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    Also known as: 23964-57-0, Articaine hcl, Carticaine hydrochloride, Ultracaine, Ultracain, Septanest
    Molecular Formula
    C13H21ClN2O3S
    Molecular Weight
    320.84  g/mol
    InChI Key
    GDWDBGSWGNEMGJ-UHFFFAOYSA-N
    FDA UNII
    QS9014Q792
    Articaine Hydrochloride
    A thiophene-containing local anesthetic pharmacologically similar to MEPIVACAINE.
    1 2D Structure

    Articaine Hydrochloride

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    methyl 4-methyl-3-[2-(propylamino)propanoylamino]thiophene-2-carboxylate;hydrochloride
    2.1.2 InChI
    InChI=1S/C13H20N2O3S.ClH/c1-5-6-14-9(3)12(16)15-10-8(2)7-19-11(10)13(17)18-4;/h7,9,14H,5-6H2,1-4H3,(H,15,16);1H
    2.1.3 InChI Key
    GDWDBGSWGNEMGJ-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CCCNC(C)C(=O)NC1=C(SC=C1C)C(=O)OC.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    QS9014Q792
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Articain

    2. Articaine

    3. Carticain

    4. Carticaine

    5. Carticaine Hydrochloride

    6. Hoe 045

    7. Hoe 40045

    8. Hoe-045

    9. Hoe-40045

    10. Hoe045

    11. Hoe40045

    12. Hydrochloride, Carticaine

    13. Ultracaine

    2.3.2 Depositor-Supplied Synonyms

    1. 23964-57-0

    2. Articaine Hcl

    3. Carticaine Hydrochloride

    4. Ultracaine

    5. Ultracain

    6. Septanest

    7. Hoe-045

    8. Articaine (hydrochloride)

    9. Hoe 045

    10. Hoe 40045

    11. Ubistesine

    12. Hoe-40045

    13. Carticaine Chlorhydrate

    14. Hoe-045 (free Base)

    15. 161448-79-9

    16. Mfcd00190157

    17. Methyl 4-methyl-3-[2-(propylamino)propanoylamino]thiophene-2-carboxylate Hydrochloride

    18. Methyl 4-methyl-3-[2-(propylamino)propanoylamino]thiophene-2-carboxylate;hydrochloride

    19. Qs9014q792

    20. Dsstox_cid_25444

    21. Dsstox_rid_80885

    22. Methyl 4-methyl-3-(2-(propylamino)propionamido)-2-thiophenecarboxylate, Monohydrochloride

    23. Dsstox_gsid_45444

    24. 2-thiophenecarboxylic Acid, 4-methyl-3-((1-oxo-2-(propylamino)propyl)amino)-, Methyl Ester, Monohydrochloride

    25. 2-thiophenecarboxylic Acid, 4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-, Methyl Ester, Monohydrochloride, (+)-

    26. 4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic Acid Methyl Ester Hydrochloride

    27. Articaine Hydrochloride [usan]

    28. Einecs 245-957-7

    29. Unii-qs9014q792

    30. Articaine Hydrochloride [usan:usp]

    31. Articain Hydrochloride

    32. Aarticaine Hydrochloride

    33. Ncgc00016784-01

    34. Cas-23964-57-0

    35. 4-methyl-3-(2-(propylamino)propionamido)-2-thiophenecarboxylic Acid Methyl Ester Hcl

    36. Methyl 4-methyl-3-(2-propylaminopropanoylamino)thiophene-2-carboxylate Hydrochloride

    37. Mls002154112

    38. Schembl329749

    39. Amy495

    40. Chembl1200819

    41. Dtxsid2045444

    42. Hms1571o05

    43. Articaine Hydrochloride (jan/usp)

    44. Bcp11709

    45. Hy-b0516

    46. Tox21_110609

    47. Articaine Hydrochloride [jan]

    48. S3150

    49. Akos005267121

    50. Methyl 4-methyl-3-[(n-propylalanyl)amino]-2-thiophenecarboxylate Hydrochloride

    51. Tox21_110609_1

    52. (+/-)-articaine Hydrochloride

    53. Ac-1918

    54. Articaine Hydrochloride [mart.]

    55. Ccg-221032

    56. H64a581

    57. Ks-1404

    58. Articaine Hydrochloride [usp-rs]

    59. Articaine Hydrochloride [who-dd]

    60. Methyl 4-methyl-3-((1-oxo-2-(propylamino)propyl)amino)-2-thenoate Monohydrochloride

    61. Ncgc00179248-03

    62. 2-thiophenecarboxylic Acid, 4-methyl-3-(2-(propylamino)propionamido)-, Methyl Ester, Monohydrochloride

