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Chemistry

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Also known as: Qinghaosu, 63968-64-9, Huanghuahaosu, Artemisinine, Artemisine, (+)-artemisinin
Molecular Formula
C15H22O5
Molecular Weight
282.33  g/mol
InChI Key
BLUAFEHZUWYNDE-NNWCWBAJSA-N
FDA UNII
9RMU91N5K2

Artemisinin
(+)-artemisinin is a natural product found in Microliabum polymnioides, Artemisia tenuisecta, and other organisms with data available.
1 2D Structure

Artemisinin

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(1R,4S,5R,8S,9R,12S,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-one
2.1.2 InChI
InChI=1S/C15H22O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8-11,13H,4-7H2,1-3H3/t8-,9-,10+,11+,13-,14-,15-/m1/s1
2.1.3 InChI Key
BLUAFEHZUWYNDE-NNWCWBAJSA-N
2.1.4 Canonical SMILES
CC1CCC2C(C(=O)OC3C24C1CCC(O3)(OO4)C)C
2.1.5 Isomeric SMILES
C[C@@H]1CC[C@H]2[C@H](C(=O)O[C@H]3[C@@]24[C@H]1CC[C@](O3)(OO4)C)C
2.2 Other Identifiers
2.2.1 UNII
9RMU91N5K2
2.3 Synonyms
2.3.1 MeSH Synonyms

1. (3r,5as,6r,8as,9r,12s,12ar)-3,6,9-trimethyloctahydro-3,12-epoxypyrano(4,3-j)-1,2-benzodioxepin-10(3h)-one

2. Arteannuin

3. Artemisinine

4. Artemisininum

5. Huanghuahaosu

6. Qing Hao Su

7. Qinghaosu

8. Quing Hau Sau

9. Quinghaosu

2.3.2 Depositor-Supplied Synonyms

1. Qinghaosu

2. 63968-64-9

3. Huanghuahaosu

4. Artemisinine

5. Artemisine

6. (+)-artemisinin

7. Artemisinina

8. Artemisininum

9. Artemisinin [inn]

10. Qing Hau Sau

11. Nsc 369397

12. Chebi:223316

13. Octahydro-3,6,9-trimethyl-3,12-epoxy-12h-pyrano(4,3-j)-1,2-benzodioxepin-10(3h)-one

14. 9rmu91n5k2

15. Qinghosu

16. Quing Hau Sau

17. Astemisinin

18. (1r,4s,5r,8s,9r,12s,13r)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-one

19. (3r,5as,6r,8as,9r,12s,12ar)-3,6,9-trimethyloctahydro-3,12-epoxypyrano[4,3-j][1,2]benzodioxepin-10(3h)-one

20. (3r,5as,6r,8as,9r,12s,12ar)-octahydro-3,6,9-trimethyl-3,12-epoxy-12h-pyrano(4,3-j)-1,2-benzodioxepin-10(3h)-one

21. Qing Hau Su

22. Qinghaosu [chinese]

23. Artemisinine [french]

24. Artemisininum [latin]

25. Artemisinina [spanish]

26. (+)-arteannuin

27. Qing Hau Sau [chinese]

28. Mfcd00081057

29. Artemisia Annua L., Extract

30. (1r,4s,5r,8s,9r,12s,13r)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.0^{4,13}.0^{8,13}]hexadecan-10-one

31. (3r,5as,6r,8as,9r,12s,12ar)-3,6,9-trimethyloctahydro-3,12-epoxypyrano(4,3-j)(1,2)benzodioxepin-10(3h)-one

32. (3r,5as,6r,8as,9r,12s,12ar)-octahydro-3,6,9-trimethyl-3,12-epoxy-12h-pyrano[4,3-j]-1,2-benzodioxepin-10(3h)-one

33. 1,5,9-trimethyl-(1r,4s,5r,9r,12s,13r)-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-one

