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Chemistry

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Also known as: 246529-22-6, C20-fabac, Arachidyl amido cholanoic acid, Qe1q24m65y, (4r)-4-[(3s,5s,7r,8r,9s,10s,12s,13r,14s,17r)-7,12-dihydroxy-3-(icosanoylamino)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]pentanoic acid, R20-fbac
Molecular Formula
C44H79NO5
Molecular Weight
702.1  g/mol
InChI Key
SHKXZIQNFMOPBS-OOMQYRRCSA-N
FDA UNII
QE1Q24M65Y

Aramchol
Aramchol has been used in trials studying the treatment of HIV, Gallstones, Fatty Liver, Metabolic Syndrome, and Nonalcoholic Steatohepatitis, among others.
1 2D Structure

Aramchol

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(4R)-4-[(3S,5S,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-dihydroxy-3-(icosanoylamino)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
2.1.2 InChI
InChI=1S/C44H79NO5/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-40(48)45-34-27-28-43(3)33(29-34)30-38(46)42-36-25-24-35(32(2)23-26-41(49)50)44(36,4)39(47)31-37(42)43/h32-39,42,46-47H,5-31H2,1-4H3,(H,45,48)(H,49,50)/t32-,33+,34+,35-,36+,37+,38-,39+,42+,43+,44-/m1/s1
2.1.3 InChI Key
SHKXZIQNFMOPBS-OOMQYRRCSA-N
2.1.4 Canonical SMILES
CCCCCCCCCCCCCCCCCCCC(=O)NC1CCC2(C(C1)CC(C3C2CC(C4(C3CCC4C(C)CCC(=O)O)C)O)O)C
2.1.5 Isomeric SMILES
CCCCCCCCCCCCCCCCCCCC(=O)N[C@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]3[C@@H]2C[C@@H]([C@]4([C@H]3CC[C@@H]4[C@H](C)CCC(=O)O)C)O)O)C
2.2 Other Identifiers
2.2.1 UNII
QE1Q24M65Y
2.3 Synonyms
2.3.1 MeSH Synonyms

1. (3beta,5beta,7alpha,12alpha)-7,12-dihydroxy-3-(icosanoylamino)cholan-24-oic Acid

2. Arachidyl Amido Cholanoic Acid

2.3.2 Depositor-Supplied Synonyms

1. 246529-22-6

2. C20-fabac

3. Arachidyl Amido Cholanoic Acid

4. Qe1q24m65y

5. (4r)-4-[(3s,5s,7r,8r,9s,10s,12s,13r,14s,17r)-7,12-dihydroxy-3-(icosanoylamino)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]pentanoic Acid

6. R20-fbac

7. (r)-4-((3s,5s,7r,8r,9s,10s,12s,13r,14s,17r)-7,12-dihydroxy-3-icosanamido-10,13-dimethylhexadecahydro-1h-cyclopenta[a]phenanthren-17-yl)pentanoic Acid

8. Arachidyl

9. Unii-qe1q24m65y

10. Amido Cholanoic Acid,

11. Icomidocholic Acid

12. Schembl548961

13. Chembl4297262

14. Icomidocholic Acid [inn]

15. Dtxsid90179395

16. Ex-a4308

17. Wja52922

18. Db11860

19. Ac-30875

20. Hy-19796

21. Cs-0016645

22. Arachidyl Amido Cholanoic Acid [who-dd]

23. A903776

24. Q27287206

25. 3beta-arachidylamido-7alpha,12alpha-dihydroxy-5beta-cholan-24-oic Acid

26. (3.beta.)-arachidylamido-7.alpha.,12.alpha.-dihydroxy-5.beta.-cholan-24-oic Acid

27. (3beta,5beta,7alpha,12alpha)-7,12-dihydroxy-3-(icosanoylamino)cholan-24-oic Acid

28. Cholan-24-oic Acid, 7,12-dihydroxy-3-((1-oxoeicosyl)amino)-, (3.beta.,5.beta.,7.alpha.,12.alpha.)-

2.4 Create Date
2007-12-04
3 Chemical and Physical Properties
Molecular Weight 702.1 g/mol
Molecular Formula C44H79NO5
XLogP313.1
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count5
Rotatable Bond Count23
Exact Mass701.59582462 g/mol
Monoisotopic Mass701.59582462 g/mol
Topological Polar Surface Area107 Ų
Heavy Atom Count50
Formal Charge0
Complexity1020
Isotope Atom Count0
Defined Atom Stereocenter Count11
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Aramchol Manufacturers

A Aramchol manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Aramchol, including repackagers and relabelers. The FDA regulates Aramchol manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Aramchol API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Aramchol Suppliers

A Aramchol supplier is an individual or a company that provides Aramchol active pharmaceutical ingredient (API) or Aramchol finished formulations upon request. The Aramchol suppliers may include Aramchol API manufacturers, exporters, distributors and traders.

Aramchol GMP

Aramchol Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Aramchol GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Aramchol GMP manufacturer or Aramchol GMP API supplier for your needs.

Aramchol CoA

A Aramchol CoA (Certificate of Analysis) is a formal document that attests to Aramchol's compliance with Aramchol specifications and serves as a tool for batch-level quality control.

Aramchol CoA mostly includes findings from lab analyses of a specific batch. For each Aramchol CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Aramchol may be tested according to a variety of international standards, such as European Pharmacopoeia (Aramchol EP), Aramchol JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Aramchol USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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