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Valsynthese, part of the SSE Group, is a CDMO focused on highly energetic and highly hazardous chemistry.

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CHEMISTRY
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ACTIVE PHARMA INGREDIENTS

47 API Suppliers, 17 USDMF, 10 CEP/COS, 4 JDMF, 9 EU WC, 9 KDMF, 15 NDC API, 33 Listed Suppliers, $ API Reference Price

47 API Suppliers
17 USDMF
10 CEP/COS
4 JDMF
9 EU WC
9 KDMF
15 NDC API
33 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

13 Drugs in Development

13 Drugs in Development

INTERMEDIATES

9 Intermediates Suppliers

9 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

71 FDF Dossiers, 16 FDA Orange Book, 11 Europe, 4 Canada, 4 Australia, 20 South Africa, 16 Listed Dossiers

71 FDF Dossiers
16 FDA Orange Book
11 Europe
4 Canada
4 Australia
20 South Africa
16 Listed Dossiers

RELATED EXCIPIENT COMPANIES

1 Minakem, 1 Rochem International Inc, 14 SPI Pharma, 1 Seqens, 8 DKSH, 1 PMC Isochem, 3 Faran Shimi Pharmaceutical, 1 Boai NKY Pharmaceuticals Ltd, 1 Chynops Pharma, 8 Gangwal Healthcare, 2 Kewpie Corporation, 5 Nanjing Well Pharmaceutical, 2 Pfanstiehl, 4 ACG Worldwide, 1 Actylis, 1 Alcedo Pharmachem, 3 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 18 BASF, 1 Bioplus Life Sciences, 2 DFE Pharma, 1 Finar, 7 Gangwal Chemicals, 1 Ideal Cures Pvt Ltd, 1 Ingredion Pharma Solutions, 6 Kerry, 3 Lonza Capsugel, 5 Microlex e.U, 1 Nanjing Bold Chemical, 1 NEWEDGE Overseas, 1 Novo Excipients, 3 Pharmatrans-Sanaq, 3 Pluviaendo, 2 Prachin Chemical, 1 Qualicaps, 13 Roquette, 1 Seppic, 2 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 1 Shijiazhuang Huaxu Pharmaceutical, 8 Sigachi Industries, 1 Valens Pharmachem, 1 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

43 Fillers, Diluents & Binders, 28 Direct Compression, 23 Thickeners and Stabilizers, 17 Granulation, 14 Taste Masking, 14 Solubilizers, 14 Chewable & Orodispersible Aids, 14 Coating Systems & Additives, 14 Co-Processed Excipients, 12 Lubricants & Glidants, 12 Parenteral, 9 Emulsifying Agents, 9 Controlled & Modified Release, 9 Disintegrants & Superdisintegrants, 8 Empty Capsules, 8 Topical, 7 Film Formers & Plasticizers, 3 Coloring Agents, 2 API Stability Enhancers, 2 Surfactant & Foaming Agents, 1 Rheology Modifiers

DIGITAL CONTENT

3 DATA COMPILATION #PharmaFlow, 14 NEWS #PharmaBuzz

media
3 DATA COMPILATION #PharmaFlow
14 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions, 8 Finished Drug Prices, 12 Annual Reports

globalSalesInformation
1 US Medicaid Prescriptions
8 Finished Drug Prices
12 Annual Reports

MARKET PLACE

11 APIs, 2 FDF Dossiers

marketPlace
11 APIs
2 FDF Dossiers

PATENTS & EXCLUSIVITIES

28 US Patents, 7 Health Canada Patents

patents
28 US Patents
7 Health Canada Patents

REF. STANDARDS & IMPURITIES

1 EDQM , 4 USP , 18 Others

otherSolutions
1 EDQM
4 USP
18 Others

Tofigh Daru Aprepitant

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 15,881

MARKET PLACE

API

FDF

9INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

13DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

8,380,869

Annual Reports (USD Million)

3,199

Finished Drug Prices

141 RELATED EXCIPIENT COMPANIES

263EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as:

Molecular Formula

C₂₃H₂₁F₇N₄O₃

Molecular Weight

534.4 g/mol

InChI Key

ATALOFNDEOCMKK-OITMNORJSA-N

1 2D Structure

Aprepitant

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one

2.1.2 InChI

InChI=1S/C23H21F7N4O3/c1-12(14-8-15(22(25,26)27)10-16(9-14)23(28,29)30)37-20-19(13-2-4-17(24)5-3-13)34(6-7-36-20)11-18-31-21(35)33-32-18/h2-5,8-10,12,19-20H,6-7,11H2,1H3,(H2,31,32,33,35)/t12-,19+,20-/m1/s1

