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Chemistry

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Also known as: E3330, 136164-66-4, E-3330, E 3330, Apx3330, Chembl578390
Molecular Formula
C21H30O6
Molecular Weight
378.5  g/mol
InChI Key
AALSSIXXBDPENJ-FYWRMAATSA-N
FDA UNII
11267UI968

APX3330
APE1/Ref-1 Redox Inhibitor APX3330 is an orally bioavailable inhibitor of apurinic/apyrimidinic endonuclease 1/reduction-oxidation (redox) effector factor-1 (APE1/Ref-1; APEX1), with potential anti-angiogenic and antineoplastic activities. Upon administration, the APE1/Ref-1 Inhibitor APX3330 selectively targets and binds to APE1/Ref-1. This inhibits the redox-dependent signaling activity of APE1/Ref-1, by preventing the reduction and activation of numerous APE1/Ref-1-dependent oncogenic transcription factors (TFs), such as nuclear factor kappa B (NF-kB), AP-1, STAT3, p53, NRF2 and HIF-1alpha, that are involved in signaling, cell proliferation, tumor progression and survival of cancer cells. Therefore, this agent inhibits the activation of multiple TF-mediated signaling pathways and inhibits tumor cell proliferation and survival. APE1/Ref-1, a multifunctional protein overexpressed in many cancer cell types, plays a key role as a redox regulator of transcription factor activation and in base excision repair upon DNA damage. It drives cancer cell proliferation, migration, drug resistance, angiogenesis and inflammation and its expression level correlates with increased tumor aggressiveness and decreased patient survival. APX3330 specifically blocks the redox activity of APE1/Ref-1 and does not affect its ability to act as a DNA repair endonuclease.
1 2D Structure

APX3330

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2E)-2-[(4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)methylidene]undecanoic acid
2.1.2 InChI
InChI=1S/C21H30O6/c1-5-6-7-8-9-10-11-12-15(21(24)25)13-16-14(2)17(22)19(26-3)20(27-4)18(16)23/h13H,5-12H2,1-4H3,(H,24,25)/b15-13+
2.1.3 InChI Key
AALSSIXXBDPENJ-FYWRMAATSA-N
2.1.4 Canonical SMILES
CCCCCCCCCC(=CC1=C(C(=O)C(=C(C1=O)OC)OC)C)C(=O)O
2.1.5 Isomeric SMILES
CCCCCCCCC/C(=C\C1=C(C(=O)C(=C(C1=O)OC)OC)C)/C(=O)O
2.2 Other Identifiers
2.2.1 UNII
11267UI968
2.3 Synonyms
2.3.1 MeSH Synonyms

1. (2e)-3-(5-(2,3-dimethoxy-6-methyl-1,4-benzoquinoyl))-2-nonyl-2-propenoic Acid

2. E 3330

3. E-3330

4. E3330

2.3.2 Depositor-Supplied Synonyms

1. E3330

2. 136164-66-4

3. E-3330

4. E 3330

5. Apx3330

6. Chembl578390

7. Apx 3330

8. 11267ui968

9. (e)-2-((4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)methylene)undecanoic Acid

10. Apx-3330

11. (2e)-3-(5-(2,3-dimethoxy-6-methyl-1,4-benzoquinoyl))-2-nonyl-2-propenoic Acid

12. Schembl3758716

13. Schembl3758719

14. Dtxsid201121926

15. Hms3886n15

16. Unii-11267ui968

17. Ex-a2212

18. Bdbm50303955

19. S7445

20. Zinc14252145

21. Ccg-268389

22. (2e)-2-[(4,5-dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)methylene]-undecanoic Acid

23. Hy-19357

24. Cs-0015424

25. E3330, >=98% (hplc)

26. Ape1/ref-1 Redox Inhibitor Apx3330

27. A14440

28. A911827

29. (e)-3-(4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dienyl)-2-nonylpropenoic Acid

30. (e)-3-(5,6-dimethoxy-3-methyl-14-dioxocyclohexa-25-dienyl)-2-nonylpropenoic Acid

31. (2e)-2-[(4,5-dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)methylene]undecanoic Acid

32. Undecanoic Acid, 2-((4,5-dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)methylene)-, (2e)-

33. Undecanoic Acid, 2-((4,5-dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)methylene)-, (e)-

2.4 Create Date
2006-04-28
3 Chemical and Physical Properties
Molecular Weight 378.5 g/mol
Molecular Formula C21H30O6
XLogP35.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count12
Exact Mass378.20423867 g/mol
Monoisotopic Mass378.20423867 g/mol
Topological Polar Surface Area89.9 Ų
Heavy Atom Count27
Formal Charge0
Complexity666
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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