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Chemistry

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Also known as: 229975-97-7, Reyataz, Atazanavir sulphate, Bms-232632-05, Atazanavir (sulfate), Atazanavir sulfate [usan]
Molecular Formula
C38H54N6O11S
Molecular Weight
802.9  g/mol
InChI Key
DQSGVVGOPRWTKI-QVFAWCHISA-N
FDA UNII
4MT4VIE29P

Atazanavir Sulfate
An azapeptide and HIV-PROTEASE INHIBITOR that is used in the treatment of HIV INFECTIONS and AIDS in combination with other ANTI-HIV AGENTS.
1 2D Structure

Atazanavir Sulfate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
methyl N-[(2S)-1-[2-[(2S,3S)-2-hydroxy-3-[[(2S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoyl]amino]-4-phenylbutyl]-2-[(4-pyridin-2-ylphenyl)methyl]hydrazinyl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate;sulfuric acid
2.1.2 InChI
InChI=1S/C38H52N6O7.H2O4S/c1-37(2,3)31(41-35(48)50-7)33(46)40-29(22-25-14-10-9-11-15-25)30(45)24-44(43-34(47)32(38(4,5)6)42-36(49)51-8)23-26-17-19-27(20-18-26)28-16-12-13-21-39-28;1-5(2,3)4/h9-21,29-32,45H,22-24H2,1-8H3,(H,40,46)(H,41,48)(H,42,49)(H,43,47);(H2,1,2,3,4)/t29-,30-,31+,32+;/m0./s1
2.1.3 InChI Key
DQSGVVGOPRWTKI-QVFAWCHISA-N
2.1.4 Canonical SMILES
CC(C)(C)C(C(=O)NC(CC1=CC=CC=C1)C(CN(CC2=CC=C(C=C2)C3=CC=CC=N3)NC(=O)C(C(C)(C)C)NC(=O)OC)O)NC(=O)OC.OS(=O)(=O)O
2.1.5 Isomeric SMILES
CC(C)(C)[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)[C@H](CN(CC2=CC=C(C=C2)C3=CC=CC=N3)NC(=O)[C@H](C(C)(C)C)NC(=O)OC)O)NC(=O)OC.OS(=O)(=O)O
2.2 Other Identifiers
2.2.1 UNII
4MT4VIE29P
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 232632, Bms

2. 3,12-bis(1,1-dimethylethyl)-8-hydroxy-4,11-dioxo-9-(phenylmethyl)-6-((4-(2-pyridinyl)phenyl)methyl)-2,5,6,10,13-pentaazatetradecanedioic Acid Dimethyl Ester

3. Atazanavir

4. Bms 232632

5. Bms 232632 05

6. Bms-232632

7. Bms-232632-05

8. Bms232632

9. Bms23263205

10. Cgp 73547

11. Cgp 75136

12. Cgp 75176

13. Cgp 75355

14. Cgp-73547

15. Cgp-75136

16. Cgp-75176

17. Cgp-75355

18. Cgp73547

19. Cgp75136

20. Cgp75176

21. Cgp75355

22. Reyataz

2.3.2 Depositor-Supplied Synonyms

1. 229975-97-7

2. Reyataz

3. Atazanavir Sulphate

4. Bms-232632-05

5. Atazanavir (sulfate)

6. Atazanavir Sulfate [usan]

7. Atazor

8. Atazanavir So4

9. 4mt4vie29p

10. Atazanavir Sulfate (bms-232632-05)

11. 229975-97-7 (sulfate)

12. Nsc-742546

13. 2,5,6,10,13-pentaazatetradecanedioic Acid, 3,12-bis(1,1-dimethylethyl)-8-hydroxy-4,11-dioxo-9-(phenylmethyl)-6-((4-(2-pyridinyl)phenyl)methyl)-, Dimethyl Ester, (3s,8s,9s,12s)-, Sulfate (1:1) (salt)

14. Reyataz (tn)

15. 2,5,6,10,13-pentaazatetradecanedioic Acid, 3-12-bis(1,1-dimethylethyl)-8-hydroxy-4,11-dioxo-9-(phenylmethyl)-6-((-4-(2-pyridinyl)phenyl)methyl)-, Dimethyl Ester, (3s,8s,9s,12s)-, Sulfate (1:1) (salt)

16. Dimethyl (3s,8s,9s,12s)-9-benzyl-3,12,di-tert-butyl-8-hydroxy-4,11-dioxo-6-(p-2-pyridylbenzyl)-2,5,6,10,13-pentaazatetradecanedioate, Sulfate (1:1) (salt)

