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    Chemistry

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    Also known as: Atomoxetine hcl, 82248-59-7, Tomoxetine hydrochloride, Strattera, (r)-tomoxetine hydrochloride, (r)-n-methyl-3-phenyl-3-(o-tolyloxy)propan-1-amine hydrochloride
    Molecular Formula
    C17H22ClNO
    Molecular Weight
    291.8  g/mol
    InChI Key
    LUCXVPAZUDVVBT-UNTBIKODSA-N
    FDA UNII
    57WVB6I2W0
    Atomoxetin Hydrochloride
    A propylamine derivative and selective ADRENERGIC UPTAKE INHIBITOR that is used in the treatment of ATTENTION DEFICIT HYPERACTIVITY DISORDER.
    1 2D Structure

    Atomoxetin Hydrochloride

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (3R)-N-methyl-3-(2-methylphenoxy)-3-phenylpropan-1-amine;hydrochloride
    2.1.2 InChI
    InChI=1S/C17H21NO.ClH/c1-14-8-6-7-11-16(14)19-17(12-13-18-2)15-9-4-3-5-10-15;/h3-11,17-18H,12-13H2,1-2H3;1H/t17-;/m1./s1
    2.1.3 InChI Key
    LUCXVPAZUDVVBT-UNTBIKODSA-N
    2.1.4 Canonical SMILES
    CC1=CC=CC=C1OC(CCNC)C2=CC=CC=C2.Cl
    2.1.5 Isomeric SMILES
    CC1=CC=CC=C1O[C@H](CCNC)C2=CC=CC=C2.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    57WVB6I2W0
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 139603, Ly

