Find ATG-017 manufacturers, exporters & distributors on PharmaCompass

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Chemistry

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Also known as: Azd-0364, Azd0364, 2097416-76-5, Vo9kx45qiq, Chembl4482864, (6r)-7-[(3,4-difluorophenyl)methyl]-6-(methoxymethyl)-2-[5-methyl-2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]-5,6-dihydroimidazo[1,2-a]pyrazin-8-one
Molecular Formula
C24H24F2N8O2
Molecular Weight
494.5  g/mol
InChI Key
HVIGNZUDBVLTLU-MRXNPFEDSA-N
FDA UNII
VO9KX45QIQ

ATG-017
Tizaterkib is an orally bioavailable inhibitor of the extracellular signal-regulated kinases 1 (ERK1) and 2 (ERK2), with potential antineoplastic activity. Upon oral administration, tizaterkib specifically targets, binds to and inhibits the activity of the serine/threonine-protein kinases ERK1 and ERK2, thereby preventing the phosphorylation of ERK1/2 substrates and the activation of mitogen-activated protein kinase (MAPK)/ERK-mediated signal transduction pathways. This results in the inhibition of ERK-dependent proliferation and survival of tumor cells. The MAPK/ERK pathway, also known as the RAS/RAF/MEK/ERK pathway, is hyperactivated in a variety of tumor cell types due to mutations in upstream targets. It plays a key role in the proliferation, differentiation and survival of tumor cells.
1 2D Structure

ATG-017

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(6R)-7-[(3,4-difluorophenyl)methyl]-6-(methoxymethyl)-2-[5-methyl-2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]-5,6-dihydroimidazo[1,2-a]pyrazin-8-one
2.1.2 InChI
InChI=1S/C24H24F2N8O2/c1-14-9-27-24(30-20-6-7-28-32(20)2)31-21(14)19-12-33-11-16(13-36-3)34(23(35)22(33)29-19)10-15-4-5-17(25)18(26)8-15/h4-9,12,16H,10-11,13H2,1-3H3,(H,27,30,31)/t16-/m1/s1
2.1.3 InChI Key
HVIGNZUDBVLTLU-MRXNPFEDSA-N
2.1.4 Canonical SMILES
CC1=CN=C(N=C1C2=CN3CC(N(C(=O)C3=N2)CC4=CC(=C(C=C4)F)F)COC)NC5=CC=NN5C
2.1.5 Isomeric SMILES
CC1=CN=C(N=C1C2=CN3C[C@@H](N(C(=O)C3=N2)CC4=CC(=C(C=C4)F)F)COC)NC5=CC=NN5C
2.2 Other Identifiers
2.2.1 UNII
VO9KX45QIQ
2.3 Synonyms
2.3.1 MeSH Synonyms

1. (6r)-7-(3,4-difluorobenzyl)-6-(methoxymethyl)-2-(5-methyl-2-((1-methyl-1h-pyrazol-5-yl)amino)-4-pyrimidinyl)-6,7-dihydroimidazo(1,2-a)pyrazin-8(5h)-one

2. Azd-0364

3. Azd0364

4. Imidazo(1,2-a)pyrazin-8(5h)-one, 7-((3,4-difluorophenyl)methyl)-6,7-dihydro-6-(methoxymethyl)-2-(5-methyl-2-((1-methyl-1h-pyrazol-5-yl)amino)-4-pyrimidinyl)-, (6r)-

2.3.2 Depositor-Supplied Synonyms

1. Azd-0364

2. Azd0364

3. 2097416-76-5

4. Vo9kx45qiq

5. Chembl4482864

6. (6r)-7-[(3,4-difluorophenyl)methyl]-6-(methoxymethyl)-2-[5-methyl-2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]-5,6-dihydroimidazo[1,2-a]pyrazin-8-one

7. (r)-7-(3,4-difluorobenzyl)-6-(methoxymethyl)-2-(5-methyl-2-((1-methyl-1h-pyrazol-5-yl)amino)pyrimidin-4-yl)-6,7-dihydroimidazo[1,2-a]pyrazin-8(5h)-one

8. (6~{r})-7-[[3,4-bis(fluoranyl)phenyl]methyl]-6-(methoxymethyl)-2-[5-methyl-2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]-5,6-dihydroimidazo[1,2-a]pyrazin-8-one

9. (r)-7-(3,4-difluorobenzyl)-6-(methoxymethyl)-2-(5-methyl-2-((1-methyl-1h-pyrazol-5-yl)amino)pyrimidin-4-yl)-6,7-dihydroimidazo(1,2-a)pyrazin-8(5h)-one

10. Tizaterkib [inn]

11. Unii-vo9kx45qiq

12. Schembl18839079

13. Gtpl11674

14. Atg-017

15. Amy14750

16. Azd 0364

17. Bcp29508

18. Ex-a1812

19. Bdbm50505988

20. Mfcd31631580

21. Nsc808790

22. S8708

23. Akos037648851

24. Azd0364; Azd 0364

25. At10135

26. Azd0364 Pound Atg-017 Pound(c)

27. Nsc-808790

28. Ac-36188

29. Ba166426

30. Bs-15828

31. Hy-111483

32. Cs-0042190

33. Q50825500

34. Lhz

2.4 Create Date
2017-08-04
3 Chemical and Physical Properties
Molecular Weight 494.5 g/mol
Molecular Formula C24H24F2N8O2
XLogP32
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count9
Rotatable Bond Count7
Exact Mass494.19902836 g/mol
Monoisotopic Mass494.19902836 g/mol
Topological Polar Surface Area103 Ų
Heavy Atom Count36
Formal Charge0
Complexity768
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

ABOUT THIS PAGE

ATG-017 Manufacturers

A ATG-017 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of ATG-017, including repackagers and relabelers. The FDA regulates ATG-017 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. ATG-017 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

ATG-017 Suppliers

A ATG-017 supplier is an individual or a company that provides ATG-017 active pharmaceutical ingredient (API) or ATG-017 finished formulations upon request. The ATG-017 suppliers may include ATG-017 API manufacturers, exporters, distributors and traders.

ATG-017 GMP

ATG-017 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of ATG-017 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right ATG-017 GMP manufacturer or ATG-017 GMP API supplier for your needs.

ATG-017 CoA

A ATG-017 CoA (Certificate of Analysis) is a formal document that attests to ATG-017's compliance with ATG-017 specifications and serves as a tool for batch-level quality control.

ATG-017 CoA mostly includes findings from lab analyses of a specific batch. For each ATG-017 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

ATG-017 may be tested according to a variety of international standards, such as European Pharmacopoeia (ATG-017 EP), ATG-017 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (ATG-017 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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