C19H20N2O3.CH4O3S.H2O/c22-18-10-21-12-5-11(18)6-13(21)8-14(7-12)24-19(23)16-9-20-17-4-2-1-3-15(16)17;1-5(2,3)4;/h1-4,9,11-14,20H,5-8,10H2;1H3,(H,2,3,4);1H2/t11?,12-,13+,14?;;
2.1.3 InChI Key
QTFFGPOXNNGTGZ-RCSCTSIBSA-N
2.1.4 Canonical SMILES
CS(=O)(=O)O.C1C2CC3CC(CC1N3CC2=O)OC(=O)C4=CNC5=CC=CC=C54.O
2.1.5 Isomeric SMILES
CS(=O)(=O)O.C1[C@@H]2CC(C[C@H]3N2CC(=O)C1C3)OC(=O)C4=CNC5=CC=CC=C54.O
2.2 Synonyms
2.2.1 MeSH Synonyms

1. 1h-indole-3-carboxylic Acid, (6r,9as)-octahydro-3-oxo-2,6-methano-2h-quinolizin-8-yl Ester, Rel-, Methanesulfonate, Hydrate (1:1:1)

2. 1h-indole-3-carboxylic Acid, Octahydro-3-oxo-2,6-methano-2h-quinolizin-8-yl Ester, (2-alpha,6-alpha,8-alpha,9a-beta)-

3. 1h-indole-3-carboxylic Acid-trans-octahydro-3-oxo-2,6-methano-2h-quinolizin-8-yl Ester Methanesulfonate

4. Anzemet

5. Dolasetron

6. Dolasetron Mesilate Monohydrate

7. Dolasetron Mesylate

8. Dolasetron Mesylate Monohydrate

9. Indole-3-carboxylic Acid, Ester With (8r)-hexahydro-8-hydroxy-2,6-methano-2h-quinolizin-3(4h)-one

10. Mdl 73,147ef

11. Mdl 73147ef

12. Mdl-73147ef

13. Octahydro-3-oxo-2,6-methano-2h-quinolizin-8-yl 1h-indole-3-carboxylate

2.2.2 Depositor-Supplied Synonyms

1. Dolasetron Mesylate

2. 878143-33-0

3. Dalasetron Mesylate Hydrate

4. Dalasetron (mesylate Hydrate)

5. 115956-13-3

6. Dolasetron Mesilate

7. Dolasetron Mesylate Monohydrate

8. Dolasetron (mesylate Hydrate)

9. Anzemet

10. Dolasetron Methanesulfonate

11. Mdl-73147ef

12. Dolasetron Mesylate Anhydrous

13. Methanesulfonic Acid;[(3s,7r)-10-oxo-8-azatricyclo[5.3.1.03,8]undecan-5-yl] 1h-indole-3-carboxylate;hydrate

14. Ncgc00181048-01

15. Dolasetron Mesilate Monohydrate

16. Anemet

17. Dolasetronmesylate

18. Schembl1237588

19. Chembl2368924

20. Hy-b0750b

21. Hms3714b12

22. Mfcd01718979

23. Ccg-220885

24. Ccg-222446

25. Cs-3746

26. As-13228

27. D71051

28. 956d133

29. A854565

30. A916136

31. Dolasetron Mesylate Hydrate, >=98% (hplc), Powder

32. (2r,5r,6s,8r,9as)-3-oxooctahydro-2h-2,6-methanoquinolizin-8-yl 1h-indole-3-carboxylate Methanesulfonate

33. Rel-(5s,6r,8r,9as)-3-oxooctahydro-1h-2,6-methanoquinolizin-8-yl 1h-indole-3-carboxylate Methanesulfonate Hydrate

2.3 Create Date
2006-07-28
3 Chemical and Physical Properties
Molecular Weight 438.5 g/mol
Molecular Formula C20H26N2O7S
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count3
Exact Mass438.14607235 g/mol
Monoisotopic Mass438.14607235 g/mol
Topological Polar Surface Area126 Ų
Heavy Atom Count30
Formal Charge0
Complexity627
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antiemetics

Drugs used to prevent NAUSEA or VOMITING. (See all compounds classified as Antiemetics.)


Serotonin 5-HT3 Receptor Antagonists

Drugs that bind to but do not activate SEROTONIN 5-HT3 RECEPTORS, thereby blocking the actions of SEROTONIN or SEROTONIN 5-HT3 RECEPTOR AGONISTS. (See all compounds classified as Serotonin 5-HT3 Receptor Antagonists.)


4.2 FDA Pharmacological Classification
4.2.1 Pharmacological Classes
Serotonin-3 Receptor Antagonist [EPC]; Serotonin 3 Receptor Antagonists [MoA]

ABOUT THIS PAGE

Anzemet Hydrate Manufacturers

A Anzemet Hydrate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Anzemet Hydrate, including repackagers and relabelers. The FDA regulates Anzemet Hydrate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Anzemet Hydrate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Anzemet Hydrate Suppliers

A Anzemet Hydrate supplier is an individual or a company that provides Anzemet Hydrate active pharmaceutical ingredient (API) or Anzemet Hydrate finished formulations upon request. The Anzemet Hydrate suppliers may include Anzemet Hydrate API manufacturers, exporters, distributors and traders.

Anzemet Hydrate GMP

Anzemet Hydrate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Anzemet Hydrate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Anzemet Hydrate GMP manufacturer or Anzemet Hydrate GMP API supplier for your needs.

Anzemet Hydrate CoA

A Anzemet Hydrate CoA (Certificate of Analysis) is a formal document that attests to Anzemet Hydrate's compliance with Anzemet Hydrate specifications and serves as a tool for batch-level quality control.

Anzemet Hydrate CoA mostly includes findings from lab analyses of a specific batch. For each Anzemet Hydrate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Anzemet Hydrate may be tested according to a variety of international standards, such as European Pharmacopoeia (Anzemet Hydrate EP), Anzemet Hydrate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Anzemet Hydrate USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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