17. Chebi:31243

18. Smr002544693

19. Atazanavir Bisulfate Salt

20. Unii-4mt4vie29p

21. Ulfuric Acid

22. Atazanaviri Sulfas

23. Mls003915641

24. Mls006010199

25. Schembl341700

26. Atazanavir So4 [vandf]

27. Atazanavir Sulfate [mi]

28. Atazanavir Sulfate (jan/usan)

29. Atazanavir Sulfate [jan]

30. Chembl1200678

31. Bms-232632-05, Reyataz

32. Dtxsid401017206

33. Atazanavir Sulfate [mart.]

34. Amy36999

35. Atazanavir Sulfate [usp-rs]

36. Atazanavir Sulfate [who-dd]

37. Atazanavir Sulfate [who-ip]

38. Ex-a4010

39. Methyl N-[(2s)-1-[2-[(2s,3s)-2-hydroxy-3-[[(2s)-2-(methoxycarbonylamino)-3,3-dimethylbutanoyl]amino]-4-phenylbutyl]-2-[(4-pyridin-2-ylphenyl)methyl]hydrazinyl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate;sulfuric Acid

40. Hy-17367a

41. Mfcd08067748

42. S1457

43. Akos016000176

44. Atazanavir Sulphate [ema Epar]

45. Ccg-270493

46. Cs-1890

47. Nsc 742546

48. Atazanavir Sulfate [orange Book]

49. Atazanavir Sulfate [ep Monograph]

50. As-14954

51. Atazanaviri Sulfas [who-ip Latin]

52. Evotaz Component Atazanavir Sulfate

53. Methyl ((5s,10s,11s,14s)-11-benzyl-5-(tert-butyl)-10-hydroxy-15,15-dimethyl-3,6,13-trioxo-8-(4-(pyridin-2-yl)benzyl)-2-oxa-4,7,8,12-tetraazahexadecan-14-yl)carbamate Sulfate

54. Atazanavir Sulfate Component Of Evotaz

55. Sw220258-1

56. D01276

57. 975a977

58. A816475

59. J-014934

60. 3-amino-3-(3-benzyloxy-phenyl)-propionicacid

61. Q27114238

62. 2,5,6,10,13-pentaazatetradecanedioic Acid, 3-12-bis(1,1-dimethylethyl)-8-hydroxy-4,11-dioxo-9-(phenylmethyl)-6-((-4-(2-pyridinyl)phenyl)methyl)-, Dimethyl Ester, (3s,8s,9s,12s)-, Sulphate (1:1) (salt)

63. Dimethyl (3s,8s,9s,12s)-9-benzyl-3,12,di-tert-butyl-8-hydroxy-4,11-dioxo-6-(p-2-pyridylbenzyl)-2,5,6,10,13-pentaazatetradecanedioate, Sulphate (1:1) (salt)

64. Dimethyl (3s,8s,9s,12s)-9-benzyl-3,12-di-tert-butyl-8-hydroxy-4,11-dioxo-6-((4-(pyridin-2-yl)phenyl)methyl)-2,5,6,10,13-pentaazatetradecanedioate Monosulfate

65. Methyl N-[(1s)-1-[[(1s,2s)-1-benzyl-2-hydroxy-3-[[[(2s)-2-(methoxycarbonylamino)-3,3-dimethyl-butanoyl]amino]-[(4-phenylphenyl)methyl]amino]propyl]carbamoyl]-2,2-dimethyl-propyl]carbamate; Sulfuric Acid;atazanavir Sulfate

66. Methyl N-[(2s)-1-[2-[(2s,3s)-2-hydroxy-3-[[(2s)-2-(methoxycarbonylamino)-3,3-dimethylbutanoyl]amino]-4-phenylbutyl]-2-[(4-pyridin-2-ylphenyl)methyl]hydrazinyl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate;s

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 802.9 g/mol
Molecular Formula C38H54N6O11S
Hydrogen Bond Donor Count7
Hydrogen Bond Acceptor Count13
Rotatable Bond Count18
Exact Mass802.35712773 g/mol
Monoisotopic Mass802.35712773 g/mol
Topological Polar Surface Area254 Ų
Heavy Atom Count56
Formal Charge0
Complexity1190
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 4  
Drug NameAtazanavir sulfate
Drug LabelREYATAZ (atazanavir sulfate) is an azapeptide inhibitor of HIV-1 protease.The chemical name for atazanavir sulfate is (3S,8S,9S,12S)-3,12-Bis(1,1-dimethylethyl)-8-hydroxy-4,11-dioxo-9-(phenylmethyl)-6-[[4-(2-pyridinyl)phenyl]methyl]-2,5,6,10,13-pen...
Active IngredientAtazanavir sulfate
Dosage FormCapsule
Routeoral; Oral
Strength300mg; eq 100mg base; 200mg; eq 200mg base; 100mg; eq 300mg base; 150mg; eq 150mg base
Market StatusTentative Approval; Prescription
CompanyMatrix Labs; Emcure Pharms; Aurobindo Pharma; Teva Pharms Usa; Emcure Pharma