    2. Atomoxetine

    3. Atomoxetine Hcl

    4. Hcl, Atomoxetine

    5. Hydrochloride, Atomoxetine

    6. Ly 139603

    7. N-methyl-gamma-(2-methylphenoxy)benzenepropanamine Hydrochloride

    8. Strattera

    9. Tomoxetine

    10. Tomoxetine Hydrochloride, (+)-isomer - T351671

    11. Tomoxetine Hydrochloride, (+-)-isomer

    12. Tomoxetine Hydrochloride, (-)-isomer

    2.3.2 Depositor-Supplied Synonyms

    1. Atomoxetine Hcl

    2. 82248-59-7

    3. Tomoxetine Hydrochloride

    4. Strattera

    5. (r)-tomoxetine Hydrochloride

    6. (r)-n-methyl-3-phenyl-3-(o-tolyloxy)propan-1-amine Hydrochloride

    7. Atomoxetine, Hcl

    8. Atomoxetine Hydrochloride [usan]

    9. (r)-(-)-tomoxetine Hydrochloride

    10. Ly 139603

    11. Atomoxetine (hydrochloride)

    12. Ly-139603

    13. Atomoxetine (as Hydrochloride)

    14. 57wvb6i2w0

    15. (-)-n-methyl-3-phenyl-3-(o-tolyloxy)propylamine Hydrochloride

    16. Chebi:331697

    17. (r)-atomoxetine Hydrochloride

    18. Nsc-759104

    19. Dsstox_cid_24266

    20. Dsstox_rid_80136

    21. Dsstox_gsid_44266

    22. Smr000469177

    23. Cas-82248-59-7

    24. Unii-57wvb6i2w0

    25. (3r)-n-methyl-3-(2-methylphenoxy)-3-phenylpropan-1-amine;hydrochloride

    26. Strattera (tn)

    27. Mfcd06410992

    28. Ncgc00016056-02

    29. Chembl1702

    30. Mls001401377

    31. Mls002153176

    32. Schembl122111

    33. Atomoxetine Hcl [vandf]

    34. Dtxsid2044266

    35. Atomoxetine Hydrochloride- Bio-x

    36. Atomoxetine Hydrochloride Solution

    37. Ly 139603 Hcl

    38. Hms3413c05

    39. Hms3677c05

    40. (r)-n-methyl-3-phenyl-3-(o-tolyloxy)propan-1-aminehydrochloride

    41. (r)-tomoxetine Hydrochloride, Solid

    42. Tox21_110292

    43. Atomoxetine Hydrochloride (jan/usp)

    44. Ly-139602 [(+)-isomer]

    45. S3175

    46. Atomoxetine Hydrochloride [mi]

    47. (3r)-n-methyl-3-(2-methylphenoxy)-3-phenylpropan-1-amine Hydrochloride

    48. Akos015920150

    49. Benzenepropanamine, N-methyl-gamma-(2-methylphenoxy)-, Hydrochloride, (-)-

    50. Tox21_110292_1

    51. Atomoxetine Hydrochloride [jan]

    52. Ccg-100874

    53. Cs-1085

    54. Ks-1223

    55. Nc00124

    56. Nsc 759104

    57. Atomoxetine For Impurity A Identification

    58. Atomoxetine Hydrochloride [mart.]

    59. Ncgc00025345-02

    60. Atomoxetine Hydrochloride [usp-rs]

    61. Atomoxetine Hydrochloride [who-dd]

    62. Bm164222

    63. Hy-17385

    64. Ly-135252

    65. Am20060733

    66. Sw197504-3

    67. Atomoxetine Hydrochloride [ep Monograph]

    68. Atomoxetine Hydrochloride [orange Book]

    69. D02574

    70. Atomoxetine Hydrochloride [usp Monograph]

    71. 248t597

    72. Sr-01000597779

    73. Sr-01000763397

    74. Sr-01000597779-1

    75. Sr-01000763397-3

    76. Q27225729

    77. F0001-2408

    78. Atomoxetine Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)

    79. (r)-n-methyl-?-(2-methylphenoxy)-benzenepropanamine Hydrochloride

    80. (r)-n-methyl-3-(2-methylphenoxy)-3-phenylpropylamine Hydrochloride

    81. (r)-n-methyl-3-phenyl-3-(o-tolyloxy)-propan-1-amine Hydrochloride

    82. (r)-n-methyl-3-phenyl-3-(o-tolyloxy)propan-1-amine Hcl

    83. (r)-(-)-n-methyl-3-(2-methylphenoxy)-3-phenylpropylamine Hydrochloride

    84. (r)-n-methyl-gamma-(2-methylphenoxy)-benzenepropanamine Hydrochloride

    85. Atomoxetine Hydrochloride, European Pharmacopoeia (ep) Reference Standard

    86. Methyl-((r)-3-phenyl-3-o-tolyloxy-propyl)-amine Hydrochloride

    87. Atomoxetine For Impurity A Identification, European Pharmacopoeia (ep) Reference Standard

    88. Atomoxetine Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

    89. Atomoxetine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

    90. Benzenepropanamine, N-methyl-.gamma.-(2-methylphenoxy)-, Hydrochloride, (-)

    91. Atomoxetine Hydrochloride Solution, 1.0 Mg/ml In Methanol (as Free Base), Ampule Of 1 Ml, Certified Reference Material

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 291.8 g/mol
    Molecular Formula C17H22ClNO
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count6
    Exact Mass291.1389920 g/mol
    Monoisotopic Mass291.1389920 g/mol
    Topological Polar Surface Area21.3 Ų
    Heavy Atom Count20
    Formal Charge0
    Complexity237
    Isotope Atom Count0
    Defined Atom Stereocenter Count1
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 4  
    Drug NameAtomoxetine hydrochloride
    Drug LabelSTRATTERA (atomoxetineHCl) is a selective norepinephrine reuptake inhibitor. AtomoxetineHCl is the R(-) isomer as determined by xray diffraction. The chemical designation is (-)-N-Methyl-3-phenyl-3-(o-tolyloxy)-propylamine hydrochloride. The...
    Active IngredientAtomoxetine hydrochloride
    Dosage FormCapsule
    Routeoral
    Strength18mg; 100mg; 25mg; 60mg; 10mg; 80mg; 40mg
    Market StatusTentative Approval
    CompanyMylan Pharms; Glenmark Generics; Aurobindo Pharma Usa; Apotex; Dr Reddys Labs; Sandoz; Sun Pharma Global

    2 of 4  
    Drug NameStrattera
    PubMed HealthAtomoxetine (By mouth)
    Drug ClassesCentral Nervous System Agent
    Drug LabelSTRATTERA (atomoxetineHCl) is a selective norepinephrine reuptake inhibitor. AtomoxetineHCl is the R(-) isomer as determined by x-ray diffraction. The chemical designation is (-)-N-Methyl-3-phenyl-3-(o-tolyloxy)-propylamine hydrochloride. The m...
    Active IngredientAtomoxetine hydrochloride
    Dosage FormCapsule
    RouteOral
    Strength18mg; 25mg; 100mg; 60mg; 10mg; 80mg; 40mg
    Market StatusPrescription
    CompanyLilly

