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Apazone

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ACTIVE PHARMA INGREDIENTS

1 API Suppliers, 1 USDMF

1 API Suppliers
1 USDMF

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Apazone, Cinnopropazone, Prolixan, Azapropazonum, Azapropazona, 13539-59-8

Molecular Formula

C₁₆H₂₀N₄O₂

Molecular Weight

300.36 g/mol

InChI Key

MPHPHYZQRGLTBO-UHFFFAOYSA-N

FDA UNII

K2VOT966ZI

An anti-inflammatory agent used in the treatment of rheumatoid arthritis. It also has uricosuric properties and has been used to treat gout.

1 2D Structure

Apazone

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

5-(dimethylamino)-9-methyl-2-propylpyrazolo[1,2-a][1,2,4]benzotriazine-1,3-dione

2.1.2 InChI

InChI=1S/C16H20N4O2/c1-5-6-11-14(21)19-13-9-10(2)7-8-12(13)17-16(18(3)4)20(19)15(11)22/h7-9,11H,5-6H2,1-4H3

2.1.3 InChI Key

MPHPHYZQRGLTBO-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CCCC1C(=O)N2C3=C(C=CC(=C3)C)N=C(N2C1=O)N(C)C

2.2 Other Identifiers

2.2.1 UNII

K2VOT966ZI

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 5-(dimethylamino)-9-methyl-2-propyl-1h-pyrazolo(1,2-a)(1,2,4)benzotriazine-1,3(2h)-dione

2. Apazone

3. Apazone Dihydrate

4. Dihydrate, Apazone

5. Prolixan

6. Rheumox

7. Tolyprin

2.3.2 Depositor-Supplied Synonyms

1. Apazone

2. Cinnopropazone

3. Prolixan

4. Azapropazonum

5. Azapropazona

6. 13539-59-8

7. Cinnamin

8. Rheumox

9. Azapropazon

10. Mitrolan

11. Sinnamin

12. Prolix

13. Xani

14. Azapropazone (anhydrous)

15. Ahr-3018

16. Apazone [usan]

17. Prolixan 300

18. Nsc-102824

19. Mi 85

20. Ahr 3018

21. Mi-85

22. Azapropazone Dihydrate

23. Azapropazon [german]

24. Nsc 102824

25. Azapropazone [inn]

26. 5-(dimethylamino)-9-methyl-2-propyl-1h-pyrazolo(1,2-a)(1,2,4)benzotriazine-1,3(2h)-dione

27. 3-dimethylamino-7-methyl-1,2-(n-propylmalonyl)-1,2-dihydro-1,2,4-benzotriazine

28. K2vot966zi

29. 1,2-dihydro-3-dimethylamino-7-methyl-1,2-(propylmalonyl)-1,2,4-benzotriazine

30. 1h-pyrazolo(1,2-a)(1,2,4)benzotriazine-1,3(2h)-dione, 5-(dimethylamino)-9-methyl-2-propyl-

31. 5-(dimethylamino)-9-methyl-2-propyl-1h-pyrazolo[1,2-a][1,2,4]benzotriazine-1,3(2h)-dione

32. Mls002703748

33. Chebi:38010

34. Apazone (usan)

35. Azapropazone (inn)

36. Nsc102824

37. Azapropazon (german)

38. 1h-pyrazolo[1,2-a][1,2,4]benzotriazine-1,3(2h)-dione, 5-(dimethylamino)-9-methyl-2-propyl-

39. 5-(dimethylamino)-9-methyl-2-propylpyrazolo[1,2-a][1,2,4]benzotriazine-1,3-dione

40. Ahr-3018;nsc-102824;nsc102824;

41. Mi-85di

42. Azapropazonum [inn-latin]

43. Azapropazona [inn-spanish]

44. 5-(dimethylamino)-9-methyl-2-propyl-1h-benzo[e]pyrazolo[1,2-a][1,2,4]triazine-1,3(2h)-dione