34. Smr000578089

35. Sr-01000802560

36. Gnf-pf-5341

37. Artemsinin

38. Brn 4194670

39. Unii-9rmu91n5k2

40. Artemesinin

41. Artesin

42. Nsc-369397

43. Qinghaosu,artemisinine

44. Spectrum_001351

45. Artemisinin [mi]

46. Prestwick0_000498

47. Prestwick1_000498

48. Prestwick2_000498

49. Prestwick3_000498

50. Spectrum2_001512

51. Spectrum3_001549

52. Spectrum4_000721

53. Spectrum5_001098

54. Artemisinin [inci]

55. Ec 700-290-5

56. Artemisinin [mart.]

57. Schembl60304

58. Artemisinin [usp-rs]

59. Artemisinin [who-dd]

60. Artemisinin [who-ip]

61. Bspbio_000395

62. Bspbio_002998

63. Kbiogr_000982

64. Kbioss_001831

65. Mls001097650

66. Mls001304036

67. Mls002153846

68. Divk1c_000656

69. Spbio_001583

70. Spbio_002316

71. Bpbio1_000435

72. Chembl269671

73. Gtpl9954

74. Dtxsid2040652

75. Kbio1_000656

76. Kbio2_001831

77. Kbio2_004399

78. Kbio2_006967

79. Kbio3_002498

80. Ninds_000656

81. Hms2090i17

82. Hms2096d17

83. Hms2267n09

84. Hms3269l13

85. Hms3413p13

86. Hms3677p13

87. Hms3713d17

88. Pharmakon1600-01503042

89. 3,12-epoxy-12h-pyrano[4,3-j]-1,2-benzodioxepin-10(3h)-one, Octahydro-3,6,9-trimethyl-, (3r,5as,6r,8as,9r,12s,12ar)-

90. Bcp02096

91. Hy-b0094

92. Zinc8143788

93. Artemisininum [who-ip Latin]

94. Bdbm50088447

95. Nsc758216

96. Akos024457231

97. Ccg-220498

98. Cs-1794

99. Db13132

100. Lmpr0103190003

101. Nsc-758216

102. Idi1_000656

103. (3r,5as,6r,8as,9r,12s,12ar)-3,6,9-trimethyloctahydro-12h-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3h)-one

104. 3,12-epoxy-12h-pyranol(4,3-j)-1,2-benzodioxepin-10(3h)-one, Octahydro-3,6,9-trimethyl-, (3-alpha,5a-beta,6-beta,8a-beta,9-alpha,12-beta,12ar*)-(+)-

105. As-12692

106. S1282

107. 968a649

108. Q426921

109. Sr-01000802560-2

110. Sr-01000802560-3

111. Sr-01000802560-4

112. Brd-k13112821-001-08-3

113. Brd-k13112821-001-17-4

114. 2ab44f63-5d0f-424a-aa3f-24062f9c1ced

115. (3r,5as,6r,8as,9r,12s,12ar)-3,6,9-trimethyloctahydro-3,12-epoxypyrano(4,3-j )-1,2-benzodioxepin-10(3h)-one

116. (3r,5as,6r,8as,9r,12s,12ar)-3,6,9-trimethyloctahydro-3h-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(12h)-one

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 282.33 g/mol
Molecular Formula C15H22O5
XLogP32.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count0
Exact Mass282.14672380 g/mol
Monoisotopic Mass282.14672380 g/mol
Topological Polar Surface Area54 Ų
Heavy Atom Count20
Formal Charge0
Complexity452
Isotope Atom Count0
Defined Atom Stereocenter Count7
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Anti-Infective Agents

Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection. (See all compounds classified as Anti-Infective Agents.)


4.2 ATC Code

P - Antiparasitic products, insecticides and repellents

P01 - Antiprotozoals

P01B - Antimalarials

P01BE - Artemisinin and derivatives, plain

P01BE01 - Artemisinin


API Reference Price

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ART563 I) (DUAL USE NOC NO- NOC\/AZ\/2024\/002982 DT.08.10.2024)","address":"A-3,SHIVSAGAR ESTATE(NORTH WING),","city":"WORLI,MUMBAI MAHARASHTRA","supplier":"BIONEXX S.A.","supplierCountry":"MADAGASCAR","foreign_port":"TAMATAVE (TOAMASINA)","customer":"SKANT HEALTHCARE LTD.","customerCountry":"INDIA","quantity":"270.00","actualQuantity":"270","unit":"KGS","unitRateFc":"130","totalValueFC":"35485.7","currency":"USD","unitRateINR":"11043.5","date":"23-Oct-2024","totalValueINR":"2981745","totalValueInUsd":"35485.7","indian_port":"JNPT","hs_no":"29420090","bill_no":"6297061","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"MADAGASCAR","selfForZScoreResived":"Pharma Grade","supplierPort":"TAMATAVE (TOAMASINA)","supplierAddress":"PARCELLE NO.34(INJET BUILDING 2ND F LOOR),LOTISSEMENT TANA WATER FRONT AMBODIVONA, 101 ANTANANARIVO, Madagascar","customerAddress":"A-3,SHIVSAGAR ESTATE(NORTH WING),"}]
02-Jan-2021
28-Oct-2024
KGS
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Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

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Drugs in Development

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Details:

OT-101 (trabedersen) has completed seven clinical trials including one phase 2 trial in COVID and two phase 2 trials in brain cancer and against pancreatic cancer. It has pediatric designation for a rare form of pediatric brain cancer known as DIPG.


