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Chemistry

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Also known as: 96301-34-7, Atamestane [inn], 1-methylandrosta-1,4-diene-3,17-dione, Sh-489, 62ga3k28b6, Atamestanum [latin]
Molecular Formula
C20H26O2
Molecular Weight
298.4  g/mol
InChI Key
PEPMWUSGRKINHX-TXTPUJOMSA-N
FDA UNII
62GA3K28B6

Atamestane
Atamestane is a synthetic steroidal substance with antineoplastic activity. Atamestane binds irreversibly to and inhibits the enzyme aromatase, thereby blocking the conversion of cholesterol to pregnenolone and the peripheral aromatization of androgenic precursors into estrogens. (NCI04)
1 2D Structure

Atamestane

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(8R,9S,10S,13S,14S)-1,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3,17-dione
2.1.2 InChI
InChI=1S/C20H26O2/c1-12-10-14(21)11-13-4-5-15-16-6-7-18(22)19(16,2)9-8-17(15)20(12,13)3/h10-11,15-17H,4-9H2,1-3H3/t15-,16-,17-,19-,20-/m0/s1
2.1.3 InChI Key
PEPMWUSGRKINHX-TXTPUJOMSA-N
2.1.4 Canonical SMILES
CC1=CC(=O)C=C2C1(C3CCC4(C(C3CC2)CCC4=O)C)C
2.1.5 Isomeric SMILES
CC1=CC(=O)C=C2[C@]1([C@H]3CC[C@]4([C@H]([C@@H]3CC2)CCC4=O)C)C
2.2 Other Identifiers
2.2.1 UNII
62GA3K28B6
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 1-methyl-1,4-androstadiene-3,17-dione

2. Sh 489

3. Sh-489

4. Sh489

2.3.2 Depositor-Supplied Synonyms

1. 96301-34-7

2. Atamestane [inn]

3. 1-methylandrosta-1,4-diene-3,17-dione

4. Sh-489

5. 62ga3k28b6

6. Atamestanum [latin]

7. Atamestano [spanish]

8. Atamestano

9. Atamestanum

10. (8r,9s,10s,13s,14s)-1,10,13-trimethyl-7,8,9,10,11,12,13,14,15,16-decahydro-3h-cyclopenta[a]phenanthrene-3,17(6h)-dione

11. Ccris 6528

12. Unii-62ga3k28b6

13. Biomed-777

14. 1-methyl-1,4-androstadiene-3,17-dione

15. Androsta-1,4-diene-3,17-dione, 1-methyl-

16. Atamestane [who-dd]

17. Schembl59128

18. Chembl2105987

19. Dtxsid30869268

20. Zinc4214890

21. Db12194

22. (8r,9s,10s,13s,14s)-1,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6h-cyclopenta[a]phenanthrene-3,17-dione

23. 1-methyl-androsta-1,4-diene-3,17-dione

24. 1-methyl-androsta-1,4 -diene-3,17-dione

25. Q4812727

2.4 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 298.4 g/mol
Molecular Formula C20H26O2
XLogP32.9
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count0
Exact Mass298.193280068 g/mol
Monoisotopic Mass298.193280068 g/mol
Topological Polar Surface Area34.1 Ų
Heavy Atom Count22
Formal Charge0
Complexity626
Isotope Atom Count0
Defined Atom Stereocenter Count5
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Enzyme Inhibitors

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)


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