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Argipressin Tannate

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15 API Suppliers, 9 USDMF, 31 NDC API, 8 Listed Suppliers, $ API Reference Price

15 API Suppliers
9 USDMF
31 NDC API
8 Listed Suppliers
$ API Reference Price

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10 Drugs in Development

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34 FDF Dossiers, 23 FDA Orange Book, 2 Europe, 2 Canada, 1 South Africa, 6 Listed Dossiers

34 FDF Dossiers
23 FDA Orange Book
2 Europe
2 Canada
1 South Africa
6 Listed Dossiers

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2 DATA COMPILATION #PharmaFlow
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1 Finished Drug Prices, 6 Annual Reports

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6 Annual Reports

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6 APIs, 4 FDF Dossiers

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4 FDF Dossiers

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43 US Patents

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43 US Patents

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1 USP , 1 JP , 5 Others

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1 USP
1 JP
5 Others

Synopsis

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Chemistry

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Also known as: Arginine vasopressin, 113-79-1, Argipressine, Pitressin, Beta-hypophamine, 8-arginine-vasopressin

Molecular Formula

C₄₆H₆₅N₁₅O₁₂S₂

Molecular Weight

1084.2 g/mol

InChI Key

KBZOIRJILGZLEJ-LGYYRGKSSA-N

The predominant form of mammalian antidiuretic hormone. It is a nonapeptide containing an ARGININE at residue 8 and two disulfide-linked cysteines at residues of 1 and 6. Arg-vasopressin is used to treat DIABETES INSIPIDUS or to improve vasomotor tone and BLOOD PRESSURE.

1 2D Structure

Arginine Vasopressin

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(2S)-1-[(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]pyrrolidine-2-carboxamide

2.1.2 InChI

InChI=1S/C46H65N15O12S2/c47-27-22-74-75-23-33(45(73)61-17-5-9-34(61)44(72)56-28(8-4-16-53-46(51)52)39(67)54-21-37(50)65)60-43(71)32(20-36(49)64)59-40(68)29(14-15-35(48)63)55-41(69)31(18-24-6-2-1-3-7-24)58-42(70)30(57-38(27)66)19-25-10-12-26(62)13-11-25/h1-3,6-7,10-13,27-34,62H,4-5,8-9,14-23,47H2,(H2,48,63)(H2,49,64)(H2,50,65)(H,54,67)(H,55,69)(H,56,72)(H,57,66)(H,58,70)(H,59,68)(H,60,71)(H4,51,52,53)/t27-,28-,29-,30-,31-,32-,33-,34-/m0/s1

2.1.3 InChI Key

KBZOIRJILGZLEJ-LGYYRGKSSA-N

2.1.4 Canonical SMILES

C1CC(N(C1)C(=O)C2CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C(C=C4)O)N)C(=O)NC(CCCN=C(N)N)C(=O)NCC(=O)N

2.1.5 Isomeric SMILES

C1C[C@H](N(C1)C(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C(C=C4)O)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(=O)N

2.2 Synonyms

2.2.1 MeSH Synonyms

1. Arg Vasopressin

2. Arg-vasopressin

3. Arginine Vasopressin

4. Argipressin Tannate

5. Vasopressin, Arginine

2.2.2 Depositor-Supplied Synonyms

1. Arginine Vasopressin

2. 113-79-1

3. Argipressine

4. Pitressin

5. Beta-hypophamine

6. 8-arginine-vasopressin

7. Argipressin Tannate

8. Vasopressin (arginine Form)

9. Arginine-vasopressin

10. Chebi:34543

11. Vasophysin

12. Arg-vasopressin

13. Chembl373742

14. (arg8)-vasopressin

15. [arg8]-vasopressin

16. (2s)-1-[(4r,7s,10s,13s,16s,19r)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-n-[(2s)-1-[(2-amino-2-oxoethyl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]pyrrolidine-2-carboxamide

