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Synopsis

ACTIVE PHARMA INGREDIENTS

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USDMF

US DMFs Filed

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CEP/COS

CEP/COS Certifications

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JDMF

JDMFs Filed

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EU WC

EU WC

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KDMF

KDMF

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NDC API

NDC API

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VMF

NDC API

API REF. PRICE (USD/KG)

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Chemistry

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Also known as: 1192500-31-4, Avibactam free acid, Nxl104, Ave-1330a free acid, Avibactam (free acid), Nxl-104 free acid
Molecular Formula
C7H11N3O6S
Molecular Weight
265.25  g/mol
InChI Key
NDCUAPJVLWFHHB-UHNVWZDZSA-N
FDA UNII
06MFO7817I

Avibactam
Avibactam is a non--lactam -lactamase inhibitor that is available in combination with ceftazidime (Avycaz). This combination was approved by the FDA on February 25, 2015 for the treatment of complicated intra-abdominal infections in combination with metronidazole, and the treatment of complicated urinary tract infections, including pyelonephritis caused by antibiotic resistant-pathogens, including those caused by multi-drug resistant gram-negative bacterial pathogens. As there is limited clinical safety and efficacy data, Avycaz should be reserved for patients over 18 years old who have limited or not alternative treatment options.
Avibactam is a beta Lactamase Inhibitor. The mechanism of action of avibactam is as a beta Lactamase Inhibitor.
1 2D Structure

Avibactam

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
[(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl] hydrogen sulfate
2.1.2 InChI
InChI=1S/C7H11N3O6S/c8-6(11)5-2-1-4-3-9(5)7(12)10(4)16-17(13,14)15/h4-5H,1-3H2,(H2,8,11)(H,13,14,15)/t4-,5+/m1/s1
2.1.3 InChI Key
NDCUAPJVLWFHHB-UHNVWZDZSA-N
2.1.4 Canonical SMILES
C1CC(N2CC1N(C2=O)OS(=O)(=O)O)C(=O)N
2.1.5 Isomeric SMILES
C1C[C@H](N2C[C@@H]1N(C2=O)OS(=O)(=O)O)C(=O)N
2.2 Other Identifiers
2.2.1 UNII
06MFO7817I
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Nxl 104

2. Nxl-104

3. Nxl104

2.3.2 Depositor-Supplied Synonyms

1. 1192500-31-4

2. Avibactam Free Acid

3. Nxl104

4. Ave-1330a Free Acid

5. Avibactam (free Acid)

6. Nxl-104 Free Acid

7. Chembl1689063

8. Chebi:85984

9. 06mfo7817i

10. [(2s,5r)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl] Hydrogen Sulfate

11. 396731-14-9

12. (2s,5r)-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide

13. 1,6-diazabicyclo(3.2.1)octane-2-carboxamide, 7-oxo-6-(sulfooxy)-, (1r,2s,5r)-rel-

14. (1r,2s,5r)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl Hydrogen Sulfate

15. Avibactam [inn]

16. Avibactam [usan:inn]

17. Unii-06mfo7817i

18. Avibactamfreeacid

19. Sulfuric Acid, Mono((1r,2s,5r)-2-(aminocarbonyl)-7-oxo-1,6-diazabicyclo(3.2.1)oct-6-yl) Ester

20. Sulfuric Acid, Mono[(1r,2s,5r)-2-(aminocarbonyl)-7-oxo-1,6-diazabicyclo[3.2.1]oct-6-yl] Ester

21. Unii-7352665165

22. Avibactam [mi]

23. Avibactam [usan]

24. Avibactam [who-dd]

25. Schembl1666807

26. Avibactam, (+/-)-

27. Gtpl10761

28. Dtxsid901026066

29. Amy24028

30. Avi

31. Zavicefta Component Avibactam

32. Zinc9302239

33. Bdbm50339145

34. Avibactam Component Of Zavicefta

35. Cs-0593

36. Db09060

37. Ac-35749

38. Hy-14879

39. E80372

40. Q15410251

41. Trans-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octan-2-carboxamide

42. (1r,2s,5r)-7-oxo-6-sulfooxy-1,6-diazabicyclo(3.2.1)octane-2-carboxamide

43. 794508-22-8

2.4 Create Date
2006-10-25
3 Chemical and Physical Properties
Molecular Weight 265.25 g/mol
Molecular Formula C7H11N3O6S
XLogP3-1.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Exact Mass265.03685625 g/mol
Monoisotopic Mass265.03685625 g/mol
Topological Polar Surface Area139 Ų
Heavy Atom Count17
Formal Charge0
Complexity457
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