Lead Product(s): Trabedersen,Artemisinin

Therapeutic Area: Infections and Infectious Diseases Brand Name: OT-101

Study Phase: Phase IIProduct Type: Large molecule

Sponsor: BARDA

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Funding October 12, 2022

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Compamed
Not Confirmed
Compamed
Not Confirmed

Details : OT-101 (trabedersen) has completed seven clinical trials including one phase 2 trial in COVID and two phase 2 trials in brain cancer and against pancreatic cancer. It has pediatric designation for a rare form of pediatric brain cancer known as DIPG.

Brand Name : OT-101

Molecule Type : Large molecule

Upfront Cash : Undisclosed

October 12, 2022

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Details:

Through this partnership, and through HempStreet’s extensive distribution reach and key institutional partnerships, Indian patients will now have access to these medicines, starting with CimetrA (Artemisinin), which had an immediate need.


Lead Product(s): Artemisinin,Curcumin,Boswellia Serrata

Therapeutic Area: Infections and Infectious Diseases Brand Name: CimetrA

Study Phase: Phase IIIProduct Type: Small molecule

Sponsor: MGC Pharmaceuticals

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Partnership May 07, 2022

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02

Hempstreet

India
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Compamed
Not Confirmed

Hempstreet

India
arrow
Compamed
Not Confirmed

Details : Through this partnership, and through HempStreet’s extensive distribution reach and key institutional partnerships, Indian patients will now have access to these medicines, starting with CimetrA (Artemisinin), which had an immediate need.

Brand Name : CimetrA

Molecule Type : Small molecule

Upfront Cash : Undisclosed

May 07, 2022

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Details:

The study includes 150 adult patients with a confirmed SARS-CoV-2 infection, at least 4 weeks of long-COVID symptoms, and a Post Covid Functional Score (PCFS) between one and four. ArtemiC Support is administered orally, in a dosage of 5 drops three times daily for 6 weeks.


Lead Product(s): Artemisinin,Curcumin,Frankincense

Therapeutic Area: Infections and Infectious Diseases Brand Name: ArtemiC

Study Phase: Phase IIProduct Type: Small molecule

Sponsor: MGC Pharmaceuticals

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable December 21, 2021

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03

Swiss PharmaCan

Switzerland
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Compamed
Not Confirmed

Swiss PharmaCan

Switzerland
arrow
Compamed
Not Confirmed

Details : The study includes 150 adult patients with a confirmed SARS-CoV-2 infection, at least 4 weeks of long-COVID symptoms, and a Post Covid Functional Score (PCFS) between one and four. ArtemiC Support is administered orally, in a dosage of 5 drops three time...

Brand Name : ArtemiC

Molecule Type : Small molecule

Upfront Cash : Not Applicable

December 21, 2021

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Details:

PulmoHeal/ ArtiVeda has proven active against COVID-19 in ARTI-19 clinical trial (A Prospective, Randomized, Multi-center, Open label, Interventional Study to Evaluate the Safety and Efficacy of Artemisinin 500 mg capsule in Treatment of Adult Subjects with COVID-19).


Lead Product(s): Artemisinin

Therapeutic Area: Infections and Infectious Diseases Brand Name: PulmoHeal

Study Phase: Phase IVProduct Type: Small molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable August 24, 2021

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04

Compamed
Not Confirmed
Compamed
Not Confirmed

Details : PulmoHeal/ ArtiVeda has proven active against COVID-19 in ARTI-19 clinical trial (A Prospective, Randomized, Multi-center, Open label, Interventional Study to Evaluate the Safety and Efficacy of Artemisinin 500 mg capsule in Treatment of Adult Subjects w...

Brand Name : PulmoHeal

Molecule Type : Small molecule

Upfront Cash : Not Applicable

August 24, 2021

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Details:

Manus Bio has received a third funding award from the Bill & Melinda Gates Foundation to accelerate the development of a scalable and cost-effective production method for artemisinin, a key therapeutic for treating malaria.


Lead Product(s): Artemisinin

Therapeutic Area: Infections and Infectious Diseases Brand Name: Undisclosed

Study Phase: ApprovedProduct Type: Small molecule

Sponsor: Bill & Melinda Gates Foundation

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Funding April 01, 2021

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05

Manus Bio

U.S.A
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Compamed
Not Confirmed

Manus Bio

U.S.A
arrow
Compamed
Not Confirmed

Details : Manus Bio has received a third funding award from the Bill & Melinda Gates Foundation to accelerate the development of a scalable and cost-effective production method for artemisinin, a key therapeutic for treating malaria.

Brand Name : Undisclosed

Molecule Type : Small molecule

Upfront Cash : Undisclosed

April 01, 2021

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Details:

Mateon has completed the enrollment of its sentinel Part 1 and Part 2 COVID-19 patients which allows for the continuing expansion to the targeted 18 patients in part 1 and 18 patients in part 2. OT-101 is an antisense against the host TGF-β protein.