45. Smr001233401

46. Einecs 236-913-8

47. Unii-k2vot966zi

48. Brn 0623763

49. Ncgc00016701-01

50. Prolixan (tn)

51. Cas-13539-59-8

52. Tolyprin (salt/mix)

53. Apazone [mi]

54. Prestwick0_001003

55. Prestwick1_001003

56. Prestwick2_001003

57. Prestwick3_001003

58. Schembl3190

59. Dsstox_cid_23735

60. Dsstox_rid_80859

61. Nciopen2_007171

62. Dsstox_gsid_45408

63. Azapropazone [mart.]

64. Bspbio_001125

65. Mls002154093

66. (+/-)-apazone

67. Apazone Dihydrate (salt/mix)

68. Azapropazone [who-dd]

69. Spbio_003006

70. Bpbio1_001239

71. Apazone, (+/-)-

72. Chembl1565476

73. Dtxsid6045408

74. Hms1571i07

75. Hms2098i07

76. Hms2231l14

77. Hms3372m10

78. Hms3715i07

79. Tox21_110569

80. Akos015914210

81. Ccg-221003

82. Ncgc00179297-01

83. Ncgc00179297-04

84. 1,2-(propylmalonyl)-1,2,4-benzotriazine

85. Hy-116442

86. Ab00513995

87. Cs-0065495

88. D02966

89. Q368222

90. Sr-01000838825

91. Sr-01000838825-2

92. Wln: T B566 Bnv Evn Hn Dhj D3 Gn1&1 L1

93. 3-dimethylamino-7-methyl-1,2-dihydro-1,2,4-benzotriazine

94. 3-dimethylamino-7-methyl-1-2-(n-propylmalonyl)-1,2,4-benzotriazine

95. 1,2-dihydro-3-(dimethylamino)-7-methyl-1,2-(propylmalonyl)-1,2,4-benzotriazine

96. 1h-pyrazolo[1,2,4]benzotriazine-1,3(2h)-dione, 5-(dimethylamine)-9-methyl-2-propyl-

97. 1h-pyrazolo[1,2,4]benzotriazine-1,3(2h)-dione, 5-(dimethylamino)-9-methyl-2-propyl-

98. 5-(dimethylamino)-9-methyl-2-propyl-1h-pyrazolo[1,2,4]benzotriazine-1,3(2h)-dione

99. 5-(dimethylamino)-9-methyl-2-propyl-1h-pyrazolo[1,2,4]benzotriazine-1,3(2h)dione

100. 5-(dimethylamino)-9-methyl-2-propyl-pyrazolo[1,2-a][1,2,4]benzotriazine-1,3-dione

101. 1h-pyrazolo(1,2-a)(1,2,4)benzotriazine-1,3(2h)-dione, 5-(dimethylamine)-9-methyl-2-propyl-

102. 5-dimethylamino-9-methyl-2-propylpyrazolo(1,2-a)(1,2,4)benzotriazine-1,3(2h)-dione

2.4 Create Date

2005-03-26

3 Chemical and Physical Properties

Molecular Formula	C₁₆H₂₀N₄O₂
Molecular Weight	300.36 g/mol
XLogP3	4
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Exact Mass	300.15862589 g/mol
Monoisotopic Mass	300.15862589 g/mol
Topological Polar Surface Area	56.2 Å²
Heavy Atom Count	22
Formal Charge	0
Complexity	516
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Anti-Inflammatory Agents, Non-Steroidal

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)

Uricosuric Agents

Gout suppressants that act directly on the renal tubule to increase the excretion of uric acid, thus reducing its concentrations in plasma. (See all compounds classified as Uricosuric Agents.)

4.2 ATC Code

M - Musculo-skeletal system

M01 - Antiinflammatory and antirheumatic products

M01A - Antiinflammatory and antirheumatic products, non-steroids

M01AX - Other antiinflammatory and antirheumatic agents, non-steroids

M01AX04 - Azapropazone

API SUPPLIERS

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ABOUT THIS PAGE

Apazone Manufacturers

A Apazone manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Apazone, including repackagers and relabelers. The FDA regulates Apazone manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Apazone API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Apazone Suppliers

A Apazone supplier is an individual or a company that provides Apazone active pharmaceutical ingredient (API) or Apazone finished formulations upon request. The Apazone suppliers may include Apazone API manufacturers, exporters, distributors and traders.

click here to find a list of Apazone suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Apazone USDMF

A Apazone DMF (Drug Master File) is a document detailing the whole manufacturing process of Apazone active pharmaceutical ingredient (API) in detail. Different forms of Apazone DMFs exist exist since differing nations have different regulations, such as Apazone USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Apazone DMF submitted to regulatory agencies in the US is known as a USDMF. Apazone USDMF includes data on Apazone's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Apazone USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Apazone suppliers with USDMF on PharmaCompass.

Apazone GMP

Apazone Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Apazone GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Apazone GMP manufacturer or Apazone GMP API supplier for your needs.

Apazone CoA

A Apazone CoA (Certificate of Analysis) is a formal document that attests to Apazone's compliance with Apazone specifications and serves as a tool for batch-level quality control.

Apazone CoA mostly includes findings from lab analyses of a specific batch. For each Apazone CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Apazone may be tested according to a variety of international standards, such as European Pharmacopoeia (Apazone EP), Apazone JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Apazone USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.