AVYCAZ (ceftazidime-avibactam), in combination with metronidazole, is indicated for the treatment of complicated intra-abdominal infections caused by the following susceptible microorganisms: Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Providencia stuartii, Enterobacter cloacae, Klebsiella oxytoca, and Pseudomonas aeruginosa in patients 18 years or older. AVYCAZ is also indicated for the treatment of complicated urinary tract infections including pyelonephritis caused by the following susceptible microorganisms: Escherichia coli, Klebsiella pneumoniae, Citrobacter koseri, Enterobacter aerogenes, Enterobacter cloacae, Citrobacter freundii, Proteus spp., and Pseudomonas aeruginosa in patients 18 years or older.


FDA Label


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

beta-Lactamase Inhibitors

Endogenous substances and drugs that inhibit or block the activity of BETA-LACTAMASES. (See all compounds classified as beta-Lactamase Inhibitors.)


5.2 FDA Pharmacological Classification
5.2.1 Active Moiety
AVIBACTAM
5.2.2 FDA UNII
7352665165
5.2.3 Pharmacological Classes
Mechanisms of Action [MoA] - beta Lactamase Inhibitors
5.3 Absorption, Distribution and Excretion

Route of Elimination

Avibactam and ceftazidime are excreted mainly by the kidneys.


Volume of Distribution

The steady state volumes of distribution of avibactam and ceftazidime is 22.2L and 17L respectively.


Clearance

Avibactam and ceftazidime has a clearance of ~12L/h and ~7L/h respectively.


5.4 Metabolism/Metabolites

No metabolism of avibactam was observed in human liver preparations. Unchanged avibactam is the major drug-related component in human plasma and urine. 80-90% of ceftazidime is eliminated as unchanged .


5.5 Biological Half-Life

Ceftazidime-avibactam has a half life of ~2.7-3.0 hours.


5.6 Mechanism of Action

Avibactam is a non- lactam -lactamase inhibitor that inactivates some -lactamases (Ambler class A -lactamases, including Klebsiella pneumoniae carbapenemases, Ambler class C and some Ambler class D -lactamases) by a unique covalent and reversible mechanism, and protects ceftazidime from degradation by certain -lactamases. Avibactam rapidly reaches the periplasm of bacteria at high enough concentrations to restore activity of ceftazidime against ceftazidime-resistant, -lactamase-producing strains. Avibactam does not decrease the activity of ceftazidime against ceftazidime susceptible organisms.


API SUPPLIERS

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01

Tecoland Corporation

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Medlab Asia & Asia Health
Not Confirmed
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02

Jing Jing Pharmaceutical

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Medlab Asia & Asia Health
Not Confirmed
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03

Shenzhen Haorui

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Medlab Asia & Asia Health
Not Confirmed
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04

Zhejiang Hisoar Pharmaceutical

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Medlab Asia & Asia Health
Not Confirmed
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Zhejiang Hisoar Pharmaceutical

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Medlab Asia & Asia Health
Not Confirmed
USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT
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Listed Suppliers

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01

Medlab Asia & Asia Health
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Medlab Asia & Asia Health
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Avibactam

About the Company : Jing Jing Pharmaceutical Co., Ltd., founded in October 2007, covers an area of 200 mu, registered capital of 257.28 million yuan, and employees of more than 700 people, is a high-t...

Jing Jing Pharmaceutical Co., Ltd., founded in October 2007, covers an area of 200 mu, registered capital of 257.28 million yuan, and employees of more than 700 people, is a high-tech enterprise specializing in the R&D, production, and marketing of sterile raw materials, amino acids, and vitamin nutrition fortifiers. The company's technical team has obtained more than 40 patents and 7 new product and new technology appraisals. The company has formed two series of products: one is sterile API products with crystallization technology; the other is an amino acid and vitamin series product with biological enzyme catalysis technology.
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02

Medlab Asia & Asia Health
Not Confirmed
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Medlab Asia & Asia Health
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Avibactam

About the Company : Haorui, established in 1997, is a manufacturer and supplier of APIs, intermediates, veterinary and food additives. Meanwhile, it is assisting global pharmaceutical companies to get...

Haorui, established in 1997, is a manufacturer and supplier of APIs, intermediates, veterinary and food additives. Meanwhile, it is assisting global pharmaceutical companies to get the domestic registration of their finished dosage for their international expansion. Our USFDA approved products Flumazenil, Granisetron HCl, Granisetron Base, Docetaxel Anhydrous, Irinotecan HCl, Dasatinib Monohydrate, Oxaliplatin and Temozolomide have been recognized by our customers globally. In addition, our Amisulpride API acquired CEP, UK GMP & USDMF.
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03

Medlab Asia & Asia Health
Not Confirmed
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Medlab Asia & Asia Health
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Avibactam

About the Company : Established in 2002, Tecoland represents selected cGMP manufacturers with proven capabilities in organic synthesis, fermentation production as well as process and method developmen...

Established in 2002, Tecoland represents selected cGMP manufacturers with proven capabilities in organic synthesis, fermentation production as well as process and method development. Tecoland provides high quality APIs to the pharmaceutical industry, with reliable technical and regulatory support such as USDMF, CEP, EDMF that are critical to the speedy approval of our customers’ regulatory filings.
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04

Medlab Asia & Asia Health
Not Confirmed
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Medlab Asia & Asia Health
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Avibactam

About the Company : Zhejiang Hisoar Pharmaceutical Co., Ltd. is located in Taizhou, Zhejiang. It is an IPO-listed company held by the DanKong Group, which mainly manufactures APIs, Formulations, Fine ...

Zhejiang Hisoar Pharmaceutical Co., Ltd. is located in Taizhou, Zhejiang. It is an IPO-listed company held by the DanKong Group, which mainly manufactures APIs, Formulations, Fine Chemicals, Dyestuffs, and Dyestuff Intermediates. It is one of the top 100 innovative companies in the national pharmaceutical industry. The main product categories are antibiotics, cardiovascular, hypoglycemic, and others, fine chemicals, formulations, dyes, and intermediates. More than 70% of pharmaceutical products are exported, in which Clindamycin series production is in the leading position worldwide.
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API Reference Price

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CHINA CHINA","customerAddress":"PLOT NO.B3,B4&B5 PT SIPCOT,INDUSTR"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1715711400,"product":"AVIBACTAM TETRABUTYLAMMONIUM SALT","address":"PLOT NO.2516 2518,","city":"DIST: VALSAD\/GUJARAT","supplier":"JINAN U-KING PHARMACHEM CO.,LTD","supplierCountry":"CHINA","foreign_port":"BEIJING","customer":"ARIHANTANAM LIFECARE PRIVATE LIMITED","customerCountry":"INDIA","quantity":"20.00","actualQuantity":"20","unit":"KGS","unitRateFc":"1415","totalValueFC":"28638.1","currency":"USD","unitRateINR":"119355.3","date":"15-May-2024","totalValueINR":"2387105","totalValueInUsd":"28638.1","indian_port":"Bombay Air","hs_no":"29241900","bill_no":"3487275","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BEIJING","supplierAddress":"ZHENHAI MARKET OF BEIKANG ERZHUANGSHIZHONG DISTRICTJINAN CITY CHINA","customerAddress":"PLOT NO.2516 2518,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1723833000,"product":"AVIBACTAM TETRABUTYLAMMONIUM SALT","address":"PLOT NO.2516 2518,","city":"DIST: VALSAD\/GUJARAT","supplier":"U-KEY PHARMACHEM CO.,LTD","supplierCountry":"CHINA","foreign_port":"BEIJING","customer":"ARIHANTANAM LIFECARE PRIVATE LIMITED","customerCountry":"INDIA","quantity":"35.00","actualQuantity":"35","unit":"KGS","unitRateFc":"1015","totalValueFC":"35936.4","currency":"USD","unitRateINR":"86122.8","date":"17-Aug-2024","totalValueINR":"3014296.25","totalValueInUsd":"35936.4","indian_port":"Bombay Air","hs_no":"29241900","bill_no":"5098257","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BEIJING","supplierAddress":"CHASE BUSINESS CENTER 39-41CHASE SIDE LONDONUNITED KINDOM N14 5BP UNITED KINGDOM","customerAddress":"PLOT NO.2516 2518,"}]
07-Jun-2023
17-Aug-2024
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