Lead Product(s): Trabedersen,Artemisinin

Therapeutic Area: Infections and Infectious Diseases Brand Name: OT-101

Study Phase: Phase IIProduct Type: Large molecule

Sponsor: Oncotelic

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable March 08, 2021

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Compamed
Not Confirmed
Compamed
Not Confirmed

Details : Mateon has completed the enrollment of its sentinel Part 1 and Part 2 COVID-19 patients which allows for the continuing expansion to the targeted 18 patients in part 1 and 18 patients in part 2. OT-101 is an antisense against the host TGF-β protein.

Brand Name : OT-101

Molecule Type : Large molecule

Upfront Cash : Not Applicable

March 08, 2021

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Details:

The Malta facility will create a European manufacturing hub for ArtemiCTM with the ability to scale production to meet expected growing demand following positive clinical trial results.


Lead Product(s): Artemisinin,Curcumin,Boswellia Serrata

Therapeutic Area: Infections and Infectious Diseases Brand Name: ArtemiC

Study Phase: Phase IIProduct Type: Small molecule

Sponsor: Malta Enerprises

Deal Size: $3.7 million Upfront Cash: $3.7 million

Deal Type: Funding December 22, 2020

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Compamed
Not Confirmed
Compamed
Not Confirmed

Details : The Malta facility will create a European manufacturing hub for ArtemiCTM with the ability to scale production to meet expected growing demand following positive clinical trial results.

Brand Name : ArtemiC

Molecule Type : Small molecule

Upfront Cash : $3.7 million

December 22, 2020

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Details:

Interim Results reported to date demonstrate ArtemiCTM has met all primary end points for safety and efficacy, and FDA primary endpoint of sustained clinical recovery of COVID-19 patients.


Lead Product(s): Artemisinin,Curcumin,Frankincense

Therapeutic Area: Infections and Infectious Diseases Brand Name: ArtemiC

Study Phase: Phase IIProduct Type: Small molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable December 07, 2020

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08

Compamed
Not Confirmed
Compamed
Not Confirmed

Details : Interim Results reported to date demonstrate ArtemiCTM has met all primary end points for safety and efficacy, and FDA primary endpoint of sustained clinical recovery of COVID-19 patients.

Brand Name : ArtemiC

Molecule Type : Small molecule

Upfront Cash : Not Applicable

December 07, 2020

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Details:

The trial is assessing the safety and efficacy of the natural anti-inflammatory formulation ArtemiCTM, a natural supplement formula based on Artemisinin and Curcumin (along with supporting ingredients Vitamin C and Boswellia serrata) on COVID-19 Patients.


Lead Product(s): Artemisinin,Curcumin,Frankincense

Therapeutic Area: Infections and Infectious Diseases Brand Name: ArtemiC

Study Phase: Phase IIProduct Type: Small molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable September 28, 2020

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09

Compamed
Not Confirmed
Compamed
Not Confirmed

Details : The trial is assessing the safety and efficacy of the natural anti-inflammatory formulation ArtemiCTM, a natural supplement formula based on Artemisinin and Curcumin (along with supporting ingredients Vitamin C and Boswellia serrata) on COVID-19 Patients...

Brand Name : ArtemiC

Molecule Type : Small molecule

Upfront Cash : Not Applicable

September 28, 2020

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  • Deals

Details:

ARTI19 is designed to rapidly establish the clinical efficacy of Artemisinin in mild and moderate COVID-19 patients. In-vitro, the medical grade version of the supplement has proven potency and safety similar to Remdesivir with an EC50 = 0.45 ug/ml and Safety Index = 140.


Lead Product(s): Artemisinin

Therapeutic Area: Infections and Infectious Diseases Brand Name: Undisclosed

Study Phase: PreclinicalProduct Type: Small molecule

Sponsor: Mateon Therapeutics

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Partnership July 20, 2020

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10

Asili Research Alliance

Country
arrow
Compamed
Not Confirmed

Asili Research Alliance

Country
arrow
Compamed
Not Confirmed

Details : ARTI19 is designed to rapidly establish the clinical efficacy of Artemisinin in mild and moderate COVID-19 patients. In-vitro, the medical grade version of the supplement has proven potency and safety similar to Remdesivir with an EC50 = 0.45 ug/ml and S...

Brand Name : Undisclosed

Molecule Type : Small molecule

Upfront Cash : Undisclosed

July 20, 2020

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INTERMEDIATES SUPPLIERS

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The Pharmacy Technology
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The Pharmacy Technology
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CAS Number :

End Use API : Artemisinin

About The Company : Manufacturers and Exporters of speciality fine chemicals, speciality solvents, Pharma Intermediates, Agro Intermediates, Cosmetic ingredients and nutraceutical ...

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