17. 8-l-arginine Vasopressin

18. Argipresina

19. Argipressina

20. Argipressinum

21. Avp

22. Arg8-vasopressin

23. Argipressin [inn]

24. Argipressina [dcit]

25. Ncgc00166306-01

26. Argipressin [inn:ban]

27. 8-l-arginine-vasopressin

28. Argipresina [inn-spanish]

29. Argipressine [inn-french]

30. Argipressinum [inn-latin]

31. Unii-y4907o6mfd

32. Rindervasopressin

33. [3h]vasopressin

34. Einecs 204-035-4

35. 3-(phenylalanine)-8-arginineoxytocin

36. Arg8-vasopressin;avp

37. Arginine-8-vasopressin

38. Argipressin Or Lypressin

39. [8-arginine]vasopressin

40. [3h]argipressin Tannate

41. Antidiuretic Hormone (adh)

42. Arginine Vasopressin (avp)

43. Argipressin Tannate [usan]

44. Arginine Antidiuretic Hormone

45. Dsstox_cid_28324

46. Dsstox_rid_82752

47. Dsstox_gsid_48349

48. Schembl43139

49. Vasopressin, 8-l-arginine-

50. [cyclo S-s]cyfqncprg-nh2

51. Gtpl2168

52. Y4907o6mfd

53. Dtxsid0048349

54. Schembl17874853

55. Bdbm35667

56. Tox21_113037

57. Bdbm50044777

58. Mfcd00076738

59. Ncgc00166306-02

60. Ncgc00188439-01

61. Cas-113-79-1

62. H-cys-tyr-phe-gln-asn-cys-pro-arg-gly-nh2

63. Oxytocin, 3-(l-phenylalanine)-8-l-arginine-

64. Vasopressin, 8-l-arginine- (7ci,8ci,9ci)

65. Roxybenzyl-6,9,12,15,18-pentaoxo- (6ci)

66. 113a791

67. Q183011

68. Cys-tyr-phe-gln-asn-cys-pro-arg-gly-nh2[disulfide Bridge: 1-6]

69. (2s)-1-[(4r,7s,10s,13s,16s,19r)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-13-(phenylmethyl)1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-n-[(2s)-1-[(2-amino-2-oxoethyl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]pyrrolidine-2-carboxamide

70. 1,2-dithia-5,8,11,14,17-pentaazacycloeicosane-10-propionamide, 19-amino-13-benzyl-7-(carbamoylmethyl)-4-[2-[[1-[(carbamoylmethyl)carbamoyl]-4-guanidinobutyl]carbamoyl]-1-pyrrolidinylcarbonyl]-16-p-hyd

71. 1-{[(4r,7s,10s,13s,16s,19r)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}-l-prolyl-l-arginylglycinamide

72. Glycinamide, L-cysteinyl-l-tyrosyl-l-phenylalanyl-l-glutaminyl-l-asparaginyl-l-cysteinyl-l-prolyl-l-arginyl-, Cyclic (1>6)-disulfide

2.3 Create Date

2005-06-01

3 Chemical and Physical Properties

Molecular Formula	C₄₆H₆₅N₁₅O₁₂S₂
Molecular Weight	1084.2 g/mol
XLogP3	-4.8
Hydrogen Bond Donor Count	14
Hydrogen Bond Acceptor Count	16
Rotatable Bond Count	19
Exact Mass	1083.43785492 g/mol
Monoisotopic Mass	1083.43785492 g/mol
Topological Polar Surface Area	515 Å²
Heavy Atom Count	75
Formal Charge	0
Complexity	2070
Isotope Atom Count	0
Defined Atom Stereocenter Count	8
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Vasoconstrictor Agents

Drugs used to cause constriction of the blood vessels. (See all compounds classified as Vasoconstrictor Agents.)

Antidiuretic Agents

Agents that reduce the excretion of URINE, most notably the octapeptide VASOPRESSINS. (See all compounds classified as Antidiuretic Agents.)

Hemostatics

Agents acting to arrest the flow of blood. Absorbable hemostatics arrest bleeding either by the formation of an artificial clot or by providing a mechanical matrix that facilitates clotting when applied directly to the bleeding surface. These agents function more at the capillary level and are not effective at stemming arterial or venous bleeding under any significant intravascular pressure. (See all compounds classified as Hemostatics.)