2.1.3 InChI Key

ATALOFNDEOCMKK-OITMNORJSA-N

2.1.4 Canonical SMILES

CC(C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)OC2C(N(CCO2)CC3=NC(=O)NN3)C4=CC=C(C=C4)F

2.1.5 Isomeric SMILES

C[C@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)O[C@@H]2[C@@H](N(CCO2)CC3=NC(=O)NN3)C4=CC=C(C=C4)F

2.2 Create Date

2006-07-28

3 Chemical and Physical Properties

Molecular Formula	C₂₃H₂₁F₇N₄O₃
Molecular Weight	534.4 g/mol
XLogP3	4.2
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	11
Rotatable Bond Count	6
Exact Mass	534.15018768 g/mol
Monoisotopic Mass	534.15018768 g/mol
Topological Polar Surface Area	75.2 A^2
Heavy Atom Count	37
Formal Charge	0
Complexity	810
Isotope Atom Count	0
Defined Atom Stereocenter Count	3
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Information

1 of 4
Drug Name	Aprepitant
PubMed Health	Aprepitant (By mouth)
Drug Classes	Antiemetic
Drug Label	EMEND (aprepitant) is a substance P/neurokinin 1 (NK1) receptor antagonist, chemically described as 5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one. Its empiric...
Active Ingredient	Aprepitant
Dosage Form	Capsule
Route	Oral
Strength	125mg; 80mg; 40mg
Market Status	Prescription
Company	Sandoz

2 of 4
Drug Name	Emend
PubMed Health	Aprepitant (By mouth)
Drug Classes	Antiemetic
Drug Label	EMEND (aprepitant) is a substance P/neurokinin 1 (NK1) receptor antagonist, chemically described as 5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one. Its empiric...
Active Ingredient	Aprepitant; Fosaprepitant dimeglumine
Dosage Form	Capsule; Powder
Route	Intravenous; Oral
Strength	eq 150mg base/vial; 125mg; 80mg; 40mg
Market Status	Prescription
Company	Merck; Merck And

3 of 4
Drug Name	Aprepitant
PubMed Health	Aprepitant (By mouth)
Drug Classes	Antiemetic
Drug Label	EMEND (aprepitant) is a substance P/neurokinin 1 (NK1) receptor antagonist, chemically described as 5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one. Its empiric...
Active Ingredient	Aprepitant
Dosage Form	Capsule
Route	Oral
Strength	125mg; 80mg; 40mg
Market Status	Prescription
Company	Sandoz

4 of 4
Drug Name	Emend
PubMed Health	Aprepitant (By mouth)
Drug Classes	Antiemetic
Drug Label	EMEND (aprepitant) is a substance P/neurokinin 1 (NK1) receptor antagonist, chemically described as 5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one. Its empiric...
Active Ingredient	Aprepitant; Fosaprepitant dimeglumine
Dosage Form	Capsule; Powder
Route	Intravenous; Oral
Strength	eq 150mg base/vial; 125mg; 80mg; 40mg
Market Status	Prescription
Company	Merck; Merck And

