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Chemistry

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Also known as: Apr-246, 5291-32-7, Eprenetapopt, 2-(hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one, Apr 246, 2-(hydroxymethyl)-2-(methoxymethyl)quinuclidin-3-one
Molecular Formula
C10H17NO3
Molecular Weight
199.25  g/mol
InChI Key
BGBNULCRKBVAKL-UHFFFAOYSA-N
FDA UNII
Z41TGB4080

APR-246
Eprenetapopt is a methylated derivative and structural analog of PRIMA-1 (p53 re-activation and induction of massive apoptosis), with potential antineoplastic activity. Upon administration, eprenetapopt covalently modifies the core domain of mutated forms of cellular tumor antigen p53 (p53) through the alkylation of thiol groups. These modifications restore both the wild-type conformation and function to mutant p53, which reconstitutes endogenous p53 activity, leading to cell cycle arrest and apoptosis in tumor cells. This agent may work synergistically with other antineoplastic agents. p53, a tumor suppressor and transcription factor normally activated upon DNA damage, is frequently mutated and overexpressed in cancer cells; it plays a key role in both DNA repair and the induction of apoptosis.
1 2D Structure

APR-246

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-(hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one
2.1.2 InChI
InChI=1S/C10H17NO3/c1-14-7-10(6-12)9(13)8-2-4-11(10)5-3-8/h8,12H,2-7H2,1H3
2.1.3 InChI Key
BGBNULCRKBVAKL-UHFFFAOYSA-N
2.1.4 Canonical SMILES
COCC1(C(=O)C2CCN1CC2)CO
2.2 Other Identifiers
2.2.1 UNII
Z41TGB4080
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one

2. Apr-246

3. Eprenetapopt

4. Prima-1(met)

2.3.2 Depositor-Supplied Synonyms

1. Apr-246

2. 5291-32-7

3. Eprenetapopt

4. 2-(hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one

5. Apr 246

6. 2-(hydroxymethyl)-2-(methoxymethyl)quinuclidin-3-one

7. Eprenetapopt [usan]

8. Z41tgb4080

9. 3-quinuclidinone, 2-(hydroxymethyl)-2-(methoxymethyl)-

10. 1-azabicyclo(2.2.2)octan-3-one, 2-(hydroxymethyl)-2-(methoxymethyl)-

11. Prima 1met

12. Unii-z41tgb4080

13. Eprenetapopt [inn]

14. Mls006010767

15. Eprenetapopt [who-dd]

16. Apr246

17. Schembl2228161

18. Chembl3186011

19. Schembl21636035

20. Prima-1met(apr-246)

21. Apr-246 (prima-1met)

22. Dtxsid401164013

23. Bcp20294

24. Ex-a2772

25. Mfcd20620963

26. Nsc791496

27. S7724

28. Who 11387

29. Akos024457764

30. Ccg-266578

31. Cs-7614

32. Db11684

33. Nsc-791496

34. Sb19737

35. Ncgc00346881-01

36. Ac-32964

37. As-72033

38. Ba176962

39. Hy-19980

40. Smr004701457

41. A901731

42. Q27294965

43. 2-hydroxymethyl-2-methoxymethyl-1-azabicyclo[2.2.2]octan-3-one

2.4 Create Date
2011-06-02
3 Chemical and Physical Properties
Molecular Weight 199.25 g/mol
Molecular Formula C10H17NO3
XLogP3-0.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass199.12084340 g/mol
Monoisotopic Mass199.12084340 g/mol
Topological Polar Surface Area49.8 Ų
Heavy Atom Count14
Formal Charge0
Complexity236
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Looking for 5291-32-7 / APR-246 API manufacturers, exporters & distributors?

APR-246 manufacturers, exporters & distributors 1

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PharmaCompass offers a list of APR-246 API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right APR-246 manufacturer or APR-246 supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred APR-246 manufacturer or APR-246 supplier.

PharmaCompass also assists you with knowing the APR-246 API Price utilized in the formulation of products. APR-246 API Price is not always fixed or binding as the APR-246 Price is obtained through a variety of data sources. The APR-246 Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

APR-246

Synonyms

5291-32-7, Eprenetapopt, 2-(hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one, Apr 246, 2-(hydroxymethyl)-2-(methoxymethyl)quinuclidin-3-one, Eprenetapopt [usan]

Cas Number

5291-32-7

Unique Ingredient Identifier (UNII)

Z41TGB4080

About APR-246

Eprenetapopt is a methylated derivative and structural analog of PRIMA-1 (p53 re-activation and induction of massive apoptosis), with potential antineoplastic activity. Upon administration, eprenetapopt covalently modifies the core domain of mutated forms of cellular tumor antigen p53 (p53) through the alkylation of thiol groups. These modifications restore both the wild-type conformation and function to mutant p53, which reconstitutes endogenous p53 activity, leading to cell cycle arrest and apoptosis in tumor cells. This agent may work synergistically with other antineoplastic agents. p53, a tumor suppressor and transcription factor normally activated upon DNA damage, is frequently mutated and overexpressed in cancer cells; it plays a key role in both DNA repair and the induction of apoptosis.

APR 246 Manufacturers

A APR 246 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of APR 246, including repackagers and relabelers. The FDA regulates APR 246 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. APR 246 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

APR 246 Suppliers

A APR 246 supplier is an individual or a company that provides APR 246 active pharmaceutical ingredient (API) or APR 246 finished formulations upon request. The APR 246 suppliers may include APR 246 API manufacturers, exporters, distributors and traders.

APR 246 GMP

APR 246 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of APR 246 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right APR 246 GMP manufacturer or APR 246 GMP API supplier for your needs.

APR 246 CoA

A APR 246 CoA (Certificate of Analysis) is a formal document that attests to APR 246's compliance with APR 246 specifications and serves as a tool for batch-level quality control.

APR 246 CoA mostly includes findings from lab analyses of a specific batch. For each APR 246 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

APR 246 may be tested according to a variety of international standards, such as European Pharmacopoeia (APR 246 EP), APR 246 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (APR 246 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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