Minakem delivers API, HPAPI, steroids & CDMO services for generics with FDA/GMP certification, regulatory know-how & proven success.

Contact Supplier

Ever Pharma, highly specialized CDMO in producing complex injectables including high potency & controlled substances, suspensions, etc.

ACCESS ALL DATA
Browse all information
CHEMISTRY
Discover Molecule Insights

DEVELOPMENTS

7 Drugs in Development

7 Drugs in Development

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

7DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown

Click the button for full data set

Also known as: Crn04894, 2392970-97-5, Chembl5414447, N-[(3s)-1-azabicyclo[2.2.2]octan-3-yl]-6-(2-ethoxyphenyl)-3-[(2r)-2-ethyl-4-[1-(trifluoromethyl)cyclobutanecarbonyl]piperazin-1-yl]pyridine-2-carboxamide, Atumelnant [inn], Nr57fh6u1n

Molecular Formula

C₃₃H₄₂F₃N₅O₃

Molecular Weight

613.7 g/mol

InChI Key

QJRFBKYETDVAJQ-ZEQKJWHPSA-N

FDA UNII

NR57FH6U1N

Atumelnant is an orally bioavailable nonpeptide antagonist of the adrenocorticotropic hormone (ACTH) receptor (ACTHR; melanocortin receptor 2; MC2R), with potential steroid hormone production inhibitory activity. Upon oral administration, atumelnant competes with ACTH for receptor binding to MC2R in the adrenal cortex and inhibits ACTH signaling. This may inhibit the synthesis and secretion of steroid hormones. MC2R, a member of the melanocortin receptor subfamily of type 1 G protein-coupled receptors, plays a key role in adrenal steroidogenesis.

1 2D Structure

Atumelnant

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

N-[(3S)-1-azabicyclo[2.2.2]octan-3-yl]-6-(2-ethoxyphenyl)-3-[(2R)-2-ethyl-4-[1-(trifluoromethyl)cyclobutanecarbonyl]piperazin-1-yl]pyridine-2-carboxamide

2.1.2 InChI

InChI=1S/C33H42F3N5O3/c1-3-23-20-40(31(43)32(14-7-15-32)33(34,35)36)18-19-41(23)27-11-10-25(24-8-5-6-9-28(24)44-4-2)37-29(27)30(42)38-26-21-39-16-12-22(26)13-17-39/h5-6,8-11,22-23,26H,3-4,7,12-21H2,1-2H3,(H,38,42)/t23-,26-/m1/s1

2.1.3 InChI Key

QJRFBKYETDVAJQ-ZEQKJWHPSA-N

2.2 Other Identifiers

2.2.1 UNII

NR57FH6U1N

2.3 Synonyms

2.3.1 Depositor-Supplied Synonyms

1. Crn04894

2. 2392970-97-5

3. Chembl5414447

4. N-[(3s)-1-azabicyclo[2.2.2]octan-3-yl]-6-(2-ethoxyphenyl)-3-[(2r)-2-ethyl-4-[1-(trifluoromethyl)cyclobutanecarbonyl]piperazin-1-yl]pyridine-2-carboxamide

5. Atumelnant [inn]

6. Nr57fh6u1n

7. Schembl21700563

8. Gtpl13339

9. Qjrfbkyetdvajq-zeqkjwhpsa-n

10. Crn-0489

11. Bdbm50623115

12. Crn04894?

13. Ex-a10367

14. At43038

15. Compound 17h [pmid: 38628803]

16. Hy-158081

17. Cs-1038003

18. 2-pyridinecarboxamide, N-(3s)-1-azabicyclo[2.2.2]oct-3-yl-6-(2-ethoxyphenyl)-3-[(2r)-2-ethyl-4-[[1-(trifluoromethyl)cyclobutyl]carbonyl]-1-piperazinyl]-

19. N-(3s)-1-azabicyclo[2.2.2]oct-3-yl-6-(2-ethoxyphenyl)-3-[(2r)-2-ethyl-4-[[1-(trifluoromethyl)cyclobutyl]carbonyl]-1-piperazinyl]-2-pyridinecarboxamide

20. N-[(3s)-1-azabicyclo[2.2.2]octan-3-yl]-6-(2-ethoxyphenyl)-3-{(2r)-2-ethyl-4-[1-(trifluoromethyl)cyclobutane-1-carbonyl]piperazin-1-yl}pyridine-2-carboxamide

2.4 Create Date

2020-06-27

3 Chemical and Physical Properties

Molecular Formula	C₃₃H₄₂F₃N₅O₃
Molecular Weight	613.7 g/mol
XLogP3	5.4
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	8
Exact Mass	Da
Monoisotopic Mass	Da
Topological Polar Surface Area	78
Heavy Atom Count	44
Formal Charge	0
Complexity	1020
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1