API SUPPLIERS

01

Bachem AG

Switzerland

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

AES 2024

Not Confirmed

Bachem Group is a public, innovation-driven company specializing in the development and manufacturing of peptides and oligonucleotides.

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Switzerland

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USDMF

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CEP/COS JDMF EU-WC NDC

KDMF VMF Others AUDIT

02

HRV Global Life Sciences

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPHI Middle east

Attending

HRV Global Life Sciences - Market Expansion Leader in Pharmaceuticals.

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India

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USDMF CEP/COS JDMF EU-WC NDC KDMF VMF AU

AUDIT

03

Omgene Life Sciences Pvt. Ltd

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

AES 2024

Not Confirmed

Omgene: R&D-based biopharmaceutical company with GMP facilities, focused on innovation and high-quality, affordable medicines.

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India

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USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

04

Auro Peptides Limited

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

AES 2024

Not Confirmed

05

PolyPeptide Group

Switzerland

Switzerland

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

AES 2024

Not Confirmed

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Listed Suppliers

01

HRV Global Life Sciences

India

Antibody Engineering

Not Confirmed

HRV Global Life Sciences - Market Expansion Leader in Pharmaceuticals.

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India

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Arginine Vasopressin

About the Company : HRV Global is a leading global manufacturer, seller & exporter of a wide range of APIs, advanced intermediates, pellets, food grade chemicals, food additives & food ingredients. It...

HRV Global is a leading global manufacturer, seller & exporter of a wide range of APIs, advanced intermediates, pellets, food grade chemicals, food additives & food ingredients. It offers services such as sourcing, manufacturing & supply, helping partners enter new markets worldwide. Its strong partnerships with major players in the pharma and food additive industries help HRV Global effectively promote projects and products. HRV Global represents over 30 large Indian drugmakers, primarily targeting Europe, the US & the Middle East markets. Headquartered in India, HRV Global has offices in the US, Switzerland, Dubai, Lithuania & Turkey.

02

Omgene Life Sciences Pvt. Ltd

India

Antibody Engineering

Not Confirmed

Omgene: R&D-based biopharmaceutical company with GMP facilities, focused on innovation and high-quality, affordable medicines.

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India

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Vasopressin

About the Company : Omgene Life Sciences Private Limited is an R&D-driven biopharmaceutical company specializing in biopharmaceuticals, peptides, semi-synthetic, and synthetic actives. As a vertically...

Omgene Life Sciences Private Limited is an R&D-driven biopharmaceutical company specializing in biopharmaceuticals, peptides, semi-synthetic, and synthetic actives. As a vertically integrated company, we focus on developing high-quality formulations based on in-house-produced actives. With GMP-certified facilities and partnerships with contract manufacturers, we excel in formulation development for injectables, lyophilized injectables, complex generics, and oral peptide delivery systems, ensuring affordable, top-quality medicines.

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Xian Harmonious Natural Bio-Techolo...

China

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Not Confirmed

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API Reference Price

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Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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Drugs in Development

01 Dr. Reddy's Laboratories

India

Antibody Engineering

Not Confirmed

DRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.

Lead Product(s) : Arginine Vasopressin

Therapeutic Area : Cardiology/Vascular Diseases

Highest Development Status : Approved

Partner/Sponsor/Collaborator : Not Applicable

Deal Size : Not Applicable

Deal Type : Not Applicable

DEALS_DEV

Dr. Reddy's Laboratories Announces the Launch of Its Authorized Generic Version of VASOSTRICT® (v...

Details : The launch of authorized generic version of Par Pharmaceutical’s VASOSTRICT® (vasopressin injection, USP) Vials in the U.S. Market was approved by the U.S. Food and Drug Administration (USFDA).

Brand Name : Vasopressin-Generic

Molecule Type : Peptide

Upfront Cash : Not Applicable

February 09, 2022