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ACTIVE PHARMA INGREDIENTS

10 API Suppliers, 6 USDMF, 3 CEP/COS, 1 JDMF, 1 EU WC, 11 NDC API, 6 Listed Suppliers, $ API Reference Price

10 API Suppliers
6 USDMF
3 CEP/COS
1 JDMF
1 EU WC
11 NDC API
6 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

14 Drugs in Development

14 Drugs in Development

FINISHED DOSAGE FORMULATIONS

61 FDF Dossiers, 8 FDA Orange Book, 29 Europe, 15 Australia, 9 Listed Dossiers

61 FDF Dossiers
8 FDA Orange Book
29 Europe
15 Australia
9 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

FILM;SUBLINGUAL - 10MG, FILM;SUBLINGUAL - 15MG, FILM;SUBLINGUAL - 20MG, FILM;SUBLINGUAL - 25MG, FILM;SUBLINGUAL - 30MG, INJECTABLE;SUBCUTANEOUS - 30MG/3ML (10MG/ML)

drugProductComposition
FILM;SUBLINGUAL - 10MG
FILM;SUBLINGUAL - 15MG
FILM;SUBLINGUAL - 20MG
FILM;SUBLINGUAL - 25MG
FILM;SUBLINGUAL - 30MG
INJECTABLE;SUBCUTANEOUS - 30MG/3ML (10MG/ML)

DIGITAL CONTENT

21 NEWS #PharmaBuzz

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21 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions, 13 Finished Drug Prices, 2 Annual Reports

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1 US Medicaid Prescriptions
13 Finished Drug Prices
2 Annual Reports

MARKET PLACE

7 APIs, 1 FDF Dossiers

marketPlace
7 APIs
1 FDF Dossiers

PATENTS & EXCLUSIVITIES

70 US Patents

patents
70 US Patents

REF. STANDARDS & IMPURITIES

1 EDQM , 2 Others

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1 EDQM
2 Others

Apomorphine Hydrochloride

Synopsis

ACTIVE PHARMA INGREDIENTS

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API REF. PRICE (USD/KG)

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FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

235,060

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

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Chemistry

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Also known as: 314-19-2, Apomorphine hcl, Apomorphine chloride, (r)-(-)-apomorphine hydrochloride, Apokinon, Apomorphinium chloride

Molecular Formula

C₁₇H₁₈ClNO₂

Molecular Weight

303.8 g/mol

InChI Key

SKYZYDSNJIOXRL-BTQNPOSSSA-N

FDA UNII

9K13MD7A0D

A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poisoning. It has also been used in the diagnosis and treatment of parkinsonism, but its adverse effects limit its use.

1 2D Structure

Apomorphine Hydrochloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol;hydrochloride

2.1.2 InChI

InChI=1S/C17H17NO2.ClH/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12;/h2-6,13,19-20H,7-9H2,1H3;1H/t13-;/m1./s1

2.1.3 InChI Key

SKYZYDSNJIOXRL-BTQNPOSSSA-N

2.1.4 Canonical SMILES

CN1CCC2=C3C1CC4=C(C3=CC=C2)C(=C(C=C4)O)O.Cl

2.1.5 Isomeric SMILES

CN1CCC2=C3[C@H]1CC4=C(C3=CC=C2)C(=C(C=C4)O)O.Cl

2.2 Other Identifiers

2.2.1 UNII

9K13MD7A0D

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Apokinon

2. Apomorphin Teclapharm

3. Apomorphin-teclapharm

4. Apomorphine

5. Apomorphine Chloride

6. Apomorphine Hydrochloride Anhydrous

7. Apomorphine Hydrochloride, Anhydrous

8. Apomorphine Hydrochloride, Hemihydrate

9. Britaject

2.3.2 Depositor-Supplied Synonyms

1. 314-19-2

2. Apomorphine Hcl

3. Apomorphine Chloride

4. (r)-(-)-apomorphine Hydrochloride

5. Apokinon

6. Apomorphinium Chloride

7. Apomorphine Hydrochloride Anhydrous

8. Uprima

9. N-methylnorapomorphine Hydrochloride

10. Nsc-11442

11. 9k13md7a0d

12. Apomorphine Sl

13. Taluvian

14. Ixense

15. 41372-20-7

16. Apomorphine Hydrochloride Hemihydrate

17. Apomorphinum Muriaticum

18. Apomorphin Hydrochlorid

19. (-)-apomorphine Hydrochloride

20. Britaject

21. Pomorphini Hydrochloridum

22. Apomorphinum Hydrochloricum

23. Apomorphine Hydrochloride Hydrate

24. Kw-6500

25. (-)-apomorphinium Hydrochloride

26. Nsc-755875

27. Einecs 206-243-0

28. Nsc 11442

29. Unii-9k13md7a0d

30. Apomorphine-hcl

31. Apomorphinehydrochloride

32. 6a-beta-aporphine-10,11-diol, Hydrochloride

33. (6ar)-6-methyl-5,6,6a,7-tetrahydro-4h-dibenzo[de,g]quinoline-10,11-diol Hydrochloride