2 of 4  
Drug NameReyataz
PubMed HealthAtazanavir (By mouth)
Drug ClassesAntiretroviral Agent, Antiviral
Drug LabelREYATAZ (atazanavir sulfate) is an azapeptide inhibitor of HIV-1 protease.The chemical name for atazanavir sulfate is (3S,8S,9S,12S)-3,12-Bis(1,1-dimethylethyl)-8-hydroxy-4,11-dioxo-9-(phenylmethyl)-6-[[4-(2-pyridinyl)phenyl]methyl]-2,5,6,10,13-pen...
Active IngredientAtazanavir sulfate
Dosage FormCapsule; Powder
RouteOral
Strengtheq 50mg base/packet; eq 150mg base; eq 200mg base; eq 300mg base
Market StatusPrescription
CompanyBristol Myers Squibb

3 of 4  
Drug NameAtazanavir sulfate
Drug LabelREYATAZ (atazanavir sulfate) is an azapeptide inhibitor of HIV-1 protease.The chemical name for atazanavir sulfate is (3S,8S,9S,12S)-3,12-Bis(1,1-dimethylethyl)-8-hydroxy-4,11-dioxo-9-(phenylmethyl)-6-[[4-(2-pyridinyl)phenyl]methyl]-2,5,6,10,13-pen...
Active IngredientAtazanavir sulfate
Dosage FormCapsule
Routeoral; Oral
Strength300mg; eq 100mg base; 200mg; eq 200mg base; 100mg; eq 300mg base; 150mg; eq 150mg base
Market StatusTentative Approval; Prescription
CompanyMatrix Labs; Emcure Pharms; Aurobindo Pharma; Teva Pharms Usa; Emcure Pharma

4 of 4  
Drug NameReyataz
PubMed HealthAtazanavir (By mouth)
Drug ClassesAntiretroviral Agent, Antiviral
Drug LabelREYATAZ (atazanavir sulfate) is an azapeptide inhibitor of HIV-1 protease.The chemical name for atazanavir sulfate is (3S,8S,9S,12S)-3,12-Bis(1,1-dimethylethyl)-8-hydroxy-4,11-dioxo-9-(phenylmethyl)-6-[[4-(2-pyridinyl)phenyl]methyl]-2,5,6,10,13-pen...
Active IngredientAtazanavir sulfate
Dosage FormCapsule; Powder
RouteOral
Strengtheq 50mg base/packet; eq 150mg base; eq 200mg base; eq 300mg base
Market StatusPrescription
CompanyBristol Myers Squibb

4.2 Drug Indication

Reyataz capsules, co-administered with low dose ritonavir, are indicated for the treatment of HIV-1 infected adults and paediatric patients 6 years of age and older in combination with other antiretroviral medicinal products (see section 4. 2).

Based on available virological and clinical data from adult patients, no benefit is expected in patients with strains resistant to multiple protease inhibitors ( 4 PI mutations).

The choice of Reyataz in treatment experienced adult and paediatric patients should be based on individual viral resistance testing and the patients treatment history (see sections 4. 4 and 5. 1).

Reyataz oral powder, co-administered with low dose ritonavir, is indicated in combination with other antiretroviral medicinal products for the treatment of HIV-1 infected paediatric patients at least 3 months of age and weighing at least 5 kg (see section 4. 2).

Based on available virological and clinical data from adult patients, no benefit is expected in patients with strains resistant to multiple protease inhibitors ( 4 PI mutations). The choice of Reyataz in treatment experienced adult and paediatric patients should be based on individual viral resistance testing and the patients treatment history (see sections 4. 4 and 5. 1).


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

HIV Protease Inhibitors

Inhibitors of HIV PROTEASE, an enzyme required for production of proteins needed for viral assembly. (See all compounds classified as HIV Protease Inhibitors.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Cytochrome P450 3A Inhibitors [MoA]; Cytochrome P450 3A4 Inhibitors [MoA]; HIV Protease Inhibitors [MoA]; Protease Inhibitor [EPC]; UDP Glucuronosyltransferases Inhibitors [MoA]; UGT1A1 Inhibitors [MoA]; Cytochrome P450 2C8 Inhibitors [MoA]
5.3 ATC Code

J05AE08


API Reference Price

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09-Jun-2021
13-Nov-2024
KGS
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DOSAGE - TABLET;ORAL - EQ 300MG BASE;150MG

USFDA APPLICATION NUMBER - 206353

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DOSAGE - CAPSULE;ORAL - EQ 100MG BASE **Feder...DOSAGE - CAPSULE;ORAL - EQ 100MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 21567

