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Chemistry

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Also known as: 197904-84-0, Tg01, Cs-706, Tg-01, R-109339, 5x5hb3vz3z
Molecular Formula
C19H20N2O3S
Molecular Weight
356.4  g/mol
InChI Key
JTMITOKKUMVWRT-UHFFFAOYSA-N
FDA UNII
5X5HB3VZ3Z

Apricoxib
Apricoxib is an orally bioavailable nonsteroidal anti-inflammatory agent (NSAID) with potential antiangiogenic and antineoplastic activities. Apricoxib binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), thereby inhibiting the conversion of arachidonic acid into prostaglandins. Apricoxib-mediated inhibition of COX-2 may induce tumor cell apoptosis and inhibit tumor cell proliferation and tumor angiogenesis. COX-related metabolic pathways may represent crucial regulators of cellular proliferation and angiogenesis.
1 2D Structure

Apricoxib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-[2-(4-ethoxyphenyl)-4-methylpyrrol-1-yl]benzenesulfonamide
2.1.2 InChI
InChI=1S/C19H20N2O3S/c1-3-24-17-8-4-15(5-9-17)19-12-14(2)13-21(19)16-6-10-18(11-7-16)25(20,22)23/h4-13H,3H2,1-2H3,(H2,20,22,23)
2.1.3 InChI Key
JTMITOKKUMVWRT-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CCOC1=CC=C(C=C1)C2=CC(=CN2C3=CC=C(C=C3)S(=O)(=O)N)C
2.2 Other Identifiers
2.2.1 UNII
5X5HB3VZ3Z
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 2-(4-ethoxyphenyl)-4-methyl 1-(4-sulfamoylphenyl)-1h-pyrrole

2. Cs 706

3. Cs-706

4. Cs706 Cpd

2.3.2 Depositor-Supplied Synonyms

1. 197904-84-0

2. Tg01

3. Cs-706

4. Tg-01

5. R-109339

6. 5x5hb3vz3z

7. 4-[2-(4-ethoxyphenyl)-4-methylpyrrol-1-yl]benzenesulfonamide

8. 4-(2-(4-ethoxyphenyl)-4-methyl-1h-pyrrol-1-yl)benzenesulfonamide

9. Cs 706; R 109339; Tg 01

10. Benzenesulfonamide, 4-(2-(4-ethoxyphenyl)-4-methyl-1h-pyrrol-1-yl)-

11. Apricoxib [usan]

12. Apricoxib [usan:inn]

13. Unii-5x5hb3vz3z

14. Capoxigem

15. Kymena

16. Tg 01

17. Cs 706

18. Apricoxib [inn]

19. Apricoxib (usan/inn)

20. Cs706 Cpd

21. Apricoxib [who-dd]

22. Schembl346028

23. R 109339

24. Chembl1835207

25. Dtxsid60173502

26. Cs701

27. Db12378

28. Tp-1001

29. Tp-2001

30. D08657

31. Q18209480

32. 2-(4-ethoxyphenyl)-4-methyl-1-(4-sulfamoylphenyl)pyrrole

33. 4-methyl-2-(4-ethoxyphenyl)-1-(4-sulfamoylphenyl)pyrrole

34. 2-(4-ethoxyphenyl)-4-methyl 1-(4-sulfamoylphenyl)-1h-pyrrole

2.4 Create Date
2006-10-25
3 Chemical and Physical Properties
Molecular Weight 356.4 g/mol
Molecular Formula C19H20N2O3S
XLogP33.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count5
Exact Mass356.11946368 g/mol
Monoisotopic Mass356.11946368 g/mol
Topological Polar Surface Area82.7 Ų
Heavy Atom Count25
Formal Charge0
Complexity517
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

ABOUT THIS PAGE

Apricoxib Manufacturers

A Apricoxib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Apricoxib, including repackagers and relabelers. The FDA regulates Apricoxib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Apricoxib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Apricoxib Suppliers

A Apricoxib supplier is an individual or a company that provides Apricoxib active pharmaceutical ingredient (API) or Apricoxib finished formulations upon request. The Apricoxib suppliers may include Apricoxib API manufacturers, exporters, distributors and traders.

click here to find a list of Apricoxib suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Apricoxib USDMF

A Apricoxib DMF (Drug Master File) is a document detailing the whole manufacturing process of Apricoxib active pharmaceutical ingredient (API) in detail. Different forms of Apricoxib DMFs exist exist since differing nations have different regulations, such as Apricoxib USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Apricoxib DMF submitted to regulatory agencies in the US is known as a USDMF. Apricoxib USDMF includes data on Apricoxib's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Apricoxib USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Apricoxib suppliers with USDMF on PharmaCompass.

Apricoxib GMP

Apricoxib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Apricoxib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Apricoxib GMP manufacturer or Apricoxib GMP API supplier for your needs.

Apricoxib CoA

A Apricoxib CoA (Certificate of Analysis) is a formal document that attests to Apricoxib's compliance with Apricoxib specifications and serves as a tool for batch-level quality control.

Apricoxib CoA mostly includes findings from lab analyses of a specific batch. For each Apricoxib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Apricoxib may be tested according to a variety of international standards, such as European Pharmacopoeia (Apricoxib EP), Apricoxib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Apricoxib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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