    3 of 4  
    Drug NameAtomoxetine hydrochloride
    Drug LabelSTRATTERA (atomoxetineHCl) is a selective norepinephrine reuptake inhibitor. AtomoxetineHCl is the R(-) isomer as determined by xray diffraction. The chemical designation is (-)-N-Methyl-3-phenyl-3-(o-tolyloxy)-propylamine hydrochloride. The...
    Active IngredientAtomoxetine hydrochloride
    Dosage FormCapsule
    Routeoral
    Strength18mg; 100mg; 25mg; 60mg; 10mg; 80mg; 40mg
    Market StatusTentative Approval
    CompanyMylan Pharms; Glenmark Generics; Aurobindo Pharma Usa; Apotex; Dr Reddys Labs; Sandoz; Sun Pharma Global

    4 of 4  
    Drug NameStrattera
    PubMed HealthAtomoxetine (By mouth)
    Drug ClassesCentral Nervous System Agent
    Drug LabelSTRATTERA (atomoxetineHCl) is a selective norepinephrine reuptake inhibitor. AtomoxetineHCl is the R(-) isomer as determined by x-ray diffraction. The chemical designation is (-)-N-Methyl-3-phenyl-3-(o-tolyloxy)-propylamine hydrochloride. The m...
    Active IngredientAtomoxetine hydrochloride
    Dosage FormCapsule
    RouteOral
    Strength18mg; 25mg; 100mg; 60mg; 10mg; 80mg; 40mg
    Market StatusPrescription
    CompanyLilly

    4.2 Drug Indication

    Treatment of Attention Deficit Hyperactivity Disorder (ADHD)

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Adrenergic Uptake Inhibitors

    Drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants (ANTIDEPRESSIVE AGENTS, TRICYCLIC) and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin. (See all compounds classified as Adrenergic Uptake Inhibitors.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Norepinephrine Uptake Inhibitors [MoA]; Norepinephrine Reuptake Inhibitor [EPC]

    API Reference Price

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    11-Jan-2021
    24-Feb-2025
    KGS
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    USFDA APPLICATION NUMBER - 21411

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    ABOUT THIS PAGE

    Looking for 82248-59-7 / Atomoxetin Hydrochloride API manufacturers, exporters & distributors?

    Atomoxetin Hydrochloride manufacturers, exporters & distributors 1

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    PharmaCompass offers a list of Atomoxetin Hydrochloride API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Atomoxetin Hydrochloride manufacturer or Atomoxetin Hydrochloride supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Atomoxetin Hydrochloride manufacturer or Atomoxetin Hydrochloride supplier.

    PharmaCompass also assists you with knowing the Atomoxetin Hydrochloride API Price utilized in the formulation of products. Atomoxetin Hydrochloride API Price is not always fixed or binding as the Atomoxetin Hydrochloride Price is obtained through a variety of data sources. The Atomoxetin Hydrochloride Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Atomoxetin Hydrochloride

    Synonyms

    Atomoxetine hcl, 82248-59-7, Tomoxetine hydrochloride, Strattera, (r)-tomoxetine hydrochloride, (r)-n-methyl-3-phenyl-3-(o-tolyloxy)propan-1-amine hydrochloride

    Cas Number

    82248-59-7

    Unique Ingredient Identifier (UNII)

    57WVB6I2W0

    About Atomoxetin Hydrochloride

    A propylamine derivative and selective ADRENERGIC UPTAKE INHIBITOR that is used in the treatment of ATTENTION DEFICIT HYPERACTIVITY DISORDER.

    Atomoxetin Hydrochloride Manufacturers

    A Atomoxetin Hydrochloride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Atomoxetin Hydrochloride, including repackagers and relabelers. The FDA regulates Atomoxetin Hydrochloride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Atomoxetin Hydrochloride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Atomoxetin Hydrochloride manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Atomoxetin Hydrochloride Suppliers

    A Atomoxetin Hydrochloride supplier is an individual or a company that provides Atomoxetin Hydrochloride active pharmaceutical ingredient (API) or Atomoxetin Hydrochloride finished formulations upon request. The Atomoxetin Hydrochloride suppliers may include Atomoxetin Hydrochloride API manufacturers, exporters, distributors and traders.

    click here to find a list of Atomoxetin Hydrochloride suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Atomoxetin Hydrochloride USDMF

    A Atomoxetin Hydrochloride DMF (Drug Master File) is a document detailing the whole manufacturing process of Atomoxetin Hydrochloride active pharmaceutical ingredient (API) in detail. Different forms of Atomoxetin Hydrochloride DMFs exist exist since differing nations have different regulations, such as Atomoxetin Hydrochloride USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Atomoxetin Hydrochloride DMF submitted to regulatory agencies in the US is known as a USDMF. Atomoxetin Hydrochloride USDMF includes data on Atomoxetin Hydrochloride's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Atomoxetin Hydrochloride USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Atomoxetin Hydrochloride suppliers with USDMF on PharmaCompass.

