Find ARQ 531 manufacturers, exporters & distributors on PharmaCompass

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Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

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NDC API

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Chemistry

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Also known as: Arq 531, 2095393-15-8, Arq-531, Nemtabrutinib, Jtz51lixn4, Arq531
Molecular Formula
C25H23ClN4O4
Molecular Weight
478.9  g/mol
InChI Key
JSFCZQSJQXFJDS-QAPCUYQASA-N
FDA UNII
JTZ51LIXN4

ARQ 531
Nemtabrutinib is an orally available reversible inhibitor of Bruton's tyrosine kinase (BTK; Bruton agammaglobulinemia tyrosine kinase), with potential antineoplastic activity. Upon administration, nemtabrutinib non-covalently binds to and inhibits the activity of both the wild-type and the C481S mutated form of BTK, a resistance mutation in the BTK active site in which cysteine is substituted for serine at residue 481. This prevents the activation of the B-cell antigen receptor (BCR) signaling pathway and BTK-mediated activation of downstream survival pathways. This leads to an inhibition of the growth of malignant B-cells that overexpress BTK. Compared to other BTK inhibitors, nemtabrutinib does not require interaction with the BTK C481 site and inhibits the proliferation of cells harboring the BTK C481S mutation. BTK, a member of the Src-related BTK/Tec family of cytoplasmic tyrosine kinases, is overexpressed or mutated in B-cell malignancies; it plays an important role in the development, activation, signaling, proliferation and survival of B-lymphocytes.
1 2D Structure

ARQ 531

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2-chloro-4-phenoxyphenyl)-[4-[[(3R,6S)-6-(hydroxymethyl)oxan-3-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]methanone
2.1.2 InChI
InChI=1S/C25H23ClN4O4/c26-21-10-17(34-16-4-2-1-3-5-16)8-9-19(21)23(32)20-11-27-24-22(20)25(29-14-28-24)30-15-6-7-18(12-31)33-13-15/h1-5,8-11,14-15,18,31H,6-7,12-13H2,(H2,27,28,29,30)/t15-,18+/m1/s1
2.1.3 InChI Key
JSFCZQSJQXFJDS-QAPCUYQASA-N
2.1.4 Canonical SMILES
C1CC(OCC1NC2=NC=NC3=C2C(=CN3)C(=O)C4=C(C=C(C=C4)OC5=CC=CC=C5)Cl)CO
2.1.5 Isomeric SMILES
C1C[C@H](OC[C@@H]1NC2=NC=NC3=C2C(=CN3)C(=O)C4=C(C=C(C=C4)OC5=CC=CC=C5)Cl)CO
2.2 Other Identifiers
2.2.1 UNII
JTZ51LIXN4
2.3 Synonyms
2.3.1 MeSH Synonyms

1. (2-chloro-4-phenoxyphenyl)(4-(((3r,6s)-6-(hydroxymethyl)tetrahydro-2h-pyran-3-yl)amino)-7h-pyrrolo(2,3-d)pyrimidin-5-yl)methanone

2. Arq-531

3. Arq531

2.3.2 Depositor-Supplied Synonyms

1. Arq 531

2. 2095393-15-8

3. Arq-531

4. Nemtabrutinib

5. Jtz51lixn4

6. Arq531

7. Mk1026

8. Mk-1026

9. (2-chloro-4-phenoxyphenyl)-[4-[[(3r,6s)-6-(hydroxymethyl)oxan-3-yl]amino]-7h-pyrrolo[2,3-d]pyrimidin-5-yl]methanone

10. (2-chloro-4-phenoxyphenyl)(4-(((3r,6s)-6-(hydroxymethyl)tetrahydro-2h-pyran-3-yl)amino)-7h-pyrrolo(2,3-d)pyrimidin-5-yl)methanone

11. 1,5-anhydro-2-{[5-(2-chloro-4-phenoxybenzene-1-carbonyl)-7h-pyrrolo[2,3-d]pyrimidin-4-yl]amino}-2,3,4-trideoxy-d-erythro-hexitol

12. Arqule 531

13. Unii-jtz51lixn4

14. Nemtabrutinib [inn]

15. Nemtabrutinib [who-dd]

16. Chembl4756476

17. Schembl18756744

18. Schembl18770934

19. Gtpl11413

20. Arq531; Arq 531

21. Bdbm499811

22. Bcp29029

23. Ex-a2727

24. Vid39315

25. Mfcd31692379

26. Nsc830201

27. S8711

28. At10312

29. Ccg-269533

30. Nsc-830201

31. Us11020398, Compound I-123

32. Ac-36883

33. As-79762

34. Hy-112215

35. Cs-0044154

36. (2-chloro-4-phenoxyphenyl)(4-(((3r,6s)-6-(hydroxymethyl)tetrahydro-2h-pyran-3-yl)amino)-3h-pyrrolo[2,3-d]pyrimidin-5-yl)methanone

37. D-erythro-hexitol, 1,5-anhydro-2-((5-(2-chloro-4-phenoxybenzoyl)-7h-pyrrolo(2,3-d)pyrimidin-4-yl)amino)-2,3,4-trideoxy-

38. Hra

2.4 Create Date
2017-08-04
3 Chemical and Physical Properties
Molecular Weight 478.9 g/mol
Molecular Formula C25H23ClN4O4
XLogP34.3
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Exact Mass478.1407829 g/mol
Monoisotopic Mass478.1407829 g/mol
Topological Polar Surface Area109 Ų
Heavy Atom Count34
Formal Charge0
Complexity681
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

ARQ 531 Manufacturers

A ARQ 531 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of ARQ 531, including repackagers and relabelers. The FDA regulates ARQ 531 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. ARQ 531 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

ARQ 531 Suppliers

A ARQ 531 supplier is an individual or a company that provides ARQ 531 active pharmaceutical ingredient (API) or ARQ 531 finished formulations upon request. The ARQ 531 suppliers may include ARQ 531 API manufacturers, exporters, distributors and traders.

ARQ 531 GMP

ARQ 531 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of ARQ 531 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right ARQ 531 GMP manufacturer or ARQ 531 GMP API supplier for your needs.

ARQ 531 CoA

A ARQ 531 CoA (Certificate of Analysis) is a formal document that attests to ARQ 531's compliance with ARQ 531 specifications and serves as a tool for batch-level quality control.

ARQ 531 CoA mostly includes findings from lab analyses of a specific batch. For each ARQ 531 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

ARQ 531 may be tested according to a variety of international standards, such as European Pharmacopoeia (ARQ 531 EP), ARQ 531 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (ARQ 531 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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