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    Also known as: 5714-73-8, Hiprex, Hexamine hippurate, Hexamethylenetetramine monohippurate, Hexamethylenetetramine hippurate, 1,3,5,7-tetraazaadamantane benzoylglycinate
    Molecular Formula
    C15H21N5O3
    Molecular Weight
    319.36  g/mol
    InChI Key
    ROAIXOJGRFKICW-UHFFFAOYSA-N
    FDA UNII
    M329791L57
    Methenamine Hippurate
    Methenamine Hippurate is the hippurate salt form of methenamine, a prodrug and inactive weak base that slowly hydrolyzes in acidic urine to ammonia and the effective, urinary tract antiseptic formaldehyde. Formaldehyde probably exerts its antibacterial effect by denaturation of protein. Depending on the urinary concentrations, formaldehyde is either bactericidal or bacteriostatic. Formaldehyde urinary concentrations are dependent on urine pH, volume, and flow rate. Formaldehyde acts as an antibacterial agent against gram-positive and gram-negative organisms.
    1 2D Structure

    Methenamine Hippurate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-benzamidoacetic acid;1,3,5,7-tetrazatricyclo[3.3.1.13,7]decane
    2.1.2 InChI
    InChI=1S/C9H9NO3.C6H12N4/c11-8(12)6-10-9(13)7-4-2-1-3-5-7;1-7-2-9-4-8(1)5-10(3-7)6-9/h1-5H,6H2,(H,10,13)(H,11,12);1-6H2
    2.1.3 InChI Key
    ROAIXOJGRFKICW-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1N2CN3CN1CN(C2)C3.C1=CC=C(C=C1)C(=O)NCC(=O)O
    2.2 Other Identifiers
    2.2.1 UNII
    M329791L57
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Hexamine Hippurate

    2. Hip-rex

    3. Hiprex

    4. Urex

    5. Urotractan

    2.3.2 Depositor-Supplied Synonyms

    1. 5714-73-8

    2. Hiprex

    3. Hexamine Hippurate

    4. Hexamethylenetetramine Monohippurate

    5. Hexamethylenetetramine Hippurate

    6. 1,3,5,7-tetraazaadamantane Benzoylglycinate

    7. Methenamine (hippurate)

    8. Hippramine

    9. Haiprex

    10. Viapta

    11. 2-benzamidoacetic Acid;1,3,5,7-tetrazatricyclo[3.3.1.13,7]decane

    12. M329791l57

    13. Glycine, N-benzoyl, Compd. With 1,3,5,7-tetraazatricyclo(3.3.1.1(sup 3,7))decane (1:1)

    14. Hexamethylenetetramine Monohippurate;hexamethylenetetramine Monohippurate

    15. Methenamine Hippurate [usan]

    16. R-657

    17. Einecs 227-206-5

    18. Hexamethylene Tetramine Hippurate

    19. Unii-m329791l57

    20. Hiprex (tn)

    21. Urex (tn)

    22. Hippuric Acid, Compd. With Hexamethylenetetramine (1:1)

    23. Methenamine Hippurate [usan:usp:inn:ban]

    24. Schembl3029

    25. Chebi:6825

    26. Chembl1201104

    27. Dtxsid10972603

    28. Methenamine Hippurate (jan/usp)

    29. Methenamine Hippurate [jan]

    30. Hy-b1691

    31. Methenamine Hippurate [vandf]

    32. Mfcd00072147

    33. S9466

    34. Methenamine Hippurate [mart.]

    35. Akos037645132

    36. Methenamine Hippurate [usp-rs]

    37. Methenamine Hippurate [who-dd]

    38. N-benzoylglycine, Compound With 1,3,5,7-tetraazatricyclo(3.3.1.13,7)decane (1:1)

    39. Methenamine Hippurate (200 Mg)

    40. As-57463

    41. Methenamine Hippurate [orange Book]

    42. Methenamine Hippurate [usp Impurity]

    43. Cs-0013675

    44. Ft-0671059

    45. Methenamine Hippurate [usp Monograph]

    46. D00855

    47. D81437

    48. 714m738

    49. Q27283414

    50. 1,3,5,7-tetraazatricyclo[3.3.1.1(3),?]decane; 2-(phenylformamido)acetic Acid

    51. N-[hydroxy(phenyl)methylidene]glycine--1,3,5,7-tetraazatricyclo[3.3.1.1~3,7~]decane (1/1)

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 319.36 g/mol
    Molecular Formula C15H21N5O3
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count7
    Rotatable Bond Count3
    Exact Mass319.16443955 g/mol
    Monoisotopic Mass319.16443955 g/mol
    Topological Polar Surface Area79.4 Ų
    Heavy Atom Count23
    Formal Charge0
    Complexity282
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 4  
    Drug NameHiprex
    Drug LabelEach yellow capsule-shaped tablet contains 1 g Methenamine Hippurate which is the Hippuric Acid Salt of Methenamine (hexamethylene tetramine). The tablet also contains inactive ingredients. FD&C Yellow No. 5 (tartrazine, see PRECAUTIONS), Magnesium S.
    Active IngredientMethenamine hippurate
    Dosage FormTablet
    RouteOral
    Strength1gm
    Market StatusPrescription
    CompanySanofi Aventis Us

    2 of 4  
    Drug NameMethenamine hippurate
    PubMed HealthMethenamine (By mouth)
    Drug ClassesAntiseptic
    Drug LabelMethenamine Hippurate Tablets are a urinary tract antiseptic drug. Each white, scored tablet contains methenamine hippurate 1g (see HOW SUPPLIED). Methenamine Hippurate Tablets also contain: magnesium stearate, povidone and saccharin sodium. Chemical...
    Active IngredientMethenamine hippurate
    Dosage FormTablet
    RouteOral
    Strength1gm
    Market StatusPrescription
    CompanyCorepharma

    3 of 4  
    Drug NameHiprex
    Drug LabelEach yellow capsule-shaped tablet contains 1 g Methenamine Hippurate which is the Hippuric Acid Salt of Methenamine (hexamethylene tetramine). The tablet also contains inactive ingredients. FD&C Yellow No. 5 (tartrazine, see PRECAUTIONS), Magnesium S.
    Active IngredientMethenamine hippurate
    Dosage FormTablet
    RouteOral
    Strength1gm
    Market StatusPrescription
    CompanySanofi Aventis Us

    4 of 4  
    Drug NameMethenamine hippurate
    PubMed HealthMethenamine (By mouth)
    Drug ClassesAntiseptic
    Drug LabelMethenamine Hippurate Tablets are a urinary tract antiseptic drug. Each white, scored tablet contains methenamine hippurate 1g (see HOW SUPPLIED). Methenamine Hippurate Tablets also contain: magnesium stearate, povidone and saccharin sodium. Chemical...
    Active IngredientMethenamine hippurate
    Dosage FormTablet
    RouteOral
    Strength1gm
    Market StatusPrescription
    CompanyCorepharma

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Anti-Bacterial Agents

    Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

    Anti-Infective Agents, Urinary

    Substances capable of killing agents causing urinary tract infections or of preventing them from spreading. (See all compounds classified as Anti-Infective Agents, Urinary.)

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    04-Feb-2021
    05-Sep-2024
    KGS
    overview
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    Average Price (USD/KGS)

    Number of Transactions

    Total Quantity (KGS)

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    Quantity (KGS) & Unit rate (USD/KGS) over time

    API Imports and Exports

    Importing Country Total Quantity
    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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    ABOUT THIS PAGE

    Aventis Behring brand of methenamine hippurate Manufacturers

    A Aventis Behring brand of methenamine hippurate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Aventis Behring brand of methenamine hippurate, including repackagers and relabelers. The FDA regulates Aventis Behring brand of methenamine hippurate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Aventis Behring brand of methenamine hippurate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Aventis Behring brand of methenamine hippurate manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Aventis Behring brand of methenamine hippurate Suppliers

    A Aventis Behring brand of methenamine hippurate supplier is an individual or a company that provides Aventis Behring brand of methenamine hippurate active pharmaceutical ingredient (API) or Aventis Behring brand of methenamine hippurate finished formulations upon request. The Aventis Behring brand of methenamine hippurate suppliers may include Aventis Behring brand of methenamine hippurate API manufacturers, exporters, distributors and traders.

    click here to find a list of Aventis Behring brand of methenamine hippurate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Aventis Behring brand of methenamine hippurate USDMF

    A Aventis Behring brand of methenamine hippurate DMF (Drug Master File) is a document detailing the whole manufacturing process of Aventis Behring brand of methenamine hippurate active pharmaceutical ingredient (API) in detail. Different forms of Aventis Behring brand of methenamine hippurate DMFs exist exist since differing nations have different regulations, such as Aventis Behring brand of methenamine hippurate USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Aventis Behring brand of methenamine hippurate DMF submitted to regulatory agencies in the US is known as a USDMF. Aventis Behring brand of methenamine hippurate USDMF includes data on Aventis Behring brand of methenamine hippurate's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Aventis Behring brand of methenamine hippurate USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Aventis Behring brand of methenamine hippurate suppliers with USDMF on PharmaCompass.

    Aventis Behring brand of methenamine hippurate WC

    A Aventis Behring brand of methenamine hippurate written confirmation (Aventis Behring brand of methenamine hippurate WC) is an official document issued by a regulatory agency to a Aventis Behring brand of methenamine hippurate manufacturer, verifying that the manufacturing facility of a Aventis Behring brand of methenamine hippurate active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Aventis Behring brand of methenamine hippurate APIs or Aventis Behring brand of methenamine hippurate finished pharmaceutical products to another nation, regulatory agencies frequently require a Aventis Behring brand of methenamine hippurate WC (written confirmation) as part of the regulatory process.

    click here to find a list of Aventis Behring brand of methenamine hippurate suppliers with Written Confirmation (WC) on PharmaCompass.

    Aventis Behring brand of methenamine hippurate NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Aventis Behring brand of methenamine hippurate as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Aventis Behring brand of methenamine hippurate API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Aventis Behring brand of methenamine hippurate as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Aventis Behring brand of methenamine hippurate and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Aventis Behring brand of methenamine hippurate NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Aventis Behring brand of methenamine hippurate suppliers with NDC on PharmaCompass.

    Aventis Behring brand of methenamine hippurate GMP

    Aventis Behring brand of methenamine hippurate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Aventis Behring brand of methenamine hippurate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Aventis Behring brand of methenamine hippurate GMP manufacturer or Aventis Behring brand of methenamine hippurate GMP API supplier for your needs.

    Aventis Behring brand of methenamine hippurate CoA

    A Aventis Behring brand of methenamine hippurate CoA (Certificate of Analysis) is a formal document that attests to Aventis Behring brand of methenamine hippurate's compliance with Aventis Behring brand of methenamine hippurate specifications and serves as a tool for batch-level quality control.

    Aventis Behring brand of methenamine hippurate CoA mostly includes findings from lab analyses of a specific batch. For each Aventis Behring brand of methenamine hippurate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Aventis Behring brand of methenamine hippurate may be tested according to a variety of international standards, such as European Pharmacopoeia (Aventis Behring brand of methenamine hippurate EP), Aventis Behring brand of methenamine hippurate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Aventis Behring brand of methenamine hippurate USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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