    63. Articaine Hydrochloride, >=98% (hplc)

    64. Smr001233419

    65. Sy110879

    66. Articaine Hydrochloride [ep Impurity]

    67. Articaine Hydrochloride [orange Book]

    68. Ft-0621704

    69. Sw196388-3

    70. Articaine Hydrochloride [ep Monograph]

    71. Articaine Hydrochloride [usp Impurity]

    72. Articaine Hydrochloride [usp Monograph]

    73. C74233

    74. D02991

    75. A924169

    76. Sr-01000841204

    77. Q-200653

    78. Sr-01000841204-2

    79. Q27287472

    80. Articaine Hydrochloride, European Pharmacopoeia (ep) Reference Standard

    81. Articaine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

    82. Articaine Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

    83. Methyl 4-methyl-3-(2-(propylamino)propanamido)thiophene-2-carboxylate Hydrochloride

    84. 2-thiophenecarboxylic Acid, 4-methyl-3-((1-oxo-2-(propylamino)propyl)amino)-, Methyl Ester, Hydrochloride (1:1)

    85. Methyl 4-methyl-3-(((2rs)-2-(propylamino)propanoyl)amino)thiophene-2-carboxylate Hydrochloride

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 320.84 g/mol
    Molecular Formula C13H21ClN2O3S
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count5
    Rotatable Bond Count7
    Exact Mass320.0961414 g/mol
    Monoisotopic Mass320.0961414 g/mol
    Topological Polar Surface Area95.7 Ų
    Heavy Atom Count20
    Formal Charge0
    Complexity325
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Anesthetics, Local

    Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate. (See all compounds classified as Anesthetics, Local.)

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    18-Jan-2021
    21-Nov-2024
    KGS
    overview
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    Average Price (USD/KGS)

    Number of Transactions

    Total Quantity (KGS)

    Total Value (USD)

    Quantity (KGS) & Unit rate (USD/KGS) over time

    API Imports and Exports

    Importing Country Total Quantity
    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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    Europe

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    01

    GALENICA SENESE Srl

    Morocco
    CPHI Middle east
    Not Confirmed
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    GALENICA SENESE Srl

    Morocco
    arrow
    CPHI Middle east
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
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    Flag Morocco
    Virtual Booth Virtual Booth
    Digital Content Digital Content

    Regulatory Info :

    Registration Country : Italy

    ARTICAINE HYDROCHLORIDE; Adrenaline Bitartrate

    Brand Name : Sarticain

    Dosage Form :

    Dosage Strength : 10 Vials 20 Ml With Adrenaline 1:100,000  

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Italy

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    Portfolio PDF

    Product Web Link

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    Corporate PDF

    02

    GALENICA SENESE Srl

    Morocco
    CPHI Middle east
    Not Confirmed
    arrow

    GALENICA SENESE Srl

    Morocco
    arrow
    CPHI Middle east
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
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    Flag Morocco
    Virtual Booth Virtual Booth
    Digital Content Digital Content

    Regulatory Info :

    Registration Country : Italy

    ARTICAINE HYDROCHLORIDE; Adrenaline Bitartrate

    Brand Name : Sarticain

    Dosage Form :

    Dosage Strength : 10 Vials 20 Ml With Adrenaline 1:200,000  

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Italy

    blank

    Portfolio PDF

    Product Web Link

    Virtual Booth

    Digital Content

    Website

    Corporate PDF

    03

    GALENICA SENESE Srl

    Morocco
    CPHI Middle east
    Not Confirmed
    arrow

    GALENICA SENESE Srl

    Morocco
    arrow
    CPHI Middle east
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
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    Flag Morocco
    Virtual Booth Virtual Booth
    Digital Content Digital Content

    Regulatory Info :

    Registration Country : Italy

    ARTICAINE HYDROCHLORIDE; Adrenaline Bitartrate

    Brand Name : Sarticain

    Dosage Form :

    Dosage Strength : 60 Tubofiale 1.7 Ml With Adrenaline 1:200,000  

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Italy

    blank

    Portfolio PDF

    Product Web Link

    Virtual Booth

    Digital Content

    Website

    Corporate PDF

    04

    GALENICA SENESE Srl

    Morocco
    CPHI Middle east
    Not Confirmed
    arrow

    GALENICA SENESE Srl

    Morocco
    arrow
    CPHI Middle east
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.
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    Flag Morocco
    Virtual Booth Virtual Booth
    Digital Content Digital Content

    Regulatory Info :

    Registration Country : Italy

    ARTICAINE HYDROCHLORIDE; Adrenaline Bitartrate

    Brand Name : Sarticain

    Dosage Form :

