Find apatinib mesylate manufacturers, exporters & distributors on PharmaCompass

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Chemistry

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Also known as: 1218779-75-9, Rivoceranib mesylate, Yn968d1, Yn-968d1, Yn 968d1, Tk02x14asj
Molecular Formula
C25H27N5O4S
Molecular Weight
493.6  g/mol
InChI Key
FYJROXRIVQPKRY-UHFFFAOYSA-N
FDA UNII
TK02X14ASJ

apatinib mesylate
Rivoceranib Mesylate is the mesylate salt of rivoceranib, an orally bioavailable, small-molecule receptor tyrosine kinase inhibitor with potential antiangiogenic and antineoplastic activities. Rivoceranib selectively binds to and inhibits vascular endothelial growth factor receptor 2, which may inhibit VEGF-stimulated endothelial cell migration and proliferation and decrease tumor microvessel density. In addition, this agent mildly inhibits c-Kit and c-SRC tyrosine kinases.
1 2D Structure

apatinib mesylate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
N-[4-(1-cyanocyclopentyl)phenyl]-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide;methanesulfonic acid
2.1.2 InChI
InChI=1S/C24H23N5O.CH4O3S/c25-17-24(11-1-2-12-24)19-5-7-20(8-6-19)29-23(30)21-4-3-13-27-22(21)28-16-18-9-14-26-15-10-18;1-5(2,3)4/h3-10,13-15H,1-2,11-12,16H2,(H,27,28)(H,29,30);1H3,(H,2,3,4)
2.1.3 InChI Key
FYJROXRIVQPKRY-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CS(=O)(=O)O.C1CCC(C1)(C#N)C2=CC=C(C=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4
2.2 Other Identifiers
2.2.1 UNII
TK02X14ASJ
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Apatinib

2. Rivoceranib

3. Rivoceranib Mesylate

4. Yn-968d1

5. Yn968d1

2.3.2 Depositor-Supplied Synonyms

1. 1218779-75-9

2. Rivoceranib Mesylate

3. Yn968d1

4. Yn-968d1

5. Yn 968d1

6. Tk02x14asj

7. Rivoceranib Mesylate (usan)

8. 3-pyridinecarboxamide, N-(4-(1-cyanocyclopentyl)phenyl)-2-((4-pyridinylmethyl)amino)-, Methanesulfonate (1:1)

9. Rivoceranib Mesylate [usan]

10. N-(4-(1-cyanocyclopentyl)phenyl)-2-((pyridin-4-ylmethyl)amino)nicotinamide Mesylate

11. N-[4-(1-cyanocyclopentyl)phenyl]-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide;methanesulfonic Acid

12. Unii-tk02x14asj

13. Apatinib?mesylate

14. 3-pyridinecarboxamide, N-[4-(1-cyanocyclopentyl)phenyl]-2-[(4-pyridinylmethyl)amino]-, Methanesulfonate (1:1)

15. Alitan (tn)

16. Apatinib-yn968d1

17. Apatinib - Yn968d1

18. Mls006011286

19. Chembl3545414

20. Schembl21847695

21. Dtxsid80153427

22. Hms3655h12

23. Bcp15234

24. Apatinib (registered Name In China)

25. Bdbm50152828

26. S2221

27. Rivoceranib Mesylate [who-dd]

28. Akos026750547

29. Bcp9000308

30. Ccg-269641

31. Cs-0694

32. Sb16589

33. N-(4-(1-cyanocyclopentyl)phenyl)-2-((pyridin-4-ylmethyl)amino)nicotinamide Methanesulfonate

34. Ac-35390

35. Hy-13342

36. Smr004703036

37. Sw220296-1

38. D11289

39. N-(4-(1-cyanocyclopentyl)phenyl)-2-(pyridin-4-ylmethylamino)nicotinamide Mesylate

40. N-(4-(1-cyanocyclopentyl)phenyl)-2-((pyridin-4-ylmethyl)amino)pyridine-3-carboxamide Mesylate

41. N-(4-(1-cyanocyclopentyl)phenyl)-2-((pyridin-4-ylmethyl)amino)pyridine-3-carboxamide Monomethanesulfonate Salt

2.4 Create Date
2010-04-26
3 Chemical and Physical Properties
Molecular Weight 493.6 g/mol
Molecular Formula C25H27N5O4S
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count6
Exact Mass493.17837553 g/mol
Monoisotopic Mass493.17837553 g/mol
Topological Polar Surface Area153 Ų
Heavy Atom Count35
Formal Charge0
Complexity701
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antineoplastic Agents

Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)


Protein Kinase Inhibitors

Agents that inhibit PROTEIN KINASES. (See all compounds classified as Protein Kinase Inhibitors.)


ABOUT THIS PAGE

Looking for 1218779-75-9 / apatinib mesylate API manufacturers, exporters & distributors?

apatinib mesylate manufacturers, exporters & distributors 1

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PharmaCompass offers a list of apatinib mesylate API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right apatinib mesylate manufacturer or apatinib mesylate supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred apatinib mesylate manufacturer or apatinib mesylate supplier.

PharmaCompass also assists you with knowing the apatinib mesylate API Price utilized in the formulation of products. apatinib mesylate API Price is not always fixed or binding as the apatinib mesylate Price is obtained through a variety of data sources. The apatinib mesylate Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

apatinib mesylate

Synonyms

1218779-75-9, Rivoceranib mesylate, Yn968d1, Yn-968d1, Yn 968d1, Tk02x14asj

Cas Number

1218779-75-9

Unique Ingredient Identifier (UNII)

TK02X14ASJ

About apatinib mesylate

Rivoceranib Mesylate is the mesylate salt of rivoceranib, an orally bioavailable, small-molecule receptor tyrosine kinase inhibitor with potential antiangiogenic and antineoplastic activities. Rivoceranib selectively binds to and inhibits vascular endothelial growth factor receptor 2, which may inhibit VEGF-stimulated endothelial cell migration and proliferation and decrease tumor microvessel density. In addition, this agent mildly inhibits c-Kit and c-SRC tyrosine kinases.

apatinib mesylate Manufacturers

A apatinib mesylate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of apatinib mesylate, including repackagers and relabelers. The FDA regulates apatinib mesylate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. apatinib mesylate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

apatinib mesylate Suppliers

A apatinib mesylate supplier is an individual or a company that provides apatinib mesylate active pharmaceutical ingredient (API) or apatinib mesylate finished formulations upon request. The apatinib mesylate suppliers may include apatinib mesylate API manufacturers, exporters, distributors and traders.

apatinib mesylate GMP

apatinib mesylate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of apatinib mesylate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right apatinib mesylate GMP manufacturer or apatinib mesylate GMP API supplier for your needs.

apatinib mesylate CoA

A apatinib mesylate CoA (Certificate of Analysis) is a formal document that attests to apatinib mesylate's compliance with apatinib mesylate specifications and serves as a tool for batch-level quality control.

apatinib mesylate CoA mostly includes findings from lab analyses of a specific batch. For each apatinib mesylate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

apatinib mesylate may be tested according to a variety of international standards, such as European Pharmacopoeia (apatinib mesylate EP), apatinib mesylate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (apatinib mesylate USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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