34. Prestwick_28

35. 6abeta-noraporphine-10,11-diol, 6-methyl-, Hydrochloride

36. 6a-beta-noraporphine-10,11-diol, 6-methyl-, Hydrochloride

37. R-(-)-apomorphine Hcl

38. 6abeta-aporphine-10,11-diol, Hydrochloride

39. 5,6,6a,7-tetrahydro-6-methyl-4h-dibenzo(de,g)chinolin-10,11-diol Hydrochlorid

40. Schembl8524

41. Chembl1616

42. (r)-(-)-apomorphine Hcl

43. Dtxsid5040598

44. Apomorphine Hydrochloride (r,-)

45. Apomorphine, Hydrochloride

46. R-(-)-apomorphine Hydrochloride

47. (-)-apomorphine (hydrochloride)

48. (r)-6-methyl-5,6,6a,7-tetrahydro-4h-dibenzo[de,g]quinoline-10,11-diol Hydrochloride

49. Anhydrous Apomorphine Hydrochloride

50. Nsc11442

51. Apomorphine Hydrochloride [mi]

52. 6a.beta.-aporphine-10, Hydrochloride

53. Akos024456928

54. H72a207

55. 4h-dibenzo(de,g)quinoline-10,11-diol, 5,6,6a,7-tetrahydro-6-methyl-, Hydrochloride, (6ar)-

56. 4h-dibenzo(de,g)quinoline-10,11-diol, 5,6,6a,7-tetrahydro-6-methyl-, Hydrochloride, (r)-

57. B6936

58. Sr-01000597777

59. J-018414

60. Sr-01000597777-1

61. 6a.beta.-aporphine-10,11-diol Hydrochloride

62. 6a.beta.-noraporphine-10, 6-methyl-, Hydrochloride

63. Q27272658

64. Wln: T C6666 1a Q Kn & Tt & J Dq Eq K1 & Gh

65. (r)-5,6,6a,7-tetrahydro-6-methyl-4h-dibenzo[de,g]quinoline-10,11-diol Hydrochloride

66. 4h-dibenzo[de,11-diol, 5,6,6a,7-tetrahydro-6-methyl-, Hydrochloride, (r)-

67. (6ar)-5,6,6a,7-tetrahydro-6-methyl-4h-dibenzo(de,g)quinoline-10,11-diol Hydrochloride

68. 4h-dibenzo(de,g)quinoline-10,11-diol, 5,6,6a,7-tetrahydro-6-methyl-, Hydrochloride (1:1), (6ar)-

2.3.3 Other Synonyms

1. Apomorphine Hydrochloride Hydrate

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₁₇H₁₈ClNO₂
Molecular Weight	303.8 g/mol
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	0
Exact Mass	303.1026065 g/mol
Monoisotopic Mass	303.1026065 g/mol
Topological Polar Surface Area	43.7 Å²
Heavy Atom Count	21
Formal Charge	0
Complexity	374
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Indication

Treatment of men with erectile dysfunction, which is the inability to achieve or maintain a penile erection sufficient for satisfactory sexual performance.

In order for Uprima to be effective, sexual stimulation is required.

Treatment of men with erectile dysfunction, which is the inability to achieve or maintain a penile erection sufficient for satisfactory sexual performance.

In order for Taluvian to be effective, sexual stimulation is required.

Treatment of men with erectile dysfunction, which is the inability to achieve or maintain a penile erection sufficient for satisfactory sexual performance.

In order for Ixense to be effective, sexual stimulation is required.

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Dopamine Agonists

Drugs that bind to and activate dopamine receptors. (See all compounds classified as Dopamine Agonists.)

Emetics

Agents that cause vomiting. They may act directly on the gastrointestinal tract, bringing about emesis through local irritant effects, or indirectly, through their effects on the chemoreceptor trigger zone in the postremal area near the medulla. (See all compounds classified as Emetics.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Dopaminergic Agonist [EPC]; Dopamine Agonists [MoA]

5.3 ATC Code

G04BE

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CEP/COS

01

FRANCOPIA Paris FR

France

DDL Conference

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EUROAPI, the leading small molecules API player, provides both API sales & CDMO services.

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France

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Apomorphine hydrochloride hemihydrate

Certificate Number : CEP 2008-332 - Rev 04

Status : Valid

Issue Date : 2024-03-01

Type : Chemical

Substance Number : 136

02

MACFARLAN SMITH LIMITED Edinburgh G...

U.S.A

BOS Manchester

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Veranova: A CDMO that manages complexity with confidence.

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U.S.A

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Apomorphine hydrochloride hemihydrate

Certificate Number : R1-CEP 2006-237 - Rev 03

Status : Valid

Issue Date : 2020-12-16

Type : Chemical

Substance Number : 136

03

RUSAN PHARMA LTD Mumbai IN

India

CPhI India 2024

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Rusan Pharma: Over 30 years of specializing in the treatment of Addiction and Pain Management.

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Apomorphine hydrochloride hemihydrate

Certificate Number : CEP 2021-135 - Rev 00

Status : Valid

Issue Date : 2024-02-14

Type : Chemical

Substance Number : 136

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API Reference Price

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Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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DOSAGE - FILM;SUBLINGUAL - 10MG