    Dosage Strength : 60 Tubofiale 1.7 Ml With Adrenaline 1:100,000  

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Italy

    blank

    Portfolio PDF

    Product Web Link

    Virtual Booth

    Digital Content

    Website

    Corporate PDF

    05

    Septodont

    U.S.A
    CPHI Middle east
    Not Confirmed
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    Septodont

    U.S.A
    arrow
    CPHI Middle east
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
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    Flag U.S.A
    Virtual Booth Virtual Booth
    Digital Content Digital Content

    Regulatory Info :

    Registration Country : Norway

    Artikainhydrochloride; Adrenalintratrait

    Brand Name : Septocaine

    Dosage Form : Solution for injection

    Dosage Strength : 40 mg/ml/5 microg/ml

    Packaging : Glass cylinders 50 1.7ml

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Norway

    blank

    Portfolio PDF

    Product Web Link

    Virtual Booth

    Digital Content

    Website

    Corporate PDF

    06

    Septodont

    U.S.A
    CPHI Middle east
    Not Confirmed
    arrow

    Septodont

    U.S.A
    arrow
    CPHI Middle east
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
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    Flag U.S.A
    Virtual Booth Virtual Booth
    Digital Content Digital Content

    Regulatory Info :

    Registration Country : Norway

    Artikainhydrochloride; Adrenalintratrait

    Brand Name : Septocaine Forte

    Dosage Form : Solution for injection

    Dosage Strength : 40 mg/ml/10 microg/ml

    Packaging : Glass cylinders 50 1.7ml

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Norway

    blank

    Portfolio PDF

    Product Web Link

    Virtual Booth

    Digital Content

    Website

    Corporate PDF

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    South Africa

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    01

    3M South Africa (Pty) Ltd

    U.S.A
    CPHI Middle east
    Not Confirmed
    arrow

    3M South Africa (Pty) Ltd

    U.S.A
    arrow
    CPHI Middle east
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
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    Flag U.S.A
    Virtual Booth Virtual Booth
    Digital Content Digital Content

    Regulatory Info : Originator

    Registration Country : South Africa

    Articaine hydrochloride

    Brand Name : Ubistesin

    Dosage Form : INJ

    Dosage Strength : 40mg/ml

    Packaging : 50X1mg/ml

    Approval Date :

    Application Number :

    Regulatory Info : Originator

    Registration Country : South Africa

    blank

    Portfolio PDF

    Product Web Link

    Virtual Booth

    Digital Content

    Website

    Corporate PDF

    02

    3M South Africa (Pty) Ltd

    U.S.A
    CPHI Middle east
    Not Confirmed
    arrow

    3M South Africa (Pty) Ltd

    U.S.A
    arrow
    CPHI Middle east
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.
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    Flag U.S.A
    Virtual Booth Virtual Booth
    Digital Content Digital Content

    Regulatory Info : Originator

    Registration Country : South Africa

    Articaine hydrochloride

    Brand Name : Ubistesin Forte

    Dosage Form : INJ

    Dosage Strength : 40mg/ml

    Packaging : 50X1mg/ml

    Approval Date :

    Application Number :

    Regulatory Info : Originator

    Registration Country : South Africa

    blank

    Portfolio PDF

    Product Web Link

    Virtual Booth

    Digital Content

    Website

    Corporate PDF

    03

    Henry Schein Dental Warehouse (Pty) Ltd

    South Africa
    CPHI Middle east
    Not Confirmed
    arrow

    Henry Schein Dental Warehouse (Pty) Ltd

    South Africa
    arrow
    CPHI Middle east
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.
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    Flag South Africa
    Virtual Booth Virtual Booth
    Digital Content Digital Content

    Regulatory Info : Generic

    Registration Country : South Africa

    Articaine hydrochloride

    Brand Name : Septanest with Adrenaline 1/100,000

    Dosage Form : INJ

    Dosage Strength : 68mg/1.7ml

    Packaging : 1.7X50mg/1.7ml

    Approval Date :

    Application Number :

    Regulatory Info : Generic

    Registration Country : South Africa

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    DRUG PRODUCT COMPOSITIONS

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    DOSAGE - INJECTABLE;INJECTION - 4%; EQ 0.0085...DOSAGE - INJECTABLE;INJECTION - 4%; EQ 0.0085MG BASE/1.7ML (4%; EQ 0.005MG BASE/ML)

    USFDA APPLICATION NUMBER - 20971

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    DOSAGE - INJECTABLE;INJECTION - 4%;EQ 0.017MG...DOSAGE - INJECTABLE;INJECTION - 4%;EQ 0.017MG BASE/1.7ML (4%;EQ 0.01MG BASE/ML)

    USFDA APPLICATION NUMBER - 20971

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