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DOSAGE - CAPSULE;ORAL - EQ 150MG BASE **Feder...DOSAGE - CAPSULE;ORAL - EQ 150MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 21567

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DOSAGE - CAPSULE;ORAL - EQ 200MG BASE

USFDA APPLICATION NUMBER - 21567

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DOSAGE - CAPSULE;ORAL - EQ 300MG BASE

USFDA APPLICATION NUMBER - 21567

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ABOUT THIS PAGE

Atazanavir Sulfate Manufacturers

A Atazanavir Sulfate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Atazanavir Sulfate, including repackagers and relabelers. The FDA regulates Atazanavir Sulfate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Atazanavir Sulfate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Atazanavir Sulfate manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Atazanavir Sulfate Suppliers

A Atazanavir Sulfate supplier is an individual or a company that provides Atazanavir Sulfate active pharmaceutical ingredient (API) or Atazanavir Sulfate finished formulations upon request. The Atazanavir Sulfate suppliers may include Atazanavir Sulfate API manufacturers, exporters, distributors and traders.

click here to find a list of Atazanavir Sulfate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Atazanavir Sulfate USDMF

A Atazanavir Sulfate DMF (Drug Master File) is a document detailing the whole manufacturing process of Atazanavir Sulfate active pharmaceutical ingredient (API) in detail. Different forms of Atazanavir Sulfate DMFs exist exist since differing nations have different regulations, such as Atazanavir Sulfate USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Atazanavir Sulfate DMF submitted to regulatory agencies in the US is known as a USDMF. Atazanavir Sulfate USDMF includes data on Atazanavir Sulfate's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Atazanavir Sulfate USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Atazanavir Sulfate suppliers with USDMF on PharmaCompass.

Atazanavir Sulfate KDMF

In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

Pharmaceutical companies submit a Atazanavir Sulfate Drug Master File in Korea (Atazanavir Sulfate KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Atazanavir Sulfate. The MFDS reviews the Atazanavir Sulfate KDMF as part of the drug registration process and uses the information provided in the Atazanavir Sulfate KDMF to evaluate the safety and efficacy of the drug.

After submitting a Atazanavir Sulfate KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Atazanavir Sulfate API can apply through the Korea Drug Master File (KDMF).

click here to find a list of Atazanavir Sulfate suppliers with KDMF on PharmaCompass.

Atazanavir Sulfate CEP

A Atazanavir Sulfate CEP of the European Pharmacopoeia monograph is often referred to as a Atazanavir Sulfate Certificate of Suitability (COS). The purpose of a Atazanavir Sulfate CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Atazanavir Sulfate EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Atazanavir Sulfate to their clients by showing that a Atazanavir Sulfate CEP has been issued for it. The manufacturer submits a Atazanavir Sulfate CEP (COS) as part of the market authorization procedure, and it takes on the role of a Atazanavir Sulfate CEP holder for the record. Additionally, the data presented in the Atazanavir Sulfate CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Atazanavir Sulfate DMF.

A Atazanavir Sulfate CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Atazanavir Sulfate CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Atazanavir Sulfate suppliers with CEP (COS) on PharmaCompass.

Atazanavir Sulfate WC

A Atazanavir Sulfate written confirmation (Atazanavir Sulfate WC) is an official document issued by a regulatory agency to a Atazanavir Sulfate manufacturer, verifying that the manufacturing facility of a Atazanavir Sulfate active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Atazanavir Sulfate APIs or Atazanavir Sulfate finished pharmaceutical products to another nation, regulatory agencies frequently require a Atazanavir Sulfate WC (written confirmation) as part of the regulatory process.

click here to find a list of Atazanavir Sulfate suppliers with Written Confirmation (WC) on PharmaCompass.

Atazanavir Sulfate NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Atazanavir Sulfate as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Atazanavir Sulfate API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Atazanavir Sulfate as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Atazanavir Sulfate and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Atazanavir Sulfate NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Atazanavir Sulfate suppliers with NDC on PharmaCompass.

Atazanavir Sulfate GMP

Atazanavir Sulfate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Atazanavir Sulfate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Atazanavir Sulfate GMP manufacturer or Atazanavir Sulfate GMP API supplier for your needs.

Atazanavir Sulfate CoA

A Atazanavir Sulfate CoA (Certificate of Analysis) is a formal document that attests to Atazanavir Sulfate's compliance with Atazanavir Sulfate specifications and serves as a tool for batch-level quality control.

Atazanavir Sulfate CoA mostly includes findings from lab analyses of a specific batch. For each Atazanavir Sulfate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Atazanavir Sulfate may be tested according to a variety of international standards, such as European Pharmacopoeia (Atazanavir Sulfate EP), Atazanavir Sulfate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Atazanavir Sulfate USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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