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Chemistry

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Also known as: 107021-12-5, Tenofovir-d6, Apropovir, 1-(6-aminopurin-9-yl)propan-2-yloxymethylphosphonic acid, (((1-(6-amino-9h-purin-9-yl)propan-2-yl)oxy)methyl)phosphonic acid, ({[1-(6-amino-9h-purin-9-yl)propan-2-yl]oxy}methyl)phosphonic acid
Molecular Formula
C9H14N5O4P
Molecular Weight
287.21  g/mol
InChI Key
SGOIRFVFHAKUTI-UHFFFAOYSA-N

Apropovir
An adenine analog REVERSE TRANSCRIPTASE INHIBITOR with antiviral activity against HIV-1 and HEPATITIS B. It is used to treat HIV INFECTIONS and CHRONIC HEPATITIS B, in combination with other ANTIVIRAL AGENTS, due to the emergence of ANTIVIRAL DRUG RESISTANCE when it is used alone.
1 2D Structure

Apropovir

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
1-(6-aminopurin-9-yl)propan-2-yloxymethylphosphonic acid
2.1.2 InChI
InChI=1S/C9H14N5O4P/c1-6(18-5-19(15,16)17)2-14-4-13-7-8(10)11-3-12-9(7)14/h3-4,6H,2,5H2,1H3,(H2,10,11,12)(H2,15,16,17)
2.1.3 InChI Key
SGOIRFVFHAKUTI-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC(CN1C=NC2=C(N=CN=C21)N)OCP(=O)(O)O
2.2 Synonyms
2.2.1 MeSH Synonyms

1. (r)-9-(2-phosphonylmethoxypropyl)adenine

2. 9-(2-phosphonylmethoxypropyl)adenine

3. 9-(2-phosphonylmethoxypropyl)adenine, (+-)-isomer

4. 9-(2-phosphonylmethoxypropyl)adenine, (r)-isomer - T357098

5. 9-(2-phosphonylmethoxypropyl)adenine, (s)-isomer

6. 9-pmpa (tenofovir)

7. Disoproxil Fumarate, Tenofovir

8. Disoproxil, Tenofovir

9. Fumarate, Tenofovir Disoproxil

10. Tenofovir

11. Tenofovir Disoproxil

12. Tenofovir Disoproxil Fumarate

13. Viread

2.2.2 Depositor-Supplied Synonyms

1. 107021-12-5

2. Tenofovir-d6

3. Apropovir

4. 1-(6-aminopurin-9-yl)propan-2-yloxymethylphosphonic Acid

5. (((1-(6-amino-9h-purin-9-yl)propan-2-yl)oxy)methyl)phosphonic Acid

6. ({[1-(6-amino-9h-purin-9-yl)propan-2-yl]oxy}methyl)phosphonic Acid

7. 1217720-14-3

8. Tenofovir (parent)

9. Mfcd21604708

10. ((2-(6-amino-9h-purin-9-yl)-1-methylethoxy)methyl)phosphonic Acid

11. Mls006011450

12. Schembl497725

13. Chembl315593

14. Dtxsid30861388

15. Bcp02416

16. Vqb71994

17. Bbl032950

18. Stl370337

19. 9-[2-(phosphonomethoxy)propyl]adenine

20. Akos015961830

21. Phosphonic Acid, ((2-(6-amino-9h-purin-9-yl)-1-methylethoxy)methyl)-

22. Smr004703253

23. Sy115900

24. Ft-0601652

25. Ft-0674851

26. Ft-0696939

27. 9-[2-(phosphonomethoxy)propyl]-9h-purin-6-amine

28. A851347

29. (r)-pmpa;gs-1278;gs 1278;gs1278;tdf;pmpa

30. (s)-[[[1-(6-amino-9h-purin-9-yl)-2-propyl]oxy]methyl]phosphonic Acid

2.3 Create Date
2005-08-01
3 Chemical and Physical Properties
Molecular Weight 287.21 g/mol
Molecular Formula C9H14N5O4P
XLogP3-1.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count5
Exact Mass287.07834094 g/mol
Monoisotopic Mass287.07834094 g/mol
Topological Polar Surface Area136 Ų
Heavy Atom Count19
Formal Charge0
Complexity354
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Anti-HIV Agents

Agents used to treat AIDS and/or stop the spread of the HIV infection. These do not include drugs used to treat symptoms or opportunistic infections associated with AIDS. (See all compounds classified as Anti-HIV Agents.)


Reverse Transcriptase Inhibitors

Inhibitors of reverse transcriptase (RNA-DIRECTED DNA POLYMERASE), an enzyme that synthesizes DNA on an RNA template. (See all compounds classified as Reverse Transcriptase Inhibitors.)


Antiviral Agents

Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. (See all compounds classified as Antiviral Agents.)


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ABOUT THIS PAGE

Apropovir Manufacturers

A Apropovir manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Apropovir, including repackagers and relabelers. The FDA regulates Apropovir manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Apropovir API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Apropovir Suppliers

A Apropovir supplier is an individual or a company that provides Apropovir active pharmaceutical ingredient (API) or Apropovir finished formulations upon request. The Apropovir suppliers may include Apropovir API manufacturers, exporters, distributors and traders.

click here to find a list of Apropovir suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Apropovir USDMF

A Apropovir DMF (Drug Master File) is a document detailing the whole manufacturing process of Apropovir active pharmaceutical ingredient (API) in detail. Different forms of Apropovir DMFs exist exist since differing nations have different regulations, such as Apropovir USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Apropovir DMF submitted to regulatory agencies in the US is known as a USDMF. Apropovir USDMF includes data on Apropovir's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Apropovir USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Apropovir suppliers with USDMF on PharmaCompass.

Apropovir GMP

Apropovir Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Apropovir GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Apropovir GMP manufacturer or Apropovir GMP API supplier for your needs.

Apropovir CoA

A Apropovir CoA (Certificate of Analysis) is a formal document that attests to Apropovir's compliance with Apropovir specifications and serves as a tool for batch-level quality control.

Apropovir CoA mostly includes findings from lab analyses of a specific batch. For each Apropovir CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Apropovir may be tested according to a variety of international standards, such as European Pharmacopoeia (Apropovir EP), Apropovir JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Apropovir USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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