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Chemistry

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Also known as: 616204-22-9, Acetyl hexapeptide, Argireline acetate, Argireline acetate anti-aging cosmetic peptide, Schembl223824, (4s)-4-acetamido-5-[[(2s)-1-[[(2s)-1-[[(2s)-5-amino-1-[[(2s)-1-[[(2s)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-5-oxopentanoic acid
Molecular Formula
C34H60N14O12S
Molecular Weight
889.0  g/mol
InChI Key
RJZNPROJTJSYLC-LLINQDLYSA-N

Argireline
1 2D Structure

Argireline

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(4S)-4-acetamido-5-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-5-oxopentanoic acid
2.1.2 InChI
InChI=1S/C34H60N14O12S/c1-17(49)43-20(8-11-25(51)52)29(57)47-22(9-12-26(53)54)31(59)48-23(13-16-61-2)32(60)46-21(7-10-24(35)50)30(58)45-19(6-4-15-42-34(39)40)28(56)44-18(27(36)55)5-3-14-41-33(37)38/h18-23H,3-16H2,1-2H3,(H2,35,50)(H2,36,55)(H,43,49)(H,44,56)(H,45,58)(H,46,60)(H,47,57)(H,48,59)(H,51,52)(H,53,54)(H4,37,38,41)(H4,39,40,42)/t18-,19-,20-,21-,22-,23-/m0/s1
2.1.3 InChI Key
RJZNPROJTJSYLC-LLINQDLYSA-N
2.1.4 Canonical SMILES
CC(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)O)C(=O)NC(CCSC)C(=O)NC(CCC(=O)N)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCCN=C(N)N)C(=O)N
2.1.5 Isomeric SMILES
CC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N
2.2 Synonyms
2.2.1 MeSH Synonyms

1. Ac-eemqrr-nh2

2. Acetyl Hexapeptide-8

3. Acetyl-glutamyl-glutamyl-methionyl-glutaminyl-arginyl-argininamide

2.2.2 Depositor-Supplied Synonyms

1. 616204-22-9

2. Acetyl Hexapeptide

3. Argireline Acetate

4. Argireline Acetate Anti-aging Cosmetic Peptide

5. Schembl223824

6. (4s)-4-acetamido-5-[[(2s)-1-[[(2s)-1-[[(2s)-5-amino-1-[[(2s)-1-[[(2s)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-5-oxopentanoic Acid

7. (6s,9s,12s,15s,18s,21s)-21-acetamido-1-amino-12-(3-amino-3-oxopropyl)-6-carbamoyl-18-(2-carboxyethyl)-9-(3-guanidinopropyl)-1-imino-15-(2-(methylthio)ethyl)-8,11,14,17,20-pentaoxo-2,7,10,13,16,19-hexaazatetracosan-24-oic Acid

8. N-acetyl-l-alpha-glutamyl-l-alpha-glutamyl-l-methionyl-l-glutaminyl-l-arginyl-l-argininamide

9. Schembl22265244

10. Argireline(acetyl Hexapeptide-3)

11. Molport-009-194-173

12. Amy25367

13. Ex-a6258

14. Hy-p0033

15. Ac8712

16. Akos015994631

17. Zinc169719042

18. Cs-5101

19. Hs-2002

20. Ac-28736

21. 204a229

22. A868667

23. J-700142

24. Q-200583

25. Ac-glu-glu-met-glu-arg-arg-nh2;n-acetyl-l-alpha-glutamyl-l-alpha-glutamyl-l-methionyl-l-glutaminyl-l-arginyl-l-argininamide

2.3 Create Date
2006-10-26
3 Chemical and Physical Properties
Molecular Weight 889.0 g/mol
Molecular Formula C34H60N14O12S
XLogP3-6.3
Hydrogen Bond Donor Count14
Hydrogen Bond Acceptor Count15
Rotatable Bond Count32
Exact Mass888.42358458 g/mol
Monoisotopic Mass888.42358458 g/mol
Topological Polar Surface Area490 Ų
Heavy Atom Count61
Formal Charge0
Complexity1610
Isotope Atom Count0
Defined Atom Stereocenter Count6
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

API Reference Price

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12-Nov-2021
13-Aug-2024
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Argireline Manufacturers

A Argireline manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Argireline, including repackagers and relabelers. The FDA regulates Argireline manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Argireline API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Argireline manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Argireline Suppliers

A Argireline supplier is an individual or a company that provides Argireline active pharmaceutical ingredient (API) or Argireline finished formulations upon request. The Argireline suppliers may include Argireline API manufacturers, exporters, distributors and traders.

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Argireline NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Argireline as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Argireline API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Argireline as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Argireline and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Argireline NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Argireline suppliers with NDC on PharmaCompass.

Argireline GMP

Argireline Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Argireline GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Argireline GMP manufacturer or Argireline GMP API supplier for your needs.

Argireline CoA

A Argireline CoA (Certificate of Analysis) is a formal document that attests to Argireline's compliance with Argireline specifications and serves as a tool for batch-level quality control.

Argireline CoA mostly includes findings from lab analyses of a specific batch. For each Argireline CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Argireline may be tested according to a variety of international standards, such as European Pharmacopoeia (Argireline EP), Argireline JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Argireline USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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