    Atomoxetin Hydrochloride JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The Atomoxetin Hydrochloride Drug Master File in Japan (Atomoxetin Hydrochloride JDMF) empowers Atomoxetin Hydrochloride API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the Atomoxetin Hydrochloride JDMF during the approval evaluation for pharmaceutical products. At the time of Atomoxetin Hydrochloride JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of Atomoxetin Hydrochloride suppliers with JDMF on PharmaCompass.

    Atomoxetin Hydrochloride KDMF

    In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

    Pharmaceutical companies submit a Atomoxetin Hydrochloride Drug Master File in Korea (Atomoxetin Hydrochloride KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Atomoxetin Hydrochloride. The MFDS reviews the Atomoxetin Hydrochloride KDMF as part of the drug registration process and uses the information provided in the Atomoxetin Hydrochloride KDMF to evaluate the safety and efficacy of the drug.

    After submitting a Atomoxetin Hydrochloride KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Atomoxetin Hydrochloride API can apply through the Korea Drug Master File (KDMF).

    click here to find a list of Atomoxetin Hydrochloride suppliers with KDMF on PharmaCompass.

    Atomoxetin Hydrochloride CEP

    A Atomoxetin Hydrochloride CEP of the European Pharmacopoeia monograph is often referred to as a Atomoxetin Hydrochloride Certificate of Suitability (COS). The purpose of a Atomoxetin Hydrochloride CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Atomoxetin Hydrochloride EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Atomoxetin Hydrochloride to their clients by showing that a Atomoxetin Hydrochloride CEP has been issued for it. The manufacturer submits a Atomoxetin Hydrochloride CEP (COS) as part of the market authorization procedure, and it takes on the role of a Atomoxetin Hydrochloride CEP holder for the record. Additionally, the data presented in the Atomoxetin Hydrochloride CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Atomoxetin Hydrochloride DMF.

    A Atomoxetin Hydrochloride CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Atomoxetin Hydrochloride CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Atomoxetin Hydrochloride suppliers with CEP (COS) on PharmaCompass.

    Atomoxetin Hydrochloride WC

    A Atomoxetin Hydrochloride written confirmation (Atomoxetin Hydrochloride WC) is an official document issued by a regulatory agency to a Atomoxetin Hydrochloride manufacturer, verifying that the manufacturing facility of a Atomoxetin Hydrochloride active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Atomoxetin Hydrochloride APIs or Atomoxetin Hydrochloride finished pharmaceutical products to another nation, regulatory agencies frequently require a Atomoxetin Hydrochloride WC (written confirmation) as part of the regulatory process.

    click here to find a list of Atomoxetin Hydrochloride suppliers with Written Confirmation (WC) on PharmaCompass.

    Atomoxetin Hydrochloride NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Atomoxetin Hydrochloride as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Atomoxetin Hydrochloride API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Atomoxetin Hydrochloride as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Atomoxetin Hydrochloride and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Atomoxetin Hydrochloride NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Atomoxetin Hydrochloride suppliers with NDC on PharmaCompass.

    Atomoxetin Hydrochloride GMP

    Atomoxetin Hydrochloride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Atomoxetin Hydrochloride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Atomoxetin Hydrochloride GMP manufacturer or Atomoxetin Hydrochloride GMP API supplier for your needs.

    Atomoxetin Hydrochloride CoA

    A Atomoxetin Hydrochloride CoA (Certificate of Analysis) is a formal document that attests to Atomoxetin Hydrochloride's compliance with Atomoxetin Hydrochloride specifications and serves as a tool for batch-level quality control.

    Atomoxetin Hydrochloride CoA mostly includes findings from lab analyses of a specific batch. For each Atomoxetin Hydrochloride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Atomoxetin Hydrochloride may be tested according to a variety of international standards, such as European Pharmacopoeia (Atomoxetin Hydrochloride EP), Atomoxetin Hydrochloride JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Atomoxetin Hydrochloride USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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