API SUPPLIERS

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USDMF

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CEP/COS

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JDMF

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EU WC

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KDMF

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NDC API

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Listed Suppliers

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API Reference Price

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K","customer":"FRESENIUS SE & CO. KGAA","customerCountry":"UNITED STATES","quantity":"27.60","actualQuantity":"27.6","unit":"KGS","unitRateFc":"42645.4","totalValueFC":"1164864.5","currency":"USD","unitRateINR":3072600.0362318838,"date":"22-Mar-2021","totalValueINR":"84803761","totalValueInUsd":"1164864.5","indian_port":"HYDERABAD AIR","hs_no":"29339990","bill_no":"9546114","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"HYDERABAD AIR","supplierAddress":"8-3-167\/D\/16, KALYAN NAGAR - I,VENGAL RAO NAGAR, HYDERABAD, A.P.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"APREPITANT","year":"2021","qtr":"Q1","strtotime":1616437800,"product":"APREPITANT - BULK DRUG","address":"PLOT 170-172, CHANDRAMOULI,INDUSTR IAL ESTATE, MOHOL BAZARPETH","city":"SOLAPUR,MAHARASHTRA","supplier":"GLENMARK PHARMACEUTICALS","supplierCountry":"INDIA","foreign_port":"ALGIERS","customer":"SARL LABORATOIRES BEKER","customerCountry":"ALGERIA","quantity":"30.00","actualQuantity":"30","unit":"KGS","unitRateFc":"7935.1","totalValueFC":"235594.4","currency":"USD","unitRateINR":571720,"date":"23-Mar-2021","totalValueINR":"17151600","totalValueInUsd":"235594.4","indian_port":"BOMBAY AIR","hs_no":"29333990","bill_no":"9568292","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"ALGERIA","selfForZScoreResived":"Pharma Grade","supplierPort":"BOMBAY AIR","supplierAddress":"PLOT 170-172, CHANDRAMOULI,INDUSTR IAL ESTATE, MOHOL BAZARPETH, SOLAPUR,MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"APREPITANT","year":"2021","qtr":"Q1","strtotime":1617129000,"product":"APREPITANT PH EUR (MFG DTD:JAN-2021 - RE","address":"PLOT NO. 1A, SECTOR 16A, INSTITUTIONAL AREA","city":"NOIDA U.P.","supplier":"JUBILANT GENERICS","supplierCountry":"INDIA","foreign_port":"PARIS - CHARLES DE G","customer":"BOLLORE LOGISTICS","customerCountry":"FRANCE","quantity":"8.00","actualQuantity":"8","unit":"KGS","unitRateFc":"5000","totalValueFC":"39312.4","currency":"USD","unitRateINR":357750,"date":"31-Mar-2021","totalValueINR":"2862000","totalValueInUsd":"39312.4","indian_port":"BANGALORE AIR","hs_no":"29349990","bill_no":"9794238","productDescription":"API","marketType":"REGULATED MARKET","country":"FRANCE","selfForZScoreResived":"Pharma Grade","supplierPort":"BANGALORE AIR","supplierAddress":"PLOT NO. 1A, SECTOR 16A, INSTITUTIONAL AREA, NOIDA U.P.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"APREPITANT","year":"2021","qtr":"Q1","strtotime":1617129000,"product":"APREPITANT PH EUR-(BATCH NO:APT2102002 A","address":"PLOT NO. 1A, SECTOR 16A, INSTITUTIONAL AREA","city":"NOIDA U.P.","supplier":"JUBILANT GENERICS","supplierCountry":"INDIA","foreign_port":"PARIS - CHARLES DE G","customer":"BOLLORE LOGISTICS","customerCountry":"FRANCE","quantity":"16.20","actualQuantity":"16.2","unit":"KGS","unitRateFc":"4500","totalValueFC":"71633.2","currency":"USD","unitRateINR":321913.5802469136,"date":"31-Mar-2021","totalValueINR":"5215000","totalValueInUsd":"71633.2","indian_port":"BANGALORE AIR","hs_no":"29349990","bill_no":"9793979","productDescription":"API","marketType":"REGULATED MARKET","country":"FRANCE","selfForZScoreResived":"Pharma Grade","supplierPort":"BANGALORE AIR","supplierAddress":"PLOT NO. 1A, SECTOR 16A, INSTITUTIONAL AREA, NOIDA U.P.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"FOSAPREPITANT DIMEGLUMINE","year":"2021","qtr":"Q2","strtotime":1618425000,"product":"FOSAPREPITANT DIMEGLUMINE","address":"8-3-167\/D\/16, KALYAN NAGAR - I,VENGAL RAO NAGAR","city":"HYDERABAD, A.P.","supplier":"MSN LABORATORIES","supplierCountry":"INDIA","foreign_port":"NEW YORK - JOHN F. 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0, , China,Peoples Republic China, Peoples Republic","customerAddress":"GALA NO-B\/307, 3RD FLOOR,NEW SARIT"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1727375400,"product":"FOSAPREPITANT DIMEGLUMINE","address":"18\/1 3 AZAMABAD","city":"HYDERABAD ,ANDHRA PRADESH","supplier":"CHEMWERTH INC","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"BIOLOGICAL E","customerCountry":"INDIA","quantity":"21.64","actualQuantity":"21640","unit":"GMS","unitRateFc":"19","totalValueFC":"427112.7","currency":"USD","unitRateINR":"1654","date":"27-Sep-2024","totalValueINR":"35792568","totalValueInUsd":"427112.7","indian_port":"Hyderabad Air","hs_no":"29349990","bill_no":"5833200","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"1764 LITCHFIELD TURNPIKE SUITE 202 WOODBRIDGE, CT, 06525 US","customerAddress":"18\/1 3 AZAMABAD"}]

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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