Find Avasopasem manganese manufacturers, exporters & distributors on PharmaCompass

PharmaCompass

Synopsis

Related ProductsRelated Products

Synopsis

ACTIVE PHARMA INGREDIENTS

0

API Suppliers

API Suppliers

0

USDMF

US DMFs Filed

0

CEP/COS

CEP/COS Certifications

0

JDMF

JDMFs Filed

0

EU WC

EU WC

0

KDMF

KDMF

0

NDC API

NDC API

0

VMF

NDC API

0

Listed Suppliers

Other Suppliers

0INTERMEDIATES

REF. STANDARDS OR IMPURITIES

0

EDQM

0

USP

0

JP

0

Others

FINISHED DOSAGE FORMULATIONS

0

FDF Dossiers

FDF Dossiers

0

FDA Orange Book

FDA (Orange Book)

0

Europe

Europe

0

Canada

Canada

0

Australia

Australia

0

South Africa

South Africa

0

Listed Dossiers

Listed Dossiers

FDF Dossiers

DRUG PRODUCT COMPOSITIONS

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

PATENTS & EXCLUSIVITIES

0

US Patents

0

US Exclusivities

0

Health Canada Patents

API REF. PRICE (USD/KG)

$
$ 0

GLOBAL SALES INFORMATION

US Medicaid

NA

Annual Reports

NA

Regulatory FDF Prices

NA

API/FDF Prices: Book a Demo to
explore the features and consider
upgrading later

MARKET PLACE

0

API

0

FDF

DIGITAL CONTENT

0

Data Compilation #PharmaFlow

0

Stock Recap #PipelineProspector

0

Weekly News Recap #Phispers

Chemistry

Click the arrow to open the dropdown
read-moreClick the button for full data set
Also known as: Ey1wa413ul, Avasopasem manganese [usan], Gc4419, Sc-72325a, M-40419, Unii-ey1wa413ul
Molecular Formula
C21H35Cl2MnN5
Molecular Weight
483.4  g/mol
InChI Key
WXEMWBBXVXHEPU-NDOCQCNASA-L
FDA UNII
EY1WA413UL

Avasopasem manganese
Avasopasem Manganese is a mimetic of the enzyme superoxide dismutase (SOD) that may potentially be used to reduce oral mucositis and esophagitis associated with radiation therapy and chemoradiotherapy. Upon administration, avasopasem manganese may mimic native SODs and catalyze the formation of molecular oxygen and hydrogen peroxide from the burst of superoxide anion present in the irradiated tissues upon radiation and/or induced by chemotherapy. This may decrease the damage of radiation and/or chemotherapy to normal tissues.
1 2D Structure

Avasopasem manganese

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
manganese(2+);(4S,9S,14S,19S)-3,10,13,20,26-pentazatetracyclo[20.3.1.04,9.014,19]hexacosa-1(26),22,24-triene;dichloride
2.1.2 InChI
InChI=1S/C21H35N5.2ClH.Mn/c1-3-10-20-18(8-1)22-12-13-23-19-9-2-4-11-21(19)25-15-17-7-5-6-16(26-17)14-24-20;;;/h5-7,18-25H,1-4,8-15H2;2*1H;/q;;;+2/p-2/t18-,19-,20-,21-;;;/m0.../s1
2.1.3 InChI Key
WXEMWBBXVXHEPU-NDOCQCNASA-L
2.1.4 Canonical SMILES
C1CCC2C(C1)NCCNC3CCCCC3NCC4=CC=CC(=N4)CN2.[Cl-].[Cl-].[Mn+2]
2.1.5 Isomeric SMILES
C1CC[C@H]2[C@H](C1)NCCN[C@H]3CCCC[C@@H]3NCC4=CC=CC(=N4)CN2.[Cl-].[Cl-].[Mn+2]
2.2 Other Identifiers
2.2.1 UNII
EY1WA413UL
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Avasopasem Manganese

2. Gc4419

2.3.2 Depositor-Supplied Synonyms

1. Ey1wa413ul

2. Avasopasem Manganese [usan]

3. Gc4419

4. Sc-72325a

5. M-40419

6. Unii-ey1wa413ul

7. Avasopasem Manganese Dichloride

8. Avasopasem Manganese [inn]

9. Avasopasem Manganese [who-dd]

10. Gc-4419

11. (pbpy-7-11-2344'3')-dichloro((4as,13as,17as,21as)-1,2,3,4,4a,5,6,12,13,13a,14,15,16,17,17a,18,19,20,21,21a-icosahydro-7,11-azeno-7h-dibenzo(b,h)(1,4,7,10)tetraazacycloheptadecine-.kappa.5n5,n13,n18,n21,n22)manganese

12. Manganese, Dichloro((4as,13as,17as,21as)-1,2,3,4,4a,5,6,12,13,13a,14,15,16,17,17a,18,19,20,21,21a-eicosahydro-7,11-nitrilo-7h-dibenzo(b,h)-5,13,18,21-tetraazacycloheptadecine-.kappa.n5,.kappa.n13,.kappa.n18,.kappa.n21,.kappa.n22)-, (pb-7-11-2344'3')-

2.4 Create Date
2013-07-08
3 Chemical and Physical Properties
Molecular Weight 483.4 g/mol
Molecular Formula C21H35Cl2MnN5
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count7
Rotatable Bond Count0
Exact Mass482.164995 g/mol
Monoisotopic Mass482.164995 g/mol
Topological Polar Surface Area61 Ų
Heavy Atom Count29
Formal Charge0
Complexity381
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count4
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Free Radical Scavengers

Substances that eliminate free radicals. Among other effects, they protect PANCREATIC ISLETS against damage by CYTOKINES and prevent myocardial and pulmonary REPERFUSION INJURY. (See all compounds classified as Free Radical Scavengers.)


4.2 Mechanism of Action

Avasopasem manganese is a superoxide dismutase mimetic that rapidly and selectively converts superoxide to hydrogen peroxide and oxygen in order to protect normal tissue from radiation therapy-induced damage. This drug is currently being investigated against oral mucositis, esophagitis, and COVID-19.


Digital Content read-more

Create Content with PharmaCompass, ask us

NEWS #PharmaBuzz

read-more
read-more

ABOUT THIS PAGE

Looking for 435327-40-5 / Avasopasem manganese API manufacturers, exporters & distributors?

Avasopasem manganese manufacturers, exporters & distributors 1

61

PharmaCompass offers a list of Avasopasem manganese API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Avasopasem manganese manufacturer or Avasopasem manganese supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Avasopasem manganese manufacturer or Avasopasem manganese supplier.

PharmaCompass also assists you with knowing the Avasopasem manganese API Price utilized in the formulation of products. Avasopasem manganese API Price is not always fixed or binding as the Avasopasem manganese Price is obtained through a variety of data sources. The Avasopasem manganese Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Avasopasem manganese

Synonyms

Ey1wa413ul, Avasopasem manganese [usan], Gc4419, Sc-72325a, M-40419, Unii-ey1wa413ul

Cas Number

435327-40-5

Unique Ingredient Identifier (UNII)

EY1WA413UL

About Avasopasem manganese

Avasopasem Manganese is a mimetic of the enzyme superoxide dismutase (SOD) that may potentially be used to reduce oral mucositis and esophagitis associated with radiation therapy and chemoradiotherapy. Upon administration, avasopasem manganese may mimic native SODs and catalyze the formation of molecular oxygen and hydrogen peroxide from the burst of superoxide anion present in the irradiated tissues upon radiation and/or induced by chemotherapy. This may decrease the damage of radiation and/or chemotherapy to normal tissues.

Avasopasem manganese Manufacturers

A Avasopasem manganese manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Avasopasem manganese, including repackagers and relabelers. The FDA regulates Avasopasem manganese manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Avasopasem manganese API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Avasopasem manganese Suppliers

A Avasopasem manganese supplier is an individual or a company that provides Avasopasem manganese active pharmaceutical ingredient (API) or Avasopasem manganese finished formulations upon request. The Avasopasem manganese suppliers may include Avasopasem manganese API manufacturers, exporters, distributors and traders.

Avasopasem manganese GMP

Avasopasem manganese Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Avasopasem manganese GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Avasopasem manganese GMP manufacturer or Avasopasem manganese GMP API supplier for your needs.

Avasopasem manganese CoA

A Avasopasem manganese CoA (Certificate of Analysis) is a formal document that attests to Avasopasem manganese's compliance with Avasopasem manganese specifications and serves as a tool for batch-level quality control.

Avasopasem manganese CoA mostly includes findings from lab analyses of a specific batch. For each Avasopasem manganese CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Avasopasem manganese may be tested according to a variety of international standards, such as European Pharmacopoeia (Avasopasem manganese EP), Avasopasem manganese JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Avasopasem manganese USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
Ask Us for Pharmaceutical Supplier and Partner
Ask Us, Find A Supplier / Partner
No Commissions, No Strings Attached, Get Connected for FREE

What are you looking for?

How can we help you?

The request can't be empty

Please read our Privacy Policy carefully

You must agree to the privacy policy

The name can't be empty
The company can't be empty.
The email can't be empty Please enter a valid email.
The mobile can't be empty