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1. Nxl 104
2. Nxl-104
3. Nxl104
1. 1192500-31-4
2. Avibactam Free Acid
3. Nxl104
4. Ave-1330a Free Acid
5. Avibactam (free Acid)
6. Nxl-104 Free Acid
7. Chembl1689063
8. Chebi:85984
9. 06mfo7817i
10. [(2s,5r)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl] Hydrogen Sulfate
11. 396731-14-9
12. (2s,5r)-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide
13. 1,6-diazabicyclo(3.2.1)octane-2-carboxamide, 7-oxo-6-(sulfooxy)-, (1r,2s,5r)-rel-
14. (1r,2s,5r)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl Hydrogen Sulfate
15. Avibactam [inn]
16. Avibactam [usan:inn]
17. Unii-06mfo7817i
18. Avibactamfreeacid
19. Sulfuric Acid, Mono((1r,2s,5r)-2-(aminocarbonyl)-7-oxo-1,6-diazabicyclo(3.2.1)oct-6-yl) Ester
20. Sulfuric Acid, Mono[(1r,2s,5r)-2-(aminocarbonyl)-7-oxo-1,6-diazabicyclo[3.2.1]oct-6-yl] Ester
21. Unii-7352665165
22. Avibactam [mi]
23. Avibactam [usan]
24. Avibactam [who-dd]
25. Schembl1666807
26. Avibactam, (+/-)-
27. Gtpl10761
28. Dtxsid901026066
29. Amy24028
30. Avi
31. Zavicefta Component Avibactam
32. Zinc9302239
33. Bdbm50339145
34. Avibactam Component Of Zavicefta
35. Cs-0593
36. Db09060
37. Ac-35749
38. Hy-14879
39. E80372
40. Q15410251
41. Trans-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octan-2-carboxamide
42. (1r,2s,5r)-7-oxo-6-sulfooxy-1,6-diazabicyclo(3.2.1)octane-2-carboxamide
43. 794508-22-8
| Molecular Weight | 265.25 g/mol |
|---|---|
| Molecular Formula | C7H11N3O6S |
| XLogP3 | -1.8 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 3 |
| Exact Mass | 265.03685625 g/mol |
| Monoisotopic Mass | 265.03685625 g/mol |
| Topological Polar Surface Area | 139 Ų |
| Heavy Atom Count | 17 |
| Formal Charge | 0 |
| Complexity | 457 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 2 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
AVYCAZ (ceftazidime-avibactam), in combination with metronidazole, is indicated for the treatment of complicated intra-abdominal infections caused by the following susceptible microorganisms: Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Providencia stuartii, Enterobacter cloacae, Klebsiella oxytoca, and Pseudomonas aeruginosa in patients 18 years or older. AVYCAZ is also indicated for the treatment of complicated urinary tract infections including pyelonephritis caused by the following susceptible microorganisms: Escherichia coli, Klebsiella pneumoniae, Citrobacter koseri, Enterobacter aerogenes, Enterobacter cloacae, Citrobacter freundii, Proteus spp., and Pseudomonas aeruginosa in patients 18 years or older.
FDA Label
beta-Lactamase Inhibitors
Endogenous substances and drugs that inhibit or block the activity of BETA-LACTAMASES. (See all compounds classified as beta-Lactamase Inhibitors.)
Route of Elimination
Avibactam and ceftazidime are excreted mainly by the kidneys.
Volume of Distribution
The steady state volumes of distribution of avibactam and ceftazidime is 22.2L and 17L respectively.
Clearance
Avibactam and ceftazidime has a clearance of ~12L/h and ~7L/h respectively.
No metabolism of avibactam was observed in human liver preparations. Unchanged avibactam is the major drug-related component in human plasma and urine. 80-90% of ceftazidime is eliminated as unchanged .
Ceftazidime-avibactam has a half life of ~2.7-3.0 hours.
Avibactam is a non- lactam -lactamase inhibitor that inactivates some -lactamases (Ambler class A -lactamases, including Klebsiella pneumoniae carbapenemases, Ambler class C and some Ambler class D -lactamases) by a unique covalent and reversible mechanism, and protects ceftazidime from degradation by certain -lactamases. Avibactam rapidly reaches the periplasm of bacteria at high enough concentrations to restore activity of ceftazidime against ceftazidime-resistant, -lactamase-producing strains. Avibactam does not decrease the activity of ceftazidime against ceftazidime susceptible organisms.
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ABOUT THIS PAGE
A Avibactam manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Avibactam, including repackagers and relabelers. The FDA regulates Avibactam manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Avibactam API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.
click here to find a list of Avibactam manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.
A Avibactam supplier is an individual or a company that provides Avibactam active pharmaceutical ingredient (API) or Avibactam finished formulations upon request. The Avibactam suppliers may include Avibactam API manufacturers, exporters, distributors and traders.
click here to find a list of Avibactam suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.
Avibactam Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.
GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).
PharmaCompass offers a list of Avibactam GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Avibactam GMP manufacturer or Avibactam GMP API supplier for your needs.
A Avibactam CoA (Certificate of Analysis) is a formal document that attests to Avibactam's compliance with Avibactam specifications and serves as a tool for batch-level quality control.
Avibactam CoA mostly includes findings from lab analyses of a specific batch. For each Avibactam CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.
Avibactam may be tested according to a variety of international standards, such as European Pharmacopoeia (Avibactam EP), Avibactam